chlorambucil has been researched along with Canine Diseases in 25 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil appears to be an effective and well tolerated prednisolone sparing agent for treatment of CEG." | 5.43 | Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil. ( Knight, EC; Shipstone, MA, 2016) |
| "The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m(-2) daily in dogs with naturally occurring cancer." | 2.77 | Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. ( Childress, MO; Greene, SN; Knapp, DW; Lahrman, SR; Leach, TN; Mohamed, AS; Moore, GE; Schrempp, DR, 2012) |
| "Pemphigus is an autoimmune skin disease that can present in a variety of forms and can be a challenging disease to manage and treat." | 2.42 | Pemphigus: current therapy. ( Rosenkrantz, WS, 2004) |
| "Chlorambucil appears to be an effective and well tolerated prednisolone sparing agent for treatment of CEG." | 1.43 | Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil. ( Knight, EC; Shipstone, MA, 2016) |
| "Treatment with prednisone and chlorambucil was initiated, and the dog had a good response." | 1.37 | Waldenström's macroglobulinemia in a dog with a bleeding diathesis. ( Fournel-Fleury, C; Jaillardon, L, 2011) |
| "The diagnosis of lymphocytic leukemia was based on the finding of a large number of mature lymphocytes in the blood and bone marrow." | 1.26 | Hyperviscosity syndrome associated with lymphocytic leukemia in three dogs. ( Hayes, A; Hurvitz, AI; MacEwen, EG, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gedon, J | 1 |
| Kehl, A | 1 |
| Aupperle-Lellbach, H | 1 |
| von Bomhard, W | 1 |
| Schmidt, JM | 1 |
| Viviano, KR | 1 |
| Ohmi, A | 3 |
| Tanaka, M | 3 |
| Rinno, J | 3 |
| Tsuboi, M | 3 |
| Chambers, JK | 3 |
| Uchida, K | 3 |
| Goto-Koshino, Y | 3 |
| Tomiyasu, H | 3 |
| Ohno, K | 3 |
| Tsujimoto, H | 3 |
| Matsuyama, A | 1 |
| Bienzle, D | 1 |
| Richardson, D | 1 |
| Deravi, N | 1 |
| Hwang, MH | 1 |
| Darzentas, N | 1 |
| Keller, SM | 1 |
| Sugita, K | 1 |
| Shima, A | 1 |
| Takahashi, K | 1 |
| Matsuda, Y | 1 |
| Miyajima, M | 1 |
| Hirokawa, M | 1 |
| Kondo, H | 1 |
| Kimura, J | 1 |
| Ishihara, G | 1 |
| Ohmori, K | 1 |
| Schrempp, DR | 2 |
| Childress, MO | 3 |
| Stewart, JC | 1 |
| Leach, TN | 2 |
| Tan, KM | 1 |
| Abbo, AH | 1 |
| de Gortari, AE | 1 |
| Bonney, PL | 1 |
| Knapp, DW | 2 |
| Dandrieux, JR | 1 |
| Noble, PJ | 1 |
| Scase, TJ | 1 |
| Cripps, PJ | 1 |
| German, AJ | 1 |
| Giuliano, A | 1 |
| Ghormley, T | 1 |
| Feldman, D | 1 |
| Nagata, N | 1 |
| Shibata, S | 1 |
| Sakai, H | 1 |
| Konno, H | 1 |
| Takashima, S | 1 |
| Kawabe, M | 1 |
| Mori, T | 1 |
| Kitagawa, H | 1 |
| Washizu, M | 1 |
| Custead, MR | 1 |
| Weng, HY | 1 |
| Knight, EC | 1 |
| Shipstone, MA | 1 |
| Taylor, F | 1 |
| Gear, R | 1 |
| Hoather, T | 1 |
| Dobson, J | 1 |
| Kim, HJ | 1 |
| Kang, MH | 1 |
| Kim, JW | 1 |
| Kim, DY | 1 |
| Park, HM | 1 |
| Jaillardon, L | 1 |
| Fournel-Fleury, C | 1 |
| Greene, SN | 1 |
| Mohamed, AS | 1 |
| Moore, GE | 1 |
| Lahrman, SR | 1 |
| Rosenkrantz, WS | 1 |
| Vail, DM | 1 |
| Kisseberth, WC | 1 |
| Obradovich, JE | 1 |
| Moore, FM | 1 |
| London, CA | 1 |
| MacEwen, EG | 4 |
| Ritter, MA | 1 |
| Miller, E | 1 |
| Patnaik, AK | 1 |
| Wilkins, RJ | 1 |
| Hurvitz, AI | 2 |
| Middaugh, CR | 1 |
| Litman, GW | 1 |
| Hayes, A | 1 |
| Mundell, AC | 1 |
| Shepard, VJ | 1 |
| Dodds-Laffin, WJ | 1 |
| Laffin, RJ | 1 |
| Brick, JO | 1 |
| Roenigk, WJ | 1 |
| Wilson, GP | 1 |
4 reviews available for chlorambucil and Canine Diseases
| Article | Year |
|---|---|
Glucocorticoids, Cyclosporine, Azathioprine, Chlorambucil, and Mycophenolate in Dogs and Cats: Clinical Uses, Pharmacology, and Side Effects.
Topics: Animals; Azathioprine; Cat Diseases; Cats; Chlorambucil; Cyclosporine; Dog Diseases; Dogs; Drug-Rela | 2022 |
Pemphigus: current therapy.
Topics: Animals; Antirheumatic Agents; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Dapsone; | 2004 |
The use of cytotoxic agents in the treatment of immune-mediated diseases of dogs and cats.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Azathioprine; Cat Disea | 1997 |
New therapeutic agents in veterinary dermatology.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Cat Diseases; Cats; Chlorambucil; Clofazimine; Dog Dis | 1990 |
2 trials available for chlorambucil and Canine Diseases
| Article | Year |
|---|---|
Metronomic administration of chlorambucil for treatment of dogs with urinary bladder transitional cell carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Chlorambucil; Dog Diseases; Dogs; Drug | 2013 |
Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Dog Diseases; | 2012 |
19 other studies available for chlorambucil and Canine Diseases
| Article | Year |
|---|---|
BRAF mutation status and its prognostic significance in 79 canine urothelial carcinomas: A retrospective study (2006-2019).
Topics: Animals; Carcinoma, Transitional Cell; Chlorambucil; Dog Diseases; Dogs; Female; Male; Meloxicam; Mi | 2022 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Japan; Lymphoma; Retrospective Studies | 2023 |
Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Chlorambucil; Dog Disea | 2019 |
Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil.
Topics: Animals; Chlorambucil; Diarrhea; Dog Diseases; Dogs; Dysbiosis; Fecal Microbiota Transplantation; Fe | 2021 |
Comparison of a chlorambucil-prednisolone combination with an azathioprine-prednisolone combination for treatment of chronic enteropathy with concurrent protein-losing enteropathy in dogs: 27 cases (2007-2010).
Topics: Animals; Azathioprine; Chlorambucil; Chronic Disease; Dog Diseases; Dogs; Drug Therapy, Combination; | 2013 |
Suspected chlorambucil-related neurotoxicity with seizures in a dog.
Topics: Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Dog Diseases; Dogs; Lymphoma; Seizures | 2013 |
Chronic enteropathy and diet.
Topics: Animals; Azathioprine; Chlorambucil; Dog Diseases; Intestinal Diseases; Prednisolone | 2013 |
Gallbladder lymphoma in a miniature dachshund.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Dog Diseases; Dogs; Female; Gallbladder Neoplasms; Lym | 2015 |
Retrospective comparison of three doses of metronomic chlorambucil for tolerability and efficacy in dogs with spontaneous cancer.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Bone Marrow; Chlorambucil; D | 2017 |
Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Dog Diseases; Do | 2016 |
Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined | 2009 |
Long-term management of vaccine-induced refractory ischemic dermatopathy in a Miniature Pinscher puppy.
Topics: Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Cyclosporine; Dog Diseases; Dogs; Drug Eru | 2011 |
Waldenström's macroglobulinemia in a dog with a bleeding diathesis.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Chlorambucil; Diarrhea; Disease Susce | 2011 |
Assessment of potential doubling time (Tpot), argyrophilic nucleolar organizer regions (AgNOR), and proliferating cell nuclear antigen (PCNA) as predictors of therapy response in canine non-Hodgkin's lymphoma.
Topics: Animals; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Chloramb | 1996 |
Diagnosis and treatment of canine hematopoietic neoplasms.
Topics: Animals; Chlorambucil; Dog Diseases; Dogs; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma | 1977 |
Monoclonal cryoglobulinemia with macroglobulinemia in a dog.
Topics: Animals; Blood Proteins; Chlorambucil; Cryoglobulins; Dog Diseases; Dogs; Female; Immunoglobulin M; | 1977 |
Hyperviscosity syndrome associated with lymphocytic leukemia in three dogs.
Topics: Animals; Blood Viscosity; Chlorambucil; Dog Diseases; Dogs; Immunoglobulin A; Immunoglobulin M; Leuk | 1977 |
Gamma A myeloma in a dog with defective hemostasis.
Topics: Animals; Blood Coagulation Disorders; Chlorambucil; Dexamethasone; Dog Diseases; Dogs; Female; Immun | 1972 |
Chemotherapy of malignant lymphoma in dogs and cats.
Topics: Animals; Blood Cells; Cat Diseases; Cats; Chlorambucil; Cyclophosphamide; Dog Diseases; Dogs; Female | 1968 |