chlorambucil has been researched along with Dermatomyositis in 16 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Dermatomyositis: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our purpose was to determine whether low-dose methotrexate administered weekly in combination with other systemic therapies or as a sole systemic agent is effective in the treatment of the cutaneous disease in patients with dermatomyositis." | 7.69 | Low-dose methotrexate administered weekly is an effective corticosteroid-sparing agent for the treatment of the cutaneous manifestations of dermatomyositis. ( Callen, JP; Kasteler, JS, 1997) |
| "To investigate the effectiveness of oral chlorambucil treatment in patients with dermatomyositis (DM) that is recalcitrant to treatment with prednisone and/or immunosuppressive agents." | 7.68 | Chlorambucil. An effective corticosteroid-sparing agent for patients with recalcitrant dermatomyositis. ( Callen, JP; Sinoway, PA, 1993) |
| "Our purpose was to determine whether low-dose methotrexate administered weekly in combination with other systemic therapies or as a sole systemic agent is effective in the treatment of the cutaneous disease in patients with dermatomyositis." | 3.69 | Low-dose methotrexate administered weekly is an effective corticosteroid-sparing agent for the treatment of the cutaneous manifestations of dermatomyositis. ( Callen, JP; Kasteler, JS, 1997) |
| "To investigate the effectiveness of oral chlorambucil treatment in patients with dermatomyositis (DM) that is recalcitrant to treatment with prednisone and/or immunosuppressive agents." | 3.68 | Chlorambucil. An effective corticosteroid-sparing agent for patients with recalcitrant dermatomyositis. ( Callen, JP; Sinoway, PA, 1993) |
| "Thirty-five patients with idiopathic inflammatory myopathy (IM) were treated with plasmapheresis." | 1.26 | Plasmapheresis in idiopathic inflammatory myopathy. Experience with 35 patients. ( Dau, PC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dau, PC | 3 |
| Le Guillou, M | 1 |
| Richard, F | 1 |
| L'Hénaff, F | 1 |
| Ferriere, JM | 1 |
| Durand, J | 1 |
| Lacert, P | 1 |
| Küss, R | 1 |
| Bennington, JL | 1 |
| Sinoway, PA | 1 |
| Callen, JP | 2 |
| Kasteler, JS | 1 |
| Villalba, L | 1 |
| Adams, EM | 1 |
| Whallett, AJ | 1 |
| Gillott, TJ | 1 |
| Klocke, R | 1 |
| Coppock, JS | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Nashel, DJ | 1 |
| Wallace, DJ | 1 |
| Metzger, AL | 1 |
| White, KK | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Richier, JL | 1 |
| Guérin, D | 1 |
| Leblay, R | 1 |
| Pony, JC | 1 |
| Marmont, A | 1 |
| Rossi, F | 1 |
| Bordo, D | 1 |
| Stögmann, W | 1 |
| Cruchaud, A | 1 |
4 reviews available for chlorambucil and Dermatomyositis
| Article | Year |
|---|---|
Update on therapy for refractory dermatomyositis and polymyositis.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Dermatomyositis; Drug Therapy, Combinati | 1996 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Mechanisms of action and clinical applications of cytotoxic drugs in rheumatic disorders.
Topics: Arthritis, Reactive; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophos | 1985 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
1 trial available for chlorambucil and Dermatomyositis
| Article | Year |
|---|---|
Plasma exchange in polymyositis and dermatomyositis.
Topics: Chlorambucil; Combined Modality Therapy; Cyclophosphamide; Dermatomyositis; Humans; Myositis; Plasma | 1992 |
11 other studies available for chlorambucil and Dermatomyositis
| Article | Year |
|---|---|
Plasmapheresis in idiopathic inflammatory myopathy. Experience with 35 patients.
Topics: Adolescent; Adult; Aged; Child; Chlorambucil; Cyclophosphamide; Dermatomyositis; Female; Humans; Mal | 1981 |
Bilateral ureteral necrosis in a child with dermatomyositis.
Topics: Adrenal Cortex Hormones; Child; Chlorambucil; Dermatomyositis; Dilatation; Female; Humans; Necrosis; | 1980 |
Plasmapheresis in childhood dermatomyositis.
Topics: Child, Preschool; Chlorambucil; Dermatomyositis; Female; Humans; Immunoglobulin G; Immunoglobulin M; | 1981 |
Chlorambucil. An effective corticosteroid-sparing agent for patients with recalcitrant dermatomyositis.
Topics: Administration, Oral; Adult; Aged; Chlorambucil; Creatine Kinase; Dermatomyositis; Drug Resistance; | 1993 |
Low-dose methotrexate administered weekly is an effective corticosteroid-sparing agent for the treatment of the cutaneous manifestations of dermatomyositis.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antimalarial | 1997 |
A case of refractory adult dermatomyositis.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Creatine Kinase; D | 1998 |
Combination immunosuppressive treatment of steroid-resistant dermatomyositis/polymyositis.
Topics: Adult; Chlorambucil; Dermatomyositis; Drug Resistance; Female; Humans; Immunosuppressive Agents; Met | 1985 |
[Therapeutic effect of alpha-tocopher- yl-quinone on muscular disorders of hyperthyroidism and of prolonged treatment by corticoids and antimitotics].
Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Asthenia; Busulfan; Chlorambucil; Cobal | 1969 |
[Current aspects of immunosuppressive therapy of collagen diseases].
Topics: Arthritis, Rheumatoid; Asparaginase; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1973 |
[Experiences in the treatment of dermatomyositis with immunosuppressiva].
Topics: Azathioprine; Child; Child, Preschool; Chlorambucil; Dermatomyositis; Drug Resistance; Drug Toleranc | 1972 |
[Immunosuppressive treatment of collagen diseases].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1969 |