chlorambucil has been researched along with Chronic Kidney Failure in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This observational study aimed to evaluate the results of treatment with low-dose chlorambucil in combination with corticosteroids in patients with idiopathic membranous nephropathy (iMGN) and nephrotic syndrome." | 5.14 | Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy. ( Idasiak-Piechocka, I; Oko, A; Skrobańska, B; Łochyńska-Bielecka, K, 2009) |
| "Twenty-one patients with membranous nephropathy, heavy proteinuria and progressive renal failure were treated with alternating monthly cycles of corticosteroids and chlorambucil for six months." | 3.69 | Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure. ( Boulton-Jones, JM; Geddes, CG; Warwick, GL, 1994) |
| " Forty of them, who presented a nephrotic syndrome, were treated by immunosuppressive drugs (prednisone, azathioprine, chlorambucil, cyclophosphamide) for 79 +/- 9." | 3.67 | Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis. ( Glyda, J; Gradowska, L; Juskowa, J; Klepacka, J; Lao, M; Morzycka-Michalik, M; Orlowski, T; Rancewicz, Z, 1988) |
| "Four chlorambucil-treated patients developed ESRD, and five needed a second course of therapy, whereas only one cyclophosphamide-treated patient developed ESRD (p < 0." | 2.69 | Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency. ( Branten, AJ; Koene, RA; Reichert, LJ; Wetzels, JF, 1998) |
| "18 patients with membranous nephropathy, a nephrotic syndrome, and deteriorating renal function." | 2.67 | Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide. ( Assmann, K; Huysmans, FT; Koene, RA; Reichert, LJ; Wetzels, JF, 1994) |
| "Levamisole was given to 56 children (13%) and cyclosporin to 53 (12%)." | 1.29 | Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome. ( Barratt, TM; Dillon, MJ; Fay, J; Neuhaus, TJ; Trompeter, RS, 1994) |
| "Treatment with chlorambucil, prednisolone, and renal bed irradiation resulted in a substantial improvement in renal function which persisted until the the patient's death from marrow failure some eight years later." | 1.29 | Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia. ( Bass, PS; Davies, DR; Jones, NF; Majumdar, G; Pearson, TC; Phillips, JK, 1993) |
| "Risk of ESRD by WHO class at 5 years was as follows: class III, 0%; IV, 9%; V, 16% (P = ." | 1.29 | Lupus in the 1980s: III. Influence of clinical variables, biopsy, and treatment on the outcome in 150 patients with lupus nephritis seen at a single center. ( Azen, C; Fichman, M; Klinenberg, JR; Metzger, AL; Nessim, S; Neumann, K; Wallace, DJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (44.44) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Idasiak-Piechocka, I | 1 |
| Oko, A | 1 |
| Łochyńska-Bielecka, K | 1 |
| Skrobańska, B | 1 |
| Hebert, LA | 1 |
| Rovin, BH | 1 |
| Agarwal, AK | 1 |
| Spetie, DN | 1 |
| Kleinknecht, C | 1 |
| Broyer, M | 1 |
| Gubler, MC | 1 |
| Palcoux, JB | 1 |
| Neuhaus, TJ | 1 |
| Fay, J | 1 |
| Dillon, MJ | 1 |
| Trompeter, RS | 1 |
| Barratt, TM | 1 |
| Reichert, LJ | 3 |
| Huysmans, FT | 1 |
| Assmann, K | 1 |
| Koene, RA | 2 |
| Wetzels, JF | 3 |
| Winearls, CG | 1 |
| Sanderson, F | 1 |
| Warwick, GL | 1 |
| Geddes, CG | 1 |
| Boulton-Jones, JM | 1 |
| Phillips, JK | 1 |
| Bass, PS | 1 |
| Majumdar, G | 1 |
| Davies, DR | 1 |
| Jones, NF | 1 |
| Pearson, TC | 1 |
| Neumann, K | 1 |
| Wallace, DJ | 1 |
| Azen, C | 1 |
| Nessim, S | 1 |
| Fichman, M | 1 |
| Metzger, AL | 1 |
| Klinenberg, JR | 1 |
| Branten, AJ | 1 |
| Donadio, JV | 1 |
| Slack, TK | 1 |
| Holley, KE | 1 |
| Ilstrup, DM | 1 |
| Mohácsi, G | 1 |
| Benkó, G | 1 |
| Mágori, A | 1 |
| György, A | 1 |
| Sonkodi, S | 1 |
| Orlowski, T | 1 |
| Rancewicz, Z | 1 |
| Lao, M | 1 |
| Juskowa, J | 1 |
| Klepacka, J | 1 |
| Gradowska, L | 1 |
| Morzycka-Michalik, M | 1 |
| Glyda, J | 1 |
| Ahlmen, M | 1 |
| Ahlmen, J | 1 |
| Svalander, C | 1 |
| Bucht, H | 1 |
| Ben Ammar, M | 1 |
| Ben Dridi, MF | 1 |
| Ben Moussa, K | 1 |
| Ben Maïz, H | 1 |
| Ben Osman, R | 1 |
| Ultmann, JE | 1 |
| Nixon, DD | 1 |
| Seaton, A | 1 |
| Meland, JM | 1 |
| Lapp, NL | 1 |
2 reviews available for chlorambucil and Chronic Kidney Failure
| Article | Year |
|---|---|
Efficacy of immunosuppressive treatment in patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membranous; Humans; Immunosuppress | 1997 |
The therapy of lymphoma.
Topics: Adrenal Cortex Hormones; Asparaginase; Bone Marrow Diseases; Chlorambucil; Cyclophosphamide; Cytarab | 1969 |
6 trials available for chlorambucil and Chronic Kidney Failure
| Article | Year |
|---|---|
Efficacy and safety of low-dose chlorambucil in nephrotic patients with idiopathic membranous nephropathy.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Female; Follow-Up | 2009 |
Irreversible renal failure after indomethacin in steroid-resistant nephrosis.
Topics: Child; Chlorambucil; Clinical Trials as Topic; Female; Glomerular Filtration Rate; Humans; Indometha | 1980 |
Preserving renal function in patients with membranous nephropathy: daily oral chlorambucil compared with intermittent monthly pulses of cyclophosphamide.
Topics: Administration, Oral; Adult; Aged; Chlorambucil; Cyclophosphamide; Drug Administration Schedule; Dru | 1994 |
Efficacy of immunosuppressive treatment in patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Chlorambucil; Follow-Up Studies; Glomerulonephritis, Membranous; Humans; Immunosuppress | 1997 |
Oral cyclophosphamide versus chlorambucil in the treatment of patients with membranous nephropathy and renal insufficiency.
Topics: Adult; Aged; Anti-Inflammatory Agents; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Fe | 1998 |
Cytotoxic drug treatment of reactive amyloidosis in rheumatoid arthritis with special reference to renal insufficiency.
Topics: Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Femal | 1987 |
11 other studies available for chlorambucil and Chronic Kidney Failure
| Article | Year |
|---|---|
Cyclophosphamide or chlorambucil therapy is indicated in idiopathic membranous nephropathy with strong risk factors for progression.
Topics: Chlorambucil; Creatinine; Cyclophosphamide; Disease Progression; Drug Therapy, Combination; Glomerul | 2005 |
Alternative treatment to corticosteroids in steroid sensitive idiopathic nephrotic syndrome.
Topics: Adrenal Cortex Hormones; Child; Child, Preschool; Chlorambucil; Chloramphenicol; Cyclophosphamide; C | 1994 |
Treatment of aggressive idiopathic membranous glomerulonephritis.
Topics: Chlorambucil; Glomerulonephritis, Membranous; Humans; Kidney Failure, Chronic; Prognosis; Proteinuri | 1994 |
Prednisolone and chlorambucil therapy for idiopathic membranous nephropathy with progressive renal failure.
Topics: Adult; Aged; Chlorambucil; Cohort Studies; Female; Glomerulonephritis, Membranous; Humans; Kidney; K | 1994 |
Renal failure caused by leukaemic infiltration in chronic lymphocytic leukaemia.
Topics: Chlorambucil; Combined Modality Therapy; Humans; Kidney; Kidney Failure, Chronic; Leukemia, Lymphocy | 1993 |
Lupus in the 1980s: III. Influence of clinical variables, biopsy, and treatment on the outcome in 150 patients with lupus nephritis seen at a single center.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Biopsy; Blood Component Removal; Chlorambucil; Cyclop | 1995 |
Idiopathic membranoproliferative (mesangiocapillary) glomerulonephritis: a clinicopathologic study.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Chlorambucil; Complement C3; Cyclophosphamide; Drug Th | 1979 |
[Polyarteritis nodosa based on a case report].
Topics: Adult; Appendectomy; Appendicitis; Appendix; Chlorambucil; Colitis, Ulcerative; Crohn Disease; Diagn | 1987 |
Long-term immunosuppressive therapy of idiopathic membranoproliferative glomerulonephritis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up St | 1988 |
[Juvenile nephrotic syndrome with diffuse mesangial sclerosis. Apropos of a case report].
Topics: Child, Preschool; Chlorambucil; Female; Glomerular Mesangium; Humans; Kidney Failure, Chronic; Nephr | 1986 |
Remission in Goodpasture's syndrome: report of two patients treated by immunosuppression and review of the literature.
Topics: Anti-Glomerular Basement Membrane Disease; Azathioprine; Chlorambucil; Humans; Immunosuppression The | 1971 |