chlorambucil has been researched along with Cell Transformation, Neoplastic in 12 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 7.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 3.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maurer, C | 1 |
| Langerbeins, P | 1 |
| Bahlo, J | 1 |
| Cramer, P | 1 |
| Fink, AM | 1 |
| Pflug, N | 1 |
| Engelke, A | 1 |
| von Tresckow, J | 1 |
| Kovacs, G | 1 |
| Stilgenbauer, S | 1 |
| Wendtner, CM | 1 |
| Müller, L | 1 |
| Ritgen, M | 1 |
| Seiler, T | 1 |
| Fischer, K | 1 |
| Hallek, M | 1 |
| Eichhorst, B | 1 |
| Leleu, X | 1 |
| Soumerai, J | 1 |
| Roccaro, A | 1 |
| Hatjiharissi, E | 1 |
| Hunter, ZR | 1 |
| Manning, R | 1 |
| Ciccarelli, BT | 1 |
| Sacco, A | 1 |
| Ioakimidis, L | 1 |
| Adamia, S | 1 |
| Moreau, AS | 1 |
| Patterson, CJ | 1 |
| Ghobrial, IM | 1 |
| Treon, SP | 1 |
| Ross, DW | 1 |
| Nand, S | 1 |
| Stock, W | 1 |
| Godwin, J | 1 |
| Fisher, SG | 1 |
| Tisdale, MJ | 1 |
| Phillips, BJ | 1 |
| Wiltshaw, E | 1 |
| Hoffman, R | 1 |
| Wasserman, LR | 1 |
| Haq, AU | 1 |
| Gobbi, M | 1 |
| Tazzari, PL | 1 |
| Raspadori, D | 1 |
| Cavo, M | 1 |
| Pileri, S | 1 |
| Tura, S | 1 |
| Hermanský, F | 1 |
| Janele, J | 1 |
| Smetana, K | 1 |
| Rubens, RD | 1 |
| Dulbecco, R | 1 |
| Fitzgerald, PH | 1 |
| Rastrick, JM | 1 |
| Hamer, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| US Post-Marketing Retrospective Observational Safety Study of Moxetumomab Pasudotox-tdfk (LUMOXITI)(TM)[NCT04125290] | 2 participants (Actual) | Observational | 2019-12-09 | Terminated (stopped due to Study stopped due to lack of recruitment.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorambucil and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Chemotherapy in chronic lymphocytic leukaemia.
Topics: Adrenal Cortex Hormones; Bacterial Infections; Bone Marrow; Cell Transformation, Neoplastic; Chloram | 1977 |
Natural history and management of polycythemia vera.
Topics: Acute Disease; Adult; Antineoplastic Agents; Bloodletting; Cell Transformation, Neoplastic; Chloramb | 1979 |
1 trial available for chlorambucil and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Effect of first-line treatment on second primary malignancies and Richter's transformation in patients with CLL.
Topics: Adult; Aged; Aged, 80 and over; Bendamustine Hydrochloride; Case-Control Studies; Cell Transformatio | 2016 |
9 other studies available for chlorambucil and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Increased incidence of transformation and myelodysplasia/acute leukemia in patients with Waldenström macroglobulinemia treated with nucleoside analogs.
Topics: Adult; Aged; Aged, 80 and over; Cell Transformation, Neoplastic; Chlorambucil; Cladribine; Female; F | 2009 |
Unbalanced cell growth and increased protein synthesis induced by chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Cell Count; Cell Transformation, Neoplastic; Cells, Cultured; Chlora | 1983 |
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; | 1996 |
Comparative effects of alkylating agents and other anti-tumour agents on the intracellular level of adenosine 3',5'-monophosphate in Walker carcinoma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkylating Agents; Animals; Bone Marrow; Carcinoma 256, Walker; | 1975 |
Transformation of polycythemia vera to Ph-positive chronic myelogenous leukemia.
Topics: Bloodletting; Cell Transformation, Neoplastic; Chlorambucil; Humans; Leukemia, Myeloid, Acute; Leuko | 1990 |
Meningeal leukemia complicating prolymphocytoid transformation of B-chronic lymphocytic leukemia.
Topics: B-Lymphocytes; Cell Transformation, Neoplastic; Chlorambucil; Cyclophosphamide; Humans; Leukemia, Ly | 1985 |
Notes on morphologically less usual forms of chronic lymphadenosis.
Topics: Aged; Blood Cell Count; Bone Marrow Examination; Cell Nucleolus; Cell Nucleus; Cell Transformation, | 1968 |
Augmentation of cytotoxic drug action by antibodies directed at cell surface.
Topics: Animals; Antibodies, Neoplasm; Cell Division; Cell Line; Cell Transformation, Neoplastic; Chlorambuc | 1974 |
Acute plasma cell leukaemia following chronic lymphatic leukaemia: transformation or two separate diseases?
Topics: Aged; Blood Protein Electrophoresis; Body Weight; Bone Marrow Examination; Cell Transformation, Neop | 1973 |