chlorambucil has been researched along with Biliary Cirrhosis in 13 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-four patients with primary biliary cirrhosis were entered into a prospective, randomized trial of chlorambucil therapy." | 9.06 | Randomized trial of chlorambucil for primary biliary cirrhosis. ( Avigan, MI; Campbell, G; Davis, GL; Dusheiko, GM; Hanson, RG; Hoofnagle, JH; Minuk, GY; Pappas, SC; Peters, M; Schafer, DF, 1986) |
| "Chlorambucil has been used for patients with primary biliary cirrhosis as it possesses immunosuppressive properties." | 8.88 | Chlorambucil for patients with primary biliary cirrhosis. ( Li, WX; Shi, CR; Yan, X; Zhang, AP, 2012) |
| "Twenty-four patients with primary biliary cirrhosis were entered into a prospective, randomized trial of chlorambucil therapy." | 5.06 | Randomized trial of chlorambucil for primary biliary cirrhosis. ( Avigan, MI; Campbell, G; Davis, GL; Dusheiko, GM; Hanson, RG; Hoofnagle, JH; Minuk, GY; Pappas, SC; Peters, M; Schafer, DF, 1986) |
| "Chlorambucil has been used for patients with primary biliary cirrhosis as it possesses immunosuppressive properties." | 4.88 | Chlorambucil for patients with primary biliary cirrhosis. ( Li, WX; Shi, CR; Yan, X; Zhang, AP, 2012) |
| "Primary biliary cirrhosis (PBC) is a disease which predominantly affects middle-aged women and is characterized by destruction of the interlobular bile ducts by chronic, often granulomatous, inflammation." | 2.40 | Evidence-based therapy of primary biliary cirrhosis. ( Heathcote, EJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, WX | 1 |
| Yan, X | 1 |
| Shi, CR | 1 |
| Zhang, AP | 1 |
| Hughes, GS | 1 |
| Kataria, YP | 1 |
| O'Brien, TF | 1 |
| Doherty, M | 1 |
| Martin, MF | 1 |
| Dieppe, PA | 1 |
| Jones, EA | 1 |
| Heathcote, EJ | 1 |
| Bray, GP | 1 |
| Williams, R | 1 |
| Wiedmann, KH | 1 |
| Weber, P | 1 |
| Lauchart, W | 1 |
| Adams, D | 1 |
| Clements, D | 1 |
| Elias, E | 1 |
| Hoofnagle, JH | 1 |
| Davis, GL | 1 |
| Schafer, DF | 1 |
| Peters, M | 1 |
| Avigan, MI | 1 |
| Pappas, SC | 1 |
| Hanson, RG | 1 |
| Minuk, GY | 1 |
| Dusheiko, GM | 1 |
| Campbell, G | 1 |
| Kaplan, MM | 1 |
| Warnes, TW | 1 |
| Pergola, F | 1 |
| Cachin, M | 1 |
| Galian, P | 1 |
8 reviews available for chlorambucil and Biliary Cirrhosis
| Article | Year |
|---|---|
Chlorambucil for patients with primary biliary cirrhosis.
Topics: Chlorambucil; Humans; Immunosuppressive Agents; Liver Cirrhosis, Biliary; Randomized Controlled Tria | 2012 |
Primary biliary cirrhosis: a challenging disease for hepatologists and immunologists.
Topics: Azathioprine; Chlorambucil; Cholestyramine Resin; Copper; Cyclophosphamide; Female; Humans; Liver; L | 1981 |
Evidence-based therapy of primary biliary cirrhosis.
Topics: Azathioprine; Bile Acids and Salts; Chlorambucil; Colchicine; Cyclosporine; Drug Therapy, Combinatio | 1999 |
Immunointervention in primary biliary cirrhosis: an overview.
Topics: Adrenal Cortex Hormones; Azathioprine; Chlorambucil; Cyclosporine; Humans; Immunosuppressive Agents; | 1992 |
[What is safe in therapy of primary biliary cirrhosis?].
Topics: Bile Acids and Salts; Chlorambucil; Colchicine; Humans; Immunosuppressive Agents; Liver Cirrhosis, B | 1988 |
The treatment of primary biliary cirrhosis.
Topics: Adrenal Cortex Hormones; Antipruritics; Azathioprine; Celiac Disease; Chlorambucil; Colchicine; Cycl | 1986 |
Treatment of primary biliary cirrhosis.
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cholelithiasis; Colchicine | 1985 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlor | 1972 |
2 trials available for chlorambucil and Biliary Cirrhosis
| Article | Year |
|---|---|
Randomized trial of chlorambucil for primary biliary cirrhosis.
Topics: Adult; Aged; Bilirubin; Biopsy; Chlorambucil; Clinical Trials as Topic; Female; Follow-Up Studies; H | 1986 |
Another treatment for primary biliary cirrhosis.
Topics: Azathioprine; Chlorambucil; Colchicine; Humans; Liver Cirrhosis, Biliary | 1987 |
3 other studies available for chlorambucil and Biliary Cirrhosis
| Article | Year |
|---|---|
Sarcoidosis presenting as biliary cirrhosis: treatment with chlorambucil.
Topics: Chlorambucil; Diabetes Mellitus, Type 1; Diagnosis, Differential; Humans; Liver; Liver Cirrhosis, Bi | 1983 |
Multicentric reticulohistiocytosis associated with primary biliary cirrhosis: successful treatment with cytotoxic agents.
Topics: Antineoplastic Agents; Arthritis, Rheumatoid; Chlorambucil; Cyclophosphamide; Diagnosis, Differentia | 1984 |
[Attempt at chlorambucil treatment of a case of primary biliary cirrhosis].
Topics: Adult; Chlorambucil; Female; Humans; Liver Cirrhosis, Biliary | 1968 |