chlorambucil has been researched along with Amyloidosis in 31 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of chlorambucil treatment in a group of six patients diagnosed by renal biopsy of renal amyloidosis secondary to rheumatoid arthritis was evaluated." | 7.70 | [Treatment with chlorambucil of renal amyloidosis secondary to rheumatoid arthritis. Study of 6 cases]. ( Alvarez Vega, JL; Arrobas, M; Robles, NR; Roncero, F; Sánchez Casado, E, 1999) |
| "Chlorambucil was found to be a very potent drug for JCA with acceptable short term, but serious longterm side effects." | 6.69 | Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis. ( Savolainen, HA, 1999) |
| " Renal biopsy confirmed the diagnosis of amyloidosis, and chlorambucil was initiated, with general improvement of the disease and reduction of proteinuria." | 3.73 | Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis. ( Correia, AJ; Duarte, C; Gomes, C; Salgado, M, 2006) |
| "Four patients of rheumatoid arthritis (RA) with biopsy confirmed AA amyloidosis were treated with chlorambucil." | 3.71 | Treatment of AA amyloidosis in rheumatoid arthritis. ( Balakrishnan, C; Deshpande, RB; Gaitonde, S; Gurmeet, M; Joshi, VR; Mittal, G; Pathan, E; Rajadhyaksha, S; Samant, R; Sule, A, 2002) |
| "The effect of chlorambucil treatment in a group of six patients diagnosed by renal biopsy of renal amyloidosis secondary to rheumatoid arthritis was evaluated." | 3.70 | [Treatment with chlorambucil of renal amyloidosis secondary to rheumatoid arthritis. Study of 6 cases]. ( Alvarez Vega, JL; Arrobas, M; Robles, NR; Roncero, F; Sánchez Casado, E, 1999) |
| "Chlorambucil was found to be a very potent drug for JCA with acceptable short term, but serious longterm side effects." | 2.69 | Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis. ( Savolainen, HA, 1999) |
| "Psoriatic spondyloarthropathy (PSA) can occasionally be complicated by AA amyloid, and renal amyloidosis should be suspected in patients with PSA who have unexplained proteinuria." | 1.32 | Cytostatic therapy for AA amyloidosis complicating psoriatic spondyloarthropathy. ( Hawkins, PN; Moots, RJ; Mpofu, S; Smith, PJ; Teh, LS, 2003) |
| "Chlorambucil alone was given in 14 treatment periods, cyclophosphamide alone in six, and both alternately in two." | 1.27 | Alkylating cytostatic treatment in renal amyloidosis secondary to rheumatic disease. ( Berglund, K; Keller, C; Thysell, H, 1987) |
| "Proteinuria is the most frequent sign in the early stage of the amyloidosis." | 1.26 | [Amyloidosis-a dreaded complication of juvenile chronic arthritis (JCA). (author's transl)]. ( Michels, H; Renaud, M; Renz, K; Schuchmann, L, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (41.94) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 8 (25.81) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Millet, A | 1 |
| Rioux-Leclercq, N | 1 |
| Le Lay, JP | 1 |
| Le Pogamp, P | 1 |
| Vigneau, C | 1 |
| Shtrasburg, S | 1 |
| Pras, M | 1 |
| Rabinovich, E | 1 |
| Gal, R | 1 |
| Livneh, A | 1 |
| Lidar, M | 1 |
| Balakrishnan, C | 2 |
| Sule, A | 1 |
| Mittal, G | 1 |
| Gaitonde, S | 1 |
| Pathan, E | 2 |
| Rajadhyaksha, S | 1 |
| Deshpande, RB | 1 |
| Gurmeet, M | 1 |
| Samant, R | 1 |
| Joshi, VR | 2 |
| Mpofu, S | 1 |
| Teh, LS | 1 |
| Smith, PJ | 1 |
| Moots, RJ | 1 |
| Hawkins, PN | 2 |
| Ben Ghorbel, I | 1 |
| Khanfir, M | 1 |
| Houman, MH | 1 |
| Khodaiji, S | 1 |
| Dasgupta, A | 1 |
| Mangat, G | 1 |
| Duarte, C | 1 |
| Gomes, C | 1 |
| Correia, AJ | 1 |
| Salgado, M | 1 |
| Sporny, S | 1 |
| Schuchmann, L | 1 |
| Michels, H | 1 |
| Renaud, M | 1 |
| Renz, K | 1 |
| Berglund, K | 3 |
| Thysell, H | 3 |
| Keller, C | 2 |
| Steuer, A | 1 |
| Leonard, N | 1 |
| Ahmed, FB | 1 |
| Price, AB | 1 |
| Gumpel, JM | 1 |
| Dussol, B | 1 |
| Kaplanski, G | 1 |
| Daniel, L | 1 |
| Brunet, P | 1 |
| Pellissier, JF | 1 |
| Berland, Y | 1 |
| Savolainen, HA | 1 |
| Robles, NR | 1 |
| Roncero, F | 1 |
| Arrobas, M | 1 |
| Alvarez Vega, JL | 1 |
| Sánchez Casado, E | 1 |
| Ortiz-Santamaría, V | 2 |
| Gumà, M | 1 |
| Olivé, A | 2 |
| Tena, X | 2 |
| Valls-Roc, M | 1 |
| Schnitzer, TJ | 1 |
| Ansell, BM | 2 |
| Missmahl, HP | 1 |
| Willemsen, M | 1 |
| Maugars, Y | 1 |
| Couverchel, L | 1 |
| Guenel, Y | 1 |
| Bureau, L | 1 |
| Buzelin, F | 1 |
| Prost, A | 1 |
| Deschênes, G | 1 |
| Prieur, AM | 1 |
| Hayem, F | 1 |
| Broyer, M | 1 |
| Gubler, MC | 1 |
| Mody, GM | 1 |
| Meyers, OL | 1 |
| Ahlmen, M | 1 |
| Ahlmen, J | 1 |
| Svalander, C | 1 |
| Bucht, H | 1 |
| Sukenik, S | 1 |
| Buskila, D | 1 |
| Horowitz, I | 1 |
| Maroko, I | 1 |
| Orlowski, T | 1 |
| Wojtulewicz-Kurkus, J | 1 |
| Glyda, J | 1 |
| Kunert, Z | 1 |
| Maldonado, JE | 1 |
| McNutt, DR | 1 |
| Kyle, RA | 1 |
| Baggenstoss, AH | 1 |
| Fudenberg, HH | 1 |
| Becq-Giraudon, B | 1 |
| de Giacomini, P | 1 |
| Babin, P | 1 |
| Gil, R | 1 |
| Sudre, Y | 1 |
| Osterberg, G | 1 |
| Rausing, A | 1 |
| Eghtedari, A | 1 |
| Bywaters, EG | 1 |
2 reviews available for chlorambucil and Amyloidosis
| Article | Year |
|---|---|
[Current theories on the possibilities of treatment of amyloidosis].
Topics: Amyloidosis; Chlorambucil; Colchicine; Dimethyl Sulfoxide; Humans; Melphalan | 1981 |
[Renal amyloidosis in rheumatoid polyarthritis stabilized for 13 years with chlorambucil].
Topics: Amyloidosis; Arthritis, Rheumatoid; Chlorambucil; Female; Humans; Kidney Diseases; Middle Aged; Time | 1990 |
2 trials available for chlorambucil and Amyloidosis
| Article | Year |
|---|---|
Chlorambucil in severe juvenile chronic arthritis: longterm followup with special reference to amyloidosis.
Topics: Adolescent; Amyloidosis; Antineoplastic Agents, Alkylating; Arthritis, Juvenile; Child; Child, Presc | 1999 |
Cytotoxic drug treatment of reactive amyloidosis in rheumatoid arthritis with special reference to renal insufficiency.
Topics: Adult; Aged; Amyloidosis; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Femal | 1987 |
27 other studies available for chlorambucil and Amyloidosis
| Article | Year |
|---|---|
Unexpected remission of renal AA amyloidosis associated with rheumatoid arthritis.
Topics: Adult; Amyloidosis; Antineoplastic Agents, Alkylating; Arthritis, Rheumatoid; Chlorambucil; Female; | 2009 |
Attempts at suppression of amyloidogenesis in a mouse model by a variety of anti-inflammatory agents.
Topics: Amyloid; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chlorambucil; Cyclophosphami | 2012 |
Treatment of AA amyloidosis in rheumatoid arthritis.
Topics: Adult; Amyloidosis; Antineoplastic Agents, Alkylating; Arthritis, Rheumatoid; Chlorambucil; Female; | 2002 |
Cytostatic therapy for AA amyloidosis complicating psoriatic spondyloarthropathy.
Topics: Amyloidosis; Arthritis, Psoriatic; Chlorambucil; Follow-Up Studies; Humans; Kidney Diseases; Male; M | 2003 |
[Amyloidosis in adult onset Still's disease].
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Amyloidosis; Chlorambucil; Colchicine; Drug Therapy, Co | 2004 |
Myelodysplasia and acute myeloid leukaemia in a case of rheumatoid arthritis with secondary amyloidosis treated with chlorambucil.
Topics: Acute Disease; Amyloidosis; Antirheumatic Agents; Arthritis, Rheumatoid; Chlorambucil; Fatal Outcome | 2004 |
Renal amyloidosis: an uncommon complication of juvenile idiopathic arthritis.
Topics: Age of Onset; Amyloidosis; Arthritis, Juvenile; Child; Chlorambucil; Female; Humans; Kidney; Protein | 2006 |
[Amyloidosis-a dreaded complication of juvenile chronic arthritis (JCA). (author's transl)].
Topics: Adolescent; Amyloidosis; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Chronic Disease | 1981 |
Results, principles and pitfalls in the management of renal AA-amyloidosis; a 10-21 year followup of 16 patients with rheumatic disease treated with alkylating cytostatics.
Topics: Albumins; Amyloidosis; Antineoplastic Agents; C-Peptide; Chlorambucil; Creatinine; Cyclophosphamide; | 1993 |
Renal amyloidosis secondary to chronic rheumatic inflammatory disease.
Topics: Amyloidosis; Antineoplastic Agents, Alkylating; Chlorambucil; Chronic Disease; Humans; Kidney Diseas | 1996 |
An unusual case of familial Mediterranean fever.
Topics: Abdominal Pain; Amyloidosis; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Arthritis; | 1997 |
Diagnosis and treatment of amyloidosis.
Topics: Amyloid; Amyloidosis; Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Iodine Radioisotopes; | 1997 |
Simultaneous occurrence of fibrillary glomerulopathy and AL amyloid.
Topics: Amyloid; Amyloidosis; Antineoplastic Agents, Alkylating; Biopsy; Chlorambucil; Follow-Up Studies; Gl | 1998 |
[Treatment with chlorambucil of renal amyloidosis secondary to rheumatoid arthritis. Study of 6 cases].
Topics: Adult; Aged; Amyloidosis; Antineoplastic Agents, Alkylating; Arthritis, Rheumatoid; Biopsy; Chloramb | 1999 |
[Chlorambucil in the treatment of secondary amyloidosis].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyloidosis; Child; Chlorambucil; Female; Humans; Male; | 2000 |
Treatment of AA amyloid with chlorambucil.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amyloidosis; Child; Chlorambucil; Creatinine; Female; Hu | 2002 |
Amyloidosis in juvenile chronic polyarthritis.
Topics: Acute Kidney Injury; Adolescent; Adult; Amyloidosis; Arthritis, Juvenile; Child; Child, Preschool; C | 1977 |
[Therapy of amyloidoses].
Topics: Amyloidosis; Azathioprine; Chlorambucil; Colchicine; Humans; Penicillamine | 1977 |
Renal amyloidosis in juvenile chronic arthritis: evolution after chlorambucil treatment.
Topics: Amyloidosis; Arthritis, Juvenile; Biopsy; Chlorambucil; Follow-Up Studies; Humans; Kidney Diseases; | 1990 |
Clinical regression of amyloid nephropathy in a patient with rheumatoid arthritis. A case report.
Topics: Adult; Amyloidosis; Arthritis, Rheumatoid; Chlorambucil; Female; Humans; Nephrotic Syndrome; Remissi | 1988 |
Alkylating cytostatic treatment in renal amyloidosis secondary to rheumatic disease.
Topics: Adult; Amyloidosis; Chlorambucil; Cyclophosphamide; Female; Humans; Kidney; Kidney Diseases; Male; R | 1987 |
[Renal amylosis and juvenile rheumatoid polyarthritis. Value of chlorambucil].
Topics: Adult; Amyloidosis; Arthritis, Juvenile; Chlorambucil; Humans; Kidney Diseases; Male | 1985 |
Immunosuppressive treatment of nephrotic syndrome.
Topics: Adolescent; Adult; Aged; Amyloidosis; Azathioprine; Biopsy; Blood Proteins; Chlorambucil; Dactinomyc | 1969 |
IgG cryoglobulinemia associated with amyloidosis.
Topics: Amyloidosis; Autoantibodies; Blood Protein Disorders; Bone Marrow Examination; Chlorambucil; Cryoglo | 1973 |
[A Portuguese case of primitive familial amyloidosis].
Topics: Adult; Amyloid; Amyloidosis; Chlorambucil; Humans; Male | 1974 |
Reticulum cell sarcoma in Waldenström's macroglobulinemia after chlorambucil treatment.
Topics: Amyloidosis; Bone Marrow Cells; Bone Neoplasms; Chlorambucil; Female; Humans; Lymphoma, Non-Hodgkin; | 1970 |
Chlorambucil in the management of juvenile chronic polyarthritis complicated by amyloidosis.
Topics: Amyloidosis; Arthritis, Juvenile; Child; Chlorambucil; Humans | 1971 |