chlorambucil has been researched along with Delayed Hypersensitivity in 15 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immunological and clinical functions were studied over a 2 year period in conjunction with a placebo controlled trial of isoprinosine and chlorambucil in 21 patients with exacerbating remitting multiple sclerosis." | 9.06 | Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. ( Buge, A; Cour, V; Delsaux, MC; Meunier, C; Pompidou, A; Rancurel, G; Telvi, L, 1987) |
| "Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins." | 7.65 | Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977) |
| "Immunological and clinical functions were studied over a 2 year period in conjunction with a placebo controlled trial of isoprinosine and chlorambucil in 21 patients with exacerbating remitting multiple sclerosis." | 5.06 | Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis. ( Buge, A; Cour, V; Delsaux, MC; Meunier, C; Pompidou, A; Rancurel, G; Telvi, L, 1987) |
| "Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins." | 3.65 | Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977) |
| "One characteristic of experimental allergic encephalomyelitis (EAE) in all species is the presence of a considerable leukocyte infiltrate in the central nervous system (CNS)." | 1.27 | Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system. ( Brostoff, S; Mason, D; Sedgwick, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bianchi, L | 1 |
| Hansel, K | 1 |
| Pelliccia, S | 1 |
| Tramontana, M | 1 |
| Stingeni, L | 1 |
| Perry, S | 1 |
| Thomas, LB | 1 |
| Johnson, RE | 1 |
| Carbone, PP | 1 |
| Haynes, HA | 1 |
| Silber, R | 1 |
| Torricelli, R | 1 |
| Kurer, SB | 1 |
| Kroner, T | 1 |
| Wüthrich, B | 1 |
| Ghose, T | 1 |
| Norvell, ST | 1 |
| Guclu, A | 1 |
| Bodurtha, A | 1 |
| Tai, J | 1 |
| MacDonald, AS | 1 |
| Sedgwick, J | 1 |
| Brostoff, S | 1 |
| Mason, D | 1 |
| Pompidou, A | 1 |
| Rancurel, G | 1 |
| Delsaux, MC | 1 |
| Meunier, C | 1 |
| Telvi, L | 1 |
| Cour, V | 1 |
| Buge, A | 1 |
| Lermusiaux, JL | 2 |
| Kuntz, D | 2 |
| Ryckewaert, A | 2 |
| Venenson, EV | 1 |
| Sokal, JE | 1 |
| Aungst, CW | 1 |
| Han, T | 1 |
| Libánský, J | 1 |
| Lukásová, M | 1 |
| Pinosová, I | 1 |
| Currey, HL | 1 |
| Brown, CH | 1 |
| Turner-Warwick, M | 1 |
| van Straaten, L | 1 |
2 reviews available for chlorambucil and Delayed Hypersensitivity
| Article | Year |
|---|---|
Systemic delayed hypersensitivity reaction to chlorambucil: a case report and literature review.
Topics: Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Drug Eruptions; Female; Humans; Hypersensitiv | 2018 |
[Delayed allergic reaction to Chlorambucil (Leukeran). Case report and literature review].
Topics: Chlorambucil; Drug Hypersensitivity; Hemorrhagic Disorders; Humans; Hypersensitivity, Delayed; Leuke | 1995 |
1 trial available for chlorambucil and Delayed Hypersensitivity
| Article | Year |
|---|---|
Immunosuppressive effects of isoprinosine in man: a comparison to chlorambucil effects in multiple sclerosis.
Topics: Adult; Chlorambucil; Clinical Trials as Topic; Double-Blind Method; Humans; Hypersensitivity, Delaye | 1987 |
12 other studies available for chlorambucil and Delayed Hypersensitivity
| Article | Year |
|---|---|
Hodgkin's disease. Combined clinical staff conference at the National Institutes of Health.
Topics: Chlorambucil; Cyclophosphamide; Drug Synergism; Hodgkin Disease; Humans; Hypersensitivity, Delayed; | 1967 |
Chronic lymphocytic leukemia in the elderly.
Topics: Aged; B-Lymphocytes; Chlorambucil; Diagnosis, Differential; Glucosephosphate Dehydrogenase; Humans; | 1982 |
Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease.
Topics: Adolescent; Adult; Aged; Antibodies, Neoplasm; Chlorambucil; Dacarbazine; Female; Humans; Hypersensi | 1977 |
Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.
Topics: Animals; Busulfan; Cells, Cultured; Central Nervous System; Cerebral Hemorrhage; Chlorambucil; Encep | 1987 |
[Delayed cutaneous immune reactivity in rheumatoid polyarthritis. Its changes during immunosuppressive therapy].
Topics: Arthritis, Rheumatoid; Candida; Chlorambucil; DNA; Female; gamma-Globulins; Humans; Hypersensitivity | 1969 |
[Mechanism of action of cytostatic agents in rheumatoid arthritis].
Topics: Adult; Antibodies; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Chlorambucil; | 1974 |
Effect of BCG on delayed hypersensitivity responses of patients with neoplastic disease.
Topics: Animals; Antigen-Antibody Reactions; BCG Vaccine; Cattle; Chlorambucil; Cyclophosphamide; Hodgkin Di | 1973 |
Blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. 3. Chronic lymphatic leukaemia.
Topics: Adult; Aged; Chlorambucil; Female; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Lectins; L | 1973 |
[Study of the modifications of delayed cutaneous immune reactivity in the course of rheumatoid polyarthritis therapy with chlorambucil].
Topics: Antigen-Antibody Reactions; Arthritis, Rheumatoid; Chlorambucil; Humans; Hypersensitivity, Delayed; | 1971 |
A comparison of immunosuppressive and anti-inflammatory agents in the rat.
Topics: Animals; Anti-Inflammatory Agents; Antibody Formation; Antilymphocyte Serum; Arthritis; Azathioprine | 1971 |
The treatment of cryptogenic fibrosing alveolitis with immunosuppressant drugs.
Topics: Adult; Agglutination Tests; Antibodies, Antinuclear; Azathioprine; Chlorambucil; Complement Fixation | 1971 |
[Treatment of certain types of asthma with immuno-depressive agents].
Topics: Adolescent; Asthma; Child; Chlorambucil; Female; Humans; Hypersensitivity, Delayed; Hypersensitivity | 1970 |