chlorambucil has been researched along with Agnogenic Myeloid Metaplasia in 21 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 7.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed." | 7.67 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. ( Cannon, GW; Clegg, DO; Jackson, CG; Samuelson, CO; Ward, JR; Williams, HJ, 1985) |
| " Randomized studies have shown that the risk of thrombosis was significantly reduced in ET with the use of hydroxyurea (HU) and in PV with the use of chlorambucil or 32P." | 4.80 | Treatment of polycythaemia vera and essential thrombocythaemia. ( Silverstein, MN; Tefferi, A, 1998) |
| "In polycythemia vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%." | 3.69 | Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. ( Fisher, SG; Godwin, J; Nand, S; Stock, W, 1996) |
| "Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed." | 3.67 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review. ( Cannon, GW; Clegg, DO; Jackson, CG; Samuelson, CO; Ward, JR; Williams, HJ, 1985) |
| "The excess risk of cancer after chlorambucil appears to persist for 5 years after stopping this treatment." | 1.29 | The very-long-term course of polycythaemia: a complement to the previously published data of the Polycythaemia Vera Study Group. ( Dresch, C; Najean, Y; Rain, JD, 1994) |
| "B-cell chronic lymphocytic leukemia (B-CLL) associated with bone marrow fibrosis is described." | 1.29 | Chronic lymphocytic leukemia associated with bone marrow fibrosis: possible role of interleukin 1 alpha in the pathogenesis. ( Hyodo, H; Kimura, A; Kuramoto, A; Nakata, Y, 1993) |
| " Although hematologic malignancies have been known to develop consequent to long-term use of alkylating agents, and bone marrow suppression is well known, acute myelofibrosis has not, to our knowledge, been reported as a complication of this therapy, nor has any specific myeloproliferative syndrome been described consequent to such therapy in a patient with PSS." | 1.26 | Acute myelofibrosis in progressive systemic sclerosis. Report of a case developing during long term chlorambucil therapy and discussion of pathogenetic factors. ( Chung, KB; Gisser, SD, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (80.95) | 18.7374 |
| 1990's | 4 (19.05) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BOOTSMA, BK | 1 |
| MOESCHLIN, S | 1 |
| Gaminara, EJ | 1 |
| Pearson, TC | 1 |
| Najman, A | 1 |
| Gorin, NC | 1 |
| Duhamel, G | 2 |
| Roger, M | 1 |
| Dry, J | 1 |
| Pegrum, GD | 1 |
| Foadi, M | 1 |
| Boots, M | 1 |
| Clarke, M | 1 |
| Najean, Y | 1 |
| Dresch, C | 1 |
| Rain, JD | 1 |
| Kimura, A | 1 |
| Hyodo, H | 1 |
| Nakata, Y | 1 |
| Kuramoto, A | 1 |
| Nand, S | 1 |
| Stock, W | 1 |
| Godwin, J | 1 |
| Fisher, SG | 1 |
| Tefferi, A | 1 |
| Silverstein, MN | 2 |
| Gisser, SD | 1 |
| Chung, KB | 1 |
| Maurice, P | 1 |
| Burger, T | 1 |
| Schmelczer, M | 1 |
| Molnár, L | 1 |
| Pajor, L | 1 |
| Koszorus, S | 1 |
| Kelsey, PR | 1 |
| Geary, CG | 1 |
| Ellis, JT | 1 |
| Peterson, P | 1 |
| Geller, SA | 1 |
| Rappaport, H | 1 |
| Landaw, SA | 1 |
| Michels, SD | 1 |
| McKenna, RW | 1 |
| Arthur, DC | 1 |
| Brunning, RD | 1 |
| Cannon, GW | 1 |
| Jackson, CG | 1 |
| Samuelson, CO | 1 |
| Ward, JR | 1 |
| Williams, HJ | 1 |
| Clegg, DO | 1 |
| Patakfalvi, A | 1 |
| Lévy, VG | 1 |
| Ouahnich, M | 1 |
| Lewis, SM | 1 |
| Szur, L | 1 |
2 reviews available for chlorambucil and Agnogenic Myeloid Metaplasia
| Article | Year |
|---|---|
Treatment of polycythaemia vera and essential thrombocythaemia.
Topics: Adult; Aged; Aspirin; Chlorambucil; Disease Progression; Female; Hemorrhage; Humans; Hydroxyurea; In | 1998 |
Management of idiopathic myelofibrosis.
Topics: Anemia; Ascites; Blood Coagulation Disorders; Bone Marrow; Busulfan; Chlorambucil; Humans; Hypertens | 1987 |
1 trial available for chlorambucil and Agnogenic Myeloid Metaplasia
| Article | Year |
|---|---|
Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies.
Topics: Acute Disease; Aged; Bloodletting; Bone Marrow; Bone Marrow Cells; Chlorambucil; Combined Modality T | 1986 |
18 other studies available for chlorambucil and Agnogenic Myeloid Metaplasia
| Article | Year |
|---|---|
[EXPERIENCE IN THE TREATMENT OF MALIGNANT DISEASES OF THE RETICULOENDOTHELIAL SYSTEM AND LEUKEMIAS. II].
Topics: Betamethasone; Busulfan; Chlorambucil; Copper; Cyclophosphamide; Dexamethasone; Genetic Diseases, X- | 1964 |
[MODERN TREATMENT OF LEUKEMIA].
Topics: Agranulocytosis; Busulfan; Chlorambucil; Cyclophosphamide; Drug Therapy; Genetic Diseases, X-Linked; | 1965 |
Chlorambucil-induced myelofibrosis.
Topics: Blood Transfusion; Chlorambucil; Female; Humans; Middle Aged; Ovarian Neoplasms; Primary Myelofibros | 1984 |
[Acute myelofibrosis after chlorambucil treatment (author's transl)].
Topics: Acute Disease; Chlorambucil; Humans; Male; Middle Aged; Multiple Sclerosis; Primary Myelofibrosis | 1980 |
How should we manage myelofibrosis?
Topics: Blood Transfusion; Chlorambucil; Humans; Prednisone; Primary Myelofibrosis; Splenectomy | 1981 |
The very-long-term course of polycythaemia: a complement to the previously published data of the Polycythaemia Vera Study Group.
Topics: Aged; Bloodletting; Chlorambucil; Follow-Up Studies; Humans; Middle Aged; Neoplasms; Phosphorus Radi | 1994 |
Chronic lymphocytic leukemia associated with bone marrow fibrosis: possible role of interleukin 1 alpha in the pathogenesis.
Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Division; Cells, Cul | 1993 |
Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Topics: Acute Disease; Anemia, Refractory, with Excess of Blasts; Busulfan; Cell Transformation, Neoplastic; | 1996 |
Acute myelofibrosis in progressive systemic sclerosis. Report of a case developing during long term chlorambucil therapy and discussion of pathogenetic factors.
Topics: Acute Disease; Adult; Bone Marrow; Cell Division; Chlorambucil; Female; Fibroblasts; Hematopoietic S | 1979 |
Myeloproliferative diseases.
Topics: Adult; Aged; Chlorambucil; Female; Humans; Male; Melphalan; Middle Aged; Myeloproliferative Disorder | 1977 |
[The treatment of myeloproliferative syndromes].
Topics: Aged; Bloodletting; Busulfan; Chlorambucil; Female; Humans; Leukemia, Myeloid; Male; Myeloproliferat | 1975 |
Course and transformation of polycythaemia vera in relation to therapy.
Topics: Adult; Aged; Aged, 80 and over; Chlorambucil; Female; Humans; Leukemia; Leukemia, Radiation-Induced; | 1988 |
Acute leukemia in polycythemia vera.
Topics: Acute Disease; Antigens, Neoplasm; Bloodletting; Chlorambucil; Chromosome Aberrations; Chromosome Di | 1986 |
Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Behcet Syndrome; Bone Marrow; Carcinoma; Child; Chil | 1985 |
Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and literature review.
Topics: Adult; Arthritis, Rheumatoid; Chlorambucil; Drug Evaluation; Female; Humans; Leukemia, Myeloid, Acut | 1985 |
Secondary antibody deficiency syndrome in haemoblastosis.
Topics: Agammaglobulinemia; Antibodies; Antigens, Bacterial; Blood Protein Disorders; Blood Proteins; Busulf | 1972 |
[A case of lymphoid myelofibrosis. Anatomo-clinical and critical study].
Topics: Adult; Chlorambucil; Diagnosis, Differential; Humans; Leukemia; Male; Prednisone; Primary Myelofibro | 1967 |
Blood and neoplastic diseases. Myeloproliferative disorders.
Topics: Adrenal Cortex Hormones; Androgens; Blood Transfusion; Bloodletting; Busulfan; Chlorambucil; Cycloph | 1974 |