chlorambucil has been researched along with Emesis in 12 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, the usefulness of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies, including CDDP, was examined." | 9.08 | [Efficacy of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies in urogenital malignant tumor]. ( Akazawa, S; Inai, T; Kagawa, S; Kanayama, H; Naruo, S; Ogawa, I; Sakurai, N; Sumitani, H; Takigawa, H; Yokoseki, H, 1996) |
| "The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy." | 7.66 | Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer. ( Dombernowsky, P; Kristensen, D; Mouridsen, HT; Nielsen, JH, 1980) |
| "In this study, the usefulness of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies, including CDDP, was examined." | 5.08 | [Efficacy of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies in urogenital malignant tumor]. ( Akazawa, S; Inai, T; Kagawa, S; Kanayama, H; Naruo, S; Ogawa, I; Sakurai, N; Sumitani, H; Takigawa, H; Yokoseki, H, 1996) |
| "A group of 47 patients with advanced breast cancer were treated with a combination of prednimustine, methotrexate, 5-FU, and tamoxifen." | 3.66 | Prednimustine in combination with methotrexate and 5-FU (PMF): a pilot study. ( Boesen, E; Mouridsen, HT, 1982) |
| "The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy." | 3.66 | Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer. ( Dombernowsky, P; Kristensen, D; Mouridsen, HT; Nielsen, JH, 1980) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Disseminated germ cell testicular cancer proved to be highly sensitive to platinum-containing chemotherapy regimens." | 1.27 | Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum for advanced germ cell testis tumors: Brazilian experience. ( de Góes, GM; Simon, SD; Srougi, M, 1985) |
| "Estramustine has been shown previously to be an effective drug in the treatment of metastatic prostatic cancer, demonstrating significant objective and subjective responses in long-term non-randomized trials and in other randomized trials." | 1.26 | The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation. ( Chu, TM; Gaeta, JF; Gibbons, RP; Johnson, DE; Loening, SA; Murphy, GP; Prout, GR; Saroff, J; Schmidt, JD; Scott, WW; Slack, N; Soloway, MS; Wajsman, Z, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghoneim, AM | 1 |
| Tadros, MI | 1 |
| Alaa-Eldin, AA | 1 |
| Else, M | 1 |
| Cocks, K | 1 |
| Crofts, S | 1 |
| Wade, R | 1 |
| Richards, SM | 1 |
| Catovsky, D | 1 |
| Smith, AG | 1 |
| Boesen, E | 1 |
| Mouridsen, HT | 2 |
| Kristensen, D | 1 |
| Nielsen, JH | 1 |
| Dombernowsky, P | 1 |
| Takigawa, H | 1 |
| Naruo, S | 1 |
| Kanayama, H | 1 |
| Kagawa, S | 1 |
| Yokoseki, H | 1 |
| Inai, T | 1 |
| Sumitani, H | 1 |
| Sakurai, N | 1 |
| Ogawa, I | 1 |
| Akazawa, S | 1 |
| Ponticelli, C | 1 |
| Altieri, P | 1 |
| Scolari, F | 1 |
| Passerini, P | 1 |
| Roccatello, D | 1 |
| Cesana, B | 1 |
| Melis, P | 1 |
| Valzorio, B | 1 |
| Sasdelli, M | 1 |
| Pasquali, S | 1 |
| Pozzi, C | 1 |
| Piccoli, G | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Grassi, C | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Cheng, E | 1 |
| Cvitkovic, E | 1 |
| Wittes, RE | 1 |
| Golbey, RB | 1 |
| Murphy, GP | 2 |
| Gibbons, RP | 1 |
| Johnson, DE | 1 |
| Prout, GR | 1 |
| Schmidt, JD | 1 |
| Soloway, MS | 1 |
| Loening, SA | 1 |
| Chu, TM | 1 |
| Gaeta, JF | 1 |
| Saroff, J | 1 |
| Wajsman, Z | 1 |
| Slack, N | 1 |
| Scott, WW | 1 |
| Slack, NH | 1 |
| Srougi, M | 1 |
| Simon, SD | 1 |
| de Góes, GM | 1 |
| Senyszyn, JJ | 1 |
| Johnson, RE | 1 |
| Curran, RE | 1 |
| Thumb, N | 1 |
| Gangl, A | 1 |
| Horak, W | 1 |
| Richter, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chronic Lymphocytic Leukemia Trial 4: A Randomized Comparison of Chlorambucil, Fludarabine and Fludarabine Plus Cyclophosphamide[NCT00004218] | Phase 3 | 0 participants | Interventional | 1999-10-31 | Completed | ||
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for chlorambucil and Emesis
| Article | Year |
|---|---|
Quality of life in chronic lymphocytic leukemia: 5-year results from the multicenter randomized LRF CLL4 trial.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Chlorambuc | 2012 |
[Efficacy of granisetron rescue therapy for nausea and vomiting induced by cancer chemotherapies in urogenital malignant tumor].
Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; C | 1996 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
Treatment of metastatic Ewing's sarcoma with actinomycin D (NSC-3053).
Topics: Adolescent; Adult; Child; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Dactinomycin; Hu | 1970 |
8 other studies available for chlorambucil and Emesis
| Article | Year |
|---|---|
Spray-Dried Silica Xerogel Nanoparticles as a Promising Gastroretentive Carrier System for the Management of Chemotherapy-Induced Nausea and Vomiting.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Delivery Systems; Drug Liberation; Gels; Male; Na | 2019 |
Prednimustine in combination with methotrexate and 5-FU (PMF): a pilot study.
Topics: Aged; Alopecia; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1982 |
Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Evaluation; Female; Humans; Leukopenia; Middle Age | 1980 |
Germ cell tumors (II): VAB II in metastatic testicular cancer.
Topics: Adolescent; Adult; Antineoplastic Agents; Bleomycin; Chlorambucil; Cisplatin; Dactinomycin; Drug Hyp | 1978 |
The use of estramustine and prednimustine versus prednimustine alone in advanced metastatic prostatic cancer patients who have received prior irradiation.
Topics: Chlorambucil; Drug Therapy, Combination; Estramustine; Humans; Male; Nausea; Neoplasm Metastasis; Ni | 1979 |
Prednimustine for prostate cancer therapy.
Topics: Chlorambucil; Estramustine; Hematopoiesis; Humans; Male; Nausea; Prednimustine; Prostatic Neoplasms; | 1979 |
Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum for advanced germ cell testis tumors: Brazilian experience.
Topics: Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brazil; Chlorambucil; Ci | 1985 |
[Experiences with the immunosuppressive treatment of rheumatoid arthritis].
Topics: Administration, Oral; Adult; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Benzoates; | 1969 |