chlorambucil has been researched along with Connective Tissue Diseases in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although multi-drug therapy is known to produce myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) in patients with CTD, treatment with single-agent therapy, particularly methotrexate, has rarely been associated with secondary MDS or AML." | 3.69 | Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy. ( Farhi, DC; Rosenthal, NS, 1996) |
| "Azathioprine is a valuable alternative to slow-acting antirheumatic drugs in older patients with rheumatoid arthritis." | 2.38 | Azathioprine, cyclophosphamide and chlorambucil. ( Bacon, PA; Luqmani, RA; Palmer, RG, 1990) |
| "If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease." | 2.37 | Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosenthal, NS | 1 |
| Farhi, DC | 1 |
| Luqmani, RA | 1 |
| Palmer, RG | 3 |
| Bacon, PA | 1 |
| Leavitt, RY | 1 |
| Fauci, AS | 1 |
| Dore, CJ | 2 |
| Denman, AM | 2 |
| Smith-Burchnell, CA | 1 |
2 reviews available for chlorambucil and Connective Tissue Diseases
| Article | Year |
|---|---|
Azathioprine, cyclophosphamide and chlorambucil.
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Connective Tissue Diseases; Cyclophosphamide; Hum | 1990 |
Pulmonary vasculitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy | 1986 |
3 other studies available for chlorambucil and Connective Tissue Diseases
| Article | Year |
|---|---|
Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy.
Topics: Acute Disease; Adult; Aged; Antigens, CD; Antirheumatic Agents; Chlorambucil; Connective Tissue Dise | 1996 |
Cyclophosphamide induces more chromosome damage than chlorambucil in patients with connective tissue diseases.
Topics: Chlorambucil; Chromosomes; Connective Tissue Diseases; Cyclophosphamide; Humans; Sister Chromatid Ex | 1986 |
Thioguanine-resistant mutations induced by cytotoxic drugs in lymphocytes of patients with connective tissue diseases.
Topics: Azathioprine; Chlorambucil; Connective Tissue Diseases; Cyclophosphamide; Drug Resistance; Humans; H | 1986 |