chlorambucil has been researched along with Carcinoma, Oat Cell in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with paclitaxel or vinblastine, but not navelbine, sensitized the subline to cisplatin and chlorambucil (P < 0." | 1.31 | Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle. ( Davey, M; Davey, R; Locke, V, 2001) |
| "For chlorambucil treatment, this increased MRPI-mRNA expression was accompanied by increased drug resistance while paclitaxel treatment had no effect on drug resistance in the H82 cells." | 1.30 | Induction of broad drug resistance in small cell lung cancer cells and its reversal by paclitaxel. ( Davey, MW; Davey, RA; Su, GM, 1998) |
| "Prednimustine was given at dose levels ranging from 130 to 220 mg/m2/daily for 5 days every 3 weeks." | 1.26 | Phase II trial of prednimustine (NSC-134087) in the treatment of small-cell anaplastic carcinoma of the lung. ( Dombernowsky, P; Hansen, HH; Jensen, HS, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jensen, HS | 1 |
| Hansen, HH | 1 |
| Dombernowsky, P | 1 |
| Su, GM | 1 |
| Davey, MW | 1 |
| Davey, RA | 1 |
| Locke, V | 1 |
| Davey, R | 1 |
| Davey, M | 1 |
| Kozin, SV | 1 |
| Shkarin, P | 1 |
| Gerweck, LE | 1 |
| Savage, PE | 1 |
| Carmody, RG | 1 |
| Highman, JH | 1 |
5 other studies available for chlorambucil and Carcinoma, Oat Cell
| Article | Year |
|---|---|
Phase II trial of prednimustine (NSC-134087) in the treatment of small-cell anaplastic carcinoma of the lung.
Topics: Aged; Carcinoma, Small Cell; Chlorambucil; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Mi | 1980 |
Induction of broad drug resistance in small cell lung cancer cells and its reversal by paclitaxel.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bacteria | 1998 |
Paclitaxel sensitization of multidrug-resistant cells to chemotherapy is independent of the cell cycle.
Topics: Amsacrine; Antineoplastic Agents; Camptothecin; Carcinoma, Small Cell; Cell Cycle; Cell Survival; Ch | 2001 |
The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics.
Topics: Animals; Antineoplastic Agents, Alkylating; Carcinoma, Small Cell; Cell Membrane; Chlorambucil; Drug | 2001 |
Evaluation of gallium-67 in the diagnosis of bronchial carcinoma.
Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Chlorambucil; | 1976 |