chlorambucil has been researched along with Blood Clot in 7 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Randomized studies have shown that the risk of thrombosis was significantly reduced in ET with the use of hydroxyurea (HU) and in PV with the use of chlorambucil or 32P." | 4.80 | Treatment of polycythaemia vera and essential thrombocythaemia. ( Silverstein, MN; Tefferi, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wasserman, LR | 2 |
| Balcerzak, SP | 1 |
| Berk, PD | 2 |
| Berlin, NI | 2 |
| Donovan, PB | 2 |
| Dresch, C | 1 |
| Ellis, JT | 1 |
| Goldberg, JD | 2 |
| Landaw, SA | 1 |
| Laszlo, J | 1 |
| McIntyre, OR | 1 |
| Najean, Y | 1 |
| Pisciotta, AV | 1 |
| Silverstein, MN | 2 |
| Tartaglia, AP | 1 |
| Tatarsky, I | 1 |
| Weinfeld, A | 1 |
| Janssen, MJ | 1 |
| Donker, AJ | 1 |
| McGregor, DO | 1 |
| Bailey, RR | 1 |
| Tefferi, A | 1 |
| Fruchtman, SM | 1 |
| Johnson, JR | 1 |
| McGovern, VJ | 1 |
| Calne, RY | 1 |
| Williams, R | 1 |
| Dawson, JL | 1 |
| Ansell, ID | 1 |
| Evans, DB | 1 |
| Flute, PT | 1 |
| Herbertson, PM | 1 |
| Joysey, V | 1 |
| Keates, GH | 1 |
| Knill-Jones, RP | 1 |
| Mason, SA | 1 |
| Millard, PR | 1 |
| Pena, JR | 1 |
| Pentlow, BD | 1 |
| Salaman, JR | 1 |
| Sells, RA | 1 |
| Cullum, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Phase 2 Study of Efficacy and Safety of Pegylated Interferon-alfa 2a in Polycythemia Vera Patients[NCT00241241] | Phase 2 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorambucil and Blood Clot
| Article | Year |
|---|---|
Treatment of polycythaemia vera and essential thrombocythaemia.
Topics: Adult; Aged; Aspirin; Chlorambucil; Disease Progression; Female; Hemorrhage; Humans; Hydroxyurea; In | 1998 |
1 trial available for chlorambucil and Blood Clot
| Article | Year |
|---|---|
Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols.
Topics: Acute Disease; Age Factors; Bloodletting; Chlorambucil; Combined Modality Therapy; False Positive Re | 1986 |
5 other studies available for chlorambucil and Blood Clot
| Article | Year |
|---|---|
Influence of therapy on causes of death in polycythemia vera.
Topics: Chlorambucil; Hematocrit; Humans; Leukemia; Platelet Count; Polycythemia Vera; Risk; Thrombosis; Vei | 1981 |
[Behçet's disease].
Topics: Adult; Azathioprine; Behcet Syndrome; Chlorambucil; Drug Therapy, Combination; Humans; Male; Prednis | 1994 |
Mesenteric arterial thrombosis complicating the nephrotic syndrome.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Glomerulonephritis | 1997 |
Focal necrotizing glomerulonephritis.
Topics: Adolescent; Adult; Aged; Anti-Glomerular Basement Membrane Disease; Biopsy; Blood Urea Nitrogen; Cap | 1973 |
Liver transplantation in man. II. A report of two orthotopic liver transplants in adult recipients.
Topics: Adult; Blood Coagulation Tests; Chlorambucil; Female; Hepatectomy; Hepatic Artery; Hepatitis A; Hist | 1968 |