chlorambucil has been researched along with Carcinoma, Anaplastic in 36 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined the effect of bestrabucil, a benzoate of an estradiol-chlorambucil conjugate, on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line." | 7.69 | Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells. ( Akaza, H; Imada, S; Koiso, K; Tsukamoto, S, 1994) |
| "Drug resistance in cancer cells involves complex molecular mechanisms and ovarian carcinoma cells become resistant to chlorambucil (Cbl) after continuous treatment." | 3.76 | Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells. ( Maiti, AK, 2010) |
| " We examined the effect of bestrabucil, a benzoate of an estradiol-chlorambucil conjugate, on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line." | 3.69 | Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells. ( Akaza, H; Imada, S; Koiso, K; Tsukamoto, S, 1994) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Chlorambucil was previously found to be a specific inhibitor of total histone synthesis without affecting total cellular protein synthesis." | 1.30 | S and G2 phase histone biosynthesis of HEp-2 cells after the influence of the bisalkylating agent, chlorambucil. ( Sekeri-Pataryas, KE; Sourlingas, TG, 1997) |
| " Eleven patients with advanced carcinoma of the lung (5 adenocarcinoma, 3 squamous cell carcinoma, 2 small cell carcinoma and 1 large cell carcinoma) were treated at a dosage of 40 mg." | 1.26 | Preliminary clinical study of prednimustine in lung cancer. ( Catane, H; Catane, R; Kaufman, JH; Mittelman, A; Murphy, GP; Takita, H, 1977) |
| "Deuterium was almost totally lost from the alpha-d2 form and from its metabolite after 30 min and partially lost in 10 min." | 1.26 | The metabolism of deuterated analogues of chlorambucil by the rat. ( Farmer, PB; Foster, AB; Jarman, M; Kiburis, JH; Newell, DR; Oddy, MR, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (80.56) | 18.7374 |
| 1990's | 6 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maiti, AK | 1 |
| VIGI, F | 1 |
| PAPAVASILIOU, C | 1 |
| KOSTOUROS, D | 1 |
| HORWITZ, H | 1 |
| WRIGHT, TL | 1 |
| PERRY, H | 1 |
| BARRETT, CM | 1 |
| BOYLAND, E | 1 |
| KINDER, CH | 1 |
| WILLIAMS, K | 1 |
| LEBHERZ, TB | 1 |
| HUSTON, JW | 1 |
| AUSTIN, JA | 1 |
| BOYCE, CR | 1 |
| MILLER, SP | 1 |
| BRENNER, SM | 1 |
| Szepesi, T | 1 |
| Szalay, S | 2 |
| Breitenecker, G | 1 |
| Schratter-Sehn, A | 1 |
| Rogan, AM | 1 |
| Riss, T | 1 |
| Wittich, G | 1 |
| Heckenthaler, W | 1 |
| Fasching, W | 1 |
| Scheiber, V | 1 |
| Bruntsch, U | 1 |
| Gallmeier, WM | 1 |
| Janisch, H | 1 |
| Goodman, GE | 1 |
| McLean, A | 1 |
| Alberts, DS | 1 |
| Chang, SY | 1 |
| Dalley, VM | 1 |
| Morales, PH | 1 |
| Fayos, JV | 1 |
| Akaza, H | 1 |
| Imada, S | 1 |
| Tsukamoto, S | 1 |
| Koiso, K | 1 |
| Taylor, AE | 1 |
| Gore, ME | 1 |
| Sourlingas, TG | 1 |
| Sekeri-Pataryas, KE | 1 |
| Ponticelli, C | 1 |
| Altieri, P | 1 |
| Scolari, F | 1 |
| Passerini, P | 1 |
| Roccatello, D | 1 |
| Cesana, B | 1 |
| Melis, P | 1 |
| Valzorio, B | 1 |
| Sasdelli, M | 1 |
| Pasquali, S | 1 |
| Pozzi, C | 1 |
| Piccoli, G | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Grassi, C | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Iglesias-Guerra, F | 1 |
| Candela, JI | 1 |
| Bautista, J | 1 |
| Alcudia, F | 1 |
| Vega-Pérez, JM | 1 |
| Catane, H | 1 |
| Catane, R | 1 |
| Takita, H | 1 |
| Kaufman, JH | 1 |
| Mittelman, A | 1 |
| Murphy, GP | 1 |
| Farmer, PB | 1 |
| Foster, AB | 1 |
| Jarman, M | 1 |
| Newell, DR | 1 |
| Oddy, MR | 1 |
| Kiburis, JH | 1 |
| Morrison, J | 1 |
| Yon, JL | 1 |
| Livingston, RB | 1 |
| Heilbrun, LH | 1 |
| Thigpen, T | 1 |
| Coltman, CA | 1 |
| Haas, C | 1 |
| Musch, E | 1 |
| Malek, M | 1 |
| Peter-Katalinic, J | 1 |
| Egge, H | 1 |
| Rink, H | 1 |
| Lathan, B | 1 |
| Riedel, E | 1 |
| Luesley, D | 1 |
| Lawton, F | 1 |
| Blackledge, G | 1 |
| Hilton, C | 1 |
| Kelly, K | 1 |
| Rollason, T | 1 |
| Wade-Evans, T | 1 |
| Jordan, J | 1 |
| Fielding, J | 1 |
| Latief, T | 1 |
| Harding, M | 1 |
| Kennedy, R | 1 |
| Mill, L | 1 |
| MacLean, A | 1 |
| Duncan, I | 1 |
| Kennedy, J | 1 |
| Soukop, M | 1 |
| Kaye, SB | 1 |
| Ciobanu, N | 1 |
| Runowicz, C | 1 |
| Gucalp, R | 1 |
| Frank, M | 1 |
| Charuvanki, V | 1 |
| Kaufman, D | 1 |
| Wiernik, PH | 1 |
| Michels, SD | 1 |
| McKenna, RW | 1 |
| Arthur, DC | 1 |
| Brunning, RD | 1 |
| Villasanta, U | 1 |
| Bloedorn, FG | 1 |
| Moore, GE | 1 |
| Bross, ID | 1 |
| Ausman, R | 1 |
| Nadler, S | 1 |
| Jones, R | 1 |
| Slack, N | 1 |
| Rimm, AA | 1 |
| Lewis, TL | 1 |
| Hartwich, G | 1 |
| Butzler, W | 1 |
| Griffiths, CT | 1 |
| Grogan, RH | 1 |
| Hall, TC | 1 |
| Lleander, VC | 1 |
| Goldstein, G | 1 |
| Horsley, JS | 1 |
| Papavasiliou, A | 1 |
| Sfikakis, P | 1 |
| Nicolaidis, C | 1 |
| Green, RA | 1 |
| Humphrey, E | 1 |
| Close, H | 1 |
| Patno, ME | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorambucil and Carcinoma, Anaplastic
| Article | Year |
|---|---|
[New trends in treatment of ovarian carcinoma (author's transl)].
Topics: Carcinoma; Chlorambucil; Cyclophosphamide; Cystadenocarcinoma; Female; Humans; Melphalan; Mesonephro | 1982 |
Trends in the treatment of pelvic malignant diseases.
Topics: Carcinoma; Chlorambucil; Cyclophosphamide; Female; Genital Neoplasms, Female; Humans; Hysterectomy; | 1971 |
6 trials available for chlorambucil and Carcinoma, Anaplastic
| Article | Year |
|---|---|
[Treatment of advanced ovarian cancer as an interdisciplinary task: surgery, histopathology, radiotherapy, and chemotherapy].
Topics: Adenocarcinoma, Mucinous; Bleomycin; Bone and Bones; Carcinoma; Chlorambucil; Cyclophosphamide; Doxo | 1983 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
Adriamycin and chlorambucil versus adriamycin and thiabendazole in the treatment of extensive, non-small cell carcinoma of the lung: a Southwest Oncology Group pilot study.
Topics: Carcinoma; Chlorambucil; Doxorubicin; Drug Therapy, Combination; Humans; Lung Neoplasms; Pilot Proje | 1978 |
Failure of second-look laparotomy to influence survival in epithelial ovarian cancer.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chlorambucil; Cisplat | 1988 |
Effects of chlorambucil (NSC-3088) in 374 patients with advanced cancer. Eastern Clinical Drug Evualuation Program.
Topics: Carcinoma; Chlorambucil; Clinical Trials as Topic; Female; Humans; Neoplasms; Ovarian Neoplasms; Pan | 1968 |
Alkylating agents in bronchogenic carcinoma.
Topics: Adenocarcinoma; Alkylating Agents; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Chl | 1969 |
28 other studies available for chlorambucil and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells.
Topics: Apoptosis; Carcinoma; Cell Line, Tumor; Chlorambucil; DNA-Activated Protein Kinase; Drug Resistance, | 2010 |
[CURRENT PRACTICE IN THE TREATMENT OF TUMORS WITH INTRA-ARTERIAL INJECTIONS OF ANTINEOPLASTIC SUBSTANCES].
Topics: Aminopterin; Antineoplastic Agents; Carcinoma; Chemotherapy, Cancer, Regional Perfusion; Chlorambuci | 1963 |
COMBINED TREATMENT OF DISSEMINATED OVARIAN CARCINOMA WITH COBALT TELETHERAPY AND CYTOSTATICS (CHLORAMBUCIL).
Topics: Carcinoma; Chlorambucil; Cobalt; Cobalt Isotopes; Combined Modality Therapy; Cytostatic Agents; Fema | 1964 |
"SUPPRESSIVE" CHEMOTHERAPY IN BRONCHOGENIC CARCINOMA: A RANDOMIZED PROSPECTIVE CLINICAL TRIAL.
Topics: Adenocarcinoma; Biomedical Research; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; C | 1965 |
THE TREATMENT OF CARCINOMA IN DOGS' BLADDERS WITH CYTOTOXIC DRUGS.
Topics: Alkylating Agents; Antineoplastic Agents; Carcinogens; Carcinoma; Chlorambucil; Cyclophosphamide; Do | 1965 |
SUSTAINED PALLIATION IN OVARIAN CARCINOMA.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Carcinoma; Chlorambucil; Dysgerminoma; Female; Gr | 1965 |
Combination therapy with cobalt-60 and chlorambucil in the treatment of disseminated ovarian carcinomatosis.
Topics: Carcinoma; Chlorambucil; Cobalt; Cobalt Radioisotopes; Combined Modality Therapy; Female; Humans; Me | 1962 |
[Chemotherapy of epithelial ovarian carcinoma].
Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Chlorambucil; Cisplatin; Cyc | 1983 |
Inhibition of human tumour clonogenicity by chlorambucil and its metabolites.
Topics: Carcinoma; Cell Line; Chlorambucil; Clone Cells; Dose-Response Relationship, Drug; Humans; Multiple | 1982 |
The role of radiotherapy and chemotherapy in the treatment of cancer of the ovary.
Topics: Brachytherapy; Carcinoma; Chlorambucil; Cisplatin; Cyclophosphamide; Female; Humans; Neoplasm Stagin | 1982 |
Epithelial carcinoma of the ovary.
Topics: Adolescent; Adult; Aged; Biopsy; Carcinoma; Chlorambucil; Female; Follow-Up Studies; Humans; Hystere | 1981 |
Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells.
Topics: Androgens; Animals; Antineoplastic Agents; Carcinoma; Cell Count; Chlorambucil; Culture Media, Condi | 1994 |
Chlorambucil for platinum-refractory ovarian cancer.
Topics: Adult; Aged; Carcinoma; Chlorambucil; Combined Modality Therapy; Drug Resistance; Female; Follow-Up | 1994 |
S and G2 phase histone biosynthesis of HEp-2 cells after the influence of the bisalkylating agent, chlorambucil.
Topics: Antineoplastic Agents, Alkylating; Aphidicolin; Carcinoma; Cell Division; Chlorambucil; DNA, Neoplas | 1997 |
Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carrier systems for chlorambucil.
Topics: Adult; Amino Sugars; Animals; Antineoplastic Agents, Alkylating; Carcinoma; Cell Division; Chlorambu | 1999 |
Preliminary clinical study of prednimustine in lung cancer.
Topics: Adenocarcinoma; Aged; Carcinoma; Carcinoma, Squamous Cell; Chlorambucil; Female; Humans; Lung Neopla | 1977 |
The metabolism of deuterated analogues of chlorambucil by the rat.
Topics: Animals; Carcinoma; Chlorambucil; Chromatography, High Pressure Liquid; Deuterium; Female; Nitrogen | 1979 |
Acute leukemia following chlorambucil therapy of advanced ovarian and fallopian tube carcinoma.
Topics: Acute Disease; Carcinoma; Chlorambucil; Fallopian Tube Neoplasms; Female; Humans; Leukemia; Middle A | 1978 |
Cellular kinetics of prednimustine versus chlorambucil plus prednisolone in vitro.
Topics: Animals; Carcinoma; Chlorambucil; Chromatography, High Pressure Liquid; Colonic Neoplasms; Mammary N | 1992 |
A pilot study of carboplatin (JM8, CBDCA) and chlorambucil in combination for advanced ovarian cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma; Chlorambucil; F | 1988 |
Reversible central nervous system toxicity associated with high-dose chlorambucil in autologous bone marrow transplantation for ovarian carcinoma.
Topics: Adult; Bone Marrow Transplantation; Carcinoma; Chlorambucil; Dose-Response Relationship, Drug; Femal | 1987 |
Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Behcet Syndrome; Bone Marrow; Carcinoma; Child; Chil | 1985 |
Operation, external irradiation, radioactive isotopes, and chemotherapy in treatment of metastatic ovarian malignancies.
Topics: Ascites; Carcinoma; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Fluorouracil; Follow-Up St | 1968 |
Cytotoxic agents in the treatment of malignant disease.
Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma; | 1968 |
[Secondary tumors in hemoblastoses during cytostatic treatment].
Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo | 1971 |
Advanced ovarian cancer: primary treatment with surgery, radiotherapy, and chemotherapy.
Topics: Adenocarcinoma; Carcinoma; Chlorambucil; Cyclophosphamide; Female; Humans; Nitrogen Mustard Compound | 1972 |
Chemotherapy in the management of metastatic cancer of unknown primary site.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Chlorambucil; Cyclopho | 1972 |
[Treatment of ascites associated with advanced ovarian cancer].
Topics: Ascites; Carcinoma; Chlorambucil; Female; Humans; Ovarian Neoplasms | 1968 |