chlorambucil has been researched along with Enlarged Spleen in 29 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hairy cell leukemia (HCL) is characterized by leukemic cells with abundant "hairy" cytoplasm, strong cytoplasmic positivity for tartrate-resistant acid phosphatase (TRAP), characteristic immunophenotype and sensitivity to treatment with purine nucleoside analogs." | 4.87 | Hairy cell leukemia and variant in Taiwan: report of a variant case and literature review. ( Chang, ST; Chuang, SS; Hsieh, YC; Li, CY; Lin, CN; Lu, CL; Tsao, CJ, 2011) |
| "Lymphadenopathy, splenomegaly and hepatomegaly were seen in 52 (55%), 63 (66%) and 60 (63%) patients, respectively." | 1.34 | Chronic lymphocytic leukemia in India--a clinico-hematological profile. ( Agrawal, N; Choudhary, VP; Kumar, R; Mahapatra, M; Naithani, R; Panigrahi, I; Pati, HP; Saxena, R, 2007) |
| "Treatment with clarithromycin, ethambutol and rifabutin resulted in improvement of anaemia and general health as well as in regression of lymphadenopathy and splenomegaly." | 1.31 | Mycobacterium genavense infection in a patient with long-standing chronic lymphocytic leukaemia. ( Bodmer, T; Krebs, T; Lämmle, B; Zimmerli, S, 2000) |
| "Bleeding tendency was seen in 17%, infections in 17%, hyperviscosity syndrome in 12%, and cardiac failure in 25% of the patients." | 1.31 | Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit. ( Angelopoulou, MK; Boussiotis, V; Dimopoulou, MN; Fessas, P; Gribabis, A; Kittas, C; Konstantopoulos, K; Kontopidou, FN; Kyrtsonis, MC; Pangalis, GA; Siakantaris, P; Vaiopoulos, GA; Vassilakopoulos, TP, 2001) |
| "Prolymphocytic leukemia is characterized by marked splenomegaly, distinctive cellular morphologic characteristics, and a poor clinical course." | 1.26 | Treatment of prolymphocytic leukemia. ( Coleman, M; Hollister, D, 1982) |
| "A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia." | 1.25 | Clinical staging of chronic lymphocytic leukemia. ( Chanana, AD; Cronkite, EP; Levy, RN; Pasternack, BS; Rai, KR; Sawitsky, A, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (68.97) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hsieh, YC | 1 |
| Chang, ST | 1 |
| Chuang, SS | 1 |
| Lu, CL | 1 |
| Tsao, CJ | 1 |
| Lin, CN | 1 |
| Li, CY | 1 |
| Cavard, A | 1 |
| Lidove, O | 1 |
| Aflak, F | 1 |
| Drupt, F | 1 |
| Goldenberg, P | 1 |
| Baglin, AC | 1 |
| Taksin, AL | 1 |
| Malek-Chehire, N | 1 |
| Wasserman, MR | 1 |
| Terré, C | 1 |
| Blétry, O | 1 |
| INNES, J | 1 |
| WANEBO, HJ | 1 |
| CLARKSON, BD | 1 |
| Stiefelhagen, P | 1 |
| Chakravorty, S | 1 |
| Johnston, R | 1 |
| Coulter, C | 1 |
| Bain, BJ | 1 |
| Agrawal, N | 1 |
| Naithani, R | 1 |
| Mahapatra, M | 1 |
| Panigrahi, I | 1 |
| Kumar, R | 1 |
| Pati, HP | 1 |
| Saxena, R | 1 |
| Choudhary, VP | 1 |
| Alfinito, F | 1 |
| Formisano, S | 1 |
| Rotoli, B | 1 |
| Hollister, D | 1 |
| Coleman, M | 1 |
| Wirthmüller, R | 1 |
| Gerhartz, H | 1 |
| Greco, MM | 1 |
| Krebs, T | 1 |
| Zimmerli, S | 1 |
| Bodmer, T | 1 |
| Lämmle, B | 1 |
| Pichon, N | 1 |
| Debette-Gratien, M | 1 |
| Cessot, F | 1 |
| Paraf, F | 1 |
| Labrousse, F | 1 |
| Sautereau, D | 1 |
| Pillegand, B | 1 |
| Kyrtsonis, MC | 1 |
| Vassilakopoulos, TP | 1 |
| Angelopoulou, MK | 1 |
| Siakantaris, P | 1 |
| Kontopidou, FN | 1 |
| Dimopoulou, MN | 1 |
| Boussiotis, V | 1 |
| Gribabis, A | 1 |
| Konstantopoulos, K | 1 |
| Vaiopoulos, GA | 1 |
| Fessas, P | 1 |
| Kittas, C | 1 |
| Pangalis, GA | 1 |
| Siemens, HJ | 1 |
| Gerke, P | 1 |
| Steinhoff, J | 1 |
| Roth-Isigkeit, A | 1 |
| Wagner, K | 1 |
| Brückner, S | 1 |
| Rai, KR | 1 |
| Sawitsky, A | 1 |
| Cronkite, EP | 1 |
| Chanana, AD | 1 |
| Levy, RN | 1 |
| Pasternack, BS | 1 |
| Lauria, F | 1 |
| Foa, R | 1 |
| Raspadori, D | 1 |
| Motta, MR | 1 |
| Tazzari, PL | 1 |
| Biagini, G | 1 |
| Preda, P | 1 |
| Algeri, R | 1 |
| Tura, S | 1 |
| Gallagher, CJ | 1 |
| Gregory, WM | 1 |
| Jones, AE | 1 |
| Stansfeld, AG | 1 |
| Richards, MA | 1 |
| Dhaliwal, HS | 1 |
| Malpas, JS | 1 |
| Lister, TA | 1 |
| Hermanský, F | 1 |
| Janele, J | 1 |
| Smetana, K | 1 |
| André, R | 1 |
| Duhamel, G | 1 |
| Salmon, C | 1 |
| Najman, A | 1 |
| Homberg, JC | 1 |
| Lebacq, E | 1 |
| Bonhomme, J | 1 |
| Seligmann, M | 1 |
| Mihaesco, C | 1 |
| Clauvel, JP | 1 |
| Danon, F | 1 |
| Brouet, JC | 1 |
| Bouvry, P | 1 |
| Martine, J | 1 |
| Clerc, M | 1 |
| Richards, F | 1 |
| Spurr, CL | 1 |
| Pajak, TF | 1 |
| Blake, DD | 1 |
| Raben, M | 1 |
| Hunold, W | 1 |
| Haak, HL | 1 |
| de Man, JC | 1 |
| Hijmans, W | 1 |
| Speck, B | 1 |
| Themi, H | 1 |
| Trepel, F | 1 |
| Schick, P | 1 |
| Kaboth, W | 1 |
| Begemann, H | 1 |
| Kutti, J | 1 |
| Han, T | 1 |
| Sokal, JE | 1 |
| Lee, SL | 1 |
| Rosner, F | 1 |
| Ruberman, W | 1 |
| Glasberg, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): DNA Microarray Gene Expression Analysis[NCT00001586] | Phase 2 | 105 participants (Actual) | Interventional | 1997-09-30 | Completed | ||
| Phase II Clinical Protocol for the Treatment of Patients With Previously Untreated CLL With Four or Six Cycles of Fludarabine and Cyclophosphamide With Rituximab (FCR) Plus Lenalidomide Followed by Lenalidomide Consolidation/ Maintenance[NCT01723839] | Phase 2 | 21 participants (Actual) | Interventional | 2012-02-22 | Completed | ||
| A Phase II Trial of Combined Weekly Bortezomib and Tositumomab I-131 in Patients With Relapsed or Refractory Follicular Non-Hodg[NCT00479167] | Phase 2 | 1 participants (Actual) | Interventional | 2007-05-31 | Terminated (stopped due to Lack of accrual and interest in study) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the number of participants with adverse events. For the detailed list of adverse events see the adverse event module. (NCT00001586)
Timeframe: 13 years, 10.5 months
| Intervention | Participants (Number) |
|---|---|
| Intermediate-high Risk B-Cell Pts | 18 |
Changes in lymphocyte gene expression was measured by deoxyribonucleic acid (DNA) microarray analysis of circulating leukemic cells after completion of study treatment. A change in expression is defined as a >50% increase in circulating leukemic cells or a 30% decrease in circulating leukemic cells. (NCT00001586)
Timeframe: 6 hours post treatment, and 24 hours post treatment
| Intervention | Percent change in cells (Number) | |
|---|---|---|
| 6 hours post treatment (e.g. ># cells) | 24 hours post treatment (e.g. > # cells) | |
| Intermediate-high Risk B-Cell Pts | 30 | 50 |
Analysis of the Primary Endpoint: The complete responses will be estimated by the number of patients with CR divided by the total number of evaluable patients. (NCT01723839)
Timeframe: 28 day cycle, up to 4 cycles
| Intervention | Percentage of Participants (Number) |
|---|---|
| FCR With Lenalidomide | 45 |
Analysis of the other Secondary Endpoints: The overall response rate will be estimated by the number of patients with complete and partial responses divided by the total number of evaluable patients. (NCT01723839)
Timeframe: 28 day cycle, up to 6 cycles
| Intervention | Percentage of Participants (Number) |
|---|---|
| FCR With Lenalidomide | 95 |
1 review available for chlorambucil and Enlarged Spleen
| Article | Year |
|---|---|
Hairy cell leukemia and variant in Taiwan: report of a variant case and literature review.
Topics: Acid Phosphatase; Aged; Antigens, CD; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Bone Mar | 2011 |
28 other studies available for chlorambucil and Enlarged Spleen
| Article | Year |
|---|---|
[IgG-secreting lymphoplasmocytoid leukemia revealed by ophthalmologic hyperviscosity symptoms].
Topics: Aged; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Blood Viscosity; Chloram | 2002 |
ANTI-LEUKAEMIC DRUGS.
Topics: Busulfan; Chlorambucil; Cyclophosphamide; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
ESSENTIAL MACROGLOBULINEMIA. REPORT OF A CASE INCLUDING IMMUNOFLUORESCENT AND ELECTRON MICROSCOPIC STUDIES.
Topics: Blood Protein Electrophoresis; Bone Marrow Cells; Chlorambucil; Electrons; Fluorescent Antibody Tech | 1965 |
[Pressure pain in the left epigastrium: blood picture provides diagnosis. Chronic lymphatic leukemia].
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Chlorambu | 2003 |
Teaching cases from the Royal Marsden and St Mary's Hospitals, case 26: refractory microcytic anaemia.
Topics: Anemia, Refractory; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bleomycin; Blood Sed | 2004 |
Chronic lymphocytic leukemia in India--a clinico-hematological profile.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Chlorambucil; Female; Hematologic Tests; Hepato | 2007 |
Familial leukemia: uncommon type of chronic lymphocytic leukemia in two sisters.
Topics: Agammaglobulinemia; Anemia; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Middle Aged; Prednison | 1982 |
Treatment of prolymphocytic leukemia.
Topics: Aged; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Middle Aged; Platelet | 1982 |
[Prolymphocytic leukemia: clinical, cytologic and immunologic findings].
Topics: Aged; B-Lymphocytes; Cell Differentiation; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Lymphoc | 1980 |
[Prognosis in chronic lymphocytic leukemia].
Topics: Agammaglobulinemia; Chlorambucil; Hematopoietic Stem Cells; Humans; Leukemia, Lymphoid; Leukocyte Co | 1981 |
Mycobacterium genavense infection in a patient with long-standing chronic lymphocytic leukaemia.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibiotics, Antitubercula | 2000 |
[Acute cholestatic hepatitis due to chlorambucil].
Topics: Acute Disease; Aged; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chemical and Drug Induced Li | 2001 |
Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit.
Topics: Adult; Aged; Aged, 80 and over; Blood Viscosity; Cardiac Output, Low; Chlorambucil; Fatigue; Female; | 2001 |
A prolonged APTT in a patient with a low grade malignant NHL - a case report.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Blood Coagulation Factors; C | 2002 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
T-cell prolymphocytic leukaemia: a clinical and immunological study.
Topics: Acid Phosphatase; Aged; Antibodies, Monoclonal; B-Lymphocytes; Chlorambucil; Cyclophosphamide; Femal | 1985 |
Follicular lymphoma: prognostic factors for response and survival.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Hepatomegaly; Hum | 1986 |
Notes on morphologically less usual forms of chronic lymphadenosis.
Topics: Aged; Blood Cell Count; Bone Marrow Examination; Cell Nucleolus; Cell Nucleus; Cell Transformation, | 1968 |
[Autoimmune hemolytic anemia with lymphatic nodules in the bone marrow].
Topics: Aged; Anemia, Hemolytic, Autoimmune; Autoantibodies; Bone Marrow; Bone Marrow Examination; Chlorambu | 1968 |
[Gastric localizations of chronic lymphoid leukemia].
Topics: Adult; Chlorambucil; Duodenal Neoplasms; Duodenal Ulcer; Gastric Mucosa; Hematemesis; Humans; Hyperp | 1969 |
MU-chain disease in an African patient.
Topics: Blood Protein Electrophoresis; Blood Viscosity; Chlorambucil; Chromatography, Gel; Chromium Radioiso | 1974 |
Thymic irradiation. An approach to chronic lymphocytic leukemia.
Topics: Adult; Agammaglobulinemia; Aged; Blood Platelets; Blood Protein Electrophoresis; Bone Marrow; Bone M | 1974 |
[Letter: Progredient liver cirrhosis in chronic lymphatic leukemia].
Topics: Chlorambucil; Diabetes Complications; Hepatitis B; Humans; Leukemia, Lymphoid; Liver Cirrhosis; Lymp | 1974 |
Further evidence for the lymphocytic nature of leukaemic reticuloendotheliosis (hairy-cell leukaemia).
Topics: Acid Phosphatase; Blood Cell Count; Chlorambucil; Fluorescent Antibody Technique; Histocytochemistry | 1974 |
Kinetics of lymphocytes in chronic lymphocytic leukemia: studies using continuous 3H-thymidine infusion in two patients.
Topics: Aged; Autoradiography; Bone Marrow Examination; Chlorambucil; Glucocorticoids; Humans; Injections, I | 1973 |
Platelet production rate in polycythemia vera after myelosuppressive therapy.
Topics: Aged; Blood Cell Count; Blood Platelets; Busulfan; Cell Division; Cell Survival; Chlorambucil; Chrom | 1972 |
Spontaneous remission of leukemic lymphoproliferative disease.
Topics: Adult; Aged; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphom | 1971 |
Mu-chain disease.
Topics: Adult; Agammaglobulinemia; Anemia; Bence Jones Protein; Chlorambucil; Female; Fractures, Bone; Heavy | 1971 |