chlorambucil has been researched along with Body Weight in 17 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil was administered to Hanover Wistar rats at regular time points, followed by a treatment-free (recovery) period." | 1.35 | Time-course study of the immunotoxic effects of the anticancer drug chlorambucil in the rat. ( Cunliffe, J; Derbyshire, N; Foster, JR; Pearse, G; Pietersma, A; Randall, KJ; Turton, J, 2009) |
| " In mol/kg, the chlorambucil-spermidine conjugate was 10-fold more toxic than chlorambucil, on the basis of their neurotoxicity, but only 2- to 3-fold more toxic on the basis of their effects on lymphocyte depression." | 1.29 | The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice. ( Carthew, P; Cohen, GM; Cullis, P; Holley, JL; Verschoyle, RD, 1994) |
| " Using this assay in the present study, dose-response relationships of cytotoxicity, PFC response and histology in the spleen were evaluated in rats receiving alkylating agents." | 1.29 | Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents. ( Doi, T; Nagai, H; Suzuki, T; Tsukuda, R, 1996) |
| "Chlorambucil was used as a standard at dose levels of 1, 5 and 10 mg/kg/day." | 1.27 | Toxicity of the alkylating agent bendamustin. ( Güttner, J; Härtl, A; Hoffmann, H; Horn, U, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pearse, G | 1 |
| Pietersma, A | 1 |
| Cunliffe, J | 1 |
| Foster, JR | 1 |
| Turton, J | 1 |
| Derbyshire, N | 1 |
| Randall, KJ | 1 |
| SYRKIN, AB | 2 |
| CHUMAKOV, VM | 1 |
| Verschoyle, RD | 1 |
| Carthew, P | 1 |
| Holley, JL | 1 |
| Cullis, P | 1 |
| Cohen, GM | 1 |
| Doi, T | 1 |
| Nagai, H | 1 |
| Tsukuda, R | 1 |
| Suzuki, T | 1 |
| Pispirigos, K | 1 |
| Paradelis, AG | 1 |
| Karakiulakis, G | 1 |
| Harrap, KR | 1 |
| Riches, PG | 1 |
| Gilby, ED | 1 |
| Sellwood, SM | 1 |
| Wilkinson, R | 1 |
| Konyves, I | 1 |
| Druker, BJ | 1 |
| Rosenthal, DS | 1 |
| Canellos, GP | 1 |
| Delic, JI | 1 |
| Stanley, JA | 1 |
| Harwood, JR | 1 |
| Kavlock, RJ | 2 |
| Rehnberg, BF | 2 |
| Rogers, EH | 2 |
| Horn, U | 1 |
| Härtl, A | 1 |
| Güttner, J | 1 |
| Hoffmann, H | 1 |
| Lokich, JJ | 1 |
| Galvanek, EG | 1 |
| Moloney, WC | 1 |
| Fitzgerald, PH | 1 |
| Rastrick, JM | 1 |
| Hamer, JW | 1 |
| Rimm, AA | 1 |
| Ahlstrom, JK | 1 |
| Bross, ID | 1 |
| Kaneko, N | 1 |
| Elson, LA | 1 |
1 review available for chlorambucil and Body Weight
| Article | Year |
|---|---|
Design of cancer chemotherapy: tailored sensitivity assays.
Topics: Animals; Antineoplastic Agents; Body Weight; Chlorambucil; Melphalan; Nitrogen Mustard Compounds; Or | 1980 |
1 trial available for chlorambucil and Body Weight
| Article | Year |
|---|---|
What is objective tumor response?
Topics: Antineoplastic Agents; Azirines; Body Weight; Chlorambucil; Clinical Trials as Topic; Electronic Dat | 1967 |
15 other studies available for chlorambucil and Body Weight
| Article | Year |
|---|---|
Time-course study of the immunotoxic effects of the anticancer drug chlorambucil in the rat.
Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Bone Marrow; Chlorambucil; Female; Immunoto | 2009 |
INFLUENCE OF SOME ANTITUMOR DRUGS ON BODY AND ORGANS GROWTH IN RATS.
Topics: Adrenal Glands; Antineoplastic Agents; Body Weight; Bone and Bones; Brain; Chlorambucil; Diaphragm; | 1964 |
The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Weight; Chlora | 1994 |
Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cell Count; Cell Survival; Chlorambucil; Cy | 1996 |
Evaluation of cardiac subacute toxicity of epirubicin, chlorambucil, cisplatin, methotrexate and a homo-aza-steroid ester with antitumor activity in rats using serum biochemical parameters.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antine | 1997 |
Studies on the toxicity and antitumour activity of prednimustine, a prednisolone ester of chlorambucil.
Topics: Animals; Body Weight; Cell Line; Chlorambucil; DNA, Neoplasm; Dose-Response Relationship, Drug; Fema | 1977 |
Chlorambucil, vinblastine, procarbazine, and prednisone. An effective but less toxic regimen than MOPP for advanced-stage Hodgkin's disease.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Chlorambucil; Female; Hodg | 1989 |
Testicular function in adult rats treated with the alkylating agent chlorambucil.
Topics: Alkylation; Animals; Body Weight; Chlorambucil; Follicle Stimulating Hormone; Luteinizing Hormone; M | 1986 |
Chlorambucil induced congenital renal hypoplasia: effects on basal renal function in the developing rat.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Chlorambucil; Dose-Response Relationship, Drug; Female; K | 1986 |
Critical prenatal periods for chlorambucil-induced functional alterations of the rat kidney.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chlorambucil; Female; Gestational Age; Kidney; Li | 1987 |
Toxicity of the alkylating agent bendamustin.
Topics: Alkylating Agents; Animals; Atrophy; Bendamustine Hydrochloride; Body Weight; Chlorambucil; Digestiv | 1985 |
Nephrosis of Hodgkin disease. An immune complex-induced lesion.
Topics: Antigen-Antibody Complex; Basement Membrane; Biopsy; Blood Urea Nitrogen; Body Weight; Capillaries; | 1973 |
Acute plasma cell leukaemia following chronic lymphatic leukaemia: transformation or two separate diseases?
Topics: Aged; Blood Protein Electrophoresis; Body Weight; Bone Marrow Examination; Cell Transformation, Neop | 1973 |
[Comparative studies of the effects of the antitumor agents on growth and hematopoiesis of mature and immature rabbits].
Topics: Age Factors; Animals; Antineoplastic Agents; Blood Cell Count; Body Weight; Chlorambucil; Cyclophosp | 1970 |
Growth inhibitory and haematological effects of alkylating agents and attempts at their modification to give greater selectivity of anti-tumour action.
Topics: Alkylating Agents; Animals; Body Weight; Carcinoma 256, Walker; Chemical Phenomena; Chemistry; Chlor | 1968 |