chlorambucil has been researched along with Dysmyelopoietic Syndromes in 19 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years." | 3.70 | Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease. ( Bangerter, M; Griesshammer, M; Hafner, M; Heil, G; Heiss, M; Kern, P; Kern, W; Krauter, J; v Tirpitz, C, 1999) |
| " Although multi-drug therapy is known to produce myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) in patients with CTD, treatment with single-agent therapy, particularly methotrexate, has rarely been associated with secondary MDS or AML." | 3.69 | Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy. ( Farhi, DC; Rosenthal, NS, 1996) |
| "Patients with chronic lymphocytic leukemia (CLL) may have disease transformation to non-Hodgkin's lymphoma or prolymphocytic leukemia; however, development of therapy-related acute myeloid leukemia (t-AML) is unusual." | 2.70 | Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. ( Appelbaum, FR; Elias, L; Hines, JD; Kolitz, JE; Larson, RA; Morrison, VA; Peterson, BL; Rai, KR; Schiffer, CA; Shepherd, L, 2002) |
| "One of the MPDs, chronic myeloid leukemia (CML), has the distinct cytogenetic abnormality of the Philadelphia chromosome." | 2.42 | Treatment paradigms in the management of myeloproliferative disorders. ( Fruchtman, SM, 2004) |
| "To date, the majority of trials on chronic lymphocytic leukemia (CLL) focused on patients considerably younger than the median age of onset for CLL." | 1.39 | First immunochemotherapy outcomes in elderly patients with CLL: a retrospective analysis. ( Bouvet, E; Cazin, B; Coiffier, B; Laurent, G; Michallet, AS; Mosser, L; Oberic, L; Salles, G; Schlaifer, D; Ysebaert, L, 2013) |
| "Cytogenetic analysis showed complex chromosomal abnormalities including 5q deletion, 12p deletion and monosomy 18." | 1.33 | Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine. ( Cho, HS; Chun, SH; Hyun, MS; Kim, KO; Kim, MK; Lee, KH; Shin, SJ, 2005) |
| "Hodgkin's disease is curable in the majority of patients, although a proportion of patients are resistant to or relapse after initial therapy." | 1.30 | High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML. ( Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| da Cunha-Bang, C | 1 |
| Rostgaard, K | 1 |
| Andersen, MA | 1 |
| Rotbain, EC | 1 |
| Grønbaek, K | 1 |
| Frederiksen, H | 1 |
| Niemann, CU | 1 |
| Hjalgrim, H | 1 |
| Michallet, AS | 1 |
| Cazin, B | 1 |
| Bouvet, E | 1 |
| Oberic, L | 1 |
| Schlaifer, D | 1 |
| Mosser, L | 1 |
| Salles, G | 1 |
| Coiffier, B | 1 |
| Laurent, G | 1 |
| Ysebaert, L | 1 |
| Leleu, X | 1 |
| Soumerai, J | 1 |
| Roccaro, A | 1 |
| Hatjiharissi, E | 1 |
| Hunter, ZR | 1 |
| Manning, R | 1 |
| Ciccarelli, BT | 1 |
| Sacco, A | 1 |
| Ioakimidis, L | 1 |
| Adamia, S | 1 |
| Moreau, AS | 1 |
| Patterson, CJ | 1 |
| Ghobrial, IM | 1 |
| Treon, SP | 1 |
| Bauer, K | 1 |
| Herbst, C | 1 |
| Brillant, C | 1 |
| Monsef, I | 1 |
| Kluge, S | 1 |
| Skoetz, N | 1 |
| Engert, A | 1 |
| Morrison, VA | 1 |
| Rai, KR | 1 |
| Peterson, BL | 1 |
| Kolitz, JE | 1 |
| Elias, L | 1 |
| Appelbaum, FR | 1 |
| Hines, JD | 1 |
| Shepherd, L | 1 |
| Larson, RA | 1 |
| Schiffer, CA | 1 |
| Metayer, C | 1 |
| Curtis, RE | 1 |
| Vose, J | 1 |
| Sobocinski, KA | 1 |
| Horowitz, MM | 1 |
| Bhatia, S | 1 |
| Fay, JW | 1 |
| Freytes, CO | 1 |
| Goldstein, SC | 1 |
| Herzig, RH | 1 |
| Keating, A | 1 |
| Miller, CB | 1 |
| Nevill, TJ | 1 |
| Pecora, AL | 1 |
| Rizzo, JD | 1 |
| Williams, SF | 1 |
| Li, CY | 1 |
| Travis, LB | 1 |
| Weisdorf, DJ | 1 |
| Fruchtman, SM | 1 |
| Yen, CJ | 1 |
| Huang, WT | 1 |
| Huang, JJ | 1 |
| Chen, FF | 1 |
| Sung, JM | 1 |
| Balakrishnan, C | 1 |
| Pathan, E | 1 |
| Khodaiji, S | 1 |
| Dasgupta, A | 1 |
| Mangat, G | 1 |
| Joshi, VR | 1 |
| Shin, SJ | 1 |
| Chun, SH | 1 |
| Kim, KO | 1 |
| Kim, MK | 1 |
| Lee, KH | 1 |
| Hyun, MS | 1 |
| Cho, HS | 1 |
| Bauer, A | 1 |
| Garbe, C | 1 |
| Detmar, M | 1 |
| Kreuser, ED | 1 |
| Gollnick, H | 1 |
| Rosenthal, NS | 1 |
| Farhi, DC | 1 |
| Shammas, FV | 1 |
| Heikkilä, R | 1 |
| McCarthy, CJ | 1 |
| Sheldon, S | 1 |
| Ross, CW | 1 |
| McCune, WJ | 1 |
| Bangerter, M | 1 |
| Griesshammer, M | 1 |
| v Tirpitz, C | 1 |
| Krauter, J | 1 |
| Heil, G | 1 |
| Hafner, M | 1 |
| Kern, W | 1 |
| Heiss, M | 1 |
| Kern, P | 1 |
| Harrison, CN | 1 |
| Gregory, W | 1 |
| Hudson, GV | 1 |
| Devereux, S | 1 |
| Goldstone, AH | 1 |
| Hancock, B | 1 |
| Winfield, D | 1 |
| MacMillan, AK | 1 |
| Hoskin, P | 1 |
| Newland, AC | 1 |
| Milligan, D | 1 |
| Linch, DC | 1 |
| Sirianni, MC | 1 |
| Barbone, B | 1 |
| Monarca, B | 1 |
| Nanni, M | 1 |
| Laganà, B | 1 |
| Aiuti, F | 1 |
| Mahoney, DH | 1 |
| McClain, KL | 1 |
| Hanson, IC | 1 |
| Taylor, LD | 1 |
| Steuber, CP | 1 |
| Bennett, JM | 1 |
| Moloney, WC | 1 |
| Greene, MH | 1 |
| Boice, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| US Post-Marketing Retrospective Observational Safety Study of Moxetumomab Pasudotox-tdfk (LUMOXITI)(TM)[NCT04125290] | 2 participants (Actual) | Observational | 2019-12-09 | Terminated (stopped due to Study stopped due to lack of recruitment.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorambucil and Dysmyelopoietic Syndromes
| Article | Year |
|---|---|
Treatment paradigms in the management of myeloproliferative disorders.
Topics: Antineoplastic Agents, Alkylating; Busulfan; Chlorambucil; Hydroxyurea; Interferon-alpha; Leukemia, | 2004 |
[Multicentric reticulohistiocytosis and myelodysplastic syndrome].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambucil; Diagnosis, Differential; | 1994 |
1 trial available for chlorambucil and Dysmyelopoietic Syndromes
| Article | Year |
|---|---|
Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambuci | 2002 |
16 other studies available for chlorambucil and Dysmyelopoietic Syndromes
| Article | Year |
|---|---|
Risk of new malignancies among patients with CLL treated with chemotherapy: results of a Danish population-based study.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Chloramb | 2021 |
First immunochemotherapy outcomes in elderly patients with CLL: a retrospective analysis.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Chlora | 2013 |
Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenström macroglobulinemia treated with nucleoside analogs.
Topics: Adult; Aged; Aged, 80 and over; Cell Transformation, Neoplastic; Chlorambucil; Cladribine; Female; F | 2009 |
Eleventh biannual report of the Cochrane Haematological Malignancies Group: Focus on Hodgkin lymphoma.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bendamustine Hydrochloride; Ble | 2010 |
Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemoth | 2003 |
Prolonged chlorambucil therapy for idiopathic membranous nephropathy may induce myelodysplastic syndrome and acute leukemia: report of a case.
Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosomes, Human, Pair 7; F | 2004 |
Myelodysplasia and acute myeloid leukaemia in a case of rheumatoid arthritis with secondary amyloidosis treated with chlorambucil.
Topics: Acute Disease; Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Chlorambucil; Fatal Outcome | 2004 |
Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow | 2005 |
Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy.
Topics: Acute Disease; Adult; Aged; Antigens, CD; Antirheumatic Agents; Chlorambucil; Connective Tissue Dise | 1996 |
[Secondary myelodysplastic syndrome].
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Bone Marrow Transplantation; Chlorambucil; Cyclophos | 1997 |
Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease.
Topics: Adult; Aged; Alkylating Agents; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1998 |
Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
Topics: Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Bone Marrow Cells; Chlorambucil; Chromoso | 1999 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; | 1999 |
A case of Behćet's disease complicated by visceral Leishmaniasis and myelodysplasia: clinical considerations.
Topics: Adult; Antineoplastic Agents, Alkylating; Autoimmune Diseases; Behcet Syndrome; Chlorambucil; Humans | 2001 |
Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis.
Topics: Chlorambucil; Chromosome Deletion; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Female; H | 1989 |
Acute myeloid leukemia and other myelopathic disorders following treatment with alkylating agents.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Anemia, Aplastic; Child; Child, Preschool; Chlorambucil; | 1987 |