chlorambucil has been researched along with B-Cell Lymphoma in 32 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with histologically verified MALT lymphoma undergoing chemotherapy with MCP were evaluated retrospectively." | 5.32 | Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with mitoxantrone, chlorambucil and prednisone (MCP). ( Chott, A; Dirisamer, A; Drach, J; Hejna, M; Püspök, A; Raderer, M; Scheithauer, W; Wöhrer, S, 2003) |
| "To evaluate the effect of epirubicin on therapeutic response and survival in patients with indolent nonfollicular B-cell lymphomas (INFL) treated with pulsed high-dose chlorambucil." | 5.10 | Treatment of indolent B-Cell nonfollicular lymphomas: final results of the LL01 randomized trial of the Gruppo Italiano per lo Studio dei Linfomi. ( Baldini, L; Brugiatelli, M; Cavanna, L; Colombi, M; Federico, M; Gobbi, P; Goldaniga, M; Liberati, M; Lombardo, M; Luminari, S; Merli, F; Morabito, F; Sacchi, S; Silingardi, V; Stelitano, C, 2003) |
| "We investigated the toxicity and efficacy of the chimaeric anti-CD20 antibody rituximab in combination with standard-dose chlorambucil in newly diagnosed and relapsed/refractory indolent B-cell lymphoma patients." | 5.10 | Chlorambucil in combination with induction and maintenance rituximab is feasible and active in indolent non-Hodgkin's lymphoma. ( Bertolini, F; Calleri, A; Cavalli, F; Laszlo, D; Mancuso, P; Martinelli, G; Pastano, R; Santoro, P; Vanazzi, A; Zucca, E, 2003) |
| "The biology of follicular lymphoma evidently includes the potential for tumor dormancy after therapies with varied mechanisms of action, resulting in clinical inactivity for many years." | 2.69 | Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone. ( Czerwinski, DK; Davis, TA; Levy, R; Liles, TM; Maloney, DG, 1998) |
| "Disease progression was significantly more frequent in patients presenting an immunological event or an M component." | 2.41 | Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients. ( Arcache, J; Arnaud, P; Berger, F; Callet-Bauchu, E; Coiffier, B; Dumontet, C; Felman, P; Hequet, O; Salles, G; Thieblemont, C, 2002) |
| "Patients with histologically verified MALT lymphoma undergoing chemotherapy with MCP were evaluated retrospectively." | 1.32 | Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with mitoxantrone, chlorambucil and prednisone (MCP). ( Chott, A; Dirisamer, A; Drach, J; Hejna, M; Püspök, A; Raderer, M; Scheithauer, W; Wöhrer, S, 2003) |
| " One exception might be CBCC patients who were younger (median age 56 years) and who were usually in good general condition so that they might qualify for high dosage chemotherapy and stem cell support." | 1.30 | Outcome of patients with low-grade B cell non-Hodgkin lymphoma and initial bone marrow involvement: data of a single institution. ( Heinz, R; Hopfinger, G; Tüchler, H, 1997) |
| "Cladribine is a purine analog with impressive activity in patients with low-grade lymphoproliferative disorders." | 1.30 | Cytotoxicity of 2-chlorodeoxadenosine (cladribine, 2-cdA) in combination with other chemotherapy drugs against two lymphoma cell lines. ( Hoffman, M; Lesser, M; Rai, K; Xu, JC, 1999) |
| "Nephrotic syndrome was observed in nine patients." | 1.28 | Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas. ( Fillastre, JP; Francois, A; Mignon, F; Mougenot, B; Moulin, B; Ronco, PM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (43.75) | 18.2507 |
| 2000's | 15 (46.88) | 29.6817 |
| 2010's | 3 (9.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vidal, L | 1 |
| Gurion, R | 1 |
| Shargian, L | 1 |
| Dreyling, M | 1 |
| Gafter-Gvili, A | 1 |
| Mezzaroba, N | 1 |
| Zorzet, S | 1 |
| Secco, E | 1 |
| Biffi, S | 1 |
| Tripodo, C | 1 |
| Calvaruso, M | 1 |
| Mendoza-Maldonado, R | 1 |
| Capolla, S | 1 |
| Granzotto, M | 1 |
| Spretz, R | 1 |
| Larsen, G | 1 |
| Noriega, S | 1 |
| Lucafò, M | 1 |
| Mansilla, E | 1 |
| Garrovo, C | 1 |
| Marín, GH | 1 |
| Baj, G | 1 |
| Gattei, V | 1 |
| Pozzato, G | 1 |
| Núñez, L | 1 |
| Macor, P | 1 |
| Lepretre, S | 1 |
| Dartigeas, C | 1 |
| Feugier, P | 1 |
| Marty, M | 1 |
| Salles, G | 2 |
| Rivera, S | 1 |
| McClearen, JR | 1 |
| Reavill, DR | 1 |
| Thieblemont, C | 1 |
| Felman, P | 1 |
| Berger, F | 1 |
| Dumontet, C | 1 |
| Arnaud, P | 1 |
| Hequet, O | 1 |
| Arcache, J | 1 |
| Callet-Bauchu, E | 1 |
| Coiffier, B | 1 |
| Cavard, A | 1 |
| Lidove, O | 1 |
| Aflak, F | 1 |
| Drupt, F | 1 |
| Goldenberg, P | 1 |
| Baglin, AC | 1 |
| Taksin, AL | 1 |
| Malek-Chehire, N | 1 |
| Wasserman, MR | 1 |
| Terré, C | 1 |
| Blétry, O | 1 |
| Baldini, L | 1 |
| Brugiatelli, M | 1 |
| Luminari, S | 1 |
| Lombardo, M | 1 |
| Merli, F | 1 |
| Sacchi, S | 1 |
| Gobbi, P | 1 |
| Liberati, M | 1 |
| Cavanna, L | 1 |
| Colombi, M | 1 |
| Stelitano, C | 1 |
| Goldaniga, M | 1 |
| Morabito, F | 1 |
| Federico, M | 1 |
| Silingardi, V | 1 |
| Martinelli, G | 1 |
| Laszlo, D | 1 |
| Bertolini, F | 1 |
| Pastano, R | 1 |
| Mancuso, P | 1 |
| Calleri, A | 1 |
| Vanazzi, A | 1 |
| Santoro, P | 1 |
| Cavalli, F | 1 |
| Zucca, E | 1 |
| Ibom, VK | 1 |
| Prosnitz, RG | 1 |
| Gong, JZ | 1 |
| Moore, JO | 1 |
| DeCastro, CM | 1 |
| Prosnitz, LR | 1 |
| Rizzieri, DA | 1 |
| Gockerman, JP | 1 |
| Wöhrer, S | 1 |
| Drach, J | 1 |
| Hejna, M | 1 |
| Scheithauer, W | 1 |
| Dirisamer, A | 1 |
| Püspök, A | 1 |
| Chott, A | 1 |
| Raderer, M | 1 |
| Stanway, A | 1 |
| Rademaker, M | 1 |
| Kennedy, I | 1 |
| Newman, P | 1 |
| Takács, I | 1 |
| Tordai, L | 1 |
| Eros, N | 1 |
| Mórocz, I | 1 |
| Bozsó, F | 1 |
| Károlyi, Z | 1 |
| Radványi, G | 1 |
| Matolcsy, A | 1 |
| Robak, E | 1 |
| Jesionek-Kupnicka, D | 1 |
| Robak, T | 1 |
| Holub, A | 1 |
| Wawrzyniak, E | 1 |
| Bartkowiak, J | 1 |
| Bednarek, A | 1 |
| Constantinu, M | 1 |
| Urbanska-Rys, H | 1 |
| Wells, P | 1 |
| Wotherspoon, A | 1 |
| Burnet, NG | 1 |
| Tobias, JS | 1 |
| Vigushin, DM | 1 |
| Hawkins, PN | 1 |
| Hsuan, JJ | 1 |
| Totty, NF | 1 |
| Pepys, MB | 1 |
| D'Amore, F | 1 |
| Christensen, BE | 1 |
| Thorling, K | 1 |
| Pedersen, M | 1 |
| Jensen, MK | 1 |
| Boesen, AM | 1 |
| Andersen, E | 1 |
| Johansen, P | 1 |
| Mortensen, LS | 1 |
| Falk, S | 1 |
| Walther, F | 1 |
| Denk, R | 1 |
| Walker, A | 1 |
| Taylor, ST | 1 |
| Hickman, JA | 1 |
| Dive, C | 1 |
| Heinz, R | 1 |
| Hopfinger, G | 1 |
| Tüchler, H | 1 |
| Piatelli, A | 1 |
| Croce, A | 1 |
| Tete, S | 1 |
| Artese, L | 1 |
| Khan, MA | 1 |
| Hellawell, GO | 1 |
| Nargund, VH | 1 |
| Davis, TA | 1 |
| Maloney, DG | 2 |
| Czerwinski, DK | 2 |
| Liles, TM | 2 |
| Levy, R | 2 |
| Hoffman, M | 1 |
| Xu, JC | 1 |
| Lesser, M | 1 |
| Rai, K | 1 |
| Lefrère, F | 1 |
| Hermine, O | 1 |
| Belanger, C | 1 |
| François, S | 1 |
| Tilly, H | 1 |
| Lebas de La Cour, JC | 1 |
| Valensi, F | 1 |
| Varet, B | 1 |
| Troussard, X | 1 |
| Várkonyi, J | 1 |
| Zalatnai, A | 1 |
| Timár, J | 1 |
| Matolcsi, A | 1 |
| Falus, A | 1 |
| Bencsáth, M | 1 |
| László, V | 1 |
| Pócsik, E | 1 |
| Kotlán, B | 1 |
| Császár, A | 1 |
| Pichon, N | 1 |
| Debette-Gratien, M | 1 |
| Cessot, F | 1 |
| Paraf, F | 1 |
| Labrousse, F | 1 |
| Sautereau, D | 1 |
| Pillegand, B | 1 |
| Morcos, F | 1 |
| Smith, E | 1 |
| Siemens, HJ | 1 |
| Gerke, P | 1 |
| Steinhoff, J | 1 |
| Roth-Isigkeit, A | 1 |
| Wagner, K | 1 |
| Brückner, S | 1 |
| Brown, S | 1 |
| Hart, SM | 1 |
| Miller, RA | 1 |
| Moulin, B | 1 |
| Ronco, PM | 1 |
| Mougenot, B | 1 |
| Francois, A | 1 |
| Fillastre, JP | 1 |
| Mignon, F | 1 |
| Mayou, SC | 1 |
| Cotter, FE | 1 |
| Norton, AJ | 1 |
| Davies, CL | 1 |
| Munro, DD | 1 |
| Williams, RE | 1 |
| Seywright, MM | 1 |
| Lever, R | 1 |
| Lucie, NP | 1 |
4 reviews available for chlorambucil and B-Cell Lymphoma
| Article | Year |
|---|---|
Bendamustine for patients with indolent B cell lymphoproliferative malignancies including chronic lymphocytic leukaemia - an updated meta-analysis.
Topics: Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bendamustine Hydrochloride; Chlorambu | 2019 |
Systematic review of the recent evidence for the efficacy and safety of chlorambucil in the treatment of B-cell malignancies.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dru | 2016 |
Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combin | 2002 |
[Metastatic malignant melanoma in treated non-Hodgkin's lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Humans; Lymph Nodes; Lymphatic | 1996 |
5 trials available for chlorambucil and B-Cell Lymphoma
| Article | Year |
|---|---|
Treatment of indolent B-Cell nonfollicular lymphomas: final results of the LL01 randomized trial of the Gruppo Italiano per lo Studio dei Linfomi.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Disease-Free Survival; Dr | 2003 |
Chlorambucil in combination with induction and maintenance rituximab is feasible and active in indolent non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined | 2003 |
Incidence, presenting features and prognosis of low-grade B-cell non-Hodgkin's lymphomas. Population-based data from a Danish lymphoma registry.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Chloram | 1993 |
Anti-idiotype antibodies can induce long-term complete remissions in non-Hodgkin's lymphoma without eradicating the malignant clone.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antibodies, Neoplasm; Antineoplastic Ag | 1998 |
Monoclonal anti-idiotype antibody therapy of B-cell lymphoma: the addition of a short course of chemotherapy does not interfere with the antitumor effect nor prevent the emergence of idiotype-negative variant cells.
Topics: Adult; Antibodies, Monoclonal; Biopsy; Chlorambucil; Female; G2 Phase; Humans; Immunoglobulin Idioty | 1992 |
23 other studies available for chlorambucil and B-Cell Lymphoma
| Article | Year |
|---|---|
New potential therapeutic approach for the treatment of B-Cell malignancies using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles.
Topics: Animals; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Apoptosis; Autophagy; Cell Survival | 2013 |
Treatment of nonepitheliotropic cutaneous B-cell lymphoma in an umbrella cockatoo (Cacatua alba).
Topics: Animals; Antineoplastic Agents; Bird Diseases; Chlorambucil; Cockatoos; Female; Lymphoma, B-Cell; Sk | 2009 |
[IgG-secreting lymphoplasmocytoid leukemia revealed by ophthalmologic hyperviscosity symptoms].
Topics: Aged; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Blood Viscosity; Chloram | 2002 |
Rituximab in lymphocyte predominance Hodgkin's disease: a case series.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; A | 2003 |
Treatment of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with mitoxantrone, chlorambucil and prednisone (MCP).
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dis | 2003 |
Cutaneous B-cell lymphoma of nails, pinna and nose treated with chlorambucil.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Ear Neoplasms; Ear, Extern | 2004 |
[Diagnosis, care, and therapeutic possibilities in intravascular B-cell lymphoma--a case report].
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemot | 2005 |
Primary cutaneous marginal zone B-cell lymphoma in a patient with chronic lymphocytic leukaemia.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosome Deletion; Chromosomes | 2007 |
Cutaneous B-cell lymphoma with subsequent laryngeal involvement.
Topics: Aged; Chlorambucil; Humans; Laryngeal Neoplasms; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Radi | 1995 |
AL kappa amyloid in a solitary extradural lymphoma.
Topics: Aged; Amino Acid Sequence; Amyloid; Chlorambucil; Combined Modality Therapy; Craniotomy; Dysarthria; | 1994 |
Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; bcl-X Protein; CD40 Antigens; Chlorambucil; Clone Cell | 1997 |
Outcome of patients with low-grade B cell non-Hodgkin lymphoma and initial bone marrow involvement: data of a single institution.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chlorambucil; Cyclophosphamide; Doxorub | 1997 |
Primary non-Hodgkin's lymphoma of the mandible: a case report.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Cell Nucleolus; Cell Nucleus; Chlorambuc | 1997 |
Ureteric obstruction due to B-cell lymphoma.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Ma | 1997 |
Cytotoxicity of 2-chlorodeoxadenosine (cladribine, 2-cdA) in combination with other chemotherapy drugs against two lymphoma cell lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Chlorambucil; | 1999 |
Fludarabine: an effective treatment in patients with splenic lymphoma with villous lymphocytes.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Comb | 2000 |
Secondary cutaneous infiltration in B cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Doxorubicin; Histidi | 2000 |
[Acute cholestatic hepatitis due to chlorambucil].
Topics: Acute Disease; Aged; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chemical and Drug Induced Li | 2001 |
Sciatica or spinal lymphoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Chlorambucil; Diagnosis, Differential; Humans; Lymphoma, B- | 2002 |
A prolonged APTT in a patient with a low grade malignant NHL - a case report.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Blood Coagulation Factors; C | 2002 |
Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas.
Topics: Adult; Aged; Aged, 80 and over; B-Lymphocytes; Chlorambucil; Female; Glomerulonephritis; Glomerulone | 1992 |
A cutaneous B-cell lymphoma of novel immunophenotype.
Topics: Adult; Blotting, Southern; Chlorambucil; Female; Humans; Immunophenotyping; Lymphocytes; Lymphoma, B | 1991 |
Angiotropic B-cell lymphoma (malignant angioendotheliomatosis): failure of systemic chemotherapy.
Topics: Aged; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; F | 1990 |