chlorambucil has been researched along with Anemia in 30 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with chlorambucil produced complete reversal of hepatosplenomegaly, anemia, neutropenia and lymphocytosis, and reduction of marrow infiltration." | 5.27 | Lymphoproliferative disorder of large granular lymphocytes: reversal of lymphocyte proliferation, anemia and neutropenia with chlorambucil. ( Cazzola, M; Ippoliti, G; Meloni, F; Pedrazzoli, P; Stella, CC, 1987) |
| "Ninety-six patients with advanced chronic lymphocytic leukemia (CLL) (Stage C; anemia and/or thrombocytopenia of nonimmune origin) were randomized to receive either chlorambucil (CLR) (0." | 5.05 | Treatment of chronic lymphocytic leukemia in advanced stages. A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine, and prednisone. ( Alcalá, A; Bueno, J; Domingo, A; Ferrán, C; García-Conde, J; Giralt, M; Montserrat, E; Parody, R; Rubio, D; Sanz, MA, 1985) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Prednisone was common to all three schedules and was given daily in an initial dosage of 0." | 2.64 | Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia. ( Glidewell, O; Rai, KR; Sawitsky, A; Silver, RT, 1977) |
| "Lymphadenopathy, splenomegaly and hepatomegaly were seen in 52 (55%), 63 (66%) and 60 (63%) patients, respectively." | 1.34 | Chronic lymphocytic leukemia in India--a clinico-hematological profile. ( Agrawal, N; Choudhary, VP; Kumar, R; Mahapatra, M; Naithani, R; Panigrahi, I; Pati, HP; Saxena, R, 2007) |
| "Treatment with chlorambucil produced complete reversal of hepatosplenomegaly, anemia, neutropenia and lymphocytosis, and reduction of marrow infiltration." | 1.27 | Lymphoproliferative disorder of large granular lymphocytes: reversal of lymphocyte proliferation, anemia and neutropenia with chlorambucil. ( Cazzola, M; Ippoliti, G; Meloni, F; Pedrazzoli, P; Stella, CC, 1987) |
| "A method of clinical staging of chronic lymphocytic leukemia (CLL) has been proposed which is based on the concept that CLL is a disease of progressive accumulation of nonfunctioning lymphocytes: stage O, bone marrow and blood lymphocytosis only; stage 1, lymphocytosis with enlarged nodes; stage II, lymphocytosis with enlarged spleen or liver or both; stage III, lymphocytosis with anemia; and stage IV:lymphocytosis with thrombocytopenia." | 1.25 | Clinical staging of chronic lymphocytic leukemia. ( Chanana, AD; Cronkite, EP; Levy, RN; Pasternack, BS; Rai, KR; Sawitsky, A, 1975) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (76.67) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 2 (6.67) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sinha, R | 1 |
| Redekop, WK | 1 |
| Bauer, K | 1 |
| Herbst, C | 1 |
| Brillant, C | 1 |
| Monsef, I | 1 |
| Kluge, S | 1 |
| Skoetz, N | 1 |
| Engert, A | 1 |
| WILLIAMS, HM | 1 |
| BURNINGHAM, RA | 1 |
| RESTREPO, A | 1 |
| PUGH, RP | 1 |
| BROWN, EB | 1 |
| SCHLOSSMAN, SF | 1 |
| KHURI, PD | 1 |
| LESSNER, HE | 1 |
| HARRINGTON, WJ | 1 |
| MOLANDER, DW | 1 |
| LADUE, JS | 1 |
| BRODY, JI | 1 |
| BEIZER, LH | 1 |
| Agrawal, N | 1 |
| Naithani, R | 1 |
| Mahapatra, M | 1 |
| Panigrahi, I | 1 |
| Kumar, R | 1 |
| Pati, HP | 1 |
| Saxena, R | 1 |
| Choudhary, VP | 1 |
| Brunner, KW | 1 |
| Alfinito, F | 1 |
| Formisano, S | 1 |
| Rotoli, B | 1 |
| Freedman, ML | 1 |
| Pascual, JF | 1 |
| Molina, M | 1 |
| Lopez, J | 1 |
| Doorduijn, JK | 1 |
| Michiels, JJ | 1 |
| Ponticelli, C | 1 |
| Altieri, P | 1 |
| Scolari, F | 1 |
| Passerini, P | 1 |
| Roccatello, D | 1 |
| Cesana, B | 1 |
| Melis, P | 1 |
| Valzorio, B | 1 |
| Sasdelli, M | 1 |
| Pasquali, S | 1 |
| Pozzi, C | 1 |
| Piccoli, G | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Grassi, C | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Siemens, HJ | 1 |
| Gerke, P | 1 |
| Steinhoff, J | 1 |
| Roth-Isigkeit, A | 1 |
| Wagner, K | 1 |
| Brückner, S | 1 |
| Sawitsky, A | 2 |
| Rai, KR | 2 |
| Glidewell, O | 1 |
| Silver, RT | 1 |
| Cronkite, EP | 1 |
| Chanana, AD | 1 |
| Levy, RN | 1 |
| Pasternack, BS | 1 |
| Thumb, N | 1 |
| Rozman, M | 1 |
| Montserrat, E | 2 |
| Cervantes, F | 1 |
| Bladé, J | 1 |
| Marín, P | 1 |
| Rozman, C | 1 |
| Kelsey, PR | 1 |
| Geary, CG | 1 |
| Pedrazzoli, P | 1 |
| Cazzola, M | 1 |
| Stella, CC | 1 |
| Ippoliti, G | 1 |
| Meloni, F | 1 |
| Alcalá, A | 1 |
| Parody, R | 1 |
| Domingo, A | 1 |
| García-Conde, J | 1 |
| Bueno, J | 1 |
| Ferrán, C | 1 |
| Sanz, MA | 1 |
| Giralt, M | 1 |
| Rubio, D | 1 |
| Buchanan, JG | 1 |
| Scott, PJ | 1 |
| McLachlan, EM | 1 |
| Smith, F | 1 |
| Richmond, DE | 1 |
| North, JD | 1 |
| Obrecht, P | 1 |
| Heilmeyer, L | 1 |
| Ruiz, VG | 1 |
| Alexanian, R | 1 |
| Deshayes, P | 1 |
| Rénier, JC | 1 |
| Bregeon, C | 1 |
| Houdent, G | 1 |
| Kassirskiĭ, IA | 1 |
| Volkova, MA | 1 |
| Lee, SL | 1 |
| Rosner, F | 1 |
| Ruberman, W | 1 |
| Glasberg, S | 1 |
| Larbi, SO | 1 |
| Philp, RB | 1 |
| Gowdey, CW | 1 |
| Norcross, JW | 1 |
| Lévèque, B | 1 |
| Debauchez, C | 1 |
| Deflandre, L | 1 |
| Marie, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| A Phase I Trial of Autologous CLL B Cells Transduced to Express Chimeric CD154 (ISF35)[NCT00779883] | Phase 1 | 9 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| A Phase 1B Extension Trial to Allow Repeat Dosing of Autologous CLL B Cells Transduced to Express Chimeric CD154 (ISF35) in Subjects Previously Treated in MDACC Protocol 2004-0914[NCT00783588] | Phase 1 | 4 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): DNA Microarray Gene Expression Analysis[NCT00001586] | Phase 2 | 105 participants (Actual) | Interventional | 1997-09-30 | Completed | ||
| Phase II Clinical Protocol for the Treatment of Patients With Previously Untreated CLL With Four or Six Cycles of Fludarabine and Cyclophosphamide With Rituximab (FCR) Plus Lenalidomide Followed by Lenalidomide Consolidation/ Maintenance[NCT01723839] | Phase 2 | 21 participants (Actual) | Interventional | 2012-02-22 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Here is the number of participants with adverse events. For the detailed list of adverse events see the adverse event module. (NCT00001586)
Timeframe: 13 years, 10.5 months
| Intervention | Participants (Number) |
|---|---|
| Intermediate-high Risk B-Cell Pts | 18 |
Changes in lymphocyte gene expression was measured by deoxyribonucleic acid (DNA) microarray analysis of circulating leukemic cells after completion of study treatment. A change in expression is defined as a >50% increase in circulating leukemic cells or a 30% decrease in circulating leukemic cells. (NCT00001586)
Timeframe: 6 hours post treatment, and 24 hours post treatment
| Intervention | Percent change in cells (Number) | |
|---|---|---|
| 6 hours post treatment (e.g. ># cells) | 24 hours post treatment (e.g. > # cells) | |
| Intermediate-high Risk B-Cell Pts | 30 | 50 |
Analysis of the Primary Endpoint: The complete responses will be estimated by the number of patients with CR divided by the total number of evaluable patients. (NCT01723839)
Timeframe: 28 day cycle, up to 4 cycles
| Intervention | Percentage of Participants (Number) |
|---|---|
| FCR With Lenalidomide | 45 |
Analysis of the other Secondary Endpoints: The overall response rate will be estimated by the number of patients with complete and partial responses divided by the total number of evaluable patients. (NCT01723839)
Timeframe: 28 day cycle, up to 6 cycles
| Intervention | Percentage of Participants (Number) |
|---|---|
| FCR With Lenalidomide | 95 |
3 reviews available for chlorambucil and Anemia
| Article | Year |
|---|---|
[Treatment with cyclosporin A of the anemia associated with chronic lymphatic leukemia].
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclosporins; Ery | 1990 |
Management of idiopathic myelofibrosis.
Topics: Anemia; Ascites; Blood Coagulation Disorders; Bone Marrow; Busulfan; Chlorambucil; Humans; Hypertens | 1987 |
Multiple myeloma and macroglobulinemia. Advances in treatment.
Topics: Anemia; Blood Protein Electrophoresis; Blood Transfusion; Blood Viscosity; Chlorambucil; Drug Therap | 1974 |
3 trials available for chlorambucil and Anemia
| Article | Year |
|---|---|
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia.
Topics: Anemia; Chlorambucil; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administratio | 1977 |
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia.
Topics: Anemia; Chlorambucil; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administratio | 1977 |
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia.
Topics: Anemia; Chlorambucil; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administratio | 1977 |
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia.
Topics: Anemia; Chlorambucil; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administratio | 1977 |
Treatment of chronic lymphocytic leukemia in advanced stages. A randomized trial comparing chlorambucil plus prednisone versus cyclophosphamide, vincristine, and prednisone.
Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Clinical Trials as Topic | 1985 |
24 other studies available for chlorambucil and Anemia
| Article | Year |
|---|---|
Cost-Effectiveness of Ibrutinib Compared With Obinutuzumab With Chlorambucil in Untreated Chronic Lymphocytic Leukemia Patients With Comorbidities in the United Kingdom.
Topics: Adenine; Aged; Anemia; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Chlorambucil; Comor | 2018 |
Eleventh biannual report of the Cochrane Haematological Malignancies Group: Focus on Hodgkin lymphoma.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bendamustine Hydrochloride; Ble | 2010 |
CLINICAL EVALUATION OF URACIL MUSTARD.
Topics: Anemia; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Hodgkin Disease; Humans; Kidn | 1963 |
WEEKLY HIGH-DOSAGE GLUCOCORTICOSTEROID TREATMENT OF LYMPHOCYTIC LEUKEMIAS AND LYMPHOMAS.
Topics: Anemia; Anemia, Hemolytic; Betamethasone; Chlorambucil; Dexamethasone; Geriatrics; Humans; Leukemia; | 1964 |
CHRONIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkylating Agents; Anemia; Anemia, Hemolytic, | 1964 |
ALTERATION OF BLOOD GROUP ANTIGENS IN LEUKEMIC LYMPHOCYTES.
Topics: ABO Blood-Group System; Anemia; Anemia, Aplastic; Antigens; Blood Group Antigens; Child; Chlorambuci | 1965 |
Chronic lymphocytic leukemia in India--a clinico-hematological profile.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Chlorambucil; Female; Hematologic Tests; Hepato | 2007 |
[Therapy of plasmocytoma].
Topics: Anemia; Blood Protein Disorders; Chlorambucil; Humans; Hypercalcemia; Leukopenia; Melphalan; Plasmac | 1967 |
Familial leukemia: uncommon type of chronic lymphocytic leukemia in two sisters.
Topics: Agammaglobulinemia; Anemia; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Middle Aged; Prednison | 1982 |
Common hematologic problems: diagnosis and treatment.
Topics: Aged; Anemia; Anemia, Macrocytic; Blood Cell Count; Blood Transfusion; Chlorambucil; Erythrocyte Ind | 1983 |
Long-term assessment of chlorambucil in children with nephrotic syndrome who fail to respond adequately to corticosteroids.
Topics: Adolescent; Anemia; Bacterial Infections; Child; Child, Preschool; Chlorambucil; Drug Resistance; Fe | 1981 |
Effectiveness of fludarabine in end-stage prolymphocytic leukemia.
Topics: Aged; Anemia; Antigens, CD; Antineoplastic Agents; Blood Transfusion; Chlorambucil; Female; Humans; | 1994 |
A prolonged APTT in a patient with a low grade malignant NHL - a case report.
Topics: Anemia; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Blood Coagulation Factors; C | 2002 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
Clinical staging of chronic lymphocytic leukemia.
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Blood Cell Count; Bone Marrow Examination; Chlor | 1975 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Lymphoproliferative disorder of large granular lymphocytes: reversal of lymphocyte proliferation, anemia and neutropenia with chlorambucil.
Topics: Anemia; Bone Marrow; Cell Division; Chlorambucil; Danazol; Drug Therapy, Combination; Female; Humans | 1987 |
A chromosome translocation in association with periarteritis nodosa and macroglobulinemia.
Topics: Anemia; Arthritis; Blood Proteins; Chlorambucil; Chromosome Aberrations; Chromosome Disorders; Diaph | 1967 |
[The treatment of chronic lymphatic leukemia].
Topics: Anabolic Agents; Anemia; Anti-Bacterial Agents; Antineoplastic Agents; Blood Transfusion; Chlorambuc | 1966 |
[Complications and sequelae of immunosuppressive therapy of rheumatoid arthritis].
Topics: Alopecia; Amenorrhea; Anemia; Arthritis, Rheumatoid; Bacterial Infections; Chlorambucil; Cyclophosph | 1971 |
[Problems of rational therapeutic procedure in chronic lymphatic leukemia].
Topics: Anemia; Chlorambucil; Humans; Leukemia, Lymphoid; Pneumonia; Thrombocytopenia | 1970 |
Mu-chain disease.
Topics: Adult; Agammaglobulinemia; Anemia; Bence Jones Protein; Chlorambucil; Female; Fractures, Bone; Heavy | 1971 |
The effects of alkoxyglycerols on haematopoiesis.
Topics: Anemia; Animals; Benzene; Blood Cell Count; Busulfan; Chlorambucil; Erythrocyte Count; Female; Hemat | 1968 |
Chronic lymphatic leukemia in the older patient.
Topics: Aged; Anemia; Chlorambucil; Diagnosis, Differential; Humans; Infections; Leukemia, Lymphoid; Lymphat | 1968 |
[Chlorambucil in the treatment of idiopathic nephrotic syndrome without glomrular lesions in childhood. Apropos of 30 cases].
Topics: Adolescent; Anemia; Biopsy; Child; Child, Preschool; Chlorambucil; Female; Glucocorticoids; Humans; | 1969 |