chlorambucil has been researched along with Arthritis, Juvenile in 27 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Arthritis, Juvenile: Arthritis in children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil was found to be a very potent drug for JCA with acceptable short term, but serious longterm side effects." | 6.69 | Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis. ( Savolainen, HA, 1999) |
| " Renal biopsy confirmed the diagnosis of amyloidosis, and chlorambucil was initiated, with general improvement of the disease and reduction of proteinuria." | 3.73 | Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis. ( Correia, AJ; Duarte, C; Gomes, C; Salgado, M, 2006) |
| "Chlorambucil was found to be a very potent drug for JCA with acceptable short term, but serious longterm side effects." | 2.69 | Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis. ( Savolainen, HA, 1999) |
| "Juvenile idiopathic arthritis was diagnosed and kidney biopsy examination showed mesangial glomerulonephritis with immunoglobulin M deposits." | 1.39 | Nephrotic syndrome due to immunoglobulin M mesangial glomerulonephritis preceding juvenile idiopathic arthritis. ( Alvarado, C; Balestracci, A; Cuttica, RJ; Lago, N; Voyer, LE; Zardini, M, 2013) |
| "Thirty-four children with juvenile rheumatoid arthritis were studied for surrogate markers of increased nitric oxide (NO) production by spectrophotometry." | 1.32 | Comparison of serum nitric oxide levels in active juvenile rheumatoid arthritis with those of patients in remission. ( Beri, A; Gupta, A; Khullar, M; Singh, S, 2004) |
| "Chlorambucil treatment was helpful in patients with amyloidosis and in those patients in whom all other drugs had failed." | 1.27 | Slow-acting antirheumatic drug use in systemic onset juvenile chronic arthritis. ( Ansell, BM; Manners, PJ, 1986) |
| "Thirty five patients with juvenile chronic arthritis who had not been treated with cytotoxic drugs served as controls." | 1.27 | Chlorambucil induced chromosome damage in juvenile chronic arthritis. ( Ansell, BM; Denman, AM; Doré, CJ; Palmer, RG; Varonos, S, 1985) |
| "Proteinuria is the most frequent sign in the early stage of the amyloidosis." | 1.26 | [Amyloidosis-a dreaded complication of juvenile chronic arthritis (JCA). (author's transl)]. ( Michels, H; Renaud, M; Renz, K; Schuchmann, L, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (70.37) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voyer, LE | 1 |
| Alvarado, C | 1 |
| Cuttica, RJ | 1 |
| Balestracci, A | 1 |
| Zardini, M | 1 |
| Lago, N | 1 |
| Beri, A | 1 |
| Singh, S | 1 |
| Gupta, A | 1 |
| Khullar, M | 1 |
| Duarte, C | 1 |
| Gomes, C | 1 |
| Correia, AJ | 1 |
| Salgado, M | 1 |
| Laplane, R | 1 |
| Bonnet-Gajdos, M | 1 |
| Gadot, J | 1 |
| Renier, JC | 1 |
| Deshayes, P | 1 |
| Besson, J | 1 |
| Barazer, C | 1 |
| Delahaye, D | 1 |
| Bregeon, C | 1 |
| Lebranchu, Y | 2 |
| Drucker, J | 1 |
| Nivet, H | 1 |
| Rolland, JC | 1 |
| Grenier, B | 1 |
| Lejars, O | 1 |
| Lamagnere, JP | 1 |
| Buriot, D | 2 |
| Dorlon, RE | 1 |
| Bailey, JP | 1 |
| Schuchmann, L | 1 |
| Michels, H | 1 |
| Renaud, M | 1 |
| Renz, K | 1 |
| Dolgopolova, AV | 1 |
| Melikhova, NI | 1 |
| Kauppi, MJ | 1 |
| Savolainen, HA | 2 |
| Anttila, VJ | 1 |
| Isomäki, HA | 1 |
| Ansell, BM | 7 |
| Rossor, E | 1 |
| Schnitzer, TJ | 1 |
| Prieur, AM | 3 |
| Balafrej, M | 1 |
| Griscelli, C | 2 |
| Mozziconacci, P | 1 |
| Messerschmitt, J | 1 |
| Nasseh, GA | 1 |
| Bywaters, EG | 2 |
| Shakhbazian, IE | 1 |
| Ulybina, OV | 1 |
| Sarsembaeva, RT | 1 |
| Sushkova, NI | 1 |
| Rozvadovskaia, OS | 1 |
| Katargina, LA | 1 |
| Deschênes, G | 1 |
| Hayem, F | 1 |
| Broyer, M | 1 |
| Gubler, MC | 1 |
| Manners, PJ | 1 |
| Sukenik, S | 1 |
| Buskila, D | 1 |
| Horowitz, I | 1 |
| Maroko, I | 1 |
| Palmer, RG | 2 |
| Varonos, S | 1 |
| Doré, CJ | 1 |
| Denman, AM | 2 |
| Kanski, JJ | 1 |
| Denman, EJ | 1 |
| Greenwood, BM | 1 |
| Gall, D | 1 |
| Heath, RB | 1 |
| Iakovleva, AA | 1 |
| Fokina, TV | 1 |
| Shkarenkova, LV | 1 |
| Maggioni, G | 1 |
| Eghtedari, A | 1 |
1 review available for chlorambucil and Arthritis, Juvenile
| Article | Year |
|---|---|
Chlorambucil therapy in juvenile chronic arthritis (juvenile idiopathic arthritis)
Topics: Arthritis, Juvenile; Child; Chlorambucil; Humans | 1999 |
2 trials available for chlorambucil and Arthritis, Juvenile
| Article | Year |
|---|---|
Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis.
Topics: Adolescent; Amyloidosis; Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Child; Child, Presc | 1999 |
[Use of chlorbutin in the complex treatment of systemic forms of juvenile rheumatoid arthritis].
Topics: Adolescent; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Cl | 1990 |
24 other studies available for chlorambucil and Arthritis, Juvenile
| Article | Year |
|---|---|
Nephrotic syndrome due to immunoglobulin M mesangial glomerulonephritis preceding juvenile idiopathic arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Biopsy; Child, Preschool; Chlorambucil; Glomeruloneph | 2013 |
Comparison of serum nitric oxide levels in active juvenile rheumatoid arthritis with those of patients in remission.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Bio | 2004 |
Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis.
Topics: Age of Onset; Amyloidosis; Arthritis, Juvenile; Child; Chlorambucil; Female; Humans; Kidney; Protein | 2006 |
[Problems posed by the indications and conduct of treatment in rheumatoid polyarthritis in children].
Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Chlorambucil; Glucocorticoids; Humans; Immunos | 1967 |
[Treatment of rheumatoid polyarthritis by chlorambucil. Apropos of 48 cases].
Topics: Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Chlorambucil; Female; Humans; M | 1967 |
Acute monoblastic leukaemia in child receiving chlorambucil for juvenile rheumatoid arthritis.
Topics: Arthritis, Juvenile; Chlorambucil; Humans; Infant; Leukemia, Monocytic, Acute; Male | 1980 |
Chlorambucil in the treatment of iridocyclitis in juvenile rheumatoid arthritis.
Topics: Arthritis, Juvenile; Chlorambucil; Humans; Uveitis, Anterior | 1983 |
[Amyloidosis-a dreaded complication of juvenile chronic arthritis (JCA). (author's transl)].
Topics: Adolescent; Amyloidosis; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chronic Disease | 1981 |
[Late observations of children receiving leukeran in rheumatoid arthritis].
Topics: Adolescent; Antineoplastic Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chrom | 1981 |
Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil.
Topics: Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Child, Preschool; Chlorambucil; Female; Huma | 1996 |
Takayasu's arteritis as a differential diagnosis of systemic juvenile chronic arthritis.
Topics: Aortic Arch Syndromes; Aortography; Arthritis, Juvenile; Child; Chlorambucil; Diagnosis, Differentia | 1979 |
Amyloidosis in juvenile chronic polyarthritis.
Topics: Acute Kidney Injury; Adolescent; Adult; Amyloidosis; Arthritis, Juvenile; Child; Child, Preschool; C | 1977 |
[Results and long-term risks of immuno-suppressive treatment in chronic juvenile arthritis. Apropos of 40 cases].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambuc | 1979 |
[Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
Topics: Acute Disease; Alkylating Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromo | 1979 |
Scleroderma in childhood.
Topics: Adolescent; Age Factors; Arthritis, Juvenile; Bone Diseases; Child; Chlorambucil; Diagnosis, Differe | 1976 |
Renal amyloidosis in juvenile chronic arthritis: evolution after chlorambucil treatment.
Topics: Amyloidosis; Arthritis, Juvenile; Biopsy; Chlorambucil; Follow-Up Studies; Humans; Kidney Diseases; | 1990 |
Slow-acting antirheumatic drug use in systemic onset juvenile chronic arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Child; Child, Preschool; Ch | 1986 |
[Renal amylosis and juvenile rheumatoid polyarthritis. Value of chlorambucil].
Topics: Adult; Amyloidosis; Arthritis, Juvenile; Chlorambucil; Humans; Kidney Diseases; Male | 1985 |
Chlorambucil induced chromosome damage in juvenile chronic arthritis.
Topics: Adolescent; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromosome Aberration | 1985 |
Chlorambucil in the treatment of intractable Uveitis associated with juvenile chronic arthritis.
Topics: Adolescent; Arthritis, Juvenile; Bone Marrow; Child; Child, Preschool; Chlorambucil; Female; Herpes | 1985 |
Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antibody Formation; Antigens; Antineoplastic Agents; Arthritis, Juvenile; A | 1970 |
[Experience with use of cytostatic preparations in the complex therapy of rheumatoid arthritis in children].
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Humans; Mercaptopurine | 1972 |
[Therapy of rheumatoid disease in the child].
Topics: Arthritis, Juvenile; Aspirin; Child; Chlorambucil; Diet Therapy; Gold; Humans; Methotrexate; Prednis | 1972 |
Chlorambucil in the management of juvenile chronic polyarthritis complicated by amyloidosis.
Topics: Amyloidosis; Arthritis, Juvenile; Child; Chlorambucil; Humans | 1971 |