chlorambucil has been researched along with Chromosome-Defective Micronuclei in 4 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mangerich, A | 1 |
| Debiak, M | 1 |
| Birtel, M | 1 |
| Ponath, V | 1 |
| Balszuweit, F | 1 |
| Lex, K | 1 |
| Martello, R | 1 |
| Burckhardt-Boer, W | 1 |
| Strobelt, R | 1 |
| Siegert, M | 1 |
| Thiermann, H | 1 |
| Steinritz, D | 1 |
| Schmidt, A | 1 |
| Bürkle, A | 1 |
| Efthimiou, M | 2 |
| Ouranou, D | 1 |
| Stephanou, G | 2 |
| Demopoulos, NA | 2 |
| Nikolaropoulos, SS | 2 |
| Alevizos, P | 1 |
| Andrianopoulos, C | 1 |
| Smetana, K | 1 |
| Subrtová, H | 1 |
| Jirásková, I | 1 |
| Rosa, L | 1 |
4 other studies available for chlorambucil and Chromosome-Defective Micronuclei
| Article | Year |
|---|---|
Sulfur and nitrogen mustards induce characteristic poly(ADP-ribosyl)ation responses in HaCaT keratinocytes with distinctive cellular consequences.
Topics: Adenosine Diphosphate Ribose; Antidotes; Antineoplastic Agents, Alkylating; Cell Line; Cell Prolifer | 2016 |
Comparative study of genetic activity of chlorambucil's active metabolite steroidal esters: the role of steroidal skeleton on aneugenic potential.
Topics: Aneugens; Animals; Antineoplastic Agents, Alkylating; Cells, Cultured; Chlorambucil; Esters; Humans; | 2010 |
Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p-N,N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro.
Topics: Adult; Aneugens; Aneuploidy; Animals; Antineoplastic Agents, Alkylating; Azasteroids; Cells, Culture | 2007 |
Micronucleoli in lymphocytes of the peripheral blood of patients suffering from chronic lymphocytic leukemia (B type).
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lym | 1995 |