chlorambucil has been researched along with Amenorrhea in 12 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Amenorrhea: Absence of menstruation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 7.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| " Chlorambucil may hold advantages over the immunosuppressive drugs normally recommended in this condition, azathioprine and cyclophosphamide, as it appears less liable to cause important marrow suppression and, unlike cyclophosphamide is not associated with alopecia and haemorrhagic cystitis." | 3.65 | Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil. ( Dunnill, MS; Halley, W; Holt, JM; Oliver, DO; Snaith, ML; Stephenson, AC, 1973) |
| "Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomized to be given methylprednisolone (1 g intravenously for 3 consecutive days followed by oral methylprednisolone, 0." | 2.69 | A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy. ( Altieri, P; Antonucci, F; Bellazzi, R; Cesana, B; Dugo, M; Farina, M; Grassi, C; Lupo, A; Melis, P; Minari, M; Pasquali, S; Passerini, P; Pedrini, L; Piccoli, G; Pisano, G; Ponticelli, C; Pozzi, C; Roccatello, D; Sasdelli, M; Scalia, A; Scolari, F; Segagni, S; Valzorio, B, 1998) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lecomte, P | 1 |
| de Meeus, MC | 1 |
| Lorette, G | 1 |
| Lansac, J | 1 |
| Soutoul, JH | 1 |
| Clark, ST | 1 |
| Radford, JA | 1 |
| Crowther, D | 1 |
| Swindell, R | 1 |
| Shalet, SM | 1 |
| Ponticelli, C | 1 |
| Altieri, P | 1 |
| Scolari, F | 1 |
| Passerini, P | 1 |
| Roccatello, D | 1 |
| Cesana, B | 1 |
| Melis, P | 1 |
| Valzorio, B | 1 |
| Sasdelli, M | 1 |
| Pasquali, S | 1 |
| Pozzi, C | 1 |
| Piccoli, G | 1 |
| Lupo, A | 1 |
| Segagni, S | 1 |
| Antonucci, F | 1 |
| Dugo, M | 1 |
| Minari, M | 1 |
| Scalia, A | 1 |
| Pedrini, L | 1 |
| Pisano, G | 1 |
| Grassi, C | 1 |
| Farina, M | 1 |
| Bellazzi, R | 1 |
| Thumb, N | 1 |
| Kalinicheva, EO | 1 |
| Papaian, AV | 1 |
| Spiers, AS | 1 |
| Sigwald, J | 1 |
| Mazalton, A | 1 |
| Raymondeaud, C | 1 |
| Piot, C | 1 |
| Jacquillat, C | 1 |
| Snaith, ML | 1 |
| Holt, JM | 1 |
| Oliver, DO | 1 |
| Dunnill, MS | 1 |
| Halley, W | 1 |
| Stephenson, AC | 1 |
| Morgenfeld, MC | 1 |
| Goldberg, V | 1 |
| Parisier, H | 1 |
| Bugnard, SC | 1 |
| Bur, GE | 1 |
| Cayla, J | 1 |
| Rondier, J | 1 |
| Deshayes, P | 1 |
| Rénier, JC | 1 |
| Bregeon, C | 1 |
| Houdent, G | 1 |
| Sobrinho, LG | 1 |
| Levine, RA | 1 |
| DeConti, RC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study of Rituximab or Cyclophosphamide Combined With Steroids in the Treatment of Idiopathic Membranous Nephropathy[NCT05514015] | Phase 4 | 72 participants (Anticipated) | Interventional | 2022-08-25 | Not yet recruiting | ||
| Random, Open, Control and Monocentric Clinical Research on Tacrolimus Monotherapy for Idiopathic Membranous Nephropathy (IMN)[NCT03549663] | 108 participants (Anticipated) | Interventional | 2018-07-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorambucil and Amenorrhea
| Article | Year |
|---|---|
[Effect of cytostatic preparations used in the treatment of glomerulonephritis in children on the functional activity of the gonads].
Topics: Amenorrhea; Chlorambucil; Cyclophosphamide; Female; Humans; Male; Nephrosis, Lipoid; Oligospermia | 1987 |
2 trials available for chlorambucil and Amenorrhea
| Article | Year |
|---|---|
Gonadal function following chemotherapy for Hodgkin's disease: a comparative study of MVPP and a seven-drug hybrid regimen.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Doxorub | 1995 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
A randomized study comparing methylprednisolone plus chlorambucil versus methylprednisolone plus cyclophosphamide in idiopathic membranous nephropathy.
Topics: Adolescent; Adult; Aged; Amenorrhea; Anemia; Antineoplastic Agents, Alkylating; Carcinoma; Chlorambu | 1998 |
9 other studies available for chlorambucil and Amenorrhea
| Article | Year |
|---|---|
[Hypogonadism and alkylating agents (author's transl)].
Topics: Adolescent; Adult; Age Factors; Amenorrhea; Child; Chlorambucil; Cyclophosphamide; Female; Humans; H | 1981 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
Chronic granulocytic leukaemia and chronic lymphocytic leukaemia.
Topics: Allopurinol; Amenorrhea; Busulfan; Chlorambucil; Chronic Disease; Drug Eruptions; Female; Hemolysis; | 1974 |
[Critic study of multiple sclerosis treatment by chlorambucil and intraspinal corticotherapy. Apropos of 100 cases followed up from 2 to 9 years].
Topics: Acetates; Adrenocorticotropic Hormone; Adult; Amenorrhea; Chlorambucil; Female; Follow-Up Studies; H | 1973 |
Treatment of patients with systemic lupus erythematosus including nephritis with chlorambucil.
Topics: Adult; Alopecia; Amenorrhea; Azathioprine; Biopsy; Bone Marrow; Chlorambucil; Cyclophosphamide; Cyst | 1973 |
Ovarian lesions due to cytostatic agents during the treatment of Hodgkin's disease.
Topics: Adolescent; Adult; Amenorrhea; Antineoplastic Agents; Biopsy; Chlorambucil; Cyclophosphamide; Female | 1972 |
[Treatment of 67 rheumatoid polyarthritis cases with chlorambucil].
Topics: Adult; Age Factors; Aged; Amenorrhea; Arthritis, Rheumatoid; Bacterial Infections; Blood Cell Count; | 1971 |
[Complications and sequelae of immunosuppressive therapy of rheumatoid arthritis].
Topics: Alopecia; Amenorrhea; Anemia; Arthritis, Rheumatoid; Bacterial Infections; Chlorambucil; Cyclophosph | 1971 |
Amenorrhea in patients with Hodgkin's disease treated with antineoplastic agents.
Topics: Adult; Amenorrhea; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Female; Follicle Stimulati | 1971 |