chlorambucil has been researched along with Cancer of Colon in 16 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The formation of the glutathione S-conjugate of monochlorobimane (GSH-bimane) in human colon adenocarcinoma cells was identified by HPLC-fluorimetry and its transport from the cells was found to be temperature-sensitive, saturable and ATP-dependent." | 3.69 | Active transport of glutathione S-conjugate in human colon adenocarcinoma cells. ( Wong, KP; Zhang, K, 1996) |
| "The diagnosis of MALT lymphoma with adenoma on a background of Crohn's disease was made." | 2.61 | Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review. ( Achraf, M; Bennani, A; Imane, K; Kharrasse, G; Mohamed, B; Wafa, K; Zahi, I, 2019) |
| "Chlorambucil was incorporated into a nanoemulsion modified with poly(ethylene glycol) to improve its pharmacokinetics and tissue distribution, and thus enhance its therapeutic efficacy." | 1.36 | Pharmacokinetics and pharmacodynamics of chlorambucil delivered in long-circulating nanoemulsion. ( Baguley, BC; Ganta, S; Garg, S; Paxton, JW; Sharma, P, 2010) |
| "Head and neck carcinomas and breast cancer had the highest incidence (5 and 3 cases, respectively)." | 1.26 | Primary malignant neoplasms associated with chronic lymphocytic leukemia. ( Franchi, F; Monfardini, S; Rilke, F; Santoro, A, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacDiarmid, JE | 1 |
| Rose, WC | 1 |
| Biddle, WC | 1 |
| Perlman, ME | 1 |
| Breiner, RG | 1 |
| Ambrus, JL | 1 |
| Bardos, TJ | 1 |
| Bennani, A | 1 |
| Kharrasse, G | 1 |
| Achraf, M | 1 |
| Wafa, K | 1 |
| Zahi, I | 1 |
| Imane, K | 1 |
| Mohamed, B | 1 |
| Schauer, C | 1 |
| Cunliffe, R | 1 |
| Schobert, R | 1 |
| Biersack, B | 1 |
| Knauer, S | 1 |
| Ocker, M | 1 |
| Ganta, S | 1 |
| Sharma, P | 1 |
| Paxton, JW | 1 |
| Baguley, BC | 1 |
| Garg, S | 1 |
| Zhang, K | 3 |
| Wong, KP | 3 |
| Chow, P | 1 |
| Gaver, RC | 1 |
| Deeb, G | 1 |
| Pittman, KA | 1 |
| Issell, BF | 1 |
| Mittelman, A | 1 |
| Smyth, RD | 1 |
| Bernier, LG | 1 |
| Page, M | 1 |
| Gaudreault, RC | 1 |
| Joly, LP | 1 |
| Santoro, A | 1 |
| Rilke, F | 1 |
| Franchi, F | 1 |
| Monfardini, S | 1 |
| Dousset, B | 1 |
| Boudet, MJ | 1 |
| Soubrane, O | 1 |
| Calmus, Y | 1 |
| Bernard, O | 1 |
| Houssin, D | 1 |
| Musch, E | 1 |
| Malek, M | 1 |
| Peter-Katalinic, J | 1 |
| Egge, H | 1 |
| Rink, H | 1 |
| Lathan, B | 1 |
| Riedel, E | 1 |
| Tisdale, MJ | 1 |
| McElwain, TJ | 1 |
| Weill, JP | 1 |
| Monath, C | 1 |
| Farcot, JM | 1 |
| Weill-Bousson, M | 1 |
| Warter, MJ | 1 |
2 reviews available for chlorambucil and Cancer of Colon
| Article | Year |
|---|---|
Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review.
Topics: Adenoma; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Biopsy; Chlorambuc | 2019 |
Chemotherapy in colorectal cancer.
Topics: Carmustine; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Fluorourac | 1973 |
14 other studies available for chlorambucil and Cancer of Colon
| Article | Year |
|---|---|
Synthesis and properties of bis(2,2-dimethylaziridinyl)phosphinic amides: a series of new antineoplastic agents.
Topics: Animals; Aziridines; Azirines; Chemical Phenomena; Chemistry; Chlorambucil; Cholinesterase Inhibitor | 1985 |
Marginal Zone Lymphoma of the Entire Gastrointestinal Tract.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Colonic Neoplasms; Duodenal Neop | 2018 |
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity.
Topics: Agaricales; Cell Line, Tumor; Chlorambucil; Colonic Neoplasms; Cytotoxins; Dicarboxylic Acids; Docos | 2008 |
Pharmacokinetics and pharmacodynamics of chlorambucil delivered in long-circulating nanoemulsion.
Topics: Animals; Antineoplastic Agents, Alkylating; Area Under Curve; Chlorambucil; Colonic Neoplasms; Delay | 2010 |
Conjugation of chlorambucil with GSH by GST purified from human colon adenocarcinoma cells and its inhibition by plant polyphenols.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Chlorambucil; Chromatography, High Pressure Liqui | 2003 |
Disposition of orally administered 14C-prednimustine in cancer patients.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Carbon Radioisotopes; Chlorambucil; Colonic Neopl | 1983 |
A chlorambucil-anti-CEA conjugate cytotoxic for human colon adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Antibodies, Neoplasm; Carcinoembryonic Antigen; Cells, Cultured; Chlorambucil; Colon | 1984 |
Primary malignant neoplasms associated with chronic lymphocytic leukemia.
Topics: Breast Neoplasms; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Female; Head and Neck Neoplasms | 1980 |
Liver transplantation in patients with preexisting malignancy.
Topics: Adenocarcinoma; Adolescent; Adult; Carcinoma, Renal Cell; Child; Child, Preschool; Chlorambucil; Col | 1995 |
Active transport of glutathione S-conjugate in human colon adenocarcinoma cells.
Topics: 2,4-Dinitrophenol; Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Agents; Biological Transpo | 1996 |
Glutathione conjugation of chlorambucil: measurement and modulation by plant polyphenols.
Topics: Antineoplastic Agents, Alkylating; Cell Division; Cell Survival; Chlorambucil; Chromatography, High | 1997 |
Cellular kinetics of prednimustine versus chlorambucil plus prednisolone in vitro.
Topics: Animals; Carcinoma; Chlorambucil; Chromatography, High Pressure Liquid; Colonic Neoplasms; Mammary N | 1992 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbaz | 1987 |
[Diffuse rectocolonic lymphoid pseudo-polyposis].
Topics: Aged; Chlorambucil; Colonic Neoplasms; Female; Humans; Intestinal Polyps; Rectal Neoplasms; Syndrome | 1972 |