chlorambucil has been researched along with Chromosome Deletion in 15 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Chromosome Deletion: Actual loss of portion of a chromosome.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Few recurrent chromosomal abnormalities have been reported, and their prognostic value is not known." | 2.78 | Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia. ( Andrieux, J; Baranger, L; Barin, C; Bilhou-Nabera, C; Blons, H; Callet-Bauchu, E; Chapiro, E; Chevret, S; Chiesa, J; Daudignon, A; Eclache, V; Gachard, N; Grelier, A; Henry, C; Lambert, J; Leblondon, V; Lejeune, J; Luquet, I; Merle-Beral, H; Mossafa, H; Mould, S; Mozziconacci, MJ; Mugneret, F; Nguyen-Khac, F; Owen, R; Penther, D; Struski, S; Terre, C; Veronese, L, 2013) |
| "The treatment landscape of chronic lymphocytic leukemia (CLL) has changed dramatically in the last few years." | 2.58 | Selecting Frontline Therapy for CLL in 2018. ( Jain, N, 2018) |
| "To date, the majority of trials on chronic lymphocytic leukemia (CLL) focused on patients considerably younger than the median age of onset for CLL." | 1.39 | First immunochemotherapy outcomes in elderly patients with CLL: a retrospective analysis. ( Bouvet, E; Cazin, B; Coiffier, B; Laurent, G; Michallet, AS; Mosser, L; Oberic, L; Salles, G; Schlaifer, D; Ysebaert, L, 2013) |
| "Cytogenetic analysis showed complex chromosomal abnormalities including 5q deletion, 12p deletion and monosomy 18." | 1.33 | Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine. ( Cho, HS; Chun, SH; Hyun, MS; Kim, KO; Kim, MK; Lee, KH; Shin, SJ, 2005) |
| "Chlorambucil was mutagenic only to strains TA102 (hisG428, rfa/pKM101) and YG2975 (hisG46, rfa/pKM101) when S9 mix was absent." | 1.28 | Preferential induction of AT-TA transversion, but not deletions, by chlorambucil at the hisG428 site of Salmonella typhimurium TA102. ( Nohmi, T; Sofuni, T; Yamada, M, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Herishanu, Y | 1 |
| Shaulov, A | 1 |
| Fineman, R | 1 |
| Bašić-Kinda, S | 1 |
| Aviv, A | 1 |
| Wasik-Szczepanek, E | 1 |
| Jaksic, O | 1 |
| Zdrenghea, M | 1 |
| Greenbaum, U | 1 |
| Mandac, I | 1 |
| Simkovic, M | 1 |
| Morawska, M | 1 |
| Benjamini, O | 1 |
| Spacek, M | 1 |
| Nemets, A | 1 |
| Bairey, O | 1 |
| Trentin, L | 1 |
| Ruchlemer, R | 1 |
| Laurenti, L | 1 |
| Stanca Ciocan, O | 1 |
| Doubek, M | 1 |
| Shvidel, L | 1 |
| Dali, N | 1 |
| Mirás, F | 1 |
| De Meûter, A | 1 |
| Dimou, M | 1 |
| Mauro, FR | 1 |
| Coscia, M | 1 |
| Bumbea, H | 1 |
| Szász, R | 1 |
| Tadmor, T | 1 |
| Gutwein, O | 1 |
| Gentile, M | 1 |
| Scarfò, L | 1 |
| Tedeschi, A | 1 |
| Sportoletti, P | 1 |
| Gimeno Vázquez, E | 1 |
| Marquet, J | 1 |
| Assouline, S | 1 |
| Papaioannou, M | 1 |
| Braester, A | 1 |
| Levato, L | 1 |
| Gregor, M | 1 |
| Rigolin, GM | 1 |
| Loscertales, J | 1 |
| Medina Perez, A | 1 |
| Nijziel, MR | 1 |
| Popov, VM | 1 |
| Collado, R | 1 |
| Slavutsky, I | 1 |
| Itchaki, G | 1 |
| Ringelstein, S | 1 |
| Goldschmidt, N | 1 |
| Perry, C | 1 |
| Levi, S | 1 |
| Polliack, A | 1 |
| Ghia, P | 1 |
| Sylvan, SE | 1 |
| Asklid, A | 1 |
| Johansson, H | 1 |
| Klintman, J | 1 |
| Bjellvi, J | 1 |
| Tolvgård, S | 1 |
| Kimby, E | 1 |
| Norin, S | 1 |
| Andersson, PO | 1 |
| Karlsson, C | 1 |
| Karlsson, K | 1 |
| Lauri, B | 1 |
| Mattsson, M | 1 |
| Sandstedt, AB | 1 |
| Strandberg, M | 1 |
| Österborg, A | 1 |
| Hansson, L | 1 |
| Jain, N | 1 |
| Metzgeroth, G | 1 |
| Schneider, S | 1 |
| Hofmann, WK | 1 |
| Hastka, J | 1 |
| Michallet, AS | 1 |
| Cazin, B | 1 |
| Bouvet, E | 1 |
| Oberic, L | 1 |
| Schlaifer, D | 1 |
| Mosser, L | 1 |
| Salles, G | 1 |
| Coiffier, B | 1 |
| Laurent, G | 1 |
| Ysebaert, L | 1 |
| Barrientos, JC | 1 |
| Nguyen-Khac, F | 1 |
| Lambert, J | 1 |
| Chapiro, E | 1 |
| Grelier, A | 1 |
| Mould, S | 1 |
| Barin, C | 1 |
| Daudignon, A | 1 |
| Gachard, N | 1 |
| Struski, S | 1 |
| Henry, C | 1 |
| Penther, D | 1 |
| Mossafa, H | 1 |
| Andrieux, J | 1 |
| Eclache, V | 1 |
| Bilhou-Nabera, C | 1 |
| Luquet, I | 1 |
| Terre, C | 1 |
| Baranger, L | 1 |
| Mugneret, F | 1 |
| Chiesa, J | 1 |
| Mozziconacci, MJ | 1 |
| Callet-Bauchu, E | 1 |
| Veronese, L | 1 |
| Blons, H | 1 |
| Owen, R | 1 |
| Lejeune, J | 1 |
| Chevret, S | 1 |
| Merle-Beral, H | 1 |
| Leblondon, V | 1 |
| Shin, SJ | 1 |
| Chun, SH | 1 |
| Kim, KO | 1 |
| Kim, MK | 1 |
| Lee, KH | 1 |
| Hyun, MS | 1 |
| Cho, HS | 1 |
| Robak, E | 1 |
| Jesionek-Kupnicka, D | 1 |
| Robak, T | 1 |
| Holub, A | 1 |
| Wawrzyniak, E | 1 |
| Bartkowiak, J | 1 |
| Bednarek, A | 1 |
| Constantinu, M | 1 |
| Urbanska-Rys, H | 1 |
| Austen, B | 1 |
| Skowronska, A | 1 |
| Baker, C | 1 |
| Powell, JE | 1 |
| Gardiner, A | 1 |
| Oscier, D | 1 |
| Majid, A | 1 |
| Dyer, M | 1 |
| Siebert, R | 1 |
| Taylor, AM | 1 |
| Moss, PA | 1 |
| Stankovic, T | 1 |
| Westin, J | 1 |
| Yamada, M | 1 |
| Sofuni, T | 1 |
| Nohmi, T | 1 |
| Rinchik, EM | 1 |
| Bangham, JW | 2 |
| Hunsicker, PR | 2 |
| Cacheiro, NL | 2 |
| Kwon, BS | 1 |
| Jackson, IJ | 1 |
| Russell, LB | 2 |
| Mahoney, DH | 1 |
| McClain, KL | 1 |
| Hanson, IC | 1 |
| Taylor, LD | 1 |
| Steuber, CP | 1 |
| Russell, WL | 1 |
| Shelby, MD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Trial Comparing the Efficacy of Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia,Lymphoplasmacytic Lymphoma or Splenic Marginal Zone Lymphoma[NCT00566332] | Phase 3 | 414 participants (Actual) | Interventional | 2001-06-30 | Completed | ||
| A Randomised Trial of Chlorambucil Versus Fludarabine as Initial Therapy of Waldenström's Macroglobulinaemia and Splenic Lymphoma With Villous Lymphocytes[NCT00608374] | Phase 3 | 400 participants (Anticipated) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorambucil and Chromosome Deletion
| Article | Year |
|---|---|
Selecting Frontline Therapy for CLL in 2018.
Topics: Adenine; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chromosome Delet | 2018 |
Sequencing of chronic lymphocytic leukemia therapies.
Topics: Alanine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothe | 2016 |
3 trials available for chlorambucil and Chromosome Deletion
| Article | Year |
|---|---|
Frontline treatment with the combination obinutuzumab ± chlorambucil for chronic lymphocytic leukemia outside clinical trials: Results of a multinational, multicenter study by ERIC and the Israeli CLL study group.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Pro | 2020 |
First-line therapy in chronic lymphocytic leukemia: a Swedish nation-wide real-world study on 1053 consecutive patients treated between 2007 and 2013.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydroch | 2019 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
10 other studies available for chlorambucil and Chromosome Deletion
| Article | Year |
|---|---|
Globular intracytoplasmic inclusions in a patient with chronic lymphocytic leukaemia.
Topics: Aged; Antineoplastic Agents, Alkylating; B-Lymphocytes; Biomarkers, Tumor; Chlorambucil; Chromosome | 2013 |
First immunochemotherapy outcomes in elderly patients with CLL: a retrospective analysis.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Chlora | 2013 |
Myelodysplastic syndrome with complex karyotypic abnormality in a patient with Waldenström's macroglobulinemia after sequential treatment with chlorambucil and fludarabine.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow | 2005 |
Primary cutaneous marginal zone B-cell lymphoma in a patient with chronic lymphocytic leukaemia.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosome Deletion; Chromosomes | 2007 |
Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.
Topics: Aged; Alleles; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; C | 2007 |
Chromosome abnormalities after chlorambucil therapy of polycythaemia vera.
Topics: Aged; Bone Marrow; Bone Marrow Cells; Chlorambucil; Chromosome Aberrations; Chromosome Deletion; Fem | 1976 |
Preferential induction of AT-TA transversion, but not deletions, by chlorambucil at the hisG428 site of Salmonella typhimurium TA102.
Topics: Animals; Base Sequence; Biotransformation; Chlorambucil; Chromosome Deletion; Genes, Bacterial; Micr | 1992 |
Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.
Topics: Animals; Blotting, Southern; Chlorambucil; Chromosome Deletion; Crosses, Genetic; Female; Fertility; | 1990 |
Acquired immune deficiency, myelodysplasia, and acute nonlymphocytic leukemia associated with monosomy 7 and t(3;3) (q21;q26) in a child with Langerhans cell histiocytosis.
Topics: Chlorambucil; Chromosome Deletion; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Female; H | 1989 |
Chlorambucil effectively induces deletion mutations in mouse germ cells.
Topics: Animals; Chlorambucil; Chromosome Banding; Chromosome Deletion; Dose-Response Relationship, Drug; Ma | 1989 |