chlorambucil has been researched along with Chromosomal Triplication in 4 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Excerpt | Relevance | Reference |
---|---|---|
"Few recurrent chromosomal abnormalities have been reported, and their prognostic value is not known." | 2.78 | Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia. ( Andrieux, J; Baranger, L; Barin, C; Bilhou-Nabera, C; Blons, H; Callet-Bauchu, E; Chapiro, E; Chevret, S; Chiesa, J; Daudignon, A; Eclache, V; Gachard, N; Grelier, A; Henry, C; Lambert, J; Leblondon, V; Lejeune, J; Luquet, I; Merle-Beral, H; Mossafa, H; Mould, S; Mozziconacci, MJ; Mugneret, F; Nguyen-Khac, F; Owen, R; Penther, D; Struski, S; Terre, C; Veronese, L, 2013) |
"Elimination of minimal residual disease has been linked to improved survival and become an important clinical goal." | 2.43 | Chronic lymphocytic leukemia: current and emerging treatment approaches. ( Kay, NE; O'Brien, S; Rai, KR, 2006) |
"The most common treatment of chronic lymphocytic leukemia (CLL) is the alkylating agent chlorambucil (CLB), with or without prednisone." | 1.32 | The effect of chlorambucil treatment on cytogenetic parameters in chronic lymphocytic leukemia patients. ( Amiel, A; Biton, I; Fejgin, MD; Gaber, E; Lishner, M; Yukla, M, 2003) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (50.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Nguyen-Khac, F | 1 |
Lambert, J | 1 |
Chapiro, E | 1 |
Grelier, A | 1 |
Mould, S | 1 |
Barin, C | 1 |
Daudignon, A | 1 |
Gachard, N | 1 |
Struski, S | 1 |
Henry, C | 1 |
Penther, D | 1 |
Mossafa, H | 1 |
Andrieux, J | 1 |
Eclache, V | 1 |
Bilhou-Nabera, C | 1 |
Luquet, I | 1 |
Terre, C | 1 |
Baranger, L | 1 |
Mugneret, F | 1 |
Chiesa, J | 1 |
Mozziconacci, MJ | 1 |
Callet-Bauchu, E | 1 |
Veronese, L | 1 |
Blons, H | 1 |
Owen, R | 1 |
Lejeune, J | 1 |
Chevret, S | 1 |
Merle-Beral, H | 1 |
Leblondon, V | 1 |
Oscier, DG | 1 |
Rose-Zerilli, MJ | 1 |
Winkelmann, N | 1 |
Gonzalez de Castro, D | 1 |
Gomez, B | 1 |
Forster, J | 1 |
Parker, H | 1 |
Parker, A | 1 |
Gardiner, A | 1 |
Collins, A | 1 |
Else, M | 1 |
Cross, NC | 1 |
Catovsky, D | 1 |
Strefford, JC | 1 |
Amiel, A | 1 |
Biton, I | 1 |
Yukla, M | 1 |
Gaber, E | 1 |
Fejgin, MD | 1 |
Lishner, M | 1 |
Kay, NE | 1 |
Rai, KR | 1 |
O'Brien, S | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Randomized Trial Comparing the Efficacy of Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia,Lymphoplasmacytic Lymphoma or Splenic Marginal Zone Lymphoma[NCT00566332] | Phase 3 | 414 participants (Actual) | Interventional | 2001-06-30 | Completed | ||
A Randomised Trial of Chlorambucil Versus Fludarabine as Initial Therapy of Waldenström's Macroglobulinaemia and Splenic Lymphoma With Villous Lymphocytes[NCT00608374] | Phase 3 | 400 participants (Anticipated) | Interventional | 2006-06-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 review available for chlorambucil and Chromosomal Triplication
Article | Year |
---|---|
Chronic lymphocytic leukemia: current and emerging treatment approaches.
Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antine | 2006 |
2 trials available for chlorambucil and Chromosomal Triplication
Article | Year |
---|---|
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos | 2013 |
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.
Topics: ADP-ribosyl Cyclase 1; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineopla | 2013 |
1 other study available for chlorambucil and Chromosomal Triplication
Article | Year |
---|---|
The effect of chlorambucil treatment on cytogenetic parameters in chronic lymphocytic leukemia patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosome Aberrations; Ch | 2003 |