chlorambucil has been researched along with Experimental Mammary Neoplasms in 14 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To demonstrate this unique approach, an amphiphilic drug-drug conjugate (ADDC) has been synthesized from the hydrophilic anticancer drug irinotecan (Ir) and the hydrophobic anticancer drug chlorambucil (Cb) via a hydrolyzable ester linkage." | 1.40 | Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy. ( Cui, D; Huang, P; Huang, W; Su, Y; Wang, D; Yan, D; Zhou, Y; Zhu, X, 2014) |
| " All of the compounds were effective against estrogen receptor-positive T-61 with a clear dose-response relationship, while estrogen receptor-negative MX-1 was sensitive to all of the agents except estradiol." | 1.27 | Mode of action of estra-1,3,5(10)-triene-3,17 beta-diol 3-benzoate 17-[4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acet ate) on human breast carcinoma xenografts in nude mice. ( Abe, O; Asano, K; Enomoto, K; Ishibiki, K; Koh, J; Kubota, T; Masui, O; Oka, S; Yamada, Y, 1988) |
| "Chlorambucil was linked to prednisolone to improve the therapeutic and toxic properties of this potent alkylating agent, which is known to induce second tumors in humans." | 1.27 | Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats. ( Berger, MR; Habs, M; Schmähl, D, 1986) |
| " The mortality figures suggested that prednimustine was considerably less toxic than equipotent doses of C + P." | 1.26 | Mammary tumour inhibition and subacute toxicity in rats of prednimustine and of its molecular components chlorambucil and prednisolone. ( Fredholm, B; Gunnarsson, K; Jensen, G; Müntzing, J, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, C | 1 |
| Ding, Y | 1 |
| Qian, J | 1 |
| Zhang, R | 1 |
| Dong, CM | 1 |
| Huang, P | 1 |
| Wang, D | 1 |
| Su, Y | 1 |
| Huang, W | 1 |
| Zhou, Y | 1 |
| Cui, D | 1 |
| Zhu, X | 1 |
| Yan, D | 1 |
| Musch, E | 2 |
| Loos, U | 1 |
| Alléra, A | 1 |
| Hügl, E | 1 |
| Pütz, I | 1 |
| Malek, M | 2 |
| Schecter, RL | 1 |
| Alaoui-Jamali, MA | 2 |
| Woo, A | 1 |
| Fahl, WE | 1 |
| Batist, G | 2 |
| Tschiersch, B | 1 |
| Schwabe, K | 1 |
| Fredholm, B | 1 |
| Gunnarsson, K | 1 |
| Jensen, G | 1 |
| Müntzing, J | 1 |
| Panasci, L | 1 |
| Centurioni, GM | 1 |
| Schecter, R | 1 |
| Lehnert, S | 1 |
| Peter-Katalinic, J | 1 |
| Egge, H | 1 |
| Rink, H | 1 |
| Lathan, B | 1 |
| Riedel, E | 1 |
| Cavaliere, A | 1 |
| Pietropaoli, N | 1 |
| Alberti, PF | 1 |
| Vitali, R | 1 |
| Jähde, E | 1 |
| Glüsenkamp, KH | 1 |
| Klünder, I | 1 |
| Hülser, DF | 1 |
| Tietze, LF | 1 |
| Rajewsky, MF | 1 |
| Chaplin, DJ | 1 |
| Acker, BD | 1 |
| Horsman, MR | 1 |
| Kubota, T | 1 |
| Koh, J | 1 |
| Yamada, Y | 1 |
| Oka, S | 1 |
| Enomoto, K | 1 |
| Ishibiki, K | 1 |
| Abe, O | 1 |
| Masui, O | 1 |
| Asano, K | 1 |
| Berger, MR | 1 |
| Habs, M | 1 |
| Schmähl, D | 1 |
| Krupnick, AB | 1 |
| Rosenkrantz, H | 1 |
14 other studies available for chlorambucil and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Achieving traceless ablation of solid tumors without recurrence by mild photothermal-chemotherapy of triple stimuli-responsive polymer-drug conjugate nanoparticles.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chlorambucil; Combined Modalit | 2019 |
Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Chlorambucil; Drug Delivery Sy | 2014 |
Pharmacokinetic and cell-biological investigation of prednimustine compared to its components chlorambucil and prednisolone.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Line; Cell Line, Tumor; Chlorambucil; Cricetinae; Fem | 1989 |
Expression of a rat glutathione-S-transferase complementary DNA in rat mammary carcinoma cells: impact upon alkylator-induced toxicity.
Topics: Alkylating Agents; Animals; Biological Transport; Cell Line; Cell Nucleus; Chlorambucil; Cisplatin; | 1993 |
[Biological effects of 4-[N.N-bis-(2-chlorethyl)-amino]-phenyl-O-beta-D-glucopyranosiduronic acid methylesters].
Topics: Animals; Antineoplastic Agents; Chlorambucil; DNA; Drug Evaluation, Preclinical; Glucosides; Glucuro | 1977 |
Mammary tumour inhibition and subacute toxicity in rats of prednimustine and of its molecular components chlorambucil and prednisolone.
Topics: Animals; Blood Cell Count; Blood Platelets; Bone Marrow; Chemical Phenomena; Chemistry; Chlorambucil | 1978 |
Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity.
Topics: Animals; Buthionine Sulfoximine; Cell Division; Cell Survival; Chlorambucil; DNA; Drug Interactions; | 1992 |
Cellular kinetics of prednimustine versus chlorambucil plus prednisolone in vitro.
Topics: Animals; Carcinoma; Chlorambucil; Chromatography, High Pressure Liquid; Colonic Neoplasms; Mammary N | 1992 |
Chlorambucil carcinogenesis in BALB/c mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Chlorambucil; Female; Incidence; Leukemia, Myeloid; L | 1990 |
Hydrogen ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro.
Topics: Alkylating Agents; Animals; Chlorambucil; Cyclophosphamide; Hydrogen-Ion Concentration; Mammary Neop | 1989 |
Reduction of tumour blood flow by vasoactive drugs: a role in cancer therapy.
Topics: Animals; Cell Survival; Chlorambucil; Hydralazine; Hyperthermia, Induced; Lung Neoplasms; Mammary Ne | 1989 |
Mode of action of estra-1,3,5(10)-triene-3,17 beta-diol 3-benzoate 17-[4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acet ate) on human breast carcinoma xenografts in nude mice.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Estradiol; Female; Humans; Mammary Neoplasms, Experime | 1988 |
Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats.
Topics: Animals; Carcinoma, Squamous Cell; Chlorambucil; Drug Therapy, Combination; Ear Neoplasms; Female; M | 1986 |
Nucleic acid content of rat neoplasms.
Topics: Animals; Chlorambucil; Cyclophosphamide; DNA; DNA, Neoplasm; Leukemia, Experimental; Mammary Neoplas | 1965 |