chlorambucil has been researched along with Experimental Neoplasms in 65 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A set of 23 aniline mustards [X-C6H4N(CH2CH2Cl)2] have been tested for their activity against B-16 melanoma in mice." | 7.66 | Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. ( Hansch, C; Leo, A; Panthananickal, A, 1979) |
| "A cell-surface localizing xenogeneic antibody against an AKR mouse lymphoma of spontaneous origin could be bound to chlorambucil without interference with either the alkylating activity of chlorambucil or the immunologic reactivity of the antibody." | 7.65 | Suppression of an AKR lymphoma by antibody and chlorambucil. ( Ghose, T; Guclu, A; Tai, J, 1975) |
| "In order to study the role of the steroidal moiety on the expression of anti-leukemic activity, we synthesized six derivatives of chlorambucil (CHL), and tested them on leukemias P388 and L1210 in vivo and in normal human lymphocytes in vitro." | 3.73 | Structure-anti-leukemic activity relationship study of B- and D-ring modified and non-modified steroidal esters of chlorambucil. ( Arsenou, ES; Fousteris, MA; Koutsourea, AI; Mourelatos, D; Nikolaropoulos, SS; Papageorgiou, A, 2006) |
| "A set of 23 aniline mustards [X-C6H4N(CH2CH2Cl)2] have been tested for their activity against B-16 melanoma in mice." | 3.66 | Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice. ( Hansch, C; Leo, A; Panthananickal, A, 1979) |
| "A cell-surface localizing xenogeneic antibody against an AKR mouse lymphoma of spontaneous origin could be bound to chlorambucil without interference with either the alkylating activity of chlorambucil or the immunologic reactivity of the antibody." | 3.65 | Suppression of an AKR lymphoma by antibody and chlorambucil. ( Ghose, T; Guclu, A; Tai, J, 1975) |
| "Cell-surface localizing heterologous antibodies against the mouse EL4 lymphoma and a human malignant melanoma could be bound to chlorambucil without causing the loss of the alkylating activity of chlorambucil or interfering with the reactivity of the antibodies with their respective tumour cells." | 3.65 | Immunochemotherapy of cancer with chlorambucil-carrying antibody. ( Bodurtha, A; Cameron, D; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST, 1972) |
| "Chlorambucil was incorporated into a nanoemulsion modified with poly(ethylene glycol) to improve its pharmacokinetics and tissue distribution, and thus enhance its therapeutic efficacy." | 1.36 | Pharmacokinetics and pharmacodynamics of chlorambucil delivered in long-circulating nanoemulsion. ( Baguley, BC; Ganta, S; Garg, S; Paxton, JW; Sharma, P, 2010) |
| "A chlorambucil-loaded PE was prepared by a high energy ultrasonication method." | 1.35 | Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion. ( Baguley, BC; Ganta, S; Garg, S; Paxton, JW, 2008) |
| " The toxicity of these compounds against hepatoma cells (MH3924A) and, to a lesser extent, against mouse fibroblast (NIH 3T3) and cervix carcinoma (HeLa) cells was also enhanced, but they were not as toxic as dacarbazine (HeLa)." | 1.32 | Alkylating benzamides with melanoma cytotoxicity. ( Bauder-Wüst, U; Eisenhut, M; Haberkorn, U; Mier, W; Mohammed, A; Schönsiegel, F; Wolf, M, 2004) |
| "Chlorambucil was linked to prednisolone to improve the therapeutic and toxic properties of this potent alkylating agent, which is known to induce second tumors in humans." | 1.27 | Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats. ( Berger, MR; Habs, M; Schmähl, D, 1986) |
| "A chlorambucil conjugate was prepared and found to have similar qualities in vitro." | 1.25 | Immunochemotherapy of hepatoma in rats. ( Grogan, JB; Lockard, J; Smith, GV; Stribling, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (80.00) | 18.7374 |
| 1990's | 4 (6.15) | 18.2507 |
| 2000's | 4 (6.15) | 29.6817 |
| 2010's | 5 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Panthananickal, A | 1 |
| Hansch, C | 1 |
| Leo, A | 1 |
| MacDiarmid, JE | 1 |
| Rose, WC | 1 |
| Biddle, WC | 1 |
| Perlman, ME | 1 |
| Breiner, RG | 1 |
| Ambrus, JL | 1 |
| Bardos, TJ | 1 |
| Koutsourea, AI | 2 |
| Fousteris, MA | 2 |
| Arsenou, ES | 2 |
| Papageorgiou, A | 4 |
| Pairas, GN | 1 |
| Nikolaropoulos, SS | 2 |
| Gilad, Y | 1 |
| Tuchinsky, H | 1 |
| Ben-David, G | 1 |
| Minnes, R | 1 |
| Gancz, A | 1 |
| Senderowitz, H | 1 |
| Luboshits, G | 1 |
| Firer, MA | 1 |
| Gellerman, G | 1 |
| Liang, C | 1 |
| Zheng, D | 1 |
| Shi, F | 1 |
| Xu, T | 1 |
| Yang, C | 1 |
| Liu, J | 3 |
| Wang, L | 1 |
| Yang, Z | 1 |
| Yang, L | 1 |
| Zhang, C | 1 |
| Ren, C | 1 |
| Zhang, Y | 1 |
| Wang, J | 1 |
| Huang, F | 1 |
| Zhang, L | 1 |
| Stíbal, D | 1 |
| Therrien, B | 1 |
| Süss-Fink, G | 1 |
| Nowak-Sliwinska, P | 1 |
| Dyson, PJ | 1 |
| Čermáková, E | 1 |
| Řezáčová, M | 1 |
| Tomšík, P | 1 |
| Ganta, S | 2 |
| Paxton, JW | 2 |
| Baguley, BC | 2 |
| Garg, S | 2 |
| Sharma, P | 1 |
| HOTCHIN, J | 1 |
| BOYLAND, E | 1 |
| KINDER, CH | 1 |
| WILLIAMS, K | 1 |
| Wolf, M | 1 |
| Bauder-Wüst, U | 1 |
| Mohammed, A | 1 |
| Schönsiegel, F | 1 |
| Mier, W | 1 |
| Haberkorn, U | 1 |
| Eisenhut, M | 1 |
| Mourelatos, D | 1 |
| Moldenhauer, H | 1 |
| Rose, H | 1 |
| Saul, G | 1 |
| Wolf, G | 1 |
| Kehrberg, G | 1 |
| De Weger, RA | 3 |
| Dullens, HF | 3 |
| Den Otter, W | 3 |
| Goodman, GE | 1 |
| McLean, A | 1 |
| Alberts, DS | 1 |
| Chang, SY | 1 |
| Mikkelsen, RB | 1 |
| Wallach, DF | 1 |
| Roehrig, GR | 1 |
| Billman, JH | 1 |
| Marcec, J | 1 |
| Fritz, P | 1 |
| Shea, F | 1 |
| Kirkpatrick, DL | 1 |
| Schroeder, HL | 1 |
| Chandler, KJ | 1 |
| Guclu, A | 4 |
| Ghose, T | 4 |
| Tai, J | 3 |
| Mammen, M | 1 |
| Wenzel, M | 1 |
| Schneider, M | 1 |
| Bier, J | 1 |
| Benders, P | 1 |
| Schachschneider, G | 1 |
| Weisburger, JH | 1 |
| Griswold, DP | 1 |
| Prejean, JD | 1 |
| Casey, AE | 1 |
| Wood, HB | 1 |
| Weisburger, EK | 1 |
| Tisdale, MJ | 1 |
| Phillips, BJ | 1 |
| Smith, GV | 1 |
| Grogan, JB | 1 |
| Stribling, J | 1 |
| Lockard, J | 1 |
| Cox, PJ | 1 |
| Farmer, PB | 1 |
| Vennegoor, C | 2 |
| Woutersen, F | 1 |
| Woutersen, RA | 1 |
| Güttner, J | 1 |
| Gutsche, W | 1 |
| Zchiesche, W | 1 |
| Wohlrabe, K | 1 |
| Jungstand, W | 1 |
| Ozegowski, W | 1 |
| Krebs, D | 1 |
| Röppnack, G | 1 |
| Catsoulacos, P | 2 |
| Politis, D | 1 |
| Boutis, L | 2 |
| Tew, KD | 1 |
| Taylor, DM | 1 |
| Stukov, AN | 1 |
| Berry, RJ | 1 |
| Laing, AH | 1 |
| Wells, J | 1 |
| Norvell, ST | 2 |
| Bodurha, A | 1 |
| Aquino, J | 1 |
| MacDonald, AS | 2 |
| Rubens, RD | 2 |
| Vaughan-Smith, S | 1 |
| Dulbecco, R | 1 |
| Skarsgard, LD | 1 |
| Chaplin, DJ | 1 |
| Wilson, DJ | 1 |
| Skwarchuk, MW | 1 |
| Vinczan, A | 1 |
| Kristl, J | 1 |
| Phillips, RM | 1 |
| Bibby, MC | 1 |
| Double, JA | 1 |
| Loadman, PM | 1 |
| Cavaliere, A | 1 |
| Pietropaoli, N | 1 |
| Alberti, PF | 1 |
| Vitali, R | 1 |
| Endresen, L | 1 |
| Rugstad, HE | 1 |
| Smyth, MJ | 2 |
| Pietersz, GA | 2 |
| Classon, BJ | 1 |
| McKenzie, IF | 2 |
| Kubota, T | 1 |
| Kawamura, E | 1 |
| Suzuki, T | 1 |
| Yamada, T | 1 |
| Toyoda, H | 1 |
| Miyagawa, T | 1 |
| Kurokawa, T | 1 |
| Pairas, G | 1 |
| Hartley-Asp, B | 1 |
| Berger, MR | 2 |
| Habs, M | 2 |
| Schmähl, D | 2 |
| Honess, DJ | 1 |
| Bleehen, NM | 1 |
| Sugiura, K | 1 |
| Berenbaum, MC | 1 |
| Sheard, CE | 1 |
| Reittie, JR | 1 |
| Bundick, RV | 1 |
| Davies, DA | 3 |
| Buckham, S | 1 |
| Manstone, AJ | 1 |
| Bhuyan, BK | 1 |
| Scheidt, LG | 1 |
| Fraser, TJ | 1 |
| O'Neill, GJ | 1 |
| Cameron, D | 1 |
| Bodurtha, A | 1 |
| Hill, BT | 1 |
| Douglas, ID | 1 |
| Grover, PL | 1 |
| Flechner, I | 1 |
| Basu, TK | 1 |
| Bishun, NP | 1 |
| Raven, RW | 1 |
| Williams, DC | 1 |
| Calcutt, G | 2 |
| Cook, JL | 1 |
| Badgett, WJ | 1 |
| Karaivanova, MKh | 1 |
| Elson, LA | 1 |
| Teller, MN | 1 |
| Abraham, D | 1 |
| Bowie, M | 1 |
| Carbone, PP | 1 |
3 reviews available for chlorambucil and Experimental Neoplasms
| Article | Year |
|---|---|
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophospha | 1984 |
Eradication of murine lymphoma and melanoma cells by chlorambucil-antibody complexes.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Cytotoxicity Tests, Immunologic; Drug Combinations; Dru | 1982 |
Towards selectivity? Approaches to the design of new anti-tumour agents--I.
Topics: Aerosols; Animals; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Antineoplastic Agents; Che | 1977 |
62 other studies available for chlorambucil and Experimental Neoplasms
| Article | Year |
|---|---|
Structure-activity relationship of aniline mustards acting against B-16 melanoma in mice.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Melanoma; Mice; Neoplasms, Experimental; Nitrogen M | 1979 |
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Cholinesterase Inhibitor | 1985 |
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters.
Topics: Alkylation; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug | 2008 |
Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relat | 2017 |
Enzyme-assisted peptide folding, assembly and anti-cancer properties.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Endopeptidase K; Enzymes; Female; HeLa Cells; Humans; | 2017 |
Supramolecular Hydrogel Based on Chlorambucil and Peptide Drug for Cancer Combination Therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Hep G2 Cells; Humans; Hydroge | 2019 |
Chlorambucil conjugates of dinuclear p-cymene ruthenium trithiolato complexes: synthesis, characterization and cytotoxicity study in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chlorambucil; Cymenes; Dose-Re | 2016 |
Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion.
Topics: Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Chemical Phenomena; Chemistry, Physica | 2008 |
Pharmacokinetics and pharmacodynamics of chlorambucil delivered in long-circulating nanoemulsion.
Topics: Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Chlorambucil; Colonic Neoplasms; Delay | 2010 |
The biology of lymphocytic choriomeningitis infection: virus-induced immune disease.
Topics: Autoimmune Diseases; Biology; Chlorambucil; Endotoxins; Immune System Diseases; Lymphocytic Choriome | 1962 |
THE TREATMENT OF CARCINOMA IN DOGS' BLADDERS WITH CYTOTOXIC DRUGS.
Topics: Alkylating Agents; Antineoplastic Agents; Carcinogens; Carcinoma; Chlorambucil; Cyclophosphamide; Do | 1965 |
Alkylating benzamides with melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Line, Tumor; Cel | 2004 |
Structure-anti-leukemic activity relationship study of B- and D-ring modified and non-modified steroidal esters of chlorambucil.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chlorambucil; Female; Humans; Leukemia | 2006 |
Chlorambucil.
Topics: Animals; Carcinogens; Chemical Phenomena; Chemistry; Chlorambucil; Drug Interactions; Female; Fetal | 1981 |
Inhibition of human tumour clonogenicity by chlorambucil and its metabolites.
Topics: Carcinoma; Cell Line; Chlorambucil; Clone Cells; Dose-Response Relationship, Drug; Humans; Multiple | 1982 |
Transmembrane ion gradients and thermochemotherapy.
Topics: Animals; Cell Line; Cell Membrane Permeability; Chlorambucil; Cricetinae; Extracellular Space; Glyco | 1982 |
Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chlorambucil; Leukemia L1210; Leukemi | 1980 |
Synthesis and bioreductive potential of a mono N-oxide derivative of the alkylating agent chlorambucil.
Topics: Animals; Cell Hypoxia; Cell Survival; Chlorambucil; Cyclic N-Oxides; Hydrogen-Ion Concentration; Mal | 1994 |
Binding of chlorambucil with antitumor globulins and its effect on drug and antibody activities.
Topics: Alkylation; Animals; Antibodies, Neoplasm; Biopharmaceutics; Blood Proteins; Cells, Cultured; Chlora | 1976 |
[Concentrations of cytostatic drugs in organs and tumors: comparison after intravenous and intratumoral injection (author's transl)].
Topics: Animals; Antineoplastic Agents; Bleomycin; Carcinoma, Ehrlich Tumor; Chlorambucil; Female; Hydrazone | 1979 |
The carcinogenic properties of some of the principal drugs used in clinical cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinogens; Chlorambucil; Cyclophosphamide; Dacarbazine; Dactinomyc | 1975 |
Adenosine 3',5'-monophosphate phosphodiesterase activity in experimental animal tumours which are either sensitive or resistant to bifunctional alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cells, Cultured; Chlorambucil; Cyclic AMP; Drug R | 1975 |
Immunochemotherapy of hepatoma in rats.
Topics: Animals; Antigen-Antibody Complex; Carcinoma, Hepatocellular; Cell Nucleus; Chlorambucil; Chromatin; | 1975 |
Comparison of various forms of therapy in two different mouse tumor systems.
Topics: Animals; BCG Vaccine; Chlorambucil; Complement System Proteins; Dacarbazine; Female; Goats; Immunogl | 1979 |
Anti-tumour effect of chlorambucil-antibody complexes in a murine melanoma system.
Topics: Animals; Carrier Proteins; Cell Survival; Cells, Cultured; Chlorambucil; Female; Immune Sera; Immuno | 1979 |
Beta-[1-Phenyl-5-bis(beta-chloroethyl)-amino-benzimidazolyl-(2)]-DL-alanine (ZIMET 3164): an immunosuppressant without marked anti-cancer effect.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Benzimidazoles; Chlorambucil; Cyclophosphamide; | 1979 |
New compounds: antitumor activity of 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Rat | 1978 |
Tissue distribution and nucleic acid binding of chlorambucil-3H in tumor-bearing rats.
Topics: Alkylation; Animals; Chlorambucil; DNA; DNA, Neoplasm; Female; Neoplasms, Experimental; Rats; RNA; R | 1978 |
[Combination chemotherapy of tumors (an experimental study)].
Topics: Animals; Antineoplastic Agents; Busulfan; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyclophosphamide; | 1975 |
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini | 1975 |
Antibodies as carriers of radionuclides and cytotoxic drugs in the treatment and diagnosis of cancer.
Topics: Animals; Antibodies, Neoplasm; Antineoplastic Agents; Chlorambucil; Female; Humans; Immunoelectropho | 1976 |
Suppression of an AKR lymphoma by antibody and chlorambucil.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Female; Fluorescent Antibody Technique; Immunization, P | 1975 |
Augmentation of cytotoxic drug action and X-irradiation by antibodies.
Topics: Antibodies, Neoplasm; Antineoplastic Agents; Cell Division; Cell Line; Cell Membrane; Chlorambucil; | 1975 |
The effect of hypoxia and low pH on the cytotoxicity of chlorambucil.
Topics: Animals; Cell Hypoxia; Cell Survival; Chlorambucil; Cricetinae; Drug Synergism; Hydralazine; Hydroge | 1992 |
The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model.
Topics: Animals; Cell Survival; Chlorambucil; Dose-Response Relationship, Drug; Metabolic Clearance Rate; Mi | 1991 |
Chlorambucil carcinogenesis in BALB/c mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Chlorambucil; Female; Incidence; Leukemia, Myeloid; L | 1990 |
Protective function of metallothionein against certain anticancer agents.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Chlorambucil; Cisplatin; Colony-Forming Un | 1987 |
Specific targeting of chlorambucil to tumors with the use of monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Chlorambucil; Mice; Mice, Inbred Strains; Neoplasm Trans | 1986 |
Potentiation of the in vitro cytotoxicity of chlorambucil by monoclonal antibodies.
Topics: Ammonium Chloride; Animals; Antibodies, Monoclonal; Antibodies, Neoplasm; Cells, Cultured; Chlorambu | 1986 |
Antitumor activity and pharmacokinetics of estra-1,3,5 (10)-triene-3,17 beta-diol, 3-benzoate, 17-((4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy) acetate) (Bestrabucil) in human tumor xenografts serially transplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Evaluation, Preclinical; Estradiol; Female; Human | 1986 |
Further studies on the antineoplastic activity of homo-aza-steroidal esters.
Topics: Animals; Antineoplastic Agents; Azasteroids; Chlorambucil; Female; Male; Mice; Mice, Inbred C57BL; N | 1986 |
The antitumor effect of prednimustine in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Chlorambucil; Cri | 1986 |
Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats.
Topics: Animals; Carcinoma, Squamous Cell; Chlorambucil; Drug Therapy, Combination; Ear Neoplasms; Female; M | 1986 |
Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; Chlorambucil; Cisplatin; Combined Modality | 1985 |
Comparative carcinogenic activity of prednimustine, chlorambucil, prednisolone and chlorambucil plus prednisolone in Sprague-Dawley rats.
Topics: Animals; Chlorambucil; Female; Neoplasms, Experimental; Prednimustine; Prednisolone; Rats | 1985 |
Antibodies as carriers of anticancer agents.
Topics: Animals; Antibodies, Neoplasm; Antigen-Antibody Reactions; Antigens, Neoplasm; Antineoplastic Agents | 1974 |
Chemotherapy of induced skin tumors in mice.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Benz(a)Anthracenes; Busulfan; Ca | 1968 |
The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; | 1974 |
Protection of mice against syngeneic lymphomata: II. Collaboration between drugs and antibodies.
Topics: Animals; Antibodies, Neoplasm; Antineoplastic Agents; Carcinoembryonic Antigen; Cell Line; Chlorambu | 1974 |
Cell cycle phase specificity of antitumor agents.
Topics: Alkaloids; Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbazole | 1972 |
The combined effect of drugs and tumor-specific antibodies in protection against a mouse lymphoma.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Cytarabine; Immune Sera; Immunotherapy; Lymphoma; Melph | 1974 |
In vivo and in vitro effects of tumour specific antibodies with chlorambucil.
Topics: Absorption; Animals; Antibodies, Neoplasm; Antilymphocyte Serum; Binding Sites; Chlorambucil; Cultur | 1973 |
Immunochemotherapy of cancer with chlorambucil-carrying antibody.
Topics: Aged; Animals; Antibodies; Cell Membrane; Chlorambucil; Fluorescent Antibody Technique; Goats; Human | 1972 |
Increased antitumour activity of chlorambucil following pretreatment with inducers of drug-metabolizing enzymes.
Topics: Animals; Benz(a)Anthracenes; Chlorambucil; DNA, Neoplasm; Drug Resistance; Drug Synergism; Enzyme In | 1973 |
The cure and concomitant immunization of mice bearing Ehrlich ascites tumors by treatment with an antibody--alkylating agent complex.
Topics: Alkylating Agents; Animals; Antibodies, Neoplasm; Carcinoma, Ehrlich Tumor; Chlorambucil; Immunizati | 1973 |
Proceedings: Accentuation of chlorambucil effect by various additives on rat tumour cells in culture.
Topics: Animals; Caffeine; Cells, Cultured; Chlorambucil; Drug Synergism; Neoplasms, Experimental; Phenobarb | 1974 |
Enhanced growth of transplanted tumours after treatment with cytotoxic agents.
Topics: Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Ethers, Cyclic; Lymphoma; Mannomustine; Meth | 1968 |
Chlorambucil-carrying antibody.
Topics: Animals; Antibodies, Neoplasm; Chlorambucil; Humans; Lymphoma; Melanoma; Mice; Neoplasms, Experiment | 1972 |
[A method of primary selection of antitumor agents].
Topics: Adenocarcinoma; Animals; Carcinoma 256, Walker; Chlorambucil; Cyclophosphamide; Melphalan; Mercaptop | 1971 |
Growth inhibitory and haematological effects of alkylating agents and attempts at their modification to give greater selectivity of anti-tumour action.
Topics: Alkylating Agents; Animals; Body Weight; Carcinoma 256, Walker; Chemical Phenomena; Chemistry; Chlor | 1968 |
Transplantable mouse plasma cell tumors in experimental chemotherapy.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Blood Protein Electrophoresis; Blood Proteins; Ch | 1969 |
The effects of some cancer chemotherapy agents on the sulphydryl levels of normal rat tissues.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Bone Marrow; Brain; Busulfan; Chlorambucil; Cyclo | 1965 |