chlorambucil has been researched along with Arthritis, Juvenile Chronic in 27 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorambucil was found to be a very potent drug for JCA with acceptable short term, but serious longterm side effects." | 6.69 | Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis. ( Savolainen, HA, 1999) |
| " Renal biopsy confirmed the diagnosis of amyloidosis, and chlorambucil was initiated, with general improvement of the disease and reduction of proteinuria." | 3.73 | Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis. ( Correia, AJ; Duarte, C; Gomes, C; Salgado, M, 2006) |
| "Chlorambucil was found to be a very potent drug for JCA with acceptable short term, but serious longterm side effects." | 2.69 | Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis. ( Savolainen, HA, 1999) |
| "Juvenile idiopathic arthritis was diagnosed and kidney biopsy examination showed mesangial glomerulonephritis with immunoglobulin M deposits." | 1.39 | Nephrotic syndrome due to immunoglobulin M mesangial glomerulonephritis preceding juvenile idiopathic arthritis. ( Alvarado, C; Balestracci, A; Cuttica, RJ; Lago, N; Voyer, LE; Zardini, M, 2013) |
| "Thirty-four children with juvenile rheumatoid arthritis were studied for surrogate markers of increased nitric oxide (NO) production by spectrophotometry." | 1.32 | Comparison of serum nitric oxide levels in active juvenile rheumatoid arthritis with those of patients in remission. ( Beri, A; Gupta, A; Khullar, M; Singh, S, 2004) |
| "Chlorambucil treatment was helpful in patients with amyloidosis and in those patients in whom all other drugs had failed." | 1.27 | Slow-acting antirheumatic drug use in systemic onset juvenile chronic arthritis. ( Ansell, BM; Manners, PJ, 1986) |
| "Thirty five patients with juvenile chronic arthritis who had not been treated with cytotoxic drugs served as controls." | 1.27 | Chlorambucil induced chromosome damage in juvenile chronic arthritis. ( Ansell, BM; Denman, AM; Doré, CJ; Palmer, RG; Varonos, S, 1985) |
| "Proteinuria is the most frequent sign in the early stage of the amyloidosis." | 1.26 | [Amyloidosis-a dreaded complication of juvenile chronic arthritis (JCA). (author's transl)]. ( Michels, H; Renaud, M; Renz, K; Schuchmann, L, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (70.37) | 18.7374 |
| 1990's | 5 (18.52) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voyer, LE | 1 |
| Alvarado, C | 1 |
| Cuttica, RJ | 1 |
| Balestracci, A | 1 |
| Zardini, M | 1 |
| Lago, N | 1 |
| Beri, A | 1 |
| Singh, S | 1 |
| Gupta, A | 1 |
| Khullar, M | 1 |
| Duarte, C | 1 |
| Gomes, C | 1 |
| Correia, AJ | 1 |
| Salgado, M | 1 |
| Laplane, R | 1 |
| Bonnet-Gajdos, M | 1 |
| Gadot, J | 1 |
| Renier, JC | 1 |
| Deshayes, P | 1 |
| Besson, J | 1 |
| Barazer, C | 1 |
| Delahaye, D | 1 |
| Bregeon, C | 1 |
| Lebranchu, Y | 2 |
| Drucker, J | 1 |
| Nivet, H | 1 |
| Rolland, JC | 1 |
| Grenier, B | 1 |
| Lejars, O | 1 |
| Lamagnere, JP | 1 |
| Buriot, D | 2 |
| Dorlon, RE | 1 |
| Bailey, JP | 1 |
| Schuchmann, L | 1 |
| Michels, H | 1 |
| Renaud, M | 1 |
| Renz, K | 1 |
| Dolgopolova, AV | 1 |
| Melikhova, NI | 1 |
| Kauppi, MJ | 1 |
| Savolainen, HA | 2 |
| Anttila, VJ | 1 |
| Isomäki, HA | 1 |
| Ansell, BM | 7 |
| Rossor, E | 1 |
| Schnitzer, TJ | 1 |
| Prieur, AM | 3 |
| Balafrej, M | 1 |
| Griscelli, C | 2 |
| Mozziconacci, P | 1 |
| Messerschmitt, J | 1 |
| Nasseh, GA | 1 |
| Bywaters, EG | 2 |
| Shakhbazian, IE | 1 |
| Ulybina, OV | 1 |
| Sarsembaeva, RT | 1 |
| Sushkova, NI | 1 |
| Rozvadovskaia, OS | 1 |
| Katargina, LA | 1 |
| Deschênes, G | 1 |
| Hayem, F | 1 |
| Broyer, M | 1 |
| Gubler, MC | 1 |
| Manners, PJ | 1 |
| Sukenik, S | 1 |
| Buskila, D | 1 |
| Horowitz, I | 1 |
| Maroko, I | 1 |
| Palmer, RG | 2 |
| Varonos, S | 1 |
| Doré, CJ | 1 |
| Denman, AM | 2 |
| Kanski, JJ | 1 |
| Denman, EJ | 1 |
| Greenwood, BM | 1 |
| Gall, D | 1 |
| Heath, RB | 1 |
| Iakovleva, AA | 1 |
| Fokina, TV | 1 |
| Shkarenkova, LV | 1 |
| Maggioni, G | 1 |
| Eghtedari, A | 1 |
1 review available for chlorambucil and Arthritis, Juvenile Chronic
| Article | Year |
|---|---|
Chlorambucil therapy in juvenile chronic arthritis (juvenile idiopathic arthritis)
Topics: Arthritis, Juvenile; Child; Chlorambucil; Humans | 1999 |
2 trials available for chlorambucil and Arthritis, Juvenile Chronic
| Article | Year |
|---|---|
Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis.
Topics: Adolescent; Amyloidosis; Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Child; Child, Presc | 1999 |
[Use of chlorbutin in the complex treatment of systemic forms of juvenile rheumatoid arthritis].
Topics: Adolescent; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Cl | 1990 |
24 other studies available for chlorambucil and Arthritis, Juvenile Chronic
| Article | Year |
|---|---|
Nephrotic syndrome due to immunoglobulin M mesangial glomerulonephritis preceding juvenile idiopathic arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Biopsy; Child, Preschool; Chlorambucil; Glomeruloneph | 2013 |
Comparison of serum nitric oxide levels in active juvenile rheumatoid arthritis with those of patients in remission.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Bio | 2004 |
Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis.
Topics: Age of Onset; Amyloidosis; Arthritis, Juvenile; Child; Chlorambucil; Female; Humans; Kidney; Protein | 2006 |
[Problems posed by the indications and conduct of treatment in rheumatoid polyarthritis in children].
Topics: Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Chlorambucil; Glucocorticoids; Humans; Immunos | 1967 |
[Treatment of rheumatoid polyarthritis by chlorambucil. Apropos of 48 cases].
Topics: Adolescent; Adult; Aged; Arthritis, Juvenile; Arthritis, Rheumatoid; Chlorambucil; Female; Humans; M | 1967 |
Acute monoblastic leukaemia in child receiving chlorambucil for juvenile rheumatoid arthritis.
Topics: Arthritis, Juvenile; Chlorambucil; Humans; Infant; Leukemia, Monocytic, Acute; Male | 1980 |
Chlorambucil in the treatment of iridocyclitis in juvenile rheumatoid arthritis.
Topics: Arthritis, Juvenile; Chlorambucil; Humans; Uveitis, Anterior | 1983 |
[Amyloidosis-a dreaded complication of juvenile chronic arthritis (JCA). (author's transl)].
Topics: Adolescent; Amyloidosis; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chronic Disease | 1981 |
[Late observations of children receiving leukeran in rheumatoid arthritis].
Topics: Adolescent; Antineoplastic Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chrom | 1981 |
Increased risk of leukaemia in patients with juvenile chronic arthritis treated with chlorambucil.
Topics: Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Child, Preschool; Chlorambucil; Female; Huma | 1996 |
Takayasu's arteritis as a differential diagnosis of systemic juvenile chronic arthritis.
Topics: Aortic Arch Syndromes; Aortography; Arthritis, Juvenile; Child; Chlorambucil; Diagnosis, Differentia | 1979 |
Amyloidosis in juvenile chronic polyarthritis.
Topics: Acute Kidney Injury; Adolescent; Adult; Amyloidosis; Arthritis, Juvenile; Child; Child, Preschool; C | 1977 |
[Results and long-term risks of immuno-suppressive treatment in chronic juvenile arthritis. Apropos of 40 cases].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambuc | 1979 |
[Acute leukemia in 3 children with chronic juvenile arthritis treated with chlorambucil].
Topics: Acute Disease; Alkylating Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromo | 1979 |
Scleroderma in childhood.
Topics: Adolescent; Age Factors; Arthritis, Juvenile; Bone Diseases; Child; Chlorambucil; Diagnosis, Differe | 1976 |
Renal amyloidosis in juvenile chronic arthritis: evolution after chlorambucil treatment.
Topics: Amyloidosis; Arthritis, Juvenile; Biopsy; Chlorambucil; Follow-Up Studies; Humans; Kidney Diseases; | 1990 |
Slow-acting antirheumatic drug use in systemic onset juvenile chronic arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Antimalarials; Arthritis, Juvenile; Child; Child, Preschool; Ch | 1986 |
[Renal amylosis and juvenile rheumatoid polyarthritis. Value of chlorambucil].
Topics: Adult; Amyloidosis; Arthritis, Juvenile; Chlorambucil; Humans; Kidney Diseases; Male | 1985 |
Chlorambucil induced chromosome damage in juvenile chronic arthritis.
Topics: Adolescent; Adult; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chromosome Aberration | 1985 |
Chlorambucil in the treatment of intractable Uveitis associated with juvenile chronic arthritis.
Topics: Adolescent; Arthritis, Juvenile; Bone Marrow; Child; Child, Preschool; Chlorambucil; Female; Herpes | 1985 |
Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antibody Formation; Antigens; Antineoplastic Agents; Arthritis, Juvenile; A | 1970 |
[Experience with use of cytostatic preparations in the complex therapy of rheumatoid arthritis in children].
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Humans; Mercaptopurine | 1972 |
[Therapy of rheumatoid disease in the child].
Topics: Arthritis, Juvenile; Aspirin; Child; Chlorambucil; Diet Therapy; Gold; Humans; Methotrexate; Prednis | 1972 |
Chlorambucil in the management of juvenile chronic polyarthritis complicated by amyloidosis.
Topics: Amyloidosis; Arthritis, Juvenile; Child; Chlorambucil; Humans | 1971 |