Page last updated: 2024-10-24

chlorambucil and Chromosomal Triplication

chlorambucil has been researched along with Chromosomal Triplication in 4 studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Research Excerpts

ExcerptRelevanceReference
"Few recurrent chromosomal abnormalities have been reported, and their prognostic value is not known."2.78Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia. ( Andrieux, J; Baranger, L; Barin, C; Bilhou-Nabera, C; Blons, H; Callet-Bauchu, E; Chapiro, E; Chevret, S; Chiesa, J; Daudignon, A; Eclache, V; Gachard, N; Grelier, A; Henry, C; Lambert, J; Leblondon, V; Lejeune, J; Luquet, I; Merle-Beral, H; Mossafa, H; Mould, S; Mozziconacci, MJ; Mugneret, F; Nguyen-Khac, F; Owen, R; Penther, D; Struski, S; Terre, C; Veronese, L, 2013)
"Elimination of minimal residual disease has been linked to improved survival and become an important clinical goal."2.43Chronic lymphocytic leukemia: current and emerging treatment approaches. ( Kay, NE; O'Brien, S; Rai, KR, 2006)
"The most common treatment of chronic lymphocytic leukemia (CLL) is the alkylating agent chlorambucil (CLB), with or without prednisone."1.32The effect of chlorambucil treatment on cytogenetic parameters in chronic lymphocytic leukemia patients. ( Amiel, A; Biton, I; Fejgin, MD; Gaber, E; Lishner, M; Yukla, M, 2003)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nguyen-Khac, F1
Lambert, J1
Chapiro, E1
Grelier, A1
Mould, S1
Barin, C1
Daudignon, A1
Gachard, N1
Struski, S1
Henry, C1
Penther, D1
Mossafa, H1
Andrieux, J1
Eclache, V1
Bilhou-Nabera, C1
Luquet, I1
Terre, C1
Baranger, L1
Mugneret, F1
Chiesa, J1
Mozziconacci, MJ1
Callet-Bauchu, E1
Veronese, L1
Blons, H1
Owen, R1
Lejeune, J1
Chevret, S1
Merle-Beral, H1
Leblondon, V1
Oscier, DG1
Rose-Zerilli, MJ1
Winkelmann, N1
Gonzalez de Castro, D1
Gomez, B1
Forster, J1
Parker, H1
Parker, A1
Gardiner, A1
Collins, A1
Else, M1
Cross, NC1
Catovsky, D1
Strefford, JC1
Amiel, A1
Biton, I1
Yukla, M1
Gaber, E1
Fejgin, MD1
Lishner, M1
Kay, NE1
Rai, KR1
O'Brien, S1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Trial Comparing the Efficacy of Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia,Lymphoplasmacytic Lymphoma or Splenic Marginal Zone Lymphoma[NCT00566332]Phase 3414 participants (Actual)Interventional2001-06-30Completed
A Randomised Trial of Chlorambucil Versus Fludarabine as Initial Therapy of Waldenström's Macroglobulinaemia and Splenic Lymphoma With Villous Lymphocytes[NCT00608374]Phase 3400 participants (Anticipated)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for chlorambucil and Chromosomal Triplication

ArticleYear
Chronic lymphocytic leukemia: current and emerging treatment approaches.
    Clinical advances in hematology & oncology : H&O, 2006, Volume: 4, Issue:11 Suppl 2

    Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antine

2006

Trials

2 trials available for chlorambucil and Chromosomal Triplication

ArticleYear
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
    Haematologica, 2013, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos

2013
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
    Haematologica, 2013, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos

2013
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
    Haematologica, 2013, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos

2013
Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenström's macroglobulinemia.
    Haematologica, 2013, Volume: 98, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Chromosome Aberrations; Chromos

2013
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial.
    Blood, 2013, Jan-17, Volume: 121, Issue:3

    Topics: ADP-ribosyl Cyclase 1; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineopla

2013

Other Studies

1 other study available for chlorambucil and Chromosomal Triplication

ArticleYear
The effect of chlorambucil treatment on cytogenetic parameters in chronic lymphocytic leukemia patients.
    Cancer genetics and cytogenetics, 2003, Volume: 143, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosome Aberrations; Ch

2003