Compounds > chlorambucil
Page last updated: 2024-10-24

chlorambucil and Disgerminoma

chlorambucil has been researched along with Disgerminoma in 47 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Research Excerpts

ExcerptRelevanceReference
"Patients with germ cell tumors may be divided into "good risk" (high likelihood of complete response) and "poor risk" (low likelihood of complete response) based on pretreatment serum tumor markers, extent of disease, histology, and primary site."2.37Chemotherapy for germ cell tumors. ( Bosl, GJ; Motzer, RJ, 1987)
"Bilateral testicular tumors were detected on palpation and ultrasonography."2.37[A case of bilateral testicular tumors showing remarkable regression of huge metastatic tumors after VAB-6 combined chemotherapy]. ( Hisazumi, H; Nakajima, K; Nakashima, T; Nitta, M; Sugata, T; Tokunaga, S; Yokoyama, O, 1988)
"Disseminated germ cell testicular cancer proved to be highly sensitive to platinum-containing chemotherapy regimens."1.27Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum for advanced germ cell testis tumors: Brazilian experience. ( de Góes, GM; Simon, SD; Srougi, M, 1985)
"Sixteen patients with metastatic testicular cancer were treated with combination chemotherapy including cisplatin (CDDP) at 3- to 4-week intervals for two to five courses."1.27[Hypomagnesemia following chemotherapy of disseminated testicular tumors]. ( Hida, S; Nishimura, K; Nishio, Y; Okada, K; Okada, Y; Yoshida, O, 1988)
"Dysgerminomas are highly sensitive not only to irradiation but also to chemotherapy."1.27[Chemotherapy of dysgerminoma]. ( Brökelmann, J; Hartlapp, JH, 1987)
"Of 250 testicular tumors treated up to May 1975 233 (93."1.26The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle. ( Vahlensieck, W; Weissbach, L, 1977)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199045 (95.74)18.7374
1990's2 (4.26)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MIALE, A1
KESLER, K1
LEBHERZ, TB1
HUSTON, JW1
AUSTIN, JA1
BOYCE, CR1
Mackenzie, AR2
Laplante, MP1
Mount, BM1
Ekman, P1
Vugrin, D3
Whitmore, WF5
Golbey, RB5
Williams, SD1
Loehrer, PJ1
Einhorn, LH1
Merrin, C1
Vahlensieck, W3
Weissbach, L3
Kamat, MR1
Kulkarni, JN1
Tongaonkar, HB1
Ravi, R1
Tiuliandin, SA1
Srougi, M1
Simon, SD1
de Góes, GM1
Israel, A1
Bosl, GJ4
Whitmore, W1
Martini, N1
Hida, S2
Kawakita, M1
Takenawa, J1
Fukuzawa, S1
Okuno, H1
Yamauchi, T1
Oishi, K1
Nishio, Y2
Takeuchi, H1
Okada, K2
Motzer, RJ2
Herr, HW1
Bosl, G1
Carter, GE1
Lieskovsky, G1
Skinner, DG2
Daniels, JR1
Geller, NL1
Penenberg, D1
Yagoda, A1
Golbey, R1
Fair, WR1
Sogani, P2
Herr, H2
Nishimura, K1
Okada, Y1
Yoshida, O1
Masuda, F1
Nakada, J1
Kondo, N1
Takahashi, T1
Mochizuki, A1
Iizuka, N1
Nakashima, T1
Nakajima, K1
Yokoyama, O1
Sugata, T1
Tokunaga, S1
Nitta, M1
Hisazumi, H1
Stanton, GF1
Morse, M1
Le Duc, A1
Gisselbrecht, C1
Le Doze, H1
Mignot, L1
Brökelmann, J1
Hartlapp, JH1
Gödde, S1
Gibson, GR1
Wilms, K3
Bonadonna, G1
Baumgartner, G1
Rathert, P1
Terhorst, B1
Lutzeyer, W1
Lange, CE1
Meyhöfer, W1
Astrakhan, VI1
Monul, FA1
Woodruff, JD1
Protos, P1
Peterson, WF1
Ryssel, HJ1
Sonntag, RW1
Brunner, KW1
Du Priest, RW1
Fletcher, WS1
Dargent, M1
Pommatau, E1
Brunat, M1
Furnari, S1
Pavone-Macaluso, M1
Veroux, G1
Mattea, E1
Hartwich, G1
Butzler, W1
Leadbetter, WF1
Wider, JA1
Marshall, JR1
Bardin, CW1
Lipsett, MB1
Ross, GT1

Reviews

5 reviews available for chlorambucil and Disgerminoma

ArticleYear
Current concepts in the management of testicular germ cell tumours in adults. A review.
    International journal of andrology, 1982, Volume: 5, Issue:4

    Topics: Adult; alpha-Fetoproteins; Bleomycin; Chlorambucil; Chorionic Gonadotropin; Chorionic Gonadotropin,

1982
Seminoma.
    The Urologic clinics of North America, 1977, Volume: 4, Issue:3

    Topics: Adult; Aging; Castration; Chlorambucil; Cryptorchidism; Cyclophosphamide; Dysgerminoma; Humans; Male

1977
Chemotherapy for germ cell tumors.
    The Urologic clinics of North America, 1987, Volume: 14, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit

1987
[A case of bilateral testicular tumors showing remarkable regression of huge metastatic tumors after VAB-6 combined chemotherapy].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:10

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined

1988
Chemotherapy of testicular tumors.
    Acta chirurgica Belgica, 1971, Volume: 70, Issue:4

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Chlorambucil; Dactinomycin; Dysgermin

1971

Other Studies

42 other studies available for chlorambucil and Disgerminoma

ArticleYear
OVARIAN DISGERMINOMA. REPORT OF A CASE TREATED WITH ACTINOMYCIN D, CHLORAMBUCIL, AND METHOTREXATE AFTER MASSIVE IRRADIATION.
    The Medical annals of the District of Columbia, 1964, Volume: 33

    Topics: Chlorambucil; Dactinomycin; Drug Therapy; Dysgerminoma; Female; Humans; Methotrexate; Neoplasms; Neo

1964
SUSTAINED PALLIATION IN OVARIAN CARCINOMA.
    Obstetrics and gynecology, 1965, Volume: 25

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Carcinoma; Chlorambucil; Dysgerminoma; Female; Gr

1965
Chemotherapy of metastatic testis cancer. Results in 154 patients.
    Cancer, 1966, Volume: 19, Issue:10

    Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Choriocarcinoma; Dactinomycin; Dy

1966
Lymphadenectomy for testicular carcinoma.
    Canadian journal of surgery. Journal canadien de chirurgie, 1982, Volume: 25, Issue:3

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Chor

1982
VAB-6 combination chemotherapy without maintenance in treatment of disseminated cancer of the testis.
    Cancer, 1983, Jan-15, Volume: 51, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin;

1983
Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum combination chemotherapy in metastatic testis cancer--a 1-year program.
    The Journal of urology, 1982, Volume: 128, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin;

1982
The VAB-6 regimen in the treatment of metastatic seminoma.
    Cancer, 1984, Jun-01, Volume: 53, Issue:11

    Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cispla

1984
Chemotherapy of advanced testicular cancer.
    Seminars in urology, 1984, Volume: 2, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit

1984
The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1977, Issue:60

    Topics: Chlorambucil; Dactinomycin; Drug Therapy, Combination; Dysgerminoma; Humans; Ifosfamide; Lymph Node

1977
Value of retroperitoneal lymph node dissection in advanced testicular seminoma.
    Journal of surgical oncology, 1992, Volume: 51, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit

1992
[Infusion of high doses of platidiam in the treatment of patients with germ cell testicular tumors].
    Voprosy onkologii, 1990, Volume: 36, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Cyclophosphamide

1990
Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum for advanced germ cell testis tumors: Brazilian experience.
    The Journal of urology, 1985, Volume: 134, Issue:1

    Topics: Adult; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Brazil; Chlorambucil; Ci

1985
The results of chemotherapy for extragonadal germ-cell tumors in the cisplatin era: the Memorial Sloan-Kettering Cancer Center experience (1975 to 1982).
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:8

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplati

1985
[VAB-6 combination chemotherapy in patients with stage II, III testicular tumor].
    Hinyokika kiyo. Acta urologica Japonica, 1986, Volume: 32, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplati

1986
Residual mass after chemotherapy for seminoma: changing concepts of management.
    The Journal of urology, 1987, Volume: 137, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit

1987
Reassessment of the role of adjunctive surgical therapy in the treatment of advanced germ cell tumors.
    The Journal of urology, 1987, Volume: 138, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit

1987
Advanced seminoma: the role of chemotherapy and adjunctive surgery.
    Annals of internal medicine, 1988, Volume: 108, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit

1988
[Hypomagnesemia following chemotherapy of disseminated testicular tumors].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis

1988
[Treatment of nonseminomatous testicular tumor with liver metastases].
    Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis

1988
VAB-6 as initial treatment of patients with advanced seminoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:3

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Cyclophos

1985
[Role of chemotherapy in the treatment of cancer of the testis in adults].
    Presse medicale (Paris, France : 1983), 1985, Feb-09, Volume: 14, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis

1985
[Chemotherapy of dysgerminoma].
    Geburtshilfe und Frauenheilkunde, 1987, Volume: 47, Issue:4

    Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined

1987
[Transperitoneal lymph node excision and cytostatic postoperative treatment of malignant germinal testicular neoplasms].
    Langenbecks Archiv fur Chirurgie, 1968, Volume: 322

    Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Synergism; Dysgerminoma; Humans; Lymph Node

1968
Lymphangiography as a diagnostic aid. Report of a case.
    The Australian and New Zealand journal of surgery, 1964, Volume: 33, Issue:3

    Topics: Abdomen; Chlorambucil; Dactinomycin; Dysgerminoma; Humans; Hydronephrosis; Lymph Nodes; Lymphography

1964
[Cytostatic treatment of malignant testicular neoplasms].
    Deutsche medizinische Wochenschrift (1946), 1971, Nov-26, Volume: 96, Issue:48

    Topics: Adult; Antibiotics, Antineoplastic; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; D

1971
[Cytostatic therapy of malignant testicular neoplasms].
    Deutsche medizinische Wochenschrift (1946), 1972, Mar-31, Volume: 97, Issue:13

    Topics: Antineoplastic Agents; Castration; Chlorambucil; Dactinomycin; Dysgerminoma; Humans; Male; Methotrex

1972
[Cytostatic therapy of malignant testicular tumors].
    Minerva medica, 1973, Mar-14, Volume: 64, Issue:14

    Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Dysgerminoma; Humans; Male; Methotrexate; Plicamy

1973
[Results with the cytostatic agent bleomycin in tumour therapy (author's transl)].
    Wiener klinische Wochenschrift, 1973, Oct-19, Volume: 85, Issue:42

    Topics: Adult; Aged; Bleomycin; Bronchial Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; Doxorubicin; Dr

1973
[Bleomycin for malignant tumours of the genitals of the male (author's transl)].
    Der Urologe. Ausg. A, 1974, Volume: 13, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil

1974
[Testicular histology, ejaculate and nucleoprotein content of spermatozoa in patients with treated testicular tumors].
    Andrologia, 1974, Volume: 6, Issue:2

    Topics: Adult; Biopsy; Chlorambucil; Dactinomycin; DNA; Dysgerminoma; Ejaculation; Fertility; Humans; Male;

1974
[The combined chemotherapy of testicular tumors resistant to sarcolysin].
    Voprosy onkologii, 1967, Volume: 13, Issue:4

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide;

1967
Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis.
    American journal of obstetrics and gynecology, 1968, Nov-01, Volume: 102, Issue:5

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin

1968
[Treatment of choriocarcinoma and malignant testicular neoplasms in internal medicine].
    Helvetica medica acta. Supplementum, 1967, May-28, Volume: 47

    Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; Humans; Lung Neoplasms;

1967
Chemotherapy of testicular germinal tumors.
    Oncology, 1973, Volume: 28, Issue:2

    Topics: Alkylating Agents; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Dysgerminoma

1973
[Apropos of an experience with the polychemotherapy of cancer].
    Le Poumon et le coeur, 1968, Volume: 24, Issue:1

    Topics: Adult; Bone Neoplasms; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgermi

1968
Cancer chemotherapy in urology.
    Urologia internationalis, 1971, Volume: 26, Issue:4

    Topics: Adenocarcinoma; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Cobal

1971
Operative and cytostatic treatment of germinal tumours of the testis.
    International urology and nephrology, 1973, Volume: 5, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents; Castration; Child; Child, Preschool; Chlorambucil; Cyclic

1973
[Secondary tumors in hemoblastoses during cytostatic treatment].
    Medizinische Klinik, 1971, Oct-22, Volume: 66, Issue:43

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo

1971
The surgical management of testis tumors.
    The Journal of urology, 1971, Volume: 106, Issue:1

    Topics: Adolescent; Adult; Castration; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin;

1971
The place of chemotherapy in the treatment of testicular tumors.
    JAMA, 1970, Jul-06, Volume: 213, Issue:1

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Chorionic Gonadot

1970
Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma.
    The New England journal of medicine, 1969, Jun-26, Volume: 280, Issue:26

    Topics: Adolescent; Adult; Child; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Dysge

1969
The chemotherapy of metastatic seminoma.
    The Journal of urology, 1966, Volume: 96, Issue:5

    Topics: Chlorambucil; Dysgerminoma; Humans; Male; Middle Aged; Testicular Neoplasms

1966