chlorambucil has been researched along with Cancer of the Uterus in 39 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It was discovered that for breast cancer cells, the new compounds were up to 4." | 5.38 | Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Leblanc, V; Parent, S, 2012) |
| "This report describes a 53-year-old white woman with metastatic gestational trophoblastic neoplasia that recurred after evacuation of an accidental pregnancy and did not respond sufficiently to treatment with a combination of methotrexate, actinomycin D, and chlorambucil." | 3.67 | Chemotherapy-resistant gestational trophoblastic neoplasia treated successfully with cisplatin, etoposide, and bleomycin. ( Aalders, JG; Bouma, J; Sleijfer, DT; Willemse, PH, 1988) |
| "It was discovered that for breast cancer cells, the new compounds were up to 4." | 1.38 | Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Leblanc, V; Parent, S, 2012) |
| "The clinical features of patients with brain metastases are reviewed in detail." | 1.29 | Brain metastases of gestational trophoblastic tumor. ( Bakri, Y; Berkowitz, RS; Goldstein, DP; Jabbar, FA; Senoussi, M; Subhi, J; von Sinner, W, 1994) |
| "Surgery combined with chemotherapy was applied in 34 out of 178 patients (19." | 1.29 | Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD). ( Kietlińska, Z; Sablińska, B; Zieliński, J, 1993) |
| "Of 19 patients with gestational trophoblastic tumor and liver metastases, 6 received MAC chemotherapy, and 8 received PEA." | 1.29 | Liver metastases of gestational trophoblastic tumor. ( Amer, M; Bakri, YN; Ezzat, A; Jabbar, FA; Sinner, W; Subhi, J; Tweijry, A, 1993) |
| "Head and neck carcinomas and breast cancer had the highest incidence (5 and 3 cases, respectively)." | 1.26 | Primary malignant neoplasms associated with chronic lymphocytic leukemia. ( Franchi, F; Monfardini, S; Rilke, F; Santoro, A, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (84.62) | 18.7374 |
| 1990's | 5 (12.82) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Descôteaux, C | 1 |
| Brasseur, K | 1 |
| Leblanc, V | 1 |
| Parent, S | 1 |
| Asselin, E | 1 |
| Bérubé, G | 1 |
| MOORE, JG | 1 |
| VANCAMPENHOUT, JL | 1 |
| BRANDKAMP, WW | 1 |
| HRESCHCHYSHYN, MM | 1 |
| BREWER, JI | 1 |
| GERBIE, AB | 1 |
| DOLKART, RE | 1 |
| SKOM, JH | 1 |
| NAGLE, RG | 1 |
| TOROK, EE | 1 |
| Harder, M | 1 |
| Limacher, F | 1 |
| Lurain, JR | 1 |
| Piver, MS | 1 |
| Sablińska, B | 2 |
| Cześnin, K | 1 |
| Ploch, E | 1 |
| Jones, WB | 1 |
| Santoro, A | 1 |
| Rilke, F | 1 |
| Franchi, F | 1 |
| Monfardini, S | 1 |
| Bakri, Y | 1 |
| Berkowitz, RS | 1 |
| Goldstein, DP | 1 |
| Subhi, J | 2 |
| Senoussi, M | 1 |
| von Sinner, W | 1 |
| Jabbar, FA | 2 |
| Hammond, CB | 2 |
| Olt, GJ | 1 |
| Kietlińska, Z | 1 |
| Zieliński, J | 1 |
| Bakri, YN | 1 |
| Amer, M | 1 |
| Ezzat, A | 1 |
| Sinner, W | 1 |
| Tweijry, A | 1 |
| Ross, GT | 1 |
| Becker, RL | 1 |
| Avioli, LV | 1 |
| Valdez, VA | 1 |
| Planas, AT | 1 |
| Lopez, VF | 1 |
| Goldberg, M | 1 |
| Herrera, NE | 1 |
| Einhorn, LH | 1 |
| Pratt, RA | 1 |
| Di Chiro, G | 1 |
| Weed, JC | 1 |
| O'Neill, E | 1 |
| Pelegrina, I | 1 |
| Vicens, R | 1 |
| Almodóvar, AR | 1 |
| Mortakis, AE | 1 |
| Braga, CA | 1 |
| Willemse, PH | 1 |
| Aalders, JG | 1 |
| Bouma, J | 1 |
| Sleijfer, DT | 1 |
| du Toit, JP | 1 |
| Curry, SL | 1 |
| Blessing, JA | 1 |
| DiSaia, PJ | 1 |
| Soper, JT | 1 |
| Twiggs, LB | 1 |
| Gerulath, AH | 1 |
| Dembo, AJ | 1 |
| Aitken, S | 1 |
| Quirt, IC | 1 |
| Osborne, R | 1 |
| Blackstein, M | 1 |
| Rider, WD | 1 |
| Takamizawa, H | 1 |
| Sekiya, S | 1 |
| Kobayashi, O | 1 |
| Matsui, H | 1 |
| Lajos, L | 1 |
| Székely, J | 1 |
| Major, A | 1 |
| Balogh, S | 1 |
| Bücs, G | 1 |
| Semenovskiĭ, AV | 1 |
| Bret, AJ | 1 |
| Grépinet, J | 1 |
| Dendy, PP | 1 |
| Ryssel, HJ | 1 |
| Sonntag, RW | 1 |
| Brunner, KW | 1 |
| Dargent, M | 1 |
| Pommatau, E | 1 |
| Brunat, M | 1 |
| Gudgeon, DH | 1 |
| Li, MC | 1 |
| Bloomfield, RD | 1 |
| Ober, WB | 1 |
| Edgcomb, JH | 1 |
| Price, EB | 1 |
| Donovan, JF | 1 |
| Sandström, B | 1 |
| Lewis, TL | 1 |
| Jacobs, EM | 1 |
| Johnson, FD | 1 |
5 reviews available for chlorambucil and Cancer of the Uterus
| Article | Year |
|---|---|
[Chemotherapy of trophoblastic disease].
Topics: Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyc | 1974 |
Trophoblastic disease: natural history, diagnosis, and treatment.
Topics: Alkylating Agents; Aminopterin; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; | 1971 |
Current cancer chemotherapy in obstetrics and gynecology.
Topics: Alkaloids; Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Blood Cell Count; Bone Marrow; | 1971 |
Nonhormonal chemotherapy of endometrial adenocarcinoma: a review.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Evaluation; Drug Therapy | 1974 |
Trends in the treatment of pelvic malignant diseases.
Topics: Carcinoma; Chlorambucil; Cyclophosphamide; Female; Genital Neoplasms, Female; Humans; Hysterectomy; | 1971 |
1 trial available for chlorambucil and Cancer of the Uterus
| Article | Year |
|---|---|
A prospective randomized comparison of methotrexate, dactinomycin, and chlorambucil versus methotrexate, dactinomycin, cyclophosphamide, doxorubicin, melphalan, hydroxyurea, and vincristine in "poor prognosis" metastatic gestational trophoblastic disease:
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Dactinomycin; | 1989 |
33 other studies available for chlorambucil and Cancer of the Uterus
| Article | Year |
|---|---|
Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines.
Topics: Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorambucil; | 2012 |
EFFECTS OF IONIZING IRRADIATION AND CHEMOTHERAPEUTIC AGENTS ON HUMAN CHROMOSOMES.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Choriocarcinoma; Chromosome Aberrations; C | 1964 |
EXPERIENCES WITH CHEMOTHERAPY IN GYNECOLOGIC CANCER.
Topics: Antineoplastic Agents; Biomedical Research; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Ge | 1964 |
CHEMOTHERAPY IN TROPHOBLASTIC DISEASES.
Topics: Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Drug Therapy; Female; Gestation | 1964 |
[Generalized metastasizing chorion carcinoma with complete remission after cytostatic therapy].
Topics: Adult; Breast Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Da | 1983 |
Metastatic gestational trophoblastic disease: secondary chemotherapy.
Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Female; Humans; Methot | 1980 |
[Management of trophoblastic disease].
Topics: Adolescent; Adult; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female; Follow-Up | 1980 |
Management of low-risk metastatic gestational trophoblastic disease.
Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Female; Humans; Hyster | 1981 |
Primary malignant neoplasms associated with chronic lymphocytic leukemia.
Topics: Breast Neoplasms; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Female; Head and Neck Neoplasms | 1980 |
Brain metastases of gestational trophoblastic tumor.
Topics: Adult; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Chlorambucil; Chorionic Gonadotrop | 1994 |
Gestational trophoblastic disease.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug A | 1994 |
Chemotherapy combined with surgery in the treatment of gestational trophoblastic disease (GTD).
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Chorioca | 1993 |
Liver metastases of gestational trophoblastic tumor.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Dactinomycin; Etopos | 1993 |
Congenital anomalies among children born of mothers receiving chemotherapy for gestational trophoblastic neoplasms.
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Chlorambucil; Drug Therapy, Combination; Female; | 1976 |
Gestational trophoblastic disease.
Topics: Adult; Brain Neoplasms; Cerebral Hemorrhage; Chlorambucil; Choriocarcinoma; Dactinomycin; Female; He | 1977 |
Adenosarcoma of uterus and ovary: a clinicopathologic study of two cases.
Topics: Adult; Chlorambucil; Cyclophosphamide; Cytoplasm; Female; Humans; Middle Aged; Neoplasm Metastasis; | 1979 |
Cancer chemotherapy.
Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Hodgkin Disease; Humans; Leuk | 1977 |
Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma.
Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Brain Neoplasms; Chlorambucil; Choriocarcinoma; | 1977 |
Normal pregnancy and delivery after cerebral metastases of choriocarcinoma: Case report.
Topics: Adolescent; Brain Neoplasms; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy, Combination; | 1976 |
"Poor prognosis" metastatic gestational trophoblastic disease: the prognostic significance of the scoring system in predicting chemotherapy failures.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Choriocarcinom | 1990 |
Chemotherapy-resistant gestational trophoblastic neoplasia treated successfully with cisplatin, etoposide, and bleomycin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Dactinomycin; Et | 1988 |
High risk malignant gestational trophoblastic disease: experience with triple chemotherapy (MAC) in Third World circumstances.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dactinomycin; Female; Humans; L | 1989 |
Poor prognosis metastatic gestational trophoblastic disease: experience with moderate dose methotrexate plus folinic acid rescue as initial therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropi | 1986 |
Chemotherapy for gestational trophoblastic tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropi | 1987 |
[Importance of chemotherapeutic agents in the treatment of malignant trophoblast tumors].
Topics: Adnexa Uteri; Adult; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Hu | 1969 |
[Uterine chorioepithelioma].
Topics: Abortion, Spontaneous; Adult; Antineoplastic Agents; Chlorambucil; Chloramines; Choriocarcinoma; Dac | 1966 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamid | 1968 |
[The treatment of choriocarcinoma and malignant testicular neoplasms].
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide; | 1967 |
[Apropos of an experience with the polychemotherapy of cancer].
Topics: Adult; Bone Neoplasms; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Dysgermi | 1968 |
Mixed mesodermal tumour of the uterus occurring after radiotherapy.
Topics: Aged; Chlorambucil; Cystadenoma; Female; Humans; Neoplasms, Germ Cell and Embryonal; Neoplasms, Mult | 1968 |
The pathology of choriocarcinoma.
Topics: Adolescent; Adult; Age Factors; Animals; Autopsy; Child; Chlorambucil; Choriocarcinoma; Chorionic Go | 1971 |
[Malignant mole and choriocarcinoma].
Topics: Chlorambucil; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Methotrexate; Pregnancy; Prognosis | 1973 |
Gestational choriocarcinoma.
Topics: Adult; California; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Huma | 1972 |