chlorambucil has been researched along with Experimental Leukemia in 17 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil is an exception." | 1.26 | Structure-activity relationships in antitumor aniline mustards. ( Hansch, C; Leo, A; Panthananickal, A, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (94.12) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loeffler, LJ | 2 |
| Sajadi, Z | 2 |
| Hall, IH | 2 |
| Panthananickal, A | 1 |
| Hansch, C | 1 |
| Leo, A | 1 |
| Gourdie, TA | 1 |
| Valu, KK | 1 |
| Gravatt, GL | 1 |
| Boritzki, TJ | 1 |
| Baguley, BC | 1 |
| Wakelin, LP | 1 |
| Wilson, WR | 1 |
| Woodgate, PD | 1 |
| Denny, WA | 1 |
| ELSON, LA | 1 |
| BURCHENAL, JH | 1 |
| Feinerman, B | 1 |
| Paul, RD | 1 |
| Feinerman, G | 1 |
| Begleiter, A | 1 |
| Goldenberg, GJ | 2 |
| Latif, ZA | 1 |
| Lozzio, BB | 1 |
| Wust, CJ | 1 |
| Krauss, S | 1 |
| Aggio, MC | 1 |
| Lozzio, CB | 1 |
| Roehrig, GR | 1 |
| Billman, JH | 1 |
| Marcec, J | 1 |
| Fritz, P | 1 |
| Shea, F | 1 |
| Brodie, AE | 1 |
| Potter, J | 1 |
| Reed, DJ | 1 |
| Schiffman, FJ | 1 |
| Uehara, Y | 1 |
| Fisher, JM | 1 |
| Rabinovitz, M | 1 |
| Kummer, D | 1 |
| Ochs, HD | 1 |
| Chu, MY | 1 |
| Hoovis, ML | 1 |
| Mishra, LC | 1 |
| Hebborn, P | 1 |
| Krupnick, AB | 1 |
| Rosenkrantz, H | 1 |
17 other studies available for chlorambucil and Experimental Leukemia
| Article | Year |
|---|---|
Antineoplastic agents. 1. N-Protected vinyl, 1,2-dihaloethyl, and cyanomethyl esters of phenylalanine.
Topics: Acetonitriles; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Leth | 1977 |
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
Topics: Acetonitriles; Amino Acids; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlic | 1977 |
Structure-activity relationships in antitumor aniline mustards.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Hydrolysis; Lethal Dose 50; | 1978 |
DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
Topics: Alkylating Agents; Alkylation; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line; Chemical | 1990 |
EXPERIMENTAL APPROACHES TO THE CHEMOTHERAPY OF LEUKAEMIA.
Topics: Busulfan; Chlorambucil; Leukemia; Leukemia, Experimental; Neoplasms; Rats; Research | 1963 |
III. IMPROVEMENT OF CANCER CHEMOTHERAPY IN MAN.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Fluorouracil; Leukemia; Leukemia, Experimental; Mercap | 1964 |
Treatment of a murine leukemia with chlorambucil bound monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Chlorambucil; DNA, Neoplasm; Immunotherapy; Leukemia | 1983 |
Uptake and decomposition of chlorambucil by L5178Y lymphoblasts in vitro.
Topics: Alkylation; Animals; Cells, Cultured; Chlorambucil; Chromatography, Thin Layer; Ethanol; Hydrolysis; | 1983 |
Evaluation of drug-antibody conjugates in the treatment of human myelosarcomas transplanted in nude mice.
Topics: Animals; Antibodies, Neoplasm; Antibody Specificity; Antineoplastic Agents; Chlorambucil; Daunorubic | 1980 |
Synthesis and antitumor activity of 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chlorambucil; Leukemia L1210; Leukemi | 1980 |
Effects of vinblastine, oncodazole, procarbazine, chlorambucil, and bleomycin in vivo on colchicine binding activity of tubulin.
Topics: Animals; Antineoplastic Agents; Benzimidazoles; Bleomycin; Carbamates; Chlorambucil; Colchicine; Leu | 1979 |
Potentiation of chlorambucil activity by phenylbutazone.
Topics: Animals; Cell Survival; Cells, Cultured; Chlorambucil; Drug Synergism; Drug Therapy, Combination; Le | 1978 |
The role of drug transport in resistance to nitrogen mustard and other alkylating agents in L518Y lymphoblsts.
Topics: Alkylating Agents; Animals; Binding, Competitive; Biological Transport; Carmustine; Cell Line; Chlor | 1975 |
[Differenciation of reaction mechanisms of alkylating cytostatics on Ehrlich ascites-carcinoma- and lymphatic leucemic cells].
Topics: Alkylating Agents; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chlorambucil; Leucine; Leukem | 1970 |
Sensitivity of human leukemic cells to anti-cancer agents in culture.
Topics: Animals; Antineoplastic Agents; Azauridine; Cells; Cells, Cultured; Chlorambucil; Culture Media; Cyc | 1974 |
Peripheral nucleated cell count as a method of assessing the response of antileukemic agents in Rauscher virus-diseased mice.
Topics: Animals; Antineoplastic Agents; Blood; Busulfan; Carbamates; Cell Count; Chlorambucil; Cyclophospham | 1973 |
Nucleic acid content of rat neoplasms.
Topics: Animals; Chlorambucil; Cyclophosphamide; DNA; DNA, Neoplasm; Leukemia, Experimental; Mammary Neoplas | 1965 |