chlorambucil has been researched along with Disease Exacerbation in 32 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective was to determine the safety and efficacy of adding a maximally tolerated dose of 2-chlorodeoxyadenosine (2-CdA) to standard chlorambucil (CLB) therapy in previously untreated B-cell chronic lymphocytic leukemia (CLL)." | 9.09 | Phase II study of 2-chlorodeoxyadenosine in combination with chlorambucil in previously untreated B-cell chronic lymphocytic leukemia. ( Krook, JE; Levitt, R; Li, CY; Michalak, JC; Schroeder, G; Tefferi, A; Tschetter, LK; Witzig, TE, 1999) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 7.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "The objective was to determine the safety and efficacy of adding a maximally tolerated dose of 2-chlorodeoxyadenosine (2-CdA) to standard chlorambucil (CLB) therapy in previously untreated B-cell chronic lymphocytic leukemia (CLL)." | 5.09 | Phase II study of 2-chlorodeoxyadenosine in combination with chlorambucil in previously untreated B-cell chronic lymphocytic leukemia. ( Krook, JE; Levitt, R; Li, CY; Michalak, JC; Schroeder, G; Tefferi, A; Tschetter, LK; Witzig, TE, 1999) |
| " Randomized studies have shown that the risk of thrombosis was significantly reduced in ET with the use of hydroxyurea (HU) and in PV with the use of chlorambucil or 32P." | 4.80 | Treatment of polycythaemia vera and essential thrombocythaemia. ( Silverstein, MN; Tefferi, A, 1998) |
| " In vitro studies of human chronic lymphocytic leukemia cells incubated with theophylline, a phosphodiesterase inhibitor, resulted in downregulation of bcl-2 concomitant with induction of apoptosis." | 3.70 | Theophylline, pentostatin (Nipent), and chlorambucil: a dose-escalation study targeting intrinsic biologic resistance mechanisms in patients with relapsed lymphoproliferative disorders. ( Byrd, JC; Flinn, IW; Goodrich, A; Grever, MR; Lucas, MA; Park, K; Shinn, C; Waselenko, JK; Willis, CR, 2000) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 3.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "A median of two cycles were given until disease progression or grade 3/4 toxicity." | 2.71 | Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial. ( Neville, F; Nystrom, ML; Oliver, RT; Shamash, J; Steele, JP, 2003) |
| "Although chlorambucil slowed disease progression, there was no effect on overall survival." | 2.69 | Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. ( Binet, JL; Cazin, B; Desablens, B; Dighiero, G; Dreyfus, B; Jaubert, J; Leblay, R; Lepeu, G; Leporrier, M; Maloum, K; Navarro, M; Travade, P, 1998) |
| "Disease progression was significantly more frequent in patients presenting an immunological event or an M component." | 2.41 | Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients. ( Arcache, J; Arnaud, P; Berger, F; Callet-Bauchu, E; Coiffier, B; Dumontet, C; Felman, P; Hequet, O; Salles, G; Thieblemont, C, 2002) |
| "We report on a case of Waldenström's macroglobulinemia (WM) treated with splenic re-irradiation." | 1.38 | Splenic re-irradiation for waldenstrőm's macroglobulinemia. ( Han, W; Wei, Z; Yanxia, Y; Ying, X; Yuhua, J, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (15.63) | 18.2507 |
| 2000's | 15 (46.88) | 29.6817 |
| 2010's | 12 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pejsa, V | 1 |
| Lucijanic, M | 1 |
| Jonjic, Z | 1 |
| Prka, Z | 1 |
| Vukorepa, G | 1 |
| Palmisano, F | 1 |
| Lorusso, V | 1 |
| Spinelli, MG | 1 |
| Dell'Orto, PG | 1 |
| Montanari, E | 1 |
| Else, M | 2 |
| Wade, R | 2 |
| Oscier, D | 2 |
| Catovsky, D | 2 |
| Vidal, L | 1 |
| Gurion, R | 1 |
| Ram, R | 1 |
| Raanani, P | 1 |
| Bairey, O | 1 |
| Robak, T | 1 |
| Gafter-Gvili, A | 1 |
| Shpilberg, O | 1 |
| Taylor, F | 1 |
| Gear, R | 1 |
| Hoather, T | 1 |
| Dobson, J | 1 |
| Friedman, DR | 1 |
| Weinberg, JB | 1 |
| Barry, WT | 1 |
| Goodman, BK | 1 |
| Volkheimer, AD | 1 |
| Bond, KM | 1 |
| Chen, Y | 1 |
| Jiang, N | 1 |
| Moore, JO | 1 |
| Gockerman, JP | 1 |
| Diehl, LF | 1 |
| Decastro, CM | 1 |
| Potti, A | 1 |
| Nevins, JR | 1 |
| Proctor, SJ | 2 |
| Lennard, AL | 1 |
| Jackson, GH | 2 |
| Jones, GL | 1 |
| Lewis, J | 1 |
| Wilkinson, J | 1 |
| White, J | 1 |
| Sieniawski, M | 1 |
| McKay, P | 1 |
| Culligan, D | 1 |
| Lucraft, HH | 2 |
| Dreyling, M | 1 |
| Polliack, A | 2 |
| Tadmor, T | 2 |
| Bejar, J | 1 |
| Attias, D | 1 |
| Pentsova, E | 1 |
| Rosenblum, M | 1 |
| Holodny, A | 1 |
| Palomba, ML | 1 |
| Omuro, A | 1 |
| Wei, Z | 1 |
| Yanxia, Y | 1 |
| Ying, X | 1 |
| Han, W | 1 |
| Yuhua, J | 1 |
| Skowronska, A | 1 |
| Parker, A | 1 |
| Ahmed, G | 1 |
| Oldreive, C | 1 |
| Davis, Z | 1 |
| Richards, S | 2 |
| Dyer, M | 1 |
| Matutes, E | 1 |
| Gonzalez, D | 1 |
| Taylor, AM | 1 |
| Moss, P | 1 |
| Thomas, P | 1 |
| Stankovic, T | 1 |
| Hapgood, G | 1 |
| Mooney, E | 1 |
| Dinh, HV | 1 |
| Gin, D | 1 |
| McLean, C | 1 |
| Ting, SB | 1 |
| Thieblemont, C | 1 |
| Felman, P | 1 |
| Berger, F | 1 |
| Dumontet, C | 1 |
| Arnaud, P | 1 |
| Hequet, O | 1 |
| Arcache, J | 1 |
| Callet-Bauchu, E | 1 |
| Salles, G | 1 |
| Coiffier, B | 1 |
| Akpek, EK | 1 |
| Jabs, DA | 1 |
| Tessler, HH | 1 |
| Joondeph, BC | 1 |
| Foster, CS | 1 |
| Nystrom, ML | 1 |
| Steele, JP | 1 |
| Shamash, J | 1 |
| Neville, F | 1 |
| Oliver, RT | 1 |
| Manoharan, A | 1 |
| Hebert, LA | 1 |
| Rovin, BH | 1 |
| Agarwal, AK | 1 |
| Spetie, DN | 1 |
| Levin, M | 1 |
| Libster, D | 1 |
| Johnson, PW | 1 |
| Radford, JA | 1 |
| Cullen, MH | 1 |
| Sydes, MR | 1 |
| Walewski, J | 1 |
| Jack, AS | 1 |
| MacLennan, KA | 1 |
| Stenning, SP | 1 |
| Clawson, S | 1 |
| Smith, P | 1 |
| Ryder, D | 1 |
| Hancock, BW | 1 |
| Taylor, PR | 1 |
| White, JM | 1 |
| Prescott, RJ | 1 |
| Angus, B | 1 |
| Galloway, MJ | 1 |
| Lessells, AM | 1 |
| Summerfield, GP | 1 |
| Dearden, C | 1 |
| Milligan, D | 1 |
| Hamblin, T | 1 |
| Deslandes, E | 1 |
| Chevret, S | 1 |
| Demko, S | 1 |
| Summers, J | 1 |
| Keegan, P | 1 |
| Pazdur, R | 1 |
| Nand, S | 1 |
| Stock, W | 1 |
| Godwin, J | 1 |
| Fisher, SG | 1 |
| Dighiero, G | 1 |
| Maloum, K | 1 |
| Desablens, B | 1 |
| Cazin, B | 1 |
| Navarro, M | 1 |
| Leblay, R | 1 |
| Leporrier, M | 1 |
| Jaubert, J | 1 |
| Lepeu, G | 1 |
| Dreyfus, B | 1 |
| Binet, JL | 1 |
| Travade, P | 1 |
| Saletti, P | 1 |
| Zucca, E | 1 |
| Gueneau, M | 1 |
| Peccatori, F | 1 |
| Cavalli, F | 2 |
| Martinelli, G | 1 |
| Tefferi, A | 2 |
| Levitt, R | 1 |
| Li, CY | 1 |
| Schroeder, G | 1 |
| Tschetter, LK | 1 |
| Michalak, JC | 1 |
| Krook, JE | 1 |
| Witzig, TE | 1 |
| Silverstein, MN | 1 |
| Byrd, JC | 1 |
| Grever, MR | 1 |
| Waselenko, JK | 1 |
| Willis, CR | 1 |
| Park, K | 1 |
| Goodrich, A | 1 |
| Lucas, MA | 1 |
| Shinn, C | 1 |
| Flinn, IW | 1 |
| Carde, P | 1 |
| Diehl, V | 1 |
| Franklin, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Chronic Lymphocytic Leukemia Trial 4: A Randomized Comparison of Chlorambucil, Fludarabine and Fludarabine Plus Cyclophosphamide[NCT00004218] | Phase 3 | 0 participants | Interventional | 1999-10-31 | Completed | ||
| A UKLG Randomised Trial of Initial Chemotherapy for Advanced Stage Hodgkins Disease[NCT00003421] | Phase 3 | 800 participants (Anticipated) | Interventional | 1998-06-30 | Completed | ||
| Phase III Randomized Study to Investigate the Use of Acalabrutinib in the Treatment of Patients With Early Stage CLL With High Risk of Early Disease Progression[NCT04178798] | Phase 3 | 22 participants (Actual) | Interventional | 2019-12-09 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for chlorambucil and Disease Exacerbation
| Article | Year |
|---|---|
Blastoid variant of mantle cell lymphoma of the female urethra mimicking a caruncle: A rare but highly aggressive subtype case with literature review.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Diagnosis, Differential; Disease | 2019 |
Chlorambucil for the treatment of patients with chronic lymphocytic leukemia (CLL) - a systematic review and meta-analysis of randomized trials.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dis | 2016 |
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Disease Progress | 2010 |
Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combin | 2002 |
Treatment of polycythaemia vera and essential thrombocythaemia.
Topics: Adult; Aged; Aspirin; Chlorambucil; Disease Progression; Female; Hemorrhage; Humans; Hydroxyurea; In | 1998 |
Is escalated BEACOPP a standard therapy for advanced Hodgkin's disease?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Clinical Trials, Phase III | 2000 |
9 trials available for chlorambucil and Disease Exacerbation
| Article | Year |
|---|---|
The long-term outcome of patients in the LRF CLL4 trial: the effect of salvage treatment and biological markers in those surviving 10 years.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Chlo | 2016 |
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.
Topics: Aged; Alleles; Antineoplastic Combined Chemotherapy Protocols; Ataxia Telangiectasia Mutated Protein | 2012 |
Low-dose continuous chemotherapy for metastatic melanoma: a phase II trial.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylatin | 2003 |
Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin's lymphoma: results of the United Kingdom Lymphoma Group LY09 Trial (ISRCTN97144519).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Co | 2005 |
The addition of oral idarubicin to a chlorambucil/dexamethasone combination has a significant impact on time to treatment failure but none on overall survival in patients with low grade non-Hodgkin's lymphoma: Results of the Scotland and Newcastle Lymphom
Topics: Administration, Oral; Adolescent; Adult; Aged; Chlorambucil; Dexamethasone; Disease Progression; Dru | 2006 |
The prognostic significance of a positive direct antiglobulin test in chronic lymphocytic leukemia: a beneficial effect of the combination of fludarabine and cyclophosphamide on the incidence of hemolytic anemia.
Topics: Aged; Anemia, Hemolytic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlo | 2008 |
FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia.
Topics: Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; | 2008 |
Chlorambucil in indolent chronic lymphocytic leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambuci | 1998 |
Phase II study of 2-chlorodeoxyadenosine in combination with chlorambucil in previously untreated B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Disease Progression; Femal | 1999 |
17 other studies available for chlorambucil and Disease Exacerbation
| Article | Year |
|---|---|
Progressive multifocal leukoencephalopathy developing after obinutuzumab treatment for chronic lymphocytic leukemia.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Che | 2019 |
Ofatumumab in previously untreated chronic lymphocytic leukaemia. No clear advantages when added to chlorambucil.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Prot | 2015 |
Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined | 2009 |
A genomic approach to improve prognosis and predict therapeutic response in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Anti | 2009 |
Chlorambucil in indolent mantle cell lymphoma--just another old drug for a new disease?
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Chlorambucil; Disease Progressio | 2011 |
Richter syndrome in chronic lymphocytic leukaemia manifesting only as tumorous hepatomegaly.
Topics: Adrenal Cortex Hormones; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemo | 2011 |
Chemotherapy-related magnetic resonance imaging abnormalities mimicking disease progression following intraventricular liposomal cytarabine and high dose methotrexate for neurolymphomatosis.
Topics: Aged; Antineoplastic Agents; Autopsy; Brain; Brain Injuries; Chlorambucil; Cytarabine; Disease Progr | 2012 |
Splenic re-irradiation for waldenstrőm's macroglobulinemia.
Topics: Aged; Antineoplastic Agents; Chlorambucil; Combined Modality Therapy; Cyclophosphamide; Disease Prog | 2012 |
Leukaemia cutis in chronic lymphocytic leukaemia following varicella zoster virus reactivation.
Topics: Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Disease Progression; Herpes Zoster; Humans; L | 2012 |
Successful treatment of serpiginous choroiditis with alkylating agents.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Choroiditis; Cyclophosphamide; Disease | 2002 |
Long-term maintenance therapy with weekly chlorambucil in patients with symptomatic or progressive follicular lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Disease Progression | 2004 |
Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progression.
Topics: Chlorambucil; Creatinine; Cyclophosphamide; Disease Progression; Drug Therapy, Combination; Glomerul | 2005 |
Allergic reaction to chlorambucil in chronic lymphocytic leukemia presenting with fever and lymphadenopathy.
Topics: Aged; Chlorambucil; Disease Progression; Drug Hypersensitivity; Female; Fever; Humans; Leukemia, Lym | 2005 |
Assessing surrogacy from the joint modelling of multivariate longitudinal data and survival: application to clinical trial data on chronic lymphocytic leukaemia.
Topics: Antineoplastic Agents, Alkylating; Biomarkers; Biometry; Cell Count; Chlorambucil; Data Interpretati | 2007 |
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; | 1996 |
ChlVPP/ABV-VP16 hybrid regimen for advanced Hodgkin's disease: a study in 36 patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Disease Progre | 1999 |
Theophylline, pentostatin (Nipent), and chlorambucil: a dose-escalation study targeting intrinsic biologic resistance mechanisms in patients with relapsed lymphoproliferative disorders.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy | 2000 |