chlorambucil has been researched along with Blood Diseases in 20 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-one consecutive patients with histologically confirmed glioblastoma multiforme were treated with prednimustine (130 mg/m2 for 5 days every 3 weeks) adjuvant to surgery and radiation therapy." | 7.67 | Phase II trial of prednimustine in glioblastoma multiforme. ( Andersen, J; Christensen, L; Kongsholm, H, 1984) |
| "Prednimustine is an ester of chlorambucil and prednisolone." | 6.65 | A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer. ( Christiansen, IE; Dombernowsky, P; Løber, J; Mattsson, W; Mouridsen, HT; Rørth, M, 1983) |
| "We investigated the toxicity and efficacy of the chimaeric anti-CD20 antibody rituximab in combination with standard-dose chlorambucil in newly diagnosed and relapsed/refractory indolent B-cell lymphoma patients." | 5.10 | Chlorambucil in combination with induction and maintenance rituximab is feasible and active in indolent non-Hodgkin's lymphoma. ( Bertolini, F; Calleri, A; Cavalli, F; Laszlo, D; Mancuso, P; Martinelli, G; Pastano, R; Santoro, P; Vanazzi, A; Zucca, E, 2003) |
| "Twenty-one consecutive patients with histologically confirmed glioblastoma multiforme were treated with prednimustine (130 mg/m2 for 5 days every 3 weeks) adjuvant to surgery and radiation therapy." | 3.67 | Phase II trial of prednimustine in glioblastoma multiforme. ( Andersen, J; Christensen, L; Kongsholm, H, 1984) |
| "Prednimustine is an ester of chlorambucil and prednisolone." | 2.65 | A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer. ( Christiansen, IE; Dombernowsky, P; Løber, J; Mattsson, W; Mouridsen, HT; Rørth, M, 1983) |
| "Many patients with advanced Hodgkin's disease continue to need palliative therapy, but where there is no curative intent, patients and doctors may prefer oral treatment only." | 1.28 | An effective oral combination in advanced relapsed Hodgkin's disease prednisolone, etoposide, chlorambucil and CCNU. ( Carey, PJ; Jackson, GH; Lennard, AL; Proctor, SJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eketorp Sylvan, S | 1 |
| Lundin, J | 1 |
| Ipek, M | 1 |
| Palma, M | 1 |
| Karlsson, C | 1 |
| Hansson, L | 1 |
| Gritti, G | 1 |
| Reda, G | 1 |
| Maura, F | 1 |
| Piciocchi, A | 1 |
| Baldini, L | 1 |
| Molica, S | 1 |
| Neri, A | 1 |
| Cortelezzi, A | 1 |
| Martinelli, G | 2 |
| Laszlo, D | 1 |
| Bertolini, F | 1 |
| Pastano, R | 2 |
| Mancuso, P | 1 |
| Calleri, A | 1 |
| Vanazzi, A | 1 |
| Santoro, P | 1 |
| Cavalli, F | 3 |
| Zucca, E | 2 |
| Cocorocchio, E | 1 |
| Peccatori, F | 1 |
| Saletti, PC | 1 |
| Calabrese, L | 1 |
| Pruneri, G | 1 |
| Mazzetta, C | 1 |
| Ghielmini, M | 1 |
| Bauwens, D | 1 |
| Maerevoet, M | 1 |
| Michaux, L | 1 |
| Théate, I | 1 |
| Hagemeijer, A | 1 |
| Stul, M | 1 |
| Danse, E | 1 |
| Costantini, S | 1 |
| Vannuffel, P | 1 |
| Straetmans, N | 1 |
| Vekemans, MC | 1 |
| Deneys, V | 1 |
| Ferrant, A | 1 |
| Van Den Neste, E | 1 |
| Andersen, J | 1 |
| Christensen, L | 1 |
| Kongsholm, H | 1 |
| Løber, J | 1 |
| Mouridsen, HT | 1 |
| Christiansen, IE | 1 |
| Dombernowsky, P | 1 |
| Mattsson, W | 1 |
| Rørth, M | 1 |
| Freedman, ML | 1 |
| Carde, P | 1 |
| Diehl, V | 1 |
| Franklin, J | 1 |
| Prieur, AM | 1 |
| Balafrej, M | 1 |
| Griscelli, C | 1 |
| Mozziconacci, P | 1 |
| Renier, JC | 1 |
| Bregeon, C | 1 |
| Bonnette, C | 1 |
| Lenoir, G | 1 |
| Guesry, P | 1 |
| Kleinknecht, C | 1 |
| Gagnadoux, MF | 1 |
| Broyer, M | 1 |
| Lennard, AL | 1 |
| Carey, PJ | 1 |
| Jackson, GH | 1 |
| Proctor, SJ | 1 |
| Mead, GM | 1 |
| Williams, CJ | 1 |
| Whitehouse, JM | 1 |
| Oken, MM | 1 |
| Griffiths, RW | 1 |
| Williams, RC | 1 |
| Reimann, BE | 1 |
| Dacie, JV | 1 |
| Kaplan, SR | 1 |
| Calabresi, P | 1 |
| Sawkar, LA | 1 |
| Saslaw, S | 1 |
| Carlisle, HN | 1 |
| Marcolongo, R | 1 |
| Di Paolo, N | 1 |
| Bianco, G | 1 |
| Bravi, A | 1 |
2 reviews available for chlorambucil and Blood Diseases
| Article | Year |
|---|---|
Is escalated BEACOPP a standard therapy for advanced Hodgkin's disease?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Clinical Trials, Phase III | 2000 |
Drug therapy. Immunosuppressive agents. I.
Topics: Adrenal Cortex Hormones; Adult; Alkylating Agents; Antimetabolites; Arthritis, Rheumatoid; Autoimmun | 1973 |
5 trials available for chlorambucil and Blood Diseases
| Article | Year |
|---|---|
Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; Alemtuzumab; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Mur | 2012 |
Chlorambucil in combination with induction and maintenance rituximab is feasible and active in indolent non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2003 |
Activity and safety of combined rituximab with chlorambucil in patients with mantle cell lymphoma.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2005 |
A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chlorambucil; Clinica | 1983 |
[Results of immunosuppressive therapy in 78 patients with rheumatoid polyarthritis, treated for at least 4 years].
Topics: Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Chlorambucil; Clin | 1975 |
13 other studies available for chlorambucil and Blood Diseases
| Article | Year |
|---|---|
Alemtuzumab (anti-CD52 monoclonal antibody) as single-agent therapy in patients with relapsed/refractory chronic lymphocytic leukaemia (CLL)-a single region experience on consecutive patients.
Topics: Aged; Aged, 80 and over; Alemtuzumab; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineopla | 2014 |
ChlVPP/ABVVP, a first line 'hybrid' combination chemotherapy for advanced Hodgkin's lymphoma: a retrospective analysis.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Di | 2004 |
Phase II trial of prednimustine in glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Chlorambucil; Combined Modality Therapy; Drug Evaluation; | 1984 |
Common hematologic problems: diagnosis and treatment.
Topics: Aged; Anemia; Anemia, Macrocytic; Blood Cell Count; Blood Transfusion; Chlorambucil; Erythrocyte Ind | 1983 |
[Results and long-term risks of immuno-suppressive treatment in chronic juvenile arthritis. Apropos of 40 cases].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambuc | 1979 |
[Extragonadal complications of chlorambucil in children. Report of 300 cases of glomerulonephritis].
Topics: Adolescent; Adult; Child; Child, Preschool; Chlorambucil; France; Glomerulonephritis; Hematologic Di | 1977 |
An effective oral combination in advanced relapsed Hodgkin's disease prednisolone, etoposide, chlorambucil and CCNU.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambuci | 1990 |
Cisplatin, adriamycin and cyclophosphamide (PACe) combination chemotherapy in patients with ovarian carcinoma resistant to chlorambucil.
Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Cyclophosphamide; | 1985 |
Possible NZB syndrome in man.
Topics: Adult; Agglutinins; Anemia, Hemolytic; Antibodies, Antinuclear; Autoimmune Diseases; Blood Protein E | 1973 |
Clinical immunology and the physician. Blood.
Topics: Adrenocorticotropic Hormone; Anemia, Hemolytic, Autoimmune; Anemia, Macrocytic; Blood Transfusion; C | 1974 |
Hyperviscosity syndrome in acute plasma cell leukaemia.
Topics: Blood Viscosity; Chlorambucil; Exchange Transfusion, Whole Blood; Hematologic Diseases; Humans; Leuk | 1972 |
Nonhuman primates in evaluation of hematotoxicity.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug-Related Side Effects and Adver | 1969 |
[Clinical usefulness of eticholanolone in the evaluation of bone marrow reserves in patients treated with myelosuppressive drugs and with radiotherapy].
Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Bone Marrow Examination | 1969 |