chlorambucil has been researched along with B-Cell Leukemia in 6 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renewed interest in chronic lymphocytic leukemia (CLL) has led to an unprecedented number of investigators contributing to all aspects of research in this disease." | 6.41 | Pentostatin (Nipent) and chlorambucil with granulocyte-macrophage colony-stimulating factor support for patients with previously untreated, treated, and fludarabine-refractory B-cell chronic lymphocytic leukemia. ( Beer, M; Byrd, JC; Grever, MR; Lucas, MA; Waselenko, JK, 2000) |
| "Renewed interest in chronic lymphocytic leukemia (CLL) has led to an unprecedented number of investigators contributing to all aspects of research in this disease." | 2.41 | Pentostatin (Nipent) and chlorambucil with granulocyte-macrophage colony-stimulating factor support for patients with previously untreated, treated, and fludarabine-refractory B-cell chronic lymphocytic leukemia. ( Beer, M; Byrd, JC; Grever, MR; Lucas, MA; Waselenko, JK, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lepretre, S | 1 |
| Dartigeas, C | 1 |
| Feugier, P | 1 |
| Marty, M | 1 |
| Salles, G | 1 |
| Waselenko, JK | 1 |
| Grever, MR | 1 |
| Beer, M | 1 |
| Lucas, MA | 1 |
| Byrd, JC | 1 |
| Bello, VE | 1 |
| Aloyz, RS | 1 |
| Christodoulopoulos, G | 1 |
| Panasci, LC | 1 |
| Lennon, SV | 1 |
| Martin, SJ | 1 |
| Cotter, TG | 1 |
| Burger, T | 1 |
| Molnár, L | 1 |
| Schmelzer, M | 1 |
| Tóvari, E | 1 |
| Szabó, A | 1 |
| Paál, M | 1 |
| Királyfalvi, L | 1 |
| Jaksić, B | 1 |
| Brugiatelli, M | 1 |
3 reviews available for chlorambucil and B-Cell Leukemia
| Article | Year |
|---|---|
Systematic review of the recent evidence for the efficacy and safety of chlorambucil in the treatment of B-cell malignancies.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Dru | 2016 |
Pentostatin (Nipent) and chlorambucil with granulocyte-macrophage colony-stimulating factor support for patients with previously untreated, treated, and fludarabine-refractory B-cell chronic lymphocytic leukemia.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplasti | 2000 |
[Changes in T lymphocyte subgroups and their effect in chronic B-lymphoid leukemia].
Topics: Chlorambucil; Humans; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; T-Lymphocytes | 1988 |
1 trial available for chlorambucil and B-Cell Leukemia
| Article | Year |
|---|---|
High dose continuous chlorambucil vs intermittent chlorambucil plus prednisone for treatment of B-CLL--IGCI CLL-01 trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Clinical Trials as Topic; Drug Adminis | 1988 |
2 other studies available for chlorambucil and B-Cell Leukemia
| Article | Year |
|---|---|
Homologous recombinational repair vis-à-vis chlorambucil resistance in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents, Alkylating; Cell Division; Chlorambucil; Chronic Disease; DNA Repair; DNA-Bin | 2002 |
Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli.
Topics: Calcium; Cell Membrane Permeability; Cell Survival; Chlorambucil; DNA Damage; Ethanol; Hot Temperatu | 1991 |