chlorambucil has been researched along with B16 Melanoma in 8 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "PDL1-expressing mouse and human ovarian cancer lines and mouse melanoma were more sensitive to chlorambucil-mediated proliferation inhibition in vitro versus corresponding genetically PDL1-depleted lines." | 1.91 | Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects. ( Bai, H; Conejo-Garcia, JR; Curiel, T; Deng, Y; Garcia, M; Gupta, HB; Kancharla, A; Kari, SJ; Kornepati, AVR; Liao, YJ; Murray, CJ; Ontiveros, C; Padron, AS; Reyes, RM, 2023) |
| " Similar side effect intensity of BZA2 and dacarbazine was observed, whereas BZA1 was more toxic." | 1.33 | Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model. ( Bauder-Wüst, U; Eisenhut, M; Eskerski, H; Haberkorn, U; Wolf, M, 2006) |
| " The toxicity of these compounds against hepatoma cells (MH3924A) and, to a lesser extent, against mouse fibroblast (NIH 3T3) and cervix carcinoma (HeLa) cells was also enhanced, but they were not as toxic as dacarbazine (HeLa)." | 1.32 | Alkylating benzamides with melanoma cytotoxicity. ( Bauder-Wüst, U; Eisenhut, M; Haberkorn, U; Mier, W; Mohammed, A; Schönsiegel, F; Wolf, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Stark, PA | 1 |
| Thrall, BD | 1 |
| Meadows, GG | 1 |
| Abdel-Monem, MM | 1 |
| Bai, H | 1 |
| Padron, AS | 1 |
| Deng, Y | 1 |
| Liao, YJ | 1 |
| Murray, CJ | 1 |
| Ontiveros, C | 1 |
| Kari, SJ | 1 |
| Kancharla, A | 1 |
| Kornepati, AVR | 1 |
| Garcia, M | 1 |
| Reyes, RM | 1 |
| Gupta, HB | 1 |
| Conejo-Garcia, JR | 1 |
| Curiel, T | 1 |
| Zhang, Q | 1 |
| Zhang, L | 1 |
| Li, Z | 1 |
| Xie, X | 1 |
| Gao, X | 1 |
| Xu, X | 1 |
| Vats, K | 1 |
| Satpati, D | 1 |
| Sharma, R | 1 |
| Kumar, C | 1 |
| Sarma, HD | 1 |
| Dash, A | 1 |
| Wolf, M | 3 |
| Bauder-Wüst, U | 3 |
| Mohammed, A | 1 |
| Schönsiegel, F | 1 |
| Mier, W | 2 |
| Haberkorn, U | 3 |
| Eisenhut, M | 3 |
| Eskerski, H | 1 |
| Musch, E | 1 |
| Malek, M | 1 |
| Peter-Katalinic, J | 1 |
| Egge, H | 1 |
| Rink, H | 1 |
| Lathan, B | 1 |
| Riedel, E | 1 |
8 other studies available for chlorambucil and B16 Melanoma
| Article | Year |
|---|---|
Synthesis and evaluation of novel spermidine derivatives as targeted cancer chemotherapeutic agents.
Topics: Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Melanoma, Experimental; | 1992 |
Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects.
Topics: Animals; B7-H1 Antigen; Chlorambucil; Female; Humans; Killer Cells, Natural; Melanoma, Experimental; | 2023 |
Inducing Controlled Release and Increased Tumor-Targeted Delivery of Chlorambucil via Albumin/Liposome Hybrid Nanoparticles.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chlorambucil; Delayed-Action Preparati | 2017 |
Topics: Animals; Chlorambucil; Hydrazines; Isotope Labeling; Melanoma, Experimental; Mice; Molecular Targete | 2017 |
Alkylating benzamides with melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Line, Tumor; Cel | 2004 |
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzamides; Cell Survival; Chlorambucil; DNA; Drug Carri | 2005 |
Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzamides; Chlorambucil; Dacarbazine; Disease Models, A | 2006 |
Cellular kinetics of prednimustine versus chlorambucil plus prednisolone in vitro.
Topics: Animals; Carcinoma; Chlorambucil; Chromatography, High Pressure Liquid; Colonic Neoplasms; Mammary N | 1992 |