chlorambucil has been researched along with Cancer, Second Primary in 26 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1976 and 1984, 574 patients with operable breast cancer and histologically negative axillary lymph nodes were randomly assigned after mastectomy to receive either no further treatment or chemotherapy with oral LMF (fluorouracil, 500 mg, methotrexate, 25 mg, and chlorambucil, 10 mg, on day 1; fluorouracil, 500 mg, and chlorambucil, 10 mg, on day 2)." | 5.07 | West Midlands Oncology Association trial of adjuvant chemotherapy in node-negative breast cancer. ( Grieve, RJ; Howell, A; Kelly, KA; Monypenny, IJ; Morrison, JM; Walker, RA; Waterhouse, JA, 1992) |
| "Patients with chronic lymphocytic leukemia (CLL) may have disease transformation to non-Hodgkin's lymphoma or prolymphocytic leukemia; however, development of therapy-related acute myeloid leukemia (t-AML) is unusual." | 2.70 | Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011. ( Appelbaum, FR; Elias, L; Hines, JD; Kolitz, JE; Larson, RA; Morrison, VA; Peterson, BL; Rai, KR; Schiffer, CA; Shepherd, L, 2002) |
| "Localized MALT lymphomas have excellent prognosis following moderate-dose RT." | 1.31 | Stage I and II MALT lymphoma: results of treatment with radiotherapy. ( Bezjak, A; Crump, M; Gospodarowicz, MK; Hodgson, DC; Pintilie, M; Tsang, RW; Wells, W, 2001) |
| "The relative risk of second cancers overall was 27." | 1.30 | Second malignancy in patients with Hodgkin's disease treated at the Royal Marsden Hospital. ( Barber, JA; Cunningham, D; Horwich, A; Milan, S; Omar, RZ; Swerdlow, AJ, 1997) |
| "Hodgkin's disease is curable in the majority of patients, although a proportion of patients are resistant to or relapse after initial therapy." | 1.30 | High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML. ( Devereux, S; Goldstone, AH; Gregory, W; Hancock, B; Harrison, CN; Hoskin, P; Hudson, GV; Linch, DC; MacMillan, AK; Milligan, D; Newland, AC; Winfield, D, 1999) |
| "Thirteen patients have died of their second malignancy, including two of a third malignancy, while four have been followed for less than one year." | 1.29 | Second malignant neoplasms in patients with Hodgkin's disease. ( Atkinson, CH; Colls, BM; Fitzharris, BM; Robinson, BA, 1994) |
| "2846 patients first treated for Hodgkin's disease during 1970-87, for whom follow up was complete in 99." | 1.28 | Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2846 patients in the British National Lymphoma Investigation. ( Bennett, MH; Douglas, AJ; Hudson, BV; Hudson, GV; MacLennan, KA; Swerdlow, AJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (42.31) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 7 (26.92) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| da Cunha-Bang, C | 1 |
| Rostgaard, K | 1 |
| Andersen, MA | 1 |
| Rotbain, EC | 1 |
| Grønbaek, K | 1 |
| Frederiksen, H | 1 |
| Niemann, CU | 1 |
| Hjalgrim, H | 1 |
| Hangül, C | 1 |
| Yücel, OK | 1 |
| Akkaya, B | 1 |
| Ündar, L | 1 |
| Berker Karaüzüm, S | 1 |
| Streu, E | 1 |
| Barzenje, DA | 1 |
| Cvancarova Småstuen, M | 1 |
| Liestøl, K | 1 |
| Fosså, A | 1 |
| Delabie, J | 1 |
| Kolstad, A | 1 |
| Holte, H | 1 |
| Vidal, L | 1 |
| Gurion, R | 1 |
| Ram, R | 1 |
| Raanani, P | 1 |
| Bairey, O | 1 |
| Robak, T | 1 |
| Gafter-Gvili, A | 1 |
| Shpilberg, O | 1 |
| Maurer, C | 1 |
| Langerbeins, P | 1 |
| Bahlo, J | 1 |
| Cramer, P | 1 |
| Fink, AM | 1 |
| Pflug, N | 1 |
| Engelke, A | 1 |
| von Tresckow, J | 1 |
| Kovacs, G | 1 |
| Stilgenbauer, S | 1 |
| Wendtner, CM | 1 |
| Müller, L | 1 |
| Ritgen, M | 1 |
| Seiler, T | 1 |
| Fischer, K | 1 |
| Hallek, M | 1 |
| Eichhorst, B | 1 |
| Mirabile, A | 1 |
| Devizzi, L | 1 |
| Gianni, AM | 1 |
| Cabras, A | 1 |
| Carbone, A | 1 |
| Breton, AL | 1 |
| Poulalhon, N | 1 |
| Balme, B | 1 |
| Thomas, L | 1 |
| Dalle, S | 1 |
| Morrison, VA | 1 |
| Rai, KR | 1 |
| Peterson, BL | 1 |
| Kolitz, JE | 1 |
| Elias, L | 1 |
| Appelbaum, FR | 1 |
| Hines, JD | 1 |
| Shepherd, L | 1 |
| Larson, RA | 1 |
| Schiffer, CA | 1 |
| Metayer, C | 1 |
| Curtis, RE | 1 |
| Vose, J | 1 |
| Sobocinski, KA | 1 |
| Horowitz, MM | 1 |
| Bhatia, S | 1 |
| Fay, JW | 1 |
| Freytes, CO | 1 |
| Goldstein, SC | 1 |
| Herzig, RH | 1 |
| Keating, A | 1 |
| Miller, CB | 1 |
| Nevill, TJ | 1 |
| Pecora, AL | 1 |
| Rizzo, JD | 1 |
| Williams, SF | 1 |
| Li, CY | 1 |
| Travis, LB | 1 |
| Weisdorf, DJ | 1 |
| Martinelli, G | 1 |
| Cocorocchio, E | 1 |
| Peccatori, F | 1 |
| Zucca, E | 1 |
| Saletti, PC | 1 |
| Calabrese, L | 1 |
| Pastano, R | 1 |
| Pruneri, G | 1 |
| Mazzetta, C | 1 |
| Ghielmini, M | 1 |
| Cavalli, F | 1 |
| Callea, V | 1 |
| Brugiatelli, M | 1 |
| Stelitano, C | 1 |
| Gentile, M | 1 |
| Nobile, F | 1 |
| Morabito, F | 1 |
| Capra, M | 1 |
| Hewitt, M | 1 |
| Radford, M | 1 |
| Hayward, J | 1 |
| Weston, CL | 1 |
| Machin, D | 1 |
| Kelsey, SM | 1 |
| Newland, AC | 2 |
| Hudson, GV | 3 |
| Jelliffe, AM | 1 |
| Robinson, BA | 1 |
| Colls, BM | 1 |
| Fitzharris, BM | 1 |
| Atkinson, CH | 1 |
| Swerdlow, AJ | 2 |
| Barber, JA | 1 |
| Horwich, A | 1 |
| Cunningham, D | 1 |
| Milan, S | 1 |
| Omar, RZ | 1 |
| Morita, K | 1 |
| Mizuno, T | 1 |
| Tanaka, I | 2 |
| Suzuki, H | 1 |
| Miwa, H | 1 |
| Nishikawa, M | 1 |
| Kita, K | 1 |
| Shiku, H | 1 |
| Harrison, CN | 1 |
| Gregory, W | 1 |
| Devereux, S | 1 |
| Goldstone, AH | 1 |
| Hancock, B | 1 |
| Winfield, D | 1 |
| MacMillan, AK | 1 |
| Hoskin, P | 1 |
| Milligan, D | 1 |
| Linch, DC | 1 |
| Calvo Villas, J | 1 |
| Ramírez Sánchez, M | 1 |
| Sicilia Guillén, F | 1 |
| Tsang, RW | 1 |
| Gospodarowicz, MK | 1 |
| Pintilie, M | 1 |
| Bezjak, A | 1 |
| Wells, W | 1 |
| Hodgson, DC | 1 |
| Crump, M | 1 |
| Radford, JA | 1 |
| Rohatiner, AZ | 1 |
| Ryder, WD | 1 |
| Deakin, DP | 1 |
| Barbui, T | 1 |
| Lucie, NP | 1 |
| Rossi, A | 1 |
| Dunlop, DJ | 1 |
| Cowan, RA | 1 |
| Wilkinson, PM | 1 |
| Gupta, RK | 1 |
| James, RD | 1 |
| Shamash, J | 1 |
| Chang, J | 1 |
| Crowther, D | 1 |
| Lister, TA | 1 |
| Majado, MJ | 1 |
| González García, C | 1 |
| Marín-Blazquez, MD | 1 |
| Morales Lázaro, A | 1 |
| Moreno Moreno, M | 1 |
| Avilés, A | 1 |
| Díaz-Maqueo, JC | 1 |
| Ayala, JR | 1 |
| Cortés, HD | 1 |
| García, EL | 1 |
| Douglas, AJ | 1 |
| Hudson, BV | 1 |
| Bennett, MH | 1 |
| MacLennan, KA | 1 |
| Dedrick, RL | 1 |
| Morrison, PF | 1 |
| Morrison, JM | 1 |
| Kelly, KA | 1 |
| Howell, A | 1 |
| Grieve, RJ | 1 |
| Monypenny, IJ | 1 |
| Walker, RA | 1 |
| Waterhouse, JA | 1 |
2 reviews available for chlorambucil and Cancer, Second Primary
| Article | Year |
|---|---|
Chlorambucil for the treatment of patients with chronic lymphocytic leukemia (CLL) - a systematic review and meta-analysis of randomized trials.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dis | 2016 |
Primary cutaneous marginal zone lymphoma as a complication of radiation therapy: Case report and review.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Hormonal; Antineoplastic Combin | 2010 |
5 trials available for chlorambucil and Cancer, Second Primary
| Article | Year |
|---|---|
Effect of first-line treatment on second primary malignancies and Richter's transformation in patients with CLL.
Topics: Adult; Aged; Aged, 80 and over; Bendamustine Hydrochloride; Case-Control Studies; Cell Transformatio | 2016 |
Therapy-related myeloid leukemias are observed in patients with chronic lymphocytic leukemia after treatment with fludarabine and chlorambucil: results of an intergroup study, cancer and leukemia group B 9011.
Topics: Acute Disease; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambuci | 2002 |
A British National Lymphoma Investigation randomised trial of single agent chlorambucil plus radiotherapy versus radiotherapy alone in low grade, localised non-Hodgkins lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Chlorambucil; Female; Follow-Up Studies; Humans; Lymphoma, Non-Hodgk | 1994 |
ChlVPP/EVA hybrid versus the weekly VAPEC-B regimen for previously untreated Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cy | 2002 |
West Midlands Oncology Association trial of adjuvant chemotherapy in node-negative breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chlorambuc | 1992 |
19 other studies available for chlorambucil and Cancer, Second Primary
| Article | Year |
|---|---|
Risk of new malignancies among patients with CLL treated with chemotherapy: results of a Danish population-based study.
Topics: Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Chloramb | 2021 |
The Coexistence of Chronic Lymphocytic Leukemia and Multiple Myeloma
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dexamethasone; Humans; Leukemia, | 2019 |
Second malignancies in chronic lymphocytic leukemia.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carcin | 2014 |
Radiotherapy Compared to Other Strategies in the Treatment of Stage I/II Follicular Lymphoma: A Study of 404 Patients with a Median Follow-Up of 15 Years.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cardiova | 2015 |
MALT lymphoma and Kaposi sarcoma in an HIV-negative patient.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, | 2010 |
Myelodysplastic syndrome and acute myeloid leukemia after autotransplantation for lymphoma: a multicenter case-control study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemoth | 2003 |
ChlVPP/ABVVP, a first line 'hybrid' combination chemotherapy for advanced Hodgkin's lymphoma: a retrospective analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Di | 2004 |
Incidence of second neoplasia in patients with B-cell chronic lymphocytic leukemia treated with chlorambucil maintenance chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Female; Humans; Incidence; Leuk | 2006 |
Long-term outcome in children with Hodgkin's lymphoma: the United Kingdom Children's Cancer Study Group HD82 trial.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Chlorambucil; D | 2007 |
Second malignant neoplasms in patients with Hodgkin's disease.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Moda | 1994 |
Second malignancy in patients with Hodgkin's disease treated at the Royal Marsden Hospital.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protoc | 1997 |
[Acute myelogenous leukemia (M4) occurring during chronic lymphocytic leukemia].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Estradiol; Etoposide; Humans; Le | 1997 |
High-dose BEAM chemotherapy with autologous haemopoietic stem cell transplantation for Hodgkin's disease is unlikely to be associated with a major increased risk of secondary MDS/AML.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; | 1999 |
[Chronic lymphatic leukemia and Hodgkin's disease].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Dacarbazine; Doxorubicin; F | 1999 |
Stage I and II MALT lymphoma: results of treatment with radiotherapy.
Topics: Adult; Aged; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Co | 2001 |
[Appearance of a chronic myeloid leukemia in Waldenström's macroglobulinemia].
Topics: Busulfan; Chlorambucil; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; | 1992 |
Hodgkin's disease and acute leukemia. Is it a true association?
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil | 1992 |
Risk of second primary cancers after Hodgkin's disease by type of treatment: analysis of 2846 patients in the British National Lymphoma Investigation.
Topics: Adolescent; Adult; Alkylating Agents; Child; Chlorambucil; Cohort Studies; Female; Follow-Up Studies | 1992 |
Carcinogenic potency of alkylating agents in rodents and humans.
Topics: Animals; Carcinogenicity Tests; Chlorambucil; Cyclophosphamide; Humans; Melphalan; Mice; Neoplasms, | 1992 |