chlorambucil has been researched along with Carcinoma 256, Walker in 33 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Carcinoma 256, Walker: A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil is an exception." | 1.26 | Structure-activity relationships in antitumor aniline mustards. ( Hansch, C; Leo, A; Panthananickal, A, 1978) |
| "Indomethacin alone acts as a growth inhibitor of the Walker carcinoma." | 1.26 | Effect of chlorambucil and indomethacin on growth and prostaglandin levels in sensitive and resistant Walker carcinoma. ( Dobrzanski, RJ; Gibbs, J; Tisdale, MJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (93.94) | 18.7374 |
| 1990's | 2 (6.06) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Loeffler, LJ | 2 |
| Sajadi, Z | 2 |
| Hall, IH | 2 |
| Panthananickal, A | 1 |
| Hansch, C | 1 |
| Leo, A | 1 |
| Tew, KD | 6 |
| Moy, BC | 1 |
| Hartley-Asp, B | 1 |
| Tisdale, MJ | 7 |
| Gibbs, J | 1 |
| Dobrzanski, RJ | 1 |
| Ramirez, ML | 1 |
| Shepherd, CR | 1 |
| Pinsky, SD | 1 |
| McGhee, KG | 1 |
| Abel, G | 1 |
| Harrap, KR | 1 |
| Powles, TJ | 2 |
| Frank, GJ | 1 |
| Millar, JL | 2 |
| McLean, A | 1 |
| Newell, D | 1 |
| Baker, G | 1 |
| Connors, T | 1 |
| Clapper, ML | 3 |
| Kuzmich, S | 1 |
| Seestaller, LM | 1 |
| Phillips, BJ | 6 |
| Srinivasan, SK | 1 |
| Gupta, VS | 1 |
| Howarth, RE | 1 |
| Ford, JM | 1 |
| Hait, WN | 1 |
| Matlin, SA | 1 |
| Benz, CC | 1 |
| Grunicke, H | 2 |
| Doppler, W | 2 |
| Hofmann, J | 2 |
| Lindner, H | 1 |
| Maly, K | 2 |
| Oberhuber, H | 1 |
| Ringsdorf, H | 1 |
| Roberts, JJ | 1 |
| Helliger, W | 1 |
| Hermann, BJ | 1 |
| Höck, W | 1 |
| Puschendorf, B | 1 |
| Bomber, AM | 1 |
| Hoffman, SJ | 1 |
| Kanemura, M | 1 |
| Ohsawa, N | 1 |
| Yamazaki, Z | 1 |
| Greig, NH | 1 |
| Sweeney, DJ | 1 |
| Rapoport, SI | 1 |
| Buller, AL | 1 |
| Wang, AL | 1 |
| Mills, FH | 1 |
| Connors, TA | 2 |
| Sladek, NE | 1 |
| Rosenoer, VM | 1 |
| Mitchley, BC | 1 |
| Roe, FJ | 1 |
| Karaivanova, MKh | 1 |
| Elson, LA | 1 |
2 reviews available for chlorambucil and Carcinoma 256, Walker
| Article | Year |
|---|---|
[Tumor-oriented anti-cancer agent with estrogen as a carrier].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chlorambucil; Drug Carriers; Estradiol; Estra | 1988 |
Alkylating agents.
Topics: Alkylating Agents; Animals; Biological Transport; Carcinoma 256, Walker; Chlorambucil; Cisplatin; Cy | 1974 |
31 other studies available for chlorambucil and Carcinoma 256, Walker
| Article | Year |
|---|---|
Antineoplastic agents. 1. N-Protected vinyl, 1,2-dihaloethyl, and cyanomethyl esters of phenylalanine.
Topics: Acetonitriles; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Leth | 1977 |
Antineoplastic agents. 2. Structure-activity studies on N-protected vinyl, 1,2-dibromoethyl, and cyanomethyl esters of several amino acids.
Topics: Acetonitriles; Amino Acids; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carcinoma, Ehrlic | 1977 |
Structure-activity relationships in antitumor aniline mustards.
Topics: Aniline Mustard; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Hydrolysis; Lethal Dose 50; | 1978 |
Acquired drug resistance is accompanied by modification in the karyotype and nuclear matrix of a rat carcinoma cell line.
Topics: Animals; Carcinoma 256, Walker; Cell Line; Cell Nucleus; Chlorambucil; Chromosome Aberrations; Chrom | 1983 |
Effect of chlorambucil and indomethacin on growth and prostaglandin levels in sensitive and resistant Walker carcinoma.
Topics: Animals; Carcinoma 256, Walker; Cell Division; Chlorambucil; Dinoprostone; Dose-Response Relationshi | 1982 |
Chlorambucil-induced changes in chromatin methylation and their modulation by sodium butyrate.
Topics: Animals; Butyrates; Butyric Acid; Carcinoma 256, Walker; Chlorambucil; Chromatin; Chromosomal Protei | 1982 |
Interactions of cytotoxic and anti-inflammatory agents on normal and neoplastic tissue.
Topics: Animals; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Flurbiprofen; Hematopoietic Stem Cells; | 1980 |
The metabolism of chlorambucil.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carcinoma 256, Walker; Chlorambucil; In Vitro Tec | 1980 |
Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure.
Topics: Animals; Carcinoma 256, Walker; Chlorambucil; Drug Resistance; Enzyme Activation; Glutathione Transf | 1993 |
Alterations in adenosine 3', 5'-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkylating Agents; Animals; Aziridines; Carcinoma 256, Walker; | 1976 |
Adenosine 3',5'-monophosphate phosphodiesterase activity in experimental animal tumours which are either sensitive or resistant to bifunctional alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cells, Cultured; Chlorambucil; Cyclic AMP; Drug R | 1975 |
Inhibition of cyclic 3',5'-nucleotide phosphodiesterase-a possible mechanism of action of bifunctional alkylating agents.
Topics: Alkylating Agents; Aminophylline; Animals; Carcinoma 256, Walker; Cattle; Cells, Cultured; Chlorambu | 1975 |
Comparative effects of alkylating agents and other anti-tumour agents on the intracellular level of adenosine 3',5'-monophosphate in Walker carcinoma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Alkylating Agents; Animals; Bone Marrow; Carcinoma 256, Walker; | 1975 |
The effect of alkylating agents on the activity of adenosine 3',5'-monophosphate-dependent protein kinase in Walker carcinoma cells.
Topics: Alkylating Agents; Animals; Aziridines; Bucladesine; Carcinoma 256, Walker; Cell Line; Cells, Cultur | 1976 |
Guanosine 3',5'-monophosphate and the action of alkylating agents.
Topics: Alkylating Agents; Animals; Aziridines; Azirines; Carcinoma 256, Walker; Cells, Cultured; Chlorambuc | 1977 |
Non-steroidal anti-inflammatory drugs and cytotoxics.
Topics: Animals; Bone Marrow; Carcinoma 256, Walker; Chlorambucil; Digestive System; Flurbiprofen; Indometha | 1979 |
Inhibition of thymidylate synthetase of Walker carcinoma by chlorambucil. A possible mechanism of action.
Topics: Animals; Carcinoma 256, Walker; Cell-Free System; Chlorambucil; Drug Administration Schedule; Drug R | 1977 |
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmust | 1991 |
Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards.
Topics: Animals; Blotting, Western; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Cytosol; Drug Resist | 1989 |
Plasma membrane as target of alkylating agents.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Calcium Channel Blockers; Carcinoma 256, Walk | 1985 |
Differential sensitivity of histone acetylation in nitrogen-mustard sensitive and resistant cells. Relation to drug uptake, formation and repair of DNA-interstrand cross-links.
Topics: Acetylation; Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chlorambucil; Cyclophosphamid | 1988 |
Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Topics: Animals; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Drug Resistance; Drug Synergism; Epopro | 1988 |
[An experimental study of cancer therapy through the augmented foreign body reaction].
Topics: Animals; Carcinoma 256, Walker; Chlorambucil; Estradiol; Foreign-Body Reaction; Rats; Rats, Inbred S | 1988 |
Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat.
Topics: Amino Acids; Animals; Blood Proteins; Brain; Carcinoma 256, Walker; Chlorambucil; Half-Life; Male; M | 1988 |
Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Chlorambucil; Cytosol; Drug Resistance; Glutathio | 1987 |
Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.
Topics: Animals; Carcinoma 256, Walker; Cell Line; Cells, Cultured; Chlorambucil; Drug Resistance; Glutathio | 1985 |
Letter: Behavior of tumours in conditions of experimental magnesium deficiency.
Topics: Animals; Carcinoma 256, Walker; Chlorambucil; Magnesium; Magnesium Deficiency; Radioisotopes; Rats | 1974 |
Bioassay and relative cytotoxic potency of cyclophosphamide metabolites generated in vitro and in vivo.
Topics: Acrolein; Animals; Biological Assay; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Cyclophosph | 1973 |
Walker carcinosarcoma 256 in study of anticancer agents. I. Method for simultaneous assessment of therapeutic value and toxicity.
Topics: Amines; Aniline Compounds; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Chlorambucil; Naph | 1966 |
[A method of primary selection of antitumor agents].
Topics: Adenocarcinoma; Animals; Carcinoma 256, Walker; Chlorambucil; Cyclophosphamide; Melphalan; Mercaptop | 1971 |
Growth inhibitory and haematological effects of alkylating agents and attempts at their modification to give greater selectivity of anti-tumour action.
Topics: Alkylating Agents; Animals; Body Weight; Carcinoma 256, Walker; Chemical Phenomena; Chemistry; Chlor | 1968 |