chlorambucil and Choriocarcinoma studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).

Research Excerpts

Excerpt	Relevance	Reference
"Surgery combined with chemotherapy was applied in 34 out of 178 patients (19."	1.29	Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD). ( Kietlińska, Z; Sablińska, B; Zieliński, J, 1993)
"Based on the diagnosis of testicular neoplasm, orchiectomy was performed on September 7, 1983."	1.27	[Case report of a non-seminomatous testicular neoplasm indicating marked efficacy of a combination chemotherapy of VBL, ACTD, BLM, CDDP and EX (VAB-4 combination therapy)]. ( Ebihara, K; Hayashi, M; Urano, E, 1984)
"Sixteen patients with metastatic testicular cancer were treated with combination chemotherapy including cisplatin (CDDP) at 3- to 4-week intervals for two to five courses."	1.27	[Hypomagnesemia following chemotherapy of disseminated testicular tumors]. ( Hida, S; Nishimura, K; Nishio, Y; Okada, K; Okada, Y; Yoshida, O, 1988)
"The histologic diagnoses were six immature teratomas, five endodermal sinus tumors, four mixed germ cell tumors, and one nongestational choriocarcinoma."	1.27	Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary. ( Cain, JM; Hakes, TB; Lewis, JL; Pierce, VK; Pippitt, CH, 1988)

Timeframe	Studies, this research(%)	All Research%
pre-1990	47 (95.92)	18.7374
1990's	2 (4.08)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
MOORE, JG	1
VANCAMPENHOUT, JL	1
BRANDKAMP, WW	1
BREWER, JI	1
GERBIE, AB	1
DOLKART, RE	1
SKOM, JH	1
NAGLE, RG	1
TOROK, EE	1
EDMONDS, LC	1
CARRERA, GM	1
Mackenzie, AR	1
Laplante, MP	1
Mount, BM	1
Vugrin, D	1
Whitmore, WF	1
Golbey, RB	2
Harder, M	1
Limacher, F	1
Hayashi, M	1
Ebihara, K	1
Urano, E	1
Sablińska, B	1
Kietlińska, Z	1
Zieliński, J	1
Jones, WB	1
Lewis, JL	2
Lehr, M	1
Galbraith, RM	1
Eddleston, AL	1
Williams, R	1
Zuckerman, AJ	1
Becker, RL	1
Avioli, LV	1
Einhorn, LH	1
Pratt, RA	1
Di Chiro, G	1
Weed, JC	1
O'Neill, E	1
Pelegrina, I	1
Hammond, CB	3
Vicens, R	1
Almodóvar, AR	1
Baumgartner, G	1
Mortakis, AE	1
Braga, CA	1
Hida, S	1
Nishimura, K	1
Nishio, Y	1
Okada, Y	1
Okada, K	1
Yoshida, O	1
Masuda, F	1
Nakada, J	1
Kondo, N	1
Takahashi, T	1
Mochizuki, A	1
Iizuka, N	1
Pippitt, CH	1
Cain, JM	1
Hakes, TB	1
Pierce, VK	1
Iwasaki, M	1
Kazama, T	1
Nakada, T	1
Katayama, T	1
Le Duc, A	1
Gisselbrecht, C	1
Le Doze, H	1
Mignot, L	1
Takamizawa, H	1
Sekiya, S	1
Kobayashi, O	1
Matsui, H	1
Lajos, L	1
Székely, J	1
Major, A	1
Balogh, S	1
Bücs, G	1
Wilms, K	1
Feustel, A	1
Rathert, P	1
Terhorst, B	1
Lutzeyer, W	1
Henry, SC	1
Walsh, PC	1
Rotner, MB	1
Semenovskiĭ, AV	1
Astrakhan, VI	1
Monul, FA	1
Bret, AJ	1
Grépinet, J	1
Woodruff, JD	1
Protos, P	1
Peterson, WF	1
Ryssel, HJ	2
Sonntag, RW	2
Brunner, KW	2
Armstrong, JG	1
Parker, RT	2
Li, MC	1
Ober, WB	1
Edgcomb, JH	1
Price, EB	1
Borchert, LG	1
Tyrey, L	1
Creasman, WT	1
Klener, P	1
Sandström, B	1
Stutzman, L	1
Sokal, JE	1
Jacobs, EM	1
Johnson, FD	1
Skinner, DG	1
Leadbetter, WF	1
Ansfield, FJ	1
Korbitz, BC	1
Davis, HL	1
Ramirez, G	1
Moore, CA	1
Wider, JA	1
Marshall, JR	1
Bardin, CW	1
Lipsett, MB	1
Ross, GT	1

Article	Year
[A case report of extragonadal germ cell tumor with special reference to VAB-6 therapy]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Chlorambucil; C	1988
[Chemotherapy of trophoblastic disease]. Voprosy onkologii, 1974, Volume: 20, Issue:2 Topics: Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyc	1974
Trophoblastic disease: natural history, diagnosis, and treatment. Annals of internal medicine, 1971, Volume: 74, Issue:1 Topics: Alkylating Agents; Aminopterin; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin;	1971
Use of anticancer drugs during pregnancy. Clinical obstetrics and gynecology, 1968, Volume: 11, Issue:2 Topics: Alkylating Agents; Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Busulfan; Chlorambu	1968

Article	Year
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES. American journal of obstetrics and gynecology, 1964, Apr-15, Volume: 88 Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C	1964
CHEMOTHERAPY IN TROPHOBLASTIC DISEASES. American journal of obstetrics and gynecology, 1964, Nov-01, Volume: 90 Topics: Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Drug Therapy; Female; Gestation	1964
EXTRAGENITAL CHORIOCARCINOMA. The Journal of pediatrics, 1965, Volume: 67 Topics: Autopsy; Brain Neoplasms; Child; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy; Epistaxi	1965
Chemotherapy of metastatic testis cancer. Results in 154 patients. Cancer, 1966, Volume: 19, Issue:10 Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Choriocarcinoma; Dactinomycin; Dy	1966
Lymphadenectomy for testicular carcinoma. Canadian journal of surgery. Journal canadien de chirurgie, 1982, Volume: 25, Issue:3 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Chor	1982
VAB-6 combination chemotherapy without maintenance in treatment of disseminated cancer of the testis. Cancer, 1983, Jan-15, Volume: 51, Issue:2 Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin;	1983
[Generalized metastasizing chorion carcinoma with complete remission after cytostatic therapy]. Gynakologische Rundschau, 1983, Volume: 22 Suppl 3 Topics: Adult; Breast Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Da	1983
[Case report of a non-seminomatous testicular neoplasm indicating marked efficacy of a combination chemotherapy of VBL, ACTD, BLM, CDDP and EX (VAB-4 combination therapy)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 2 Topics: Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil;	1984
Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD). European journal of gynaecological oncology, 1993, Volume: 14 Suppl Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chorioca	1993
Monitor of chemotherapy in gestational trophoblastic neoplasm by radioimmunoassay of the beta-subunit of human chorionic gonadotropin. American journal of obstetrics and gynecology, 1975, Mar-01, Volume: 121, Issue:5 Topics: Adult; Antineoplastic Agents; Biological Assay; Bleomycin; Chlorambucil; Choriocarcinoma; Chorionic	1975
Fulminant hepatic failure in leukaemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy. Lancet (London, England), 1975, Sep-20, Volume: 2, Issue:7934 Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female;	1975
Gestational trophoblastic disease. Archives of internal medicine, 1977, Volume: 137, Issue:2 Topics: Adult; Brain Neoplasms; Cerebral Hemorrhage; Chlorambucil; Choriocarcinoma; Dactinomycin; Female; He	1977
Cancer chemotherapy. American family physician, 1977, Volume: 15, Issue:3 Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leuk	1977
Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma. Surgical neurology, 1977, Volume: 7, Issue:3 Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Brain Neoplasms; Chlorambucil; Choriocarcinoma;	1977
Normal pregnancy and delivery after cerebral metastases of choriocarcinoma: Case report. Cancer, 1976, Volume: 38, Issue:2 Topics: Adolescent; Brain Neoplasms; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy, Combination;	1976
[Cytostatic therapy of inoperable carcinomas]. Wiener medizinische Wochenschrift (1946), 1976, Jan-30, Volume: 126, Issue:5 Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin	1976
"Poor prognosis" metastatic gestational trophoblastic disease: the prognostic significance of the scoring system in predicting chemotherapy failures. Obstetrics and gynecology, 1990, Volume: 76, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Choriocarcinom	1990
[Hypomagnesemia following chemotherapy of disseminated testicular tumors]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis	1988
[Treatment of nonseminomatous testicular tumor with liver metastases]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis	1988
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary. Gynecologic oncology, 1988, Volume: 31, Issue:2 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Chorioca	1988
[Role of chemotherapy in the treatment of cancer of the testis in adults]. Presse medicale (Paris, France : 1983), 1985, Feb-09, Volume: 14, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis	1985
Chemotherapy for gestational trophoblastic tumors. Seminars in surgical oncology, 1987, Volume: 3, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropi	1987
[Importance of chemotherapeutic agents in the treatment of malignant trophoblast tumors]. Zeitschrift fur Geburtshilfe und Gynakologie, 1969, Volume: 171, Issue:3 Topics: Adnexa Uteri; Adult; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Hu	1969
[Cytostatic treatment of malignant testicular neoplasms]. Deutsche medizinische Wochenschrift (1946), 1971, Nov-26, Volume: 96, Issue:48 Topics: Adult; Antibiotics, Antineoplastic; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; D	1971
[Therapy of the most important male genital carcinomas]. Zentralblatt fur Chirurgie, 1973, Mar-30, Volume: 98, Issue:13 Topics: Chlorambucil; Choriocarcinoma; Cyproterone; Dactinomycin; Estrogens; Humans; Lymph Node Excision; Ma	1973
[Bleomycin for malignant tumours of the genitals of the male (author's transl)]. Der Urologe. Ausg. A, 1974, Volume: 13, Issue:2 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil	1974
Choriocarcinoma of the testis. The Journal of urology, 1974, Volume: 112, Issue:1 Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamid	1974
[The combined chemotherapy of testicular tumors resistant to sarcolysin]. Voprosy onkologii, 1967, Volume: 13, Issue:4 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide;	1967
[Uterine chorioepithelioma]. Munchener medizinische Wochenschrift (1950), 1966, Sep-23, Volume: 108, Issue:38 Topics: Abortion, Spontaneous; Adult; Antineoplastic Agents; Chlorambucil; Chloramines; Choriocarcinoma; Dac	1966
Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis. American journal of obstetrics and gynecology, 1968, Nov-01, Volume: 102, Issue:5 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin	1968
[Treatment of choriocarcinoma and malignant testicular neoplasms in internal medicine]. Helvetica medica acta. Supplementum, 1967, May-28, Volume: 47 Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; Humans; Lung Neoplasms;	1967
[The treatment of choriocarcinoma and malignant testicular neoplasms]. Helvetica medica acta, 1967, Volume: 34, Issue:1 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide;	1967
Current problems in the use of the oncolytic drugs. Acta geneticae medicae et gemellologiae, 1968, Volume: 17, Issue:1 Topics: Antineoplastic Agents; Busulfan; Carcinoma, Squamous Cell; Child; Chlorambucil; Choriocarcinoma; Dac	1968
Diagnosis and treatment of trophoblastic disease. A report from the Southeastern Regional Center. Obstetrics and gynecology, 1970, Volume: 35, Issue:1 Topics: Adult; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; D	1970
The pathology of choriocarcinoma. Annals of the New York Academy of Sciences, 1971, Jan-28, Volume: 172, Issue:10 Topics: Adolescent; Adult; Age Factors; Animals; Autopsy; Child; Chlorambucil; Choriocarcinoma; Chorionic Go	1971
Treatment of metastatic trophoblastic disease: good and poor prognosis. American journal of obstetrics and gynecology, 1973, Feb-15, Volume: 115, Issue:4 Topics: Brain Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Follow	1973
[Malignant mole and choriocarcinoma]. Lakartidningen, 1973, Oct-10, Volume: 70, Issue:41 Topics: Chlorambucil; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Methotrexate; Pregnancy; Prognosis	1973
Cytotoxic agents in the treatment of malignant disease. British medical journal, 1968, Nov-16, Volume: 4, Issue:5628 Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma;	1968
Gestational choriocarcinoma. Oncology, 1972, Volume: 26, Issue:2 Topics: Adult; California; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Huma	1972
The surgical management of testis tumors. The Journal of urology, 1971, Volume: 106, Issue:1 Topics: Adolescent; Adult; Castration; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin;	1971
Triple drug therapy in testicular tumors. Cancer, 1969, Volume: 24, Issue:3 Topics: Adolescent; Adult; Chlorambucil; Choriocarcinoma; Dactinomycin; Humans; Male; Methotrexate; Middle A	1969
The place of chemotherapy in the treatment of testicular tumors. JAMA, 1970, Jul-06, Volume: 213, Issue:1 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Chorionic Gonadot	1970
Triple chemotherapy in the treatment of metastatic testicular neoplasms. The Journal of urology, 1968, Volume: 100, Issue:4 Topics: Adult; Chlorambucil; Choriocarcinoma; Dactinomycin; Humans; Male; Methotrexate; Neoplasm Metastasis;	1968
Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma. The New England journal of medicine, 1969, Jun-26, Volume: 280, Issue:26 Topics: Adolescent; Adult; Child; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Dysge	1969

chlorambucil and Choriocarcinoma

Research Excerpts

Research

Studies (49)

Authors

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