chlorambucil has been researched along with Benign Neoplasms, Brain in 18 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 7.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "Twenty-one consecutive patients with histologically confirmed glioblastoma multiforme were treated with prednimustine (130 mg/m2 for 5 days every 3 weeks) adjuvant to surgery and radiation therapy." | 7.67 | Phase II trial of prednimustine in glioblastoma multiforme. ( Andersen, J; Christensen, L; Kongsholm, H, 1984) |
| "Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma." | 3.88 | Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial. ( Bentley, RT; Cohen-Gadol, AA; Knapp, DW; Miller, MA; Thomovsky, SA, 2018) |
| "Twenty-one consecutive patients with histologically confirmed glioblastoma multiforme were treated with prednimustine (130 mg/m2 for 5 days every 3 weeks) adjuvant to surgery and radiation therapy." | 3.67 | Phase II trial of prednimustine in glioblastoma multiforme. ( Andersen, J; Christensen, L; Kongsholm, H, 1984) |
| "The clinical features of patients with brain metastases are reviewed in detail." | 1.29 | Brain metastases of gestational trophoblastic tumor. ( Bakri, Y; Berkowitz, RS; Goldstein, DP; Jabbar, FA; Senoussi, M; Subhi, J; von Sinner, W, 1994) |
| "This report describes the physicochemical and pharmacokinetic parameters of seven chlorambucil esters, which were compared with those of chlorambucil." | 1.28 | Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration. ( Daly, EM; Genka, S; Greig, NH; Rapoport, SI; Sweeney, DJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bentley, RT | 1 |
| Thomovsky, SA | 1 |
| Miller, MA | 1 |
| Knapp, DW | 1 |
| Cohen-Gadol, AA | 1 |
| EDMONDS, LC | 1 |
| CARRERA, GM | 1 |
| Andersen, J | 1 |
| Christensen, L | 1 |
| Kongsholm, H | 1 |
| Bakri, Y | 1 |
| Berkowitz, RS | 1 |
| Goldstein, DP | 1 |
| Subhi, J | 1 |
| Senoussi, M | 1 |
| von Sinner, W | 1 |
| Jabbar, FA | 1 |
| Genka, S | 2 |
| Deutsch, J | 1 |
| Shetty, UH | 1 |
| Stahle, PL | 1 |
| John, V | 1 |
| Lieberburg, IM | 1 |
| Ali-Osman, F | 1 |
| Rapoport, SI | 2 |
| Greig, NH | 2 |
| Becker, RL | 1 |
| Avioli, LV | 1 |
| Tscherne, G | 1 |
| Pratt, RA | 1 |
| Di Chiro, G | 1 |
| Weed, JC | 1 |
| Jandl, H | 1 |
| Fuchs, R | 1 |
| O'Neill, E | 1 |
| Pelegrina, I | 1 |
| Hammond, CB | 2 |
| Vicens, R | 1 |
| Almodóvar, AR | 1 |
| Mortakis, AE | 1 |
| Braga, CA | 1 |
| Daly, EM | 1 |
| Sweeney, DJ | 1 |
| Gerulath, AH | 1 |
| Dembo, AJ | 1 |
| Aitken, S | 1 |
| Quirt, IC | 1 |
| Osborne, R | 1 |
| Blackstein, M | 1 |
| Rider, WD | 1 |
| Ashby, MA | 1 |
| Bowen, D | 1 |
| Watson, JV | 1 |
| Mark, JB | 1 |
| Flanigan, S | 1 |
| Borchert, LG | 1 |
| Tyrey, L | 1 |
| Creasman, WT | 1 |
| Parker, RT | 1 |
| Le Goff, P | 1 |
| Le Menn, G | 1 |
| Biran, S | 1 |
| Herishianu, Y | 1 |
1 review available for chlorambucil and Benign Neoplasms, Brain
| Article | Year |
|---|---|
[New aspects of diagnosis, treatment and follow-up of trophoblastic tumours (author's transl)].
Topics: Adult; Aftercare; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropin; Dactinomycin; Drug Therapy, | 1979 |
17 other studies available for chlorambucil and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Canine (Pet Dog) Tumor Microsurgery and Intratumoral Concentration and Safety of Metronomic Chlorambucil for Spontaneous Glioma: A Phase I Clinical Trial.
Topics: Administration, Metronomic; Animals; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chlorambuci | 2018 |
EXTRAGENITAL CHORIOCARCINOMA.
Topics: Autopsy; Brain Neoplasms; Child; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy; Epistaxi | 1965 |
Phase II trial of prednimustine in glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Chlorambucil; Combined Modality Therapy; Drug Evaluation; | 1984 |
Brain metastases of gestational trophoblastic tumor.
Topics: Adult; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Chlorambucil; Chorionic Gonadotrop | 1994 |
Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Blood-Brain Barrier; Brain; Brain Neoplasms; Chlo | 1993 |
Gestational trophoblastic disease.
Topics: Adult; Brain Neoplasms; Cerebral Hemorrhage; Chlorambucil; Choriocarcinoma; Dactinomycin; Female; He | 1977 |
Cerebral necrosis following irradiation and chemotherapy for metastatic choriocarcinoma.
Topics: Adult; Antineoplastic Agents; Brain; Brain Diseases; Brain Neoplasms; Chlorambucil; Choriocarcinoma; | 1977 |
[Therapy of malignant non-Hodgkin's lymphoma].
Topics: Brain Neoplasms; Chlorambucil; Cyclophosphamide; Humans; Injections, Spinal; Lymphoma; Methotrexate; | 1979 |
Normal pregnancy and delivery after cerebral metastases of choriocarcinoma: Case report.
Topics: Adolescent; Brain Neoplasms; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy, Combination; | 1976 |
"Poor prognosis" metastatic gestational trophoblastic disease: the prognostic significance of the scoring system in predicting chemotherapy failures.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Choriocarcinom | 1990 |
Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration.
Topics: Alkylating Agents; Animals; Brain; Brain Neoplasms; Chlorambucil; Esters; Female; Half-Life; Humans; | 1990 |
Poor prognosis metastatic gestational trophoblastic disease: experience with moderate dose methotrexate plus folinic acid rescue as initial therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Chorionic Gonadotropi | 1986 |
Intracranial Hodgkin's disease: a primary presentation and access of cytotoxic agents.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chlorambucil; Combined | 1986 |
Chemotherapy of malignant brain tumors.
Topics: Brain Neoplasms; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Glioblast | 1966 |
Treatment of metastatic trophoblastic disease: good and poor prognosis.
Topics: Brain Neoplasms; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Follow | 1973 |
[Cancer and immunosuppressive treatment. Apropos of 2 cases].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Brain Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; | 1974 |
Brain involvement in Hodgkin's disease. Report of a case.
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Cerebral Angiography; Chlorambucil; Echoencephal | 1972 |