chlorambucil has been researched along with Anemia, Aplastic in 6 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis." | 7.66 | A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts. ( Carter, SK; Gandara, DR; George, CB; Koretz, MM; Lewis, JP; Ries, CA; Schiff, SA, 1982) |
| "Prednimustine, an ester of chlorambucil and prednisolone, was evaluated for efficacy and toxicity in a selected group of leukemia patients with a poor prognosis." | 3.66 | A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts. ( Carter, SK; Gandara, DR; George, CB; Koretz, MM; Lewis, JP; Ries, CA; Schiff, SA, 1982) |
| " Each case was associated with prior chlorambucil administration, effective in controlling the clinical manifestations (total dosage 398 and 1,764 mg respectively)." | 1.25 | Irreversible bone marrow failure with chlorambucil. ( Epstein, WV; Fries, JF; Rudd, P, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BRODY, JI | 1 |
| BEIZER, LH | 1 |
| Gandara, DR | 1 |
| Ries, CA | 1 |
| Schiff, SA | 1 |
| George, CB | 1 |
| Lewis, JP | 1 |
| Koretz, MM | 1 |
| Carter, SK | 1 |
| Bonnet, M | 1 |
| Rudd, P | 1 |
| Fries, JF | 1 |
| Epstein, WV | 1 |
| Bennett, JM | 1 |
| Moloney, WC | 1 |
| Greene, MH | 1 |
| Boice, JD | 1 |
| Stacher, A | 1 |
6 other studies available for chlorambucil and Anemia, Aplastic
| Article | Year |
|---|---|
ALTERATION OF BLOOD GROUP ANTIGENS IN LEUKEMIC LYMPHOCYTES.
Topics: ABO Blood-Group System; Anemia; Anemia, Aplastic; Antigens; Blood Group Antigens; Child; Chlorambuci | 1965 |
A phase II study of prednimustine in acute non-lymphocytic leukemia, smouldering leukemia, and refractory anemia with excess blasts.
Topics: Acute Disease; Adult; Aged; Anemia, Aplastic; Chlorambucil; Drug Evaluation; Female; Humans; Leukemi | 1982 |
[Evaluation of immunosuppressives in Behçet's syndrome].
Topics: Anemia, Aplastic; Antilymphocyte Serum; Behcet Syndrome; Chlorambucil; Eye Diseases; Humans; Immunos | 1981 |
Irreversible bone marrow failure with chlorambucil.
Topics: Adolescent; Anemia, Aplastic; Arthritis, Rheumatoid; Bone Marrow; Chlorambucil; Female; Humans; Leuk | 1975 |
Acute myeloid leukemia and other myelopathic disorders following treatment with alkylating agents.
Topics: Adolescent; Adult; Aged; Alkylating Agents; Anemia, Aplastic; Child; Child, Preschool; Chlorambucil; | 1987 |
[Immunosuppressive therapy in hematology].
Topics: Adrenal Cortex Hormones; Adult; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Myelophthis | 1972 |