chlorambucil has been researched along with Disease Models, Animal in 15 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to determine if Rituximab coated Biodegradable Nanoparticles (BNPs) loaded with Chlorambucil and Hydroxychloroquine could induce apoptosis of B-Chronic Lymphocytic Leukemia (B-CLL), MEC-1 and BJAB cells in vitro and evaluate their toxic and therapeutic effects on a Human/Mouse Model of Burkitt Lymphoma at an exploratory, proof of concept scale." | 3.76 | Exploratory study on the effects of biodegradable nanoparticles with drugs on malignant B cells and on a human/mouse model of Burkitt lymphoma. ( Ingrao, S; Larsen, G; Maceira, A; Macor, P; Mansilla, E; Marín, GH; Mertz, C; Mezzaroba, N; Núñez, L; Spretz, R; Tau, JM; Tedesco, F; Tripodo, C; Zorzet, S, 2010) |
| " Similar side effect intensity of BZA2 and dacarbazine was observed, whereas BZA1 was more toxic." | 1.33 | Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model. ( Bauder-Wüst, U; Eisenhut, M; Eskerski, H; Haberkorn, U; Wolf, M, 2006) |
| " The toxicity of these compounds against hepatoma cells (MH3924A) and, to a lesser extent, against mouse fibroblast (NIH 3T3) and cervix carcinoma (HeLa) cells was also enhanced, but they were not as toxic as dacarbazine (HeLa)." | 1.32 | Alkylating benzamides with melanoma cytotoxicity. ( Bauder-Wüst, U; Eisenhut, M; Haberkorn, U; Mier, W; Mohammed, A; Schönsiegel, F; Wolf, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Koutsourea, AI | 1 |
| Fousteris, MA | 1 |
| Arsenou, ES | 1 |
| Papageorgiou, A | 1 |
| Pairas, GN | 1 |
| Nikolaropoulos, SS | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Daifu, T | 1 |
| Mikami, M | 1 |
| Hiramatsu, H | 1 |
| Iwai, A | 1 |
| Umeda, K | 1 |
| Noura, M | 1 |
| Kubota, H | 1 |
| Masuda, T | 1 |
| Furuichi, K | 1 |
| Takasaki, S | 1 |
| Noguchi, Y | 1 |
| Morita, K | 1 |
| Bando, T | 1 |
| Hirata, M | 1 |
| Kataoka, TR | 1 |
| Nakahata, T | 1 |
| Kuwahara, Y | 1 |
| Iehara, T | 1 |
| Hosoi, H | 1 |
| Takita, J | 1 |
| Sugiyama, H | 1 |
| Adachi, S | 1 |
| Kamikubo, Y | 1 |
| Mezzaroba, N | 2 |
| Zorzet, S | 2 |
| Secco, E | 1 |
| Biffi, S | 1 |
| Tripodo, C | 2 |
| Calvaruso, M | 1 |
| Mendoza-Maldonado, R | 1 |
| Capolla, S | 1 |
| Granzotto, M | 1 |
| Spretz, R | 2 |
| Larsen, G | 2 |
| Noriega, S | 1 |
| Lucafò, M | 1 |
| Mansilla, E | 2 |
| Garrovo, C | 1 |
| Marín, GH | 2 |
| Baj, G | 1 |
| Gattei, V | 1 |
| Pozzato, G | 1 |
| Núñez, L | 2 |
| Macor, P | 2 |
| Tau, JM | 1 |
| Maceira, A | 1 |
| Mertz, C | 1 |
| Ingrao, S | 1 |
| Tedesco, F | 1 |
| Shtrasburg, S | 1 |
| Pras, M | 1 |
| Rabinovich, E | 1 |
| Gal, R | 1 |
| Livneh, A | 1 |
| Lidar, M | 1 |
| Oskooii, AE | 1 |
| Gholizad, LM | 1 |
| Zare, S | 1 |
| Nejati, V | 1 |
| Wolf, M | 2 |
| Bauder-Wüst, U | 2 |
| Mohammed, A | 1 |
| Schönsiegel, F | 1 |
| Mier, W | 1 |
| Haberkorn, U | 2 |
| Eisenhut, M | 2 |
| Eskerski, H | 1 |
| Flaherty, L | 1 |
| Bryda, EC | 1 |
| Collins, D | 1 |
| Rudofsky, U | 1 |
| Montogomery, JC | 1 |
| Wittman, MD | 1 |
| Kadow, JF | 1 |
| Vyas, DM | 1 |
| Lee, FL | 1 |
| Rose, WC | 1 |
| Long, BH | 1 |
| Fairchild, C | 1 |
| Johnston, K | 1 |
| Barnett, EV | 1 |
| Bluestone, R | 1 |
| Cracchiolo, A | 1 |
| Goldberg, LS | 1 |
| Kantor, GL | 1 |
| McIntosh, RM | 1 |
| Berenbaum, MC | 1 |
| Sheard, CE | 1 |
| Reittie, JR | 1 |
| Bundick, RV | 1 |
| Palestini, M | 1 |
| Meglio, M | 1 |
| Rossi, GF | 1 |
15 other studies available for chlorambucil and Disease Models, Animal
| Article | Year |
|---|---|
Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters.
Topics: Alkylation; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug | 2008 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chlorambucil; Core Binding Factor Alph | 2021 |
New potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Apoptosis; Autophagy; Cell Survival | 2013 |
Exploratory study on the effects of biodegradable nanoparticles with drugs on malignant B cells and on a human/mouse model of Burkitt lymphoma.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; B-Lymphocytes; Burkitt Lymph | 2010 |
Attempts at suppression of amyloidogenesis in a mouse model by a variety of anti-inflammatory agents.
Topics: Amyloid; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chlorambucil; Cyclophosphami | 2012 |
A comparison of effects of ABVD and ChlVPP chemotherapeutic protocols for Hodgkin's disease on rats' epididiymal and testicular tissues.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Dacarbazine; Disea | 2010 |
Alkylating benzamides with melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Line, Tumor; Cel | 2004 |
Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzamides; Chlorambucil; Dacarbazine; Disease Models, A | 2006 |
New mouse model for polycystic kidney disease with both recessive and dominant gene effects.
Topics: Animals; Chlorambucil; Chromosome Mapping; Disease Models, Animal; DNA, Mitochondrial; Genes, Domina | 1995 |
Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic | 2001 |
Cryoglobulinemia and disease.
Topics: Adult; Anemia, Hemolytic; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Beta-Globulins | 1970 |
The growth of human tumours in immunosuppressed mice and their response to chemotherapy.
Topics: Animals; Chlorambucil; Cyclophosphamide; Dactinomycin; Disease Models, Animal; Female; Fluorouracil; | 1974 |
[A model of experimental epilepsy (chlorambucil)].
Topics: Animals; Cats; Chlorambucil; Disease Models, Animal; Electroencephalography; Epilepsy, Absence | 1972 |