chlorambucil has been researched along with Brain Neoplasms in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 7.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "Twenty-one consecutive patients with histologically confirmed glioblastoma multiforme were treated with prednimustine (130 mg/m2 for 5 days every 3 weeks) adjuvant to surgery and radiation therapy." | 7.67 | Phase II trial of prednimustine in glioblastoma multiforme. ( Andersen, J; Christensen, L; Kongsholm, H, 1984) |
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 3.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "Twenty-one consecutive patients with histologically confirmed glioblastoma multiforme were treated with prednimustine (130 mg/m2 for 5 days every 3 weeks) adjuvant to surgery and radiation therapy." | 3.67 | Phase II trial of prednimustine in glioblastoma multiforme. ( Andersen, J; Christensen, L; Kongsholm, H, 1984) |
| "The clinical features of patients with brain metastases are reviewed in detail." | 1.29 | Brain metastases of gestational trophoblastic tumor. ( Bakri, Y; Berkowitz, RS; Goldstein, DP; Jabbar, FA; Senoussi, M; Subhi, J; von Sinner, W, 1994) |
| "This report describes the physicochemical and pharmacokinetic parameters of seven chlorambucil esters, which were compared with those of chlorambucil." | 1.28 | Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration. ( Daly, EM; Genka, S; Greig, NH; Rapoport, SI; Sweeney, DJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bentley, RT | 1 |
| Thomovsky, SA | 1 |
| Miller, MA | 1 |
| Knapp, DW | 1 |
| Cohen-Gadol, AA | 1 |
| EDMONDS, LC | 1 |
| CARRERA, GM | 1 |
| Andersen, J | 1 |
| Christensen, L | 1 |
| Kongsholm, H | 1 |
| Bakri, Y | 1 |
| Berkowitz, RS | 1 |
| Goldstein, DP | 1 |
| Subhi, J | 1 |
| Senoussi, M | 1 |
| von Sinner, W | 1 |
| Jabbar, FA | 1 |
| Genka, S | 2 |
| Deutsch, J | 1 |
| Shetty, UH | 1 |
| Stahle, PL | 1 |
| John, V | 1 |
| Lieberburg, IM | 1 |
| Ali-Osman, F | 1 |
| Rapoport, SI | 2 |
| Greig, NH | 2 |
| Becker, RL | 1 |
| Avioli, LV | 1 |
| Tscherne, G | 1 |
| Pratt, RA | 1 |
| Di Chiro, G | 1 |
| Weed, JC | 1 |
| Jandl, H | 1 |
| Fuchs, R | 1 |
| O'Neill, E | 1 |
| Pelegrina, I | 1 |
| Hammond, CB | 2 |
| Vicens, R | 1 |
| Almodóvar, AR | 1 |
| Mortakis, AE | 1 |
| Braga, CA | 1 |
| Daly, EM | 1 |
| Sweeney, DJ | 1 |
| Gerulath, AH | 1 |
| Dembo, AJ | 1 |
| Aitken, S | 1 |
| Quirt, IC | 1 |
| Osborne, R | 1 |
| Blackstein, M | 1 |
| Rider, WD | 1 |
| Ashby, MA | 1 |
| Bowen, D | 1 |
| Watson, JV | 1 |
| Mark, JB | 1 |
| Flanigan, S | 1 |
| Borchert, LG | 1 |
| Tyrey, L | 1 |
| Creasman, WT | 1 |
| Parker, RT | 1 |
| Le Goff, P | 1 |
| Le Menn, G | 1 |
| Biran, S | 1 |
| Herishianu, Y | 1 |
1 review available for chlorambucil and Brain Neoplasms
| Article | Year |
|---|---|
[New aspects of diagnosis, treatment and follow-up of trophoblastic tumours (author's transl)].
Topics: Adult; Aftercare; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropin; Dactinomycin; Drug Therapy, | 1979 |
17 other studies available for chlorambucil and Brain Neoplasms
| Article | Year |
|---|---|
Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chlorambuci | 2018 |
EXTRAGENITAL CHORIOCARCINOMA.
Topics: Autopsy; Brain Neoplasms; Child; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy; Epistaxi | 1965 |
Phase II trial of prednimustine in glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Chlorambucil; Combined Modality Therapy; Drug Evaluation; | 1984 |
Brain metastases of gestational trophoblastic tumor.
Topics: Adult; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Chlorambucil; Chorionic Gonadotrop | 1994 |
Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain; Brain Neoplasms; Chlo | 1993 |
Gestational trophoblastic disease.
Topics: Adult; Brain Neoplasms; Cerebral Hemorrhage; Chlorambucil; Choriocarcinoma; Dactinomycin; Female; He | 1977 |
Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma.
Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Brain Neoplasms; Chlorambucil; Choriocarcinoma; | 1977 |
[Therapy of malignant non-Hodgkin's lymphoma].
Topics: Brain Neoplasms; Chlorambucil; Cyclophosphamide; Humans; Injections, Spinal; Lymphoma; Methotrexate; | 1979 |
Normal pregnancy and delivery after cerebral metastases of choriocarcinoma: Case report.
Topics: Adolescent; Brain Neoplasms; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy, Combination; | 1976 |
"Poor prognosis" metastatic gestational trophoblastic disease: the prognostic significance of the scoring system in predicting chemotherapy failures.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Choriocarcinom | 1990 |
Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration.
Topics: Alkylating Agents; Animals; Brain; Brain Neoplasms; Chlorambucil; Esters; Female; Half-Life; Humans; | 1990 |
Poor prognosis metastatic gestational trophoblastic disease: experience with moderate dose methotrexate plus folinic acid rescue as initial therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropi | 1986 |
Intracranial Hodgkin's disease: a primary presentation and access of cytotoxic agents.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Combined | 1986 |
Chemotherapy of malignant brain tumors.
Topics: Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Glioblast | 1966 |
Treatment of metastatic trophoblastic disease: good and poor prognosis.
Topics: Brain Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Follow | 1973 |
[Cancer and immunosuppressive treatment. Apropos of 2 cases].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Brain Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; | 1974 |
Brain involvement in Hodgkin's disease. Report of a case.
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Cerebral Angiography; Chlorambucil; Echoencephal | 1972 |