chlorambucil has been researched along with Ear Neoplasms in 3 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Ear Neoplasms: Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil was linked to prednisolone to improve the therapeutic and toxic properties of this potent alkylating agent, which is known to induce second tumors in humans." | 1.27 | Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats. ( Berger, MR; Habs, M; Schmähl, D, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Streu, E | 1 |
| Stanway, A | 1 |
| Rademaker, M | 1 |
| Kennedy, I | 1 |
| Newman, P | 1 |
| Berger, MR | 1 |
| Habs, M | 1 |
| Schmähl, D | 1 |
3 other studies available for chlorambucil and Ear Neoplasms
| Article | Year |
|---|---|
Second malignancies in chronic lymphocytic leukemia.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carcin | 2014 |
Cutaneous B-cell lymphoma of nails, pinna and nose treated with chlorambucil.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Ear Neoplasms; Ear, Extern | 2004 |
Long-term toxicology effects of prednimustine in comparison with chlorambucil, prednisolone, and chlorambucil plus prednisolone in Sprague-Dawley rats.
Topics: Animals; Carcinoma, Squamous Cell; Chlorambucil; Drug Therapy, Combination; Ear Neoplasms; Female; M | 1986 |