chlorambucil has been researched along with Cancer of Pancreas in 5 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two retrovirally complemented pancreatic cancer cell lines having defects in the Fanconi anemia pathway, PL11 (FANCC-mutated) and Hs766T (FANCG-mutated), as well as several parental pancreatic cancer cell lines with or without mutations in the Fanconi anemia/BRCA2 pathway, were assayed for in vitro and in vivo sensitivities to various chemotherapeutic agents." | 1.33 | In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor. ( Brody, JR; Cunningham, SC; DeMarzo, AM; Dezentje, DA; Gallmeier, E; Hruban, RH; Isacoff, WH; Kern, SE; Offerhaus, GJ; Swartz, MJ; van der Heijden, MS, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Millard, M | 1 |
| Gallagher, JD | 1 |
| Olenyuk, BZ | 1 |
| Neamati, N | 1 |
| Schobert, R | 1 |
| Biersack, B | 1 |
| Knauer, S | 1 |
| Ocker, M | 1 |
| Jespersen, C | 1 |
| Soragni, E | 1 |
| James Chou, C | 1 |
| Arora, PS | 1 |
| Dervan, PB | 1 |
| Gottesfeld, JM | 1 |
| van der Heijden, MS | 1 |
| Brody, JR | 1 |
| Dezentje, DA | 1 |
| Gallmeier, E | 1 |
| Cunningham, SC | 1 |
| Swartz, MJ | 1 |
| DeMarzo, AM | 1 |
| Offerhaus, GJ | 1 |
| Isacoff, WH | 1 |
| Hruban, RH | 1 |
| Kern, SE | 1 |
| Moore, GE | 1 |
| Bross, ID | 1 |
| Ausman, R | 1 |
| Nadler, S | 1 |
| Jones, R | 1 |
| Slack, N | 1 |
| Rimm, AA | 1 |
1 trial available for chlorambucil and Cancer of Pancreas
| Article | Year |
|---|---|
Effects of chlorambucil (NSC-3088) in 374 patients with advanced cancer. Eastern Clinical Drug Evualuation Program.
Topics: Carcinoma; Chlorambucil; Clinical Trials as Topic; Female; Humans; Neoplasms; Ovarian Neoplasms; Pan | 1968 |
4 other studies available for chlorambucil and Cancer of Pancreas
| Article | Year |
|---|---|
A selective mitochondrial-targeted chlorambucil with remarkable cytotoxicity in breast and pancreatic cancers.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Proliferation; Chloramb | 2013 |
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
Topics: Agaricales; Cell Line, Tumor; Chlorambucil; Colonic Neoplasms; Cytotoxins; Dicarboxylic Acids; Docos | 2008 |
Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.
Topics: Acetylation; Antineoplastic Agents, Alkylating; Cell Cycle Checkpoints; Cell Line, Tumor; Chlorambuc | 2012 |
In vivo therapeutic responses contingent on Fanconi anemia/BRCA2 status of the tumor.
Topics: Animals; Antineoplastic Agents; Apoptosis; BRCA2 Protein; Caspases; Cell Cycle; Cell Line, Tumor; Ce | 2005 |