chlorambucil has been researched along with Autoimmune Disease in 34 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Disease progression was significantly more frequent in patients presenting an immunological event or an M component." | 2.41 | Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients. ( Arcache, J; Arnaud, P; Berger, F; Callet-Bauchu, E; Coiffier, B; Dumontet, C; Felman, P; Hequet, O; Salles, G; Thieblemont, C, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (73.53) | 18.7374 |
| 1990's | 5 (14.71) | 18.2507 |
| 2000's | 3 (8.82) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smolej, L | 1 |
| Belada, D | 1 |
| Cermanová, M | 1 |
| Maisnar, V | 1 |
| Lunáková, E | 1 |
| Thieblemont, C | 1 |
| Felman, P | 1 |
| Berger, F | 1 |
| Dumontet, C | 1 |
| Arnaud, P | 1 |
| Hequet, O | 1 |
| Arcache, J | 1 |
| Callet-Bauchu, E | 1 |
| Salles, G | 1 |
| Coiffier, B | 1 |
| HOTCHIN, J | 1 |
| THOMSON, JD | 1 |
| AUSTIN, RW | 1 |
| STREETMAN, RP | 1 |
| DAMESHEK, W | 1 |
| Jójárt, G | 1 |
| Záborszky, B | 1 |
| Szondy, E | 1 |
| Horváth, M | 1 |
| Hegedüs, I | 1 |
| Goerz, G | 1 |
| Merk, H | 1 |
| O'Brien, S | 1 |
| del Giglio, A | 1 |
| Keating, M | 1 |
| Antich Rojas, J | 1 |
| Balaguer, H | 1 |
| Cladera, A | 1 |
| Hall, RL | 1 |
| Leahy, MF | 1 |
| Sirianni, MC | 1 |
| Barbone, B | 1 |
| Monarca, B | 1 |
| Nanni, M | 1 |
| Laganà, B | 1 |
| Aiuti, F | 1 |
| Ruszczak, Z | 1 |
| Sönnichsen, N | 1 |
| Alberecht-Nebe, H | 1 |
| Schulze, P | 1 |
| Apostoloff, E | 1 |
| Cazalis, P | 1 |
| Caroit, M | 1 |
| Zittoun, R | 1 |
| Kahn, MF | 2 |
| Sèze, S | 1 |
| Kuntzer, T | 1 |
| Steck, AJ | 1 |
| Adams, D | 1 |
| Regli, F | 1 |
| Counihan, TJ | 1 |
| Feighery, C | 1 |
| Areal Méndez, C | 1 |
| Lite Alvarez, JM | 1 |
| Sánchez Varela, JM | 1 |
| Shpilberg, O | 1 |
| Ehrenfeld, M | 1 |
| Berkovitz, M | 1 |
| Maier, MK | 1 |
| Samra, Y | 1 |
| Seitzer, B | 1 |
| Spieker, C | 1 |
| Zidek, W | 1 |
| Vetter, H | 1 |
| Ferreiro, JE | 1 |
| Pasarin, G | 1 |
| Quesada, R | 1 |
| Gould, E | 1 |
| Warnes, TW | 1 |
| Stacher, A | 1 |
| Oken, MM | 1 |
| Griffiths, RW | 1 |
| Williams, RC | 1 |
| Reimann, BE | 1 |
| Delespesse, G | 2 |
| Kennes, B | 2 |
| Duchateau, J | 2 |
| Barnett, EV | 1 |
| Bluestone, R | 1 |
| Cracchiolo, A | 1 |
| Goldberg, LS | 1 |
| Kantor, GL | 1 |
| McIntosh, RM | 1 |
| Venenson, EV | 1 |
| Druet, P | 1 |
| Dryll, A | 1 |
| Ryckewaert, A | 1 |
| de Sèze, S | 1 |
| Currey, HL | 1 |
| Le Goff, P | 1 |
| Le Menn, G | 1 |
| Kaplan, SR | 1 |
| Calabresi, P | 1 |
| Petrányi, G | 1 |
| Leövey, A | 1 |
| Szegedi, G | 1 |
| Kakuk, G | 1 |
| Bobory, J | 1 |
| Cattan, D | 1 |
| Caen, J | 1 |
| Fernandez, Y | 1 |
| Izard, J | 1 |
| Leclere, H | 1 |
| Tanguy, A | 1 |
| Lemenager, J | 1 |
| Orlowski, Z | 1 |
| Jedrzejewska, T | 1 |
9 reviews available for chlorambucil and Autoimmune Disease
| Article | Year |
|---|---|
Treatment of splenic marginal zone B-cell lymphoma: an analysis of 81 patients.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combin | 2002 |
Advances in the biology and treatment of B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; Bone Marrow Transplantation; Ch | 1995 |
[Treatment of autoimmune skin diseases].
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cyclophosphamide; Drug The | 1975 |
[Immunosuppressive therapy in auto-immune diseases i. general fundamentals (author's transl)].
Topics: Antigen-Antibody Reactions; Autoimmune Diseases; Azathioprine; B-Lymphocytes; Chlorambucil; Cyclopho | 1978 |
Immunosuppressive therapy in autoimmune disease--a review.
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclospo | 1991 |
Treatment of primary biliary cirrhosis.
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cholelithiasis; Colchicine | 1985 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
Immunosuppressive drugs in rheumatoid arthritis.
Topics: Adrenocorticotropic Hormone; Aminopterin; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmun | 1971 |
Drug therapy. Immunosuppressive agents. I.
Topics: Adrenal Cortex Hormones; Adult; Alkylating Agents; Antimetabolites; Arthritis, Rheumatoid; Autoimmun | 1973 |
1 trial available for chlorambucil and Autoimmune Disease
| Article | Year |
|---|---|
Immunosuppressive drugs in rheumatoid arthritis.
Topics: Adrenocorticotropic Hormone; Aminopterin; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoimmun | 1971 |
25 other studies available for chlorambucil and Autoimmune Disease
| Article | Year |
|---|---|
Severe anemia caused by combination of autoimmune hemolysis, pure red cell aplasia and massive bone marrow infiltration in an elderly patient with chronic lymphocytic leukemia: successful treatment with rituximab.
Topics: Aged; Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplas | 2010 |
The biology of lymphocytic choriomeningitis infection: virus-induced immune disease.
Topics: Autoimmune Diseases; Biology; Chlorambucil; Endotoxins; Immune System Diseases; Lymphocytic Choriome | 1962 |
The influence of chlorambucil on experimental allergic encephalomyelitis.
Topics: Animals; Autoimmune Diseases; Chlorambucil; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experi | 1963 |
[THOUGHTS ON LUPUS ERYTHEMATOSUS].
Topics: Adrenal Cortex Hormones; Allergy and Immunology; Antimalarials; Autoimmune Diseases; Chlorambucil; D | 1964 |
Primary aortitis in childhood.
Topics: Antibody Formation; Aortitis; Aortography; Autoimmune Diseases; Cell Migration Inhibition; Child, Pr | 1983 |
[Medicamental immunosuppression in dermatology (author's transl)].
Topics: Autoimmune Diseases; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Glucocorticoid | 1981 |
[Selective aplasia of the red-cell series after fludarabine administration in a patient with chronic B-cell lymphatic leukemia].
Topics: Anemia, Hemolytic, Autoimmune; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 1997 |
Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Azathiop | 2001 |
A case of Behćet's disease complicated by visceral Leishmaniasis and myelodysplasia: clinical considerations.
Topics: Adult; Antineoplastic Agents, Alkylating; Autoimmune Diseases; Behcet Syndrome; Chlorambucil; Humans | 2001 |
[A particular risk of prolonged immunosuppressive treatment: a case of acute myelomonocytic leukemia after chlorambucil treatment of severe rheumatoid arhtritis].
Topics: Adult; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Carcinogens; Chlorambucil; | 1976 |
Chlorambucil fails to improve patients with motor neuropathies and antibodies to gangliosides.
Topics: Adult; Aged; Autoantibodies; Autoimmune Diseases; Chlorambucil; Female; G(M1) Ganglioside; Humans; M | 1992 |
[Cyclosporin A in the treatment of acquired erythroblastopenia in the course of B-cell chronic lymphatic leukemia].
Topics: Autoimmune Diseases; Chlorambucil; Combined Modality Therapy; Cyclophosphamide; Cyclosporine; Humans | 1991 |
Hairy cell leukemia with an autoimmune syndrome, paraproteinemia, and cryoglobulinemia.
Topics: Aged; Aged, 80 and over; Autoimmune Diseases; Chlorambucil; Cryoglobulinemia; Humans; Immunoglobulin | 1989 |
[Muscle weakness, polyneuropathy].
Topics: Autoimmune Diseases; Chlorambucil; Humans; Immunoglobulin M; Male; Middle Aged; Muscle Hypotonia; Pa | 1987 |
Benign hypergammaglobulinemic purpura of Waldenström associated with Sjögren's syndrome. Case report and review of immunologic aspects.
Topics: Adult; Autoimmune Diseases; Chlorambucil; Female; Humans; Purpura, Hyperglobulinemic; Sjogren's Synd | 1986 |
[Immunosuppressive therapy in hematology].
Topics: Adrenal Cortex Hormones; Adult; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Myelophthis | 1972 |
Possible NZB syndrome in man.
Topics: Adult; Agglutinins; Anemia, Hemolytic; Antibodies, Antinuclear; Autoimmune Diseases; Blood Protein E | 1973 |
Cryoglobulinemia and disease.
Topics: Adult; Anemia, Hemolytic; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Beta-Globulins | 1970 |
[Mechanism of action of cytostatic agents in rheumatoid arthritis].
Topics: Adult; Antibodies; Antineoplastic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Chlorambucil; | 1974 |
[Rheumatoid polyarthritis and chronic lymphoid leukemia. Studies of 7 cases of association of these 2 diseases].
Topics: Adult; Age Factors; Aged; Animals; Antibodies; Arthritis, Rheumatoid; Autoimmune Diseases; Chlorambu | 1969 |
[Cancer and immunosuppressive treatment. Apropos of 2 cases].
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Brain Neoplasms; Carcinoma, Squamous Cell; Chlorambucil; | 1974 |
[Autoimmune diseases and immunosuppressive therapy. I. Immunosuppressive agents].
Topics: Adrenal Cortex Hormones; Autoimmune Diseases; Azathioprine; Chlorambucil; Cyclophosphamide; Female; | 1974 |
Therapy of autoimmune nephropathy with steroids and cytostatics. A follow-up study of 80 patients and of 16 years.
Topics: Adolescent; Adult; Aged; Antimalarials; Autoimmune Diseases; Azathioprine; Chlorambucil; Cyclophosph | 1971 |
[Chronic thrombopenic purpura. Hyperthyroidism, pretibial myxedema and L.A.T.S].
Topics: Autoimmune Diseases; Azathioprine; Chlorambucil; Chronic Disease; Exophthalmos; Female; Glucocortico | 1970 |
[Immunosuppression in Sjogren's syndrome with a pseudo-leukemic lymphocyte reaction].
Topics: Adult; Autoimmune Diseases; Chlorambucil; Female; Humans; Immunosuppressive Agents; Prednisone; Sjog | 1970 |