chlorambucil has been researched along with Carcinoma, Hepatocellular in 8 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Expression of hepatocellular carcinoma mRNA in oocytes resulted in mainly Na(+)-dependent uptake of chlorambucil-taurocholate." | 7.69 | Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. ( Beuers, U; Böker, C; Glasa, J; Grützner, U; Hagenbuch, B; Kramer, W; Kullak-Ublick, GA; Meier, PJ; Oswald, M; Paumgartner, G; Stieger, B; Wess, G, 1997) |
| "Expression of hepatocellular carcinoma mRNA in oocytes resulted in mainly Na(+)-dependent uptake of chlorambucil-taurocholate." | 3.69 | Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. ( Beuers, U; Böker, C; Glasa, J; Grützner, U; Hagenbuch, B; Kramer, W; Kullak-Ublick, GA; Meier, PJ; Oswald, M; Paumgartner, G; Stieger, B; Wess, G, 1997) |
| "Self-assembly of anticancer small molecules into nanostructures may represent an attractive approach to improve the treatment of experimental solid tumors." | 1.42 | Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy. ( Fan, M; Li, Z; Liang, X; Shi, B; Wang, H; Yang, D, 2015) |
| "A chlorambucil conjugate was prepared and found to have similar qualities in vitro." | 1.25 | Immunochemotherapy of hepatoma in rats. ( Grogan, JB; Lockard, J; Smith, GV; Stribling, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Sang, L | 1 |
| Li, J | 1 |
| Zhang, F | 1 |
| Jia, J | 1 |
| Zhang, J | 1 |
| Ding, P | 1 |
| Sun, T | 1 |
| Wang, D | 1 |
| Fan, M | 1 |
| Liang, X | 1 |
| Li, Z | 1 |
| Wang, H | 1 |
| Yang, D | 1 |
| Shi, B | 1 |
| Gaynon, PS | 1 |
| Baum, ES | 1 |
| Krivit, W | 1 |
| Hammond, D | 1 |
| Parlier, H | 1 |
| Poupon, R | 1 |
| Darnis, F | 1 |
| Kullak-Ublick, GA | 1 |
| Glasa, J | 1 |
| Böker, C | 1 |
| Oswald, M | 1 |
| Grützner, U | 1 |
| Hagenbuch, B | 1 |
| Stieger, B | 1 |
| Meier, PJ | 1 |
| Beuers, U | 1 |
| Kramer, W | 1 |
| Wess, G | 1 |
| Paumgartner, G | 1 |
| Smith, GV | 2 |
| Grogan, JB | 2 |
| Stribling, J | 2 |
| Lockard, J | 2 |
| Brock, PR | 1 |
| Yeomans, EC | 1 |
| Bellman, SC | 1 |
| Pritchard, J | 1 |
8 other studies available for chlorambucil and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Glycyrrhetinic acid modified chlorambucil prodrug for hepatocellular carcinoma treatment based on DNA replication and tumor microenvironment.
Topics: Carcinoma, Hepatocellular; Chlorambucil; DNA Replication; Glycyrrhetinic Acid; Humans; Liver Neoplas | 2022 |
Chlorambucil gemcitabine conjugate nanomedicine for cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Carcinoma, H | 2015 |
Phase II trial of prednimustine in children with recurrent cancer: a Children's Cancer Study Group report.
Topics: Adolescent; Adult; Carcinoma, Hepatocellular; Child; Child, Preschool; Chlorambucil; Drug Administra | 1982 |
[Relation between monoclonal gammopathy and hepatobiliary disease].
Topics: Adult; Aged; Carcinoma, Hepatocellular; Chlorambucil; Cholestasis; Chronic Disease; Female; Hepatiti | 1982 |
Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carcinoma, Hepatocellular; Carrier Proteins; C | 1997 |
Immunochemotherapy of hepatoma in rats.
Topics: Animals; Antigen-Antibody Complex; Carcinoma, Hepatocellular; Cell Nucleus; Chlorambucil; Chromatin; | 1975 |
Cisplatin therapy in infants: short and long-term morbidity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chlorambucil; Cisplatin; | 1992 |
Immunochemotherapy of hepatoma in rats.
Topics: Animals; Carcinoma, Hepatocellular; Chlorambucil; Immunoglobulin G; Immunotherapy; Liver Neoplasms; | 1974 |