chlorambucil has been researched along with Breast Neoplasms in 121 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This review summarizes the available data of phase II and phase III single-agent trials with predminustine and one phase II trial of prednimustine in combination with methotrexate, 5-fluorouracil, and tamoxifen in the treatment of advanced breast cancer." | 10.15 | Prednimustine in advanced breast cancer: a review. ( Mouridsen, HT, 1986) |
| "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity." | 9.08 | Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82. ( Castiglione, M; Cavalli, F; Jungi, WF; Leyvraz, S; Maibach, R; Obrecht, JP; Schildknecht, O; Senn, HJ; Siegenthaler, P, 1997) |
| "Between 1974 and 1977, a total of 254 patients with stages T1-3a, N0-1, and M0 operable breast cancer (node negative and node positive, stratified) were randomized to either modified radical mastectomy alone or the same surgery and adjuvant chlorambucil, methotrexate, 5-fluorouracil (LMF) plus BCG." | 9.06 | Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results. ( Amgwerd, R; Ammann, J; Creux, G; Enderlin, F; Engelhart, G; Heinz, C; Hochuli, E; Jungi, WF; Senn, HJ; Wick, A, 1986) |
| "A clinical protocol outline of a study randomizing prednimustine v doxorubicin in patients with metastatic breast cancer is presented." | 9.06 | A randomized comparative study of prednimustine and doxorubicin in patients with metastatic breast cancer. ( Allegra, JC, 1986) |
| "Thirty-four women with first recurrence of breast cancer were randomized into two groups, and received either Diethylstilbestrol (DES) 5 mg orally (PO) t." | 9.04 | Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer. ( Harvey, HA; Holzer, D; Lipton, A, 1979) |
| " The objectives of this study were to (a) synthesize LAT1-targeted chlorambucil derivatives and (b) evaluate their LAT1-mediated cellular uptake as well as antiproliferative activity in vitro in the human breast cancer MCF-7 cell line." | 7.96 | Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7. ( Järvinen, J; Kärkkäinen, J; Leppänen, J; Pocasap, P; Rautio, J; Timonen, J; Weerapreeyakul, N, 2020) |
| "Amino acids were transformed and coupled to chlorambucil, a well-known chemotherapeutic agent, in an attempt to create new anticancer drugs with selectivity for breast cancer cells." | 7.78 | SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Leblanc, V; Parent, S, 2012) |
| "Evaluation of the cytotoxicity of a novel G3 PAMAM-NH(2) dendrimer-chlorambucil conjugate employing a MTT assay and inhibition of [(3)H]thymidine incorporation into DNA in both MDA-MB-231 and MCF-7 breast cancer cells demonstrated that the conjugate was more potent antiproliferative agent than chlorambucil." | 7.77 | Cytotoxic activity of G3 PAMAM-NH₂ dendrimer-chlorambucil conjugate in human breast cancer cells. ( Bielawska, A; Bielawski, K; Czarnomysy, R; Muszyńska, A; Popławska, B, 2011) |
| "A series of D- and L-tyrosine-chlorambucil analogs was synthesized as anticancer drugs for chemotherapy of breast cancer." | 7.76 | Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Gupta, A; Leblanc, V, 2010) |
| "Thirty-three patients with metastatic breast cancer received 135 cycles of chemotherapy consisting of mitoxantrone, methotrexate and chlorambucil." | 7.68 | Mitoxantrone, methotrexate and chlorambucil in metastatic breast cancer, a combination with relatively low subjective toxicity. ( Burghouts, JT, 1990) |
| "We investigated the effects of a benzoate of an estradiol-chlorambucil conjugate (KM2210) and chlorambucil on growth, estrogen receptor, and secretion of transforming growth factor (TGF)-alpha in the hormone-dependent human breast cancer cell line MCF-7." | 7.68 | Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion. ( Abe, O; Inagaki, H; Kosano, H; Kubota, T; Nagata, N; Ohsawa, N; Yamamori, S, 1992) |
| "Thirty patients with advanced and mainly pretreated breast cancer were treated with a combination of premarin, prednimustine, high-dose folinic acid and 5-fluorouracil." | 7.67 | Premarin priming before prednimustine, high-dose folinic acid and 5-fluorouracil as salvage chemotherapy for advanced breast cancer. ( Arcangeli, G; Ferrari, V; Marini, G; Marpicati, P; Montini, E; Simoncini, E; Zaniboni, A, 1988) |
| "In this case report the clinical course of a female patient with metastatic breast cancer receiving a mild cytostatic regimen with chlorambucil, methotrexate and prednisone is described." | 7.67 | [Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone]. ( Voigtmann, R, 1989) |
| "Forty-seven patients with advanced breast cancer were treated with a combination of prednimustine (P), methotrexate (M), 5-fluorouracil (F), and tamoxifen (TAM)." | 7.66 | Prednimustine in combination with methotrexate and 5-fluorouracil in advanced breast cancer: a phase I-II study. ( Boesen, E; Mouridsen, HT, 1983) |
| "Thirteen consecutive stage II breast cancer patients were treated with long-term adjuvant chemotherapy using chlorambucil." | 7.66 | Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer. ( Lerner, HJ, 1978) |
| "The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy." | 7.66 | Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer. ( Dombernowsky, P; Kristensen, D; Mouridsen, HT; Nielsen, JH, 1980) |
| "Prednimustine is an ester of chlorambucil and prednisolone." | 6.65 | A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer. ( Christiansen, IE; Dombernowsky, P; Løber, J; Mattsson, W; Mouridsen, HT; Rørth, M, 1983) |
| "This review summarizes the available data of phase II and phase III single-agent trials with predminustine and one phase II trial of prednimustine in combination with methotrexate, 5-fluorouracil, and tamoxifen in the treatment of advanced breast cancer." | 6.15 | Prednimustine in advanced breast cancer: a review. ( Mouridsen, HT, 1986) |
| "Chlorambucil is an anticancer drug that is still commonly used as a primary treatment in treating some cancers, but it can cause side effects." | 5.62 | Chlorambucil-Chitosan Nano-Conjugate: An Efficient Agent Against Breast Cancer Targeted Therapy. ( Ali, V; Ardestani, MS; Ebrahimi, SES; Farzaneh, J; Hadadian, S; Hamedani, MP; Hejazinia, H; Khalatbari, F; Monavvari, F; Seyedhamzeh, M; Shayegh, A; Zarazvand, F; Zonoubi, N, 2021) |
| " Chlorambucil, an anticancer drug that is used to treat prostate and breast cancer, suffers from poor aqueous solubility and specificity, a short half-life, and severe side effects, including anaemia and bone marrow suppression." | 5.41 | Chlorambucil-Bearing Hybrid Molecules in the Development of Potential Anticancer Agents. ( Aderibigbe, BA; Peter, S, 2023) |
| "It was discovered that for breast cancer cells, the new compounds were up to 4." | 5.38 | Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Leblanc, V; Parent, S, 2012) |
| "To compare two adjuvant combination chemotherapies, cyclophosphamide, methotrexate, and fluorouracil (CMF) and chlorambucil, methotrexate, and fluorouracil (LMF), for patients who had undergone potentially curative surgery for unilateral breast cancer, in terms of relapse, survival, and toxicity." | 5.08 | Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82. ( Castiglione, M; Cavalli, F; Jungi, WF; Leyvraz, S; Maibach, R; Obrecht, JP; Schildknecht, O; Senn, HJ; Siegenthaler, P, 1997) |
| "Between 1976 and 1984, 574 patients with operable breast cancer and histologically negative axillary lymph nodes were randomly assigned after mastectomy to receive either no further treatment or chemotherapy with oral LMF (fluorouracil, 500 mg, methotrexate, 25 mg, and chlorambucil, 10 mg, on day 1; fluorouracil, 500 mg, and chlorambucil, 10 mg, on day 2)." | 5.07 | West Midlands Oncology Association trial of adjuvant chemotherapy in node-negative breast cancer. ( Grieve, RJ; Howell, A; Kelly, KA; Monypenny, IJ; Morrison, JM; Walker, RA; Waterhouse, JA, 1992) |
| "Between 1974 and 1977, a total of 254 patients with stages T1-3a, N0-1, and M0 operable breast cancer (node negative and node positive, stratified) were randomized to either modified radical mastectomy alone or the same surgery and adjuvant chlorambucil, methotrexate, 5-fluorouracil (LMF) plus BCG." | 5.06 | Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results. ( Amgwerd, R; Ammann, J; Creux, G; Enderlin, F; Engelhart, G; Heinz, C; Hochuli, E; Jungi, WF; Senn, HJ; Wick, A, 1986) |
| "The aim of this study was to evaluate the significance of response to the first two cycles of FEC (5-fluorouracil, 4-epirubicin, cyclophosphamide) in patients with advanced breast cancer." | 5.06 | High-intensity therapy versus low-intensity therapy in advanced breast cancer patients. ( Buchelt, L; Heissmeyer, HH; Hiemeyer, V; Krause, HH; Kreuser, ED; Mende, S; Meuret, G; Porzsolt, F; Redenbacher, M; Strigl, P, 1990) |
| "A clinical protocol outline of a study randomizing prednimustine v doxorubicin in patients with metastatic breast cancer is presented." | 5.06 | A randomized comparative study of prednimustine and doxorubicin in patients with metastatic breast cancer. ( Allegra, JC, 1986) |
| "We report the results of a randomized trial carried out by the Swiss Group for Clinical Cancer Research (SAKK) and in which 230 patients with advanced breast cancer receiving concurrently a hormonal treatment (oophorectomy for pre- and tamoxifen for postmenopausal women) were randomly allocated to three different regimens of combination chemotherapy." | 5.05 | Randomized trial of 3 different regimens of combination chemotherapy in patients receiving simultaneously a hormonal treatment for advanced breast cancer. ( Alberto, P; Brunner, KW; Cavalli, F; Goldhirsch, A; Jungi, WF; Martz, G; Mermillod, B; Pedrazzini, A, 1983) |
| "Thirty-four women with first recurrence of breast cancer were randomized into two groups, and received either Diethylstilbestrol (DES) 5 mg orally (PO) t." | 5.04 | Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer. ( Harvey, HA; Holzer, D; Lipton, A, 1979) |
| " The proof-of-concept analysis was carried out for conjugates of chlorambucil (CLB) in GLUT5-positive breast cancer cells and normal breast cells." | 4.02 | Targeting of GLUT5 for Transporter-Mediated Drug-Delivery Is Contingent upon Substrate Hydrophilicity. ( Ghosh, A; Nahrjou, N; Tanasova, M, 2021) |
| " The objectives of this study were to (a) synthesize LAT1-targeted chlorambucil derivatives and (b) evaluate their LAT1-mediated cellular uptake as well as antiproliferative activity in vitro in the human breast cancer MCF-7 cell line." | 3.96 | Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7. ( Järvinen, J; Kärkkäinen, J; Leppänen, J; Pocasap, P; Rautio, J; Timonen, J; Weerapreeyakul, N, 2020) |
| " The present study investigated the synthesis and efficacy of carbazole-coumarin (CC)-fused heterocycles as a PTDDS platform for the photocontrolled release of a chemotherapeutic agent, chlorambucil, in an in vitro model of human breast and leukemia cancer cells." | 3.96 | Targeted photoresponsive carbazole-coumarin and drug conjugates for efficient combination therapy in leukemia cancer cells. ( Chang, WW; Chu, CC; Lai, YT; Lin, YC; Ou, JY; Wang, BY, 2020) |
| "Amino acids were transformed and coupled to chlorambucil, a well-known chemotherapeutic agent, in an attempt to create new anticancer drugs with selectivity for breast cancer cells." | 3.78 | SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Leblanc, V; Parent, S, 2012) |
| "Evaluation of the cytotoxicity of a novel G3 PAMAM-NH(2) dendrimer-chlorambucil conjugate employing a MTT assay and inhibition of [(3)H]thymidine incorporation into DNA in both MDA-MB-231 and MCF-7 breast cancer cells demonstrated that the conjugate was more potent antiproliferative agent than chlorambucil." | 3.77 | Cytotoxic activity of G3 PAMAM-NH₂ dendrimer-chlorambucil conjugate in human breast cancer cells. ( Bielawska, A; Bielawski, K; Czarnomysy, R; Muszyńska, A; Popławska, B, 2011) |
| "A series of D- and L-tyrosine-chlorambucil analogs was synthesized as anticancer drugs for chemotherapy of breast cancer." | 3.76 | Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Gupta, A; Leblanc, V, 2010) |
| "A number of novel cyclic amidine analogs of chlorambucil were synthesized and examined for cytotoxicity in breast cancer cell cultures and for inhibition of topoisomerases I and II." | 3.72 | Synthesis and biological evaluation of new cyclic amidine analogs of chlorambucil. ( Bielawska, A; Bielawski, K; Muszyńska, A, 2004) |
| "We investigated the effects of a benzoate of an estradiol-chlorambucil conjugate (KM2210) and chlorambucil on growth, estrogen receptor, and secretion of transforming growth factor (TGF)-alpha in the hormone-dependent human breast cancer cell line MCF-7." | 3.68 | Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion. ( Abe, O; Inagaki, H; Kosano, H; Kubota, T; Nagata, N; Ohsawa, N; Yamamori, S, 1992) |
| " Nineteen regularly menstruating patients with primary breast cancer were given either cyclophosphamide or chlorambucil in combination with methotrexate and fluorouracil as adjuvant therapy." | 3.68 | Effects of cytotoxic chemotherapy on ovarian and adrenal steroidogenesis in pre-menopausal breast cancer patients. ( Dowsett, M; Richner, J, 1991) |
| "Thirty-three patients with metastatic breast cancer received 135 cycles of chemotherapy consisting of mitoxantrone, methotrexate and chlorambucil." | 3.68 | Mitoxantrone, methotrexate and chlorambucil in metastatic breast cancer, a combination with relatively low subjective toxicity. ( Burghouts, JT, 1990) |
| "Bestrabucil, the benzoate of an estradiol-chlorambucil conjugate, was initially developed as a target-oriented anticancer agent for breast cancers with positive estrogen receptors, by conjugating a tumoricidal agent, chlorambucil, to a vehicle, estradiol." | 3.67 | [Bestrabacil: a possible target-oriented anticancer agent]. ( Isurugi, K; Ohsawa, N; Wagatsuma, T; Yamazaki, Z, 1984) |
| "In this case report the clinical course of a female patient with metastatic breast cancer receiving a mild cytostatic regimen with chlorambucil, methotrexate and prednisone is described." | 3.67 | [Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone]. ( Voigtmann, R, 1989) |
| "Thirty patients with advanced and mainly pretreated breast cancer were treated with a combination of premarin, prednimustine, high-dose folinic acid and 5-fluorouracil." | 3.67 | Premarin priming before prednimustine, high-dose folinic acid and 5-fluorouracil as salvage chemotherapy for advanced breast cancer. ( Arcangeli, G; Ferrari, V; Marini, G; Marpicati, P; Montini, E; Simoncini, E; Zaniboni, A, 1988) |
| "We administered Bestrabucil, a benzoate ester of a complex of beta-estradiol and chlorambucil, continuously to six patients with breast cancer recurrent to local and regional lymph nodes, at a dose level of 200 mg/day." | 3.67 | [Therapeutic results in recurrent breast cancer with the use of Bestrabucil (KM2210)]. ( Morimoto, K; Nakatani, S; Sakai, K; Ueda, T, 1987) |
| "The therapeutic effect of prednimustine was studied in 35 patients with advanced breast cancer resistant to previous cytotoxic and/or endocrine therapy." | 3.66 | Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer. ( Dombernowsky, P; Kristensen, D; Mouridsen, HT; Nielsen, JH, 1980) |
| "A group of 47 patients with advanced breast cancer were treated with a combination of prednimustine, methotrexate, 5-FU, and tamoxifen." | 3.66 | Prednimustine in combination with methotrexate and 5-FU (PMF): a pilot study. ( Boesen, E; Mouridsen, HT, 1982) |
| "Thirteen consecutive stage II breast cancer patients were treated with long-term adjuvant chemotherapy using chlorambucil." | 3.66 | Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer. ( Lerner, HJ, 1978) |
| "Forty-seven patients with advanced breast cancer were treated with a combination of prednimustine (P), methotrexate (M), 5-fluorouracil (F), and tamoxifen (TAM)." | 3.66 | Prednimustine in combination with methotrexate and 5-fluorouracil in advanced breast cancer: a phase I-II study. ( Boesen, E; Mouridsen, HT, 1983) |
| "A group of 17 patients, having undergone modified radical mastectomy for breast cancer, received 12 cycles of chemotherapy with methotrexate, 5-fluorouracil, and chlorambucil during 17 months." | 3.66 | Immunologic monitoring in breast cancer patients receiving postoperative adjuvant chemotherapy. ( Baral, E; Blomgren, H; Forsgren, M; Norberg, R; Petrini, B; Strender, LE; Wallgren, A; Wasserman, J, 1981) |
| "Women with node-negative breast cancer have a 30% chance of relapse 5 years after mastectomy." | 2.67 | Swiss adjuvant trials in women with node-negative breast cancer. OSAKO. ( Jungi, WF; Senn, HJ, 1992) |
| " The mean bioavailability was 14% for chlorambucil, 21% for phenylacetic acid mustard, and 22% for prednisolone, when given as prednimustine, compared to the administration of free compounds in stoichiometrically equivalent doses." | 2.67 | Comparative pharmacokinetics of chlorambucil and prednimustine after oral administration. ( Loos, U; Malek, M; Musch, E; Riedel, E, 1991) |
| "Since in the treatment of advanced breast cancer chemotherapy and the various hormonal manipulations seem recently to have reached a plateau of effectiveness when used alone, it is widely assumed that the combination of both treatment modalities could improve therapeutic results." | 2.65 | [Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer]. ( Alberto, P; Beer, M; Brunner, KW; Cavalli, F; Jungi, WF; Martz, G; Mermillod, B; Obrecht, JP, 1982) |
| "Prednimustine is an ester of chlorambucil and prednisolone." | 2.65 | A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer. ( Christiansen, IE; Dombernowsky, P; Løber, J; Mattsson, W; Mouridsen, HT; Rørth, M, 1983) |
| " Cyclic treatment with a combination of chlorambucil, methotrexate and 5-fluorouracil was more myelotoxic and required more extensive dose reductions than treatment with cyclophosphamide, methotrexate and 5-fluorouracil with the dosage used." | 2.65 | Influence of adjuvant chemotherapy on the blood lymphocyte population in operable breast carcinoma. Comparison between two types of treatments. ( Baral, E; Blomgren, H; Petrini, B; Strender, LE; Wallgren, A; Wasserman, J, 1982) |
| "Chlorambucil is an anticancer drug that is still commonly used as a primary treatment in treating some cancers, but it can cause side effects." | 1.62 | Chlorambucil-Chitosan Nano-Conjugate: An Efficient Agent Against Breast Cancer Targeted Therapy. ( Ali, V; Ardestani, MS; Ebrahimi, SES; Farzaneh, J; Hadadian, S; Hamedani, MP; Hejazinia, H; Khalatbari, F; Monavvari, F; Seyedhamzeh, M; Shayegh, A; Zarazvand, F; Zonoubi, N, 2021) |
| "The design of a new personalized anti-breast cancer drug has been explained in the third phase." | 1.46 | Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach. ( Iyer, PM; Karthikeyan, S; Krishnan Namboori, PK; Sanjay Kumar, P, 2017) |
| " To demonstrate this unique approach, an amphiphilic drug-drug conjugate (ADDC) has been synthesized from the hydrophilic anticancer drug irinotecan (Ir) and the hydrophobic anticancer drug chlorambucil (Cb) via a hydrolyzable ester linkage." | 1.40 | Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy. ( Cui, D; Huang, P; Huang, W; Su, Y; Wang, D; Yan, D; Zhou, Y; Zhu, X, 2014) |
| "It was discovered that for breast cancer cells, the new compounds were up to 4." | 1.38 | Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. ( Asselin, E; Bérubé, G; Brasseur, K; Descôteaux, C; Leblanc, V; Parent, S, 2012) |
| "Three human breast carcinoma xenografts, MCF-7, R-27 and T-61 serially transplanted into nude mice were treated with mitomycin C (MMC) alone, KM2210 (estra-1, 3, 5(10)-triene-3, 17 beta-diol, 3 benzoate 17-[4-(4-bis(2-chloroethyl)amino)phenyl)-1-oxobutoxy)acetate) alone and KM2210 followed by MMC." | 1.28 | [Enhancement of antitumor activity of mitomycin C against human breast carcinoma xenografts by pretreatment with KM 2210]. ( Arisawa, Y; Fujita, S; Inoue, S; Ishibiki, K; Josui, K; Kubota, T; Kuzuoka, M; Oka, S; Suto, A; Yamamoto, T, 1990) |
| "Two cases of recurrent breast carcinoma were treated with KM2210 in an early phase II study conducted at our institute and complete response (CR) was obtained." | 1.27 | [Two cases of recurrent breast carcinoma achieving CR (complete response) with KM2210]. ( Kawamura, E; Kubota, T; Kurokawa, T; Miyagawa, T; Toyoda, H; Yamada, Y, 1987) |
| " It is suggested that prednisolone plasma levels are as good a parameter of Prednimustine absorption and bioavailability as chlorambucil levels, Prednimustine itself having never been detected in plasma." | 1.26 | Prednisolone plasma levels after oral administration of Prednimustine. Comparison with levels obtained after administration of an equimolar dose of prednisolone. ( Hove, WV; Sayed, A; Vermeulen, A, 1981) |
| "In 16 of these (19." | 1.26 | Primary malignant neoplasms associated with chronic lymphocytic leukemia. ( Franchi, F; Monfardini, S; Rilke, F; Santoro, A, 1980) |
| "Generally, metastases responded better than the advanced primaries from which they were derived, except for those from breast tumours." | 1.25 | The influence of site of metastasis on tumour growth and response to chemotherapy. ( Bross, ID; Slack, NH, 1975) |
| " Dosage adjustments were often necessary during the initial phases of therapy." | 1.25 | A controlled study in the use of combined drug therapy for metastatic breast cancer. ( Alberto, P; Brunner, KW; Martz, G; Obrecht, P; Senn, HJ; Sonntag, RW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 86 (71.07) | 18.7374 |
| 1990's | 13 (10.74) | 18.2507 |
| 2000's | 4 (3.31) | 29.6817 |
| 2010's | 12 (9.92) | 24.3611 |
| 2020's | 6 (4.96) | 2.80 |
| Authors | Studies |
|---|---|
| Descôteaux, C | 3 |
| Leblanc, V | 3 |
| Brasseur, K | 3 |
| Gupta, A | 1 |
| Asselin, E | 3 |
| Bérubé, G | 3 |
| Millard, M | 1 |
| Gallagher, JD | 1 |
| Olenyuk, BZ | 1 |
| Neamati, N | 1 |
| Ronayne, CT | 1 |
| Solano, LN | 1 |
| Nelson, GL | 1 |
| Lueth, EA | 1 |
| Hubbard, SL | 1 |
| Schumacher, TJ | 1 |
| Gardner, ZS | 1 |
| Jonnalagadda, SK | 1 |
| Gurrapu, S | 1 |
| Holy, J | 1 |
| Mereddy, VR | 1 |
| Sun, F | 1 |
| Wang, Y | 1 |
| Wang, Q | 2 |
| Wang, X | 1 |
| Yao, P | 1 |
| Feng, W | 1 |
| Yuan, Q | 1 |
| Qi, X | 1 |
| Chen, S | 1 |
| Pu, W | 1 |
| Huang, R | 1 |
| Dai, Q | 1 |
| Lv, J | 1 |
| Shen, W | 1 |
| Xia, P | 1 |
| Zhang, D | 1 |
| Peter, S | 1 |
| Aderibigbe, BA | 1 |
| Pocasap, P | 1 |
| Weerapreeyakul, N | 1 |
| Timonen, J | 1 |
| Järvinen, J | 1 |
| Leppänen, J | 1 |
| Kärkkäinen, J | 1 |
| Rautio, J | 1 |
| Du, C | 1 |
| Ding, Y | 1 |
| Qian, J | 1 |
| Zhang, R | 1 |
| Dong, CM | 1 |
| Wang, BY | 1 |
| Lin, YC | 1 |
| Lai, YT | 1 |
| Ou, JY | 1 |
| Chang, WW | 1 |
| Chu, CC | 1 |
| Shayegh, A | 1 |
| Khalatbari, F | 1 |
| Zonoubi, N | 1 |
| Zarazvand, F | 1 |
| Monavvari, F | 1 |
| Hejazinia, H | 1 |
| Ebrahimi, SES | 1 |
| Hamedani, MP | 1 |
| Ali, V | 1 |
| Hadadian, S | 1 |
| Farzaneh, J | 1 |
| Seyedhamzeh, M | 1 |
| Ardestani, MS | 1 |
| Nahrjou, N | 1 |
| Ghosh, A | 1 |
| Tanasova, M | 1 |
| Iyer, PM | 1 |
| Karthikeyan, S | 1 |
| Sanjay Kumar, P | 1 |
| Krishnan Namboori, PK | 1 |
| Luo, CQ | 1 |
| Zhou, YX | 1 |
| Zhou, TJ | 1 |
| Xing, L | 1 |
| Cui, PF | 1 |
| Sun, M | 1 |
| Jin, L | 1 |
| Lu, N | 1 |
| Jiang, HL | 1 |
| Karthik, S | 1 |
| Puvvada, N | 1 |
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9 reviews available for chlorambucil and Breast Neoplasms
| Article | Year |
|---|---|
Chlorambucil-Bearing Hybrid Molecules in the Development of Potential Anticancer Agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Humans; Male; Pharmacophore; Structure-Activi | 2023 |
Primary cutaneous marginal zone lymphoma as a complication of radiation therapy: Case report and review.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Hormonal; Antineoplastic Combin | 2010 |
[Adjuvant chemotherapy in breast cancer].
Topics: Antineoplastic Agents; Axilla; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Doxorubicin; Drug T | 1981 |
[Adjuvant (preventive) postoperative chemotherapy in breast carcinoma].
Topics: Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Melphalan; Menopause | 1978 |
Adjuvant chemotherapy for node-negative breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Combined Modality Th | 1989 |
Prednimustine in advanced breast cancer: a review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trials as T | 1986 |
Single and combination nonhormonal chemotherapy in breast cancer.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic Agents; Bre | 1972 |
Calcified metastases from malignant ovarian neoplasm. Review of the literature.
Topics: Abdominal Neoplasms; Adult; Aged; Axilla; Biopsy; Breast Neoplasms; Calcinosis; Chlorambucil; Cystad | 1974 |
[Combination chemotherapy in the treatment of cancer].
Topics: Administration, Oral; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Dacti | 1972 |
31 trials available for chlorambucil and Breast Neoplasms
| Article | Year |
|---|---|
Adjuvant radiation therapy compared with cyclic chemotherapy in patients with mammary carcinoma. I. Changes of blood lymphocyte subpopulations.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Cobalt Radioisotopes; Female; Fluorouracil; Humans; Leu | 1981 |
Influence of adjuvant chemotherapy on the blood lymphocyte population in operable breast carcinoma. Comparison between two types of treatments.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Cyclophosphamide; Drug Therap | 1982 |
A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinica | 1983 |
Short- or long-term chemotherapy for node-positive breast cancer: LMF 6 versus 18 cycles. SAKK study 27/76.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trials as T | 1984 |
Tamoxifen and combination chemotherapy as adjuvant treatment in postmenopausal women with breast cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trial | 1984 |
Randomized trial of 3 different regimens of combination chemotherapy in patients receiving simultaneously a hormonal treatment for advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Castration; Chlorambucil; Combined | 1983 |
Hormono-chemotherapy versus hormonotherapy followed by chemotherapy in the treatment of disseminated breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Doxorubicin; Drug A | 1980 |
A phase III study of prednimustine (LEO 1031) in advanced breast cancer. A preliminary report.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Fe | 1980 |
Adjuvant chemotherapy with chlorambucil and 5-fluorouracil in primary breast cancer (Cooperative Study Heidelberg).
Topics: Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorou | 1980 |
Divergent effect of adjuvant chemo-immunotherapy on recurrence rates in node-negative and node-positive breast cancer patients.
Topics: BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Fe | 1980 |
Adjuvant chemoimmunotherapy with LMF plus BCG in node-negative and node-positive breast cancer - intermediate report at 4 years.
Topics: Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Female; Fluorou | 1982 |
[Simultaneous or sequential hormono/chemotherapy and a comparison of various polychemotherapies in the treatment of metastatic breast cancer].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Castration; Chlorambucil; Clinical Trials as T | 1982 |
Adjuvant chemotherapy in operable breast cancer: cyclophosphamide, methotrexate, and fluorouracil versus chlorambucil, methotrexate, and fluorouracil--11-year results of Swiss Group for Clinical Cancer Research trial SAKK 27/82.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 1997 |
Combined chemo- and hormonal therapy in advanced breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Castration; Chlorambucil; Clinical Trials as Topic; Cycloph | 1977 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer patients. Intermediate report of a randomized trial in 242 patients.
Topics: Administration, Oral; Aged; BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; F | 1978 |
Adjuvant chemotherapy in breast cancer--Swiss co-operative studies.
Topics: Antineoplastic Agents; BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Drug T | 1979 |
Comparison of DES vs DES + chlorambucil in women with first recurrence of breast cancer.
Topics: Aged; Breast Neoplasms; Chlorambucil; Diethylstilbestrol; Drug Therapy, Combination; Female; Humans; | 1979 |
Swiss adjuvant trials in women with node-negative breast cancer. OSAKO.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chemotherapy, Adjuvan | 1992 |
West Midlands Oncology Association trial of adjuvant chemotherapy in node-negative breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Chlorambuc | 1992 |
Comparative pharmacokinetics of chlorambucil and prednimustine after oral administration.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlora | 1991 |
[Therapy of metastatic breast cancer at the Ulm Tumor Center in 1980 and 1990].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Combined Modality Th | 1990 |
High-intensity therapy versus low-intensity therapy in advanced breast cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ch | 1990 |
Adjuvant chemotherapy for node-negative breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Combined Modality Th | 1989 |
West Midlands Oncology Association trials of adjuvant chemotherapy in operable breast cancer: results after a median follow-up of 7 years. II. Patients without involved axillary lymph nodes.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Combined Moda | 1989 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer patients: 10 year results.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chlorambucil; Combine | 1989 |
A randomized, prospective, comparative, multicentre trial of a single combination versus alternating combinations of antitumour drugs in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinica | 1987 |
Prednimustine in advanced breast cancer: a review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinical Trials as T | 1986 |
A randomized comparative study of prednimustine and doxorubicin in patients with metastatic breast cancer.
Topics: Breast Neoplasms; Chlorambucil; Clinical Trials as Topic; Doxorubicin; Female; Humans; Neoplasm Meta | 1986 |
Swiss adjuvant trial (OSAKO 06/74) with chlorambucil, methotrexate, and 5-fluorouracil plus BCG in node-negative breast cancer patients: nine-year results.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chlorambucil; Clinica | 1986 |
Oral anticoagulant therapy of human cancer.
Topics: Administration, Oral; Anticoagulants; Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambuci | 1974 |
[Experiences with cytostatic combination therapy in hormone-resistant metastasizing breast cancer].
Topics: Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; He | 1969 |
83 other studies available for chlorambucil and Breast Neoplasms
| Article | Year |
|---|---|
Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chlorambucil; Female; Humans; Receptor, E | 2010 |
A selective mitochondrial-targeted chlorambucil with remarkable cytotoxicity in breast and pancreatic cancers.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Proliferation; Chloramb | 2013 |
Synthesis and biological evaluation of 2-alkoxycarbonylallyl esters as potential anticancer agents.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carboxylic Acids; Cell Line, Tumor; Cell Survival; | 2017 |
Self-Illuminating Triggered Release of Therapeutics from Photocleavable Nanoprodrug for the Targeted Treatment of Breast Cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Humans; Luminol; Reactive Ox | 2022 |
Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7.
Topics: Breast Neoplasms; Cell Proliferation; Chlorambucil; Endocytosis; Female; Humans; Large Neutral Amino | 2020 |
Achieving traceless ablation of solid tumors without recurrence by mild photothermal-chemotherapy of triple stimuli-responsive polymer-drug conjugate nanoparticles.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chlorambucil; Combined Modalit | 2019 |
Targeted photoresponsive carbazole-coumarin and drug conjugates for efficient combination therapy in leukemia cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Carbazoles; Chlorambucil; Coumarins; Delayed-Action Prepara | 2020 |
Chlorambucil-Chitosan Nano-Conjugate: An Efficient Agent Against Breast Cancer Targeted Therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chitosan; Chlorambucil; Humans; MCF-7 C | 2021 |
Targeting of GLUT5 for Transporter-Mediated Drug-Delivery Is Contingent upon Substrate Hydrophilicity.
Topics: Antineoplastic Agents, Alkylating; Breast; Breast Neoplasms; Chlorambucil; Female; Glucose Transport | 2021 |
Comprehensive strategy for the design of precision drugs and identification of genetic signature behind proneness of the disease-a pharmacogenomic approach.
Topics: Antineoplastic Agents; BRCA1 Protein; Breast Neoplasms; Chlorambucil; Drug Design; Female; Genetic P | 2017 |
Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Chlorambucil; Drug Carriers; Female; G | 2018 |
Photoresponsive coumarin-tethered multifunctional magnetic nanoparticles for release of anticancer drug.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Line | 2013 |
Combination of small molecule prodrug and nanodrug delivery: amphiphilic drug-drug conjugate for cancer therapy.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Chlorambucil; Drug Delivery Sy | 2014 |
Cytotoxic activity of G3 PAMAM-NH₂ dendrimer-chlorambucil conjugate in human breast cancer cells.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation | 2011 |
SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines.
Topics: Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorambuci | 2012 |
Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines.
Topics: Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorambucil; | 2012 |
CLINICAL EVALUATION OF URACIL MUSTARD.
Topics: Anemia; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Hodgkin Disease; Humans; Kidn | 1963 |
[CYTOSTATIC THERAPY].
Topics: Antineoplastic Agents; Breast Neoplasms; Busulfan; Chlorambucil; Colchicine; Cyclophosphamide; Femal | 1964 |
CHLORAMBUCIL-PREDNISOLONE THERAPY FOR DISSEMINATED BREAST CARCINOMA.
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Biomedical Research; Breast Neopl | 1964 |
NONSURGICAL TREATMENT OF PULMONARY CANCER.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agen | 1964 |
THE TREATMENT OF INCURABLE MALIGNANT DISEASE.
Topics: Adrenalectomy; Androgens; Breast Neoplasms; Busulfan; Chlorambucil; Estrogens; Heroin; Hormones; Hum | 1964 |
Synthesis and biological evaluation of new cyclic amidine analogs of chlorambucil.
Topics: Antineoplastic Agents, Alkylating; Binding, Competitive; Breast Neoplasms; Cell Line, Tumor; Cell Su | 2004 |
Pharmacokinetic and cell-biological investigation of prednimustine compared to its components chlorambucil and prednisolone.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Line; Cell Line, Tumor; Chlorambucil; Cricetinae; Fem | 1989 |
Design of a tumor-homing cell-penetrating peptide.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Chlorambuci | 2008 |
[The meaning of maintenance therapy in oncology].
Topics: Breast Neoplasms; Chlorambucil; Hodgkin Disease; Leukemia, Myeloid, Acute; Lymphoma; Methotrexate; N | 1980 |
[Generalized metastasizing chorion carcinoma with complete remission after cytostatic therapy].
Topics: Adult; Breast Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Da | 1983 |
Adjuvant radiation therapy compared with cyclic chemotherapy in patients with mammary carcinoma. II. Changes of mitogen responses of blood lymphocytes.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Fluorouracil; Humans | 1981 |
Immunologic monitoring in breast cancer patients receiving postoperative adjuvant chemotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Fluorouracil; Humans; Im | 1981 |
Adjuvant chemoimmunotherapy with LMF + BCG in node-negative and node-positive breast cancer: 8 year results.
Topics: Antineoplastic Combined Chemotherapy Protocols; BCG Vaccine; Breast Neoplasms; Chlorambucil; Combine | 1984 |
[Bestrabacil: a possible target-oriented anticancer agent].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Chloram | 1984 |
[Chemotherapy of metastasizing breast cancer. Adriamycin mono and combination therapy after LMFP pretreatment].
Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Cyclophosp | 1983 |
Prednimustine in combination with methotrexate and 5-fluorouracil in advanced breast cancer: a phase I-II study.
Topics: Aged; Breast Neoplasms; Chlorambucil; Drug Administration Schedule; Drug Evaluation; Drug Therapy, C | 1983 |
[Acute myelogenous leukemia after cytostatic therapy of breast cancer].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acut | 1981 |
Phase II Study of AMSA, prednisone, and chlorambucil (APC) in the treatment of refractory breast cancer: a Northern California Oncology Group Study.
Topics: Adult; Aged; Aminoacridines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1982 |
Prednimustine in combination with methotrexate and 5-FU (PMF): a pilot study.
Topics: Aged; Alopecia; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Fluorouracil; Hum | 1982 |
A study over a 5-year period of adjuvant chemotherapy after mastectomy for breast cancer.
Topics: Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Fluorouracil; Follow-Up Studies; | 1981 |
Prednisolone plasma levels after oral administration of Prednimustine. Comparison with levels obtained after administration of an equimolar dose of prednisolone.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Chlorambucil; Female; Humans; Lymphoma; Middle | 1981 |
[Adjuvant chemotherapy of breast neoplasms. Review of the up-to-date results of various studies including the Heidelberg study].
Topics: Adult; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Evaluation Studies as Topic; Female; Fluoro | 1980 |
Phase II trial of prednimustine, L-1031, (NSC-134087) in advanced breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Evaluation; Female; Humans; Leukopenia; Middle Age | 1980 |
Primary malignant neoplasms associated with chronic lymphocytic leukemia.
Topics: Breast Neoplasms; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Female; Head and Neck Neoplasms | 1980 |
[Quantitative assay of growth response of clinical breast cancer cells against E2 or E2-conjugated drugs].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Drug Screening Assays, Antitum | 1994 |
Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1-1- and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Dicumarol; DNA-Binding Proteins; Drug Resista | 1998 |
Decreased cytotoxicity and increased antimitotic activity of proline analogue of chlorambucil as a prodrug in breast cancer MCF-7 cells.
Topics: Antineoplastic Agents, Alkylating; Breast Neoplasms; Chlorambucil; Dipeptidases; DNA; Dose-Response | 2000 |
Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Azathiop | 2001 |
Letter: Chemotherapy after mastectomy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Drug Evaluation; Drug Thera | 1976 |
[Chemotherapy as an adjuvant treatment in breast cancer (author's transl)].
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Fluorouracil; Humans; Melph | 1978 |
Cryopathic gangrene with an IgM lambda cryoprecipitating cold agglutinin.
Topics: Adult; Agglutinins; Autoantibodies; Breast Neoplasms; Chlorambucil; Cryoglobulins; Female; Gangrene; | 1978 |
Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Female; Humans; Leukemia, Myeloid, Acute; Middle Aged; | 1978 |
Adjuvant chemo-immuno-therapy with LMF+BCG in node-negeative and node-positive breast cancer.
Topics: Antineoplastic Agents; BCG Vaccine; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Femal | 1978 |
[Secondary carcinoma: a complication of cytostatic therapy?].
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Chlorambucil; Female; Humans; Immunosuppressio | 1979 |
A well tolerated oral combination of chlorambucil (Leukeran R), methotrexate, fluorouracil, prednisone (LMFP) in disseminated breast cancer.
Topics: Aged; Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; | 1979 |
Cyclophosphamide-induced urticaria. Occurrence in a patient with no cross-sensitivity to chlorambucil.
Topics: Breast Neoplasms; Chlorambucil; Cross Reactions; Cyclophosphamide; Drug Hypersensitivity; Female; Hu | 1978 |
Fresh explant culture of human tumours in vitro and the assessment of sensitivity to cytotoxic chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Culture Techniques; Drug Evaluation, Preclini | 1975 |
Combination therapy in metastatic breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Humans; Middle Aged; | 1977 |
[Combined leukeran-prednisolone therapy in metastasizing breast cancer].
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Huma | 1977 |
[Cytostatic therapy of inoperable carcinomas].
Topics: Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin | 1976 |
Hyperlucent lung after radiation therapy.
Topics: Angiography; Bone Neoplasms; Breast Neoplasms; Chlorambucil; Dyspnea, Paroxysmal; Female; Humans; Lu | 1975 |
The influence of site of metastasis on tumour growth and response to chemotherapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Fluorouracil; Genital Neoplasms, Fema | 1975 |
A controlled study in the use of combined drug therapy for metastatic breast cancer.
Topics: Age Factors; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Drug Therapy, | 1975 |
Growth-inhibitory action of an estrogen-chlorambucil conjugate (KM2210) in human breast cancer cell line MCF-7: its relation to reduction of estrogen receptor and transforming growth factor-alpha secretion.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Chlorambucil; Drug Screening Assays, Antitum | 1992 |
Modulation of resistance to alkylating agents in cancer cell by gossypol enantiomers.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Buthionine Sulfoximine; Carcinoma 256, Walker; Carmust | 1991 |
Effects of cytotoxic chemotherapy on ovarian and adrenal steroidogenesis in pre-menopausal breast cancer patients.
Topics: Acetone; Adrenal Glands; Adult; Aged; Androstenedione; Antineoplastic Combined Chemotherapy Protocol | 1991 |
[Enhancement of antitumor activity of mitomycin C against human breast carcinoma xenografts by pretreatment with KM 2210].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Estradiol; | 1990 |
Mitoxantrone, methotrexate and chlorambucil in metastatic breast cancer, a combination with relatively low subjective toxicity.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ch | 1990 |
[Bone marrow necrosis in a patient with metastatic breast cancer in chemotherapy with chlorambucil, methotrexate and prednisone].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neopl | 1989 |
Highly potent analogues of luteinizing hormone-releasing hormone containing D-phenylalanine nitrogen mustard in position 6.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Membrane; Chlorambucil; Female; Gonadotropin-Re | 1989 |
Premarin priming before prednimustine, high-dose folinic acid and 5-fluorouracil as salvage chemotherapy for advanced breast cancer.
Topics: Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Estrogens, Conjugated (USP); Female; Fluo | 1988 |
Phase II trial of prednimustine as first-line chemotherapy in patients with advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Chlorambucil; Diagnosis-Related Groups; Drug Evalu | 1987 |
[A case of breast carcinoma with lung metastasis].
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Humans; L | 1987 |
[Two cases of recurrent breast carcinoma achieving CR (complete response) with KM2210].
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Papillary; Chlorambucil; Drug Combinations; Drug Evalua | 1987 |
[Therapeutic results in recurrent breast cancer with the use of Bestrabucil (KM2210)].
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Hu | 1987 |
Systemic chemotherapy of mammary carcinoma.
Topics: Amines; Antineoplastic Agents; Azirines; Azo Compounds; Breast Neoplasms; Caproates; Carbohydrates; | 1971 |
Acute leukemia complicating metastatic breast cancer.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil | 1973 |
Secondary chemotherapy of advanced breast cancer.
Topics: Adult; Aged; Breast Neoplasms; Chlorambucil; Female; Humans; Hydrocortisone; Middle Aged; Neoplasm M | 1973 |
Cytotoxic agents in the treatment of malignant disease.
Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma; | 1968 |
Systemic chemotherapy for advanced breast cancer.
Topics: Adrenal Cortex Hormones; Adult; Aged; Androgens; Antineoplastic Agents; Breast Neoplasms; Chlorambuc | 1970 |
Phase I study of phenesterin (NSC-104469).
Topics: Administration, Oral; Adult; Aged; Androgens; Antineoplastic Agents; Blood Cell Count; Blood Platele | 1971 |
Chemotherapy of breast carcinoma.
Topics: Adult; Amines; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Imida | 1972 |
[Internal cancer therapy: cooperative clinical studies. Principles, organization and first results of the Swiss chemotherapy group].
Topics: Adenocarcinoma; Androgens; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Car | 1967 |
[Combined chemotherapy in metastatic breast cancer].
Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Drug Synergism; Female; Hum | 1967 |
[Antitumor polychemotherapy].
Topics: Adult; Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Chlorambucil; | 1968 |
Hodgkin's disease and some solid tumours.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma, Bronchogenic; Chlorambucil; Cyclophosphamide; Fe | 1966 |
[Cytostatic therapy of choroid membrane metastases].
Topics: Aged; Breast Neoplasms; Chlorambucil; Choroid Neoplasms; Cyclophosphamide; Female; Humans; Mastectom | 1966 |