chlorambucil has been researched along with Adverse Drug Event in 10 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The most frequent adverse events were neutropenia and infusion‑related reactions (IRRs)." | 1.48 | Efficacy and safety of the obinutuzumab-chlorambucil combination in the frontline treatment of elderly CLL patients with comorbidities - Polish Adult Leukemia Group (PALG) real-life analysis. ( Chmielowska, E; Dudziński, M; Długosz-Danecka, M; Gawroński, K; Hus, I; Jurczak, W; Morawska, M; Wąsik-Szczepanek, E; Wdowiak, K; Wiśniewska, A; Łabędź, A; Łątka-Cabała, E, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Viviano, KR | 1 |
| Autore, F | 1 |
| Fresa, A | 1 |
| Innocenti, I | 1 |
| Tomasso, A | 1 |
| Morelli, F | 1 |
| Corbingi, A | 1 |
| Sorà, F | 1 |
| Laurenti, L | 1 |
| Długosz-Danecka, M | 1 |
| Jurczak, W | 1 |
| Łątka-Cabała, E | 1 |
| Morawska, M | 1 |
| Gawroński, K | 1 |
| Wiśniewska, A | 1 |
| Dudziński, M | 1 |
| Wąsik-Szczepanek, E | 1 |
| Chmielowska, E | 1 |
| Łabędź, A | 1 |
| Wdowiak, K | 1 |
| Hus, I | 1 |
| WOLFSON, S | 1 |
| OLNEY, MB | 1 |
| Aymard, JP | 1 |
| Lederlin, P | 1 |
| Witz, F | 1 |
| Rumilly, F | 1 |
| Eisemann, JC | 1 |
| Buisine, J | 1 |
| Gregoire, MJ | 1 |
| Guerci, O | 1 |
| Streiff, F | 1 |
| Brahams, D | 1 |
| Saslaw, S | 1 |
| Carlisle, HN | 1 |
| Morgenfeld, MC | 1 |
| Prada, OE | 1 |
| Richter, P | 1 |
2 reviews available for chlorambucil and Adverse Drug Event
| Article | Year |
|---|---|
Glucocorticoids, Cyclosporine, Azathioprine, Chlorambucil, and Mycophenolate in Dogs and Cats: Clinical Uses, Pharmacology, and Side Effects.
Topics: Animals; Azathioprine; Cat Diseases; Cats; Chlorambucil; Cyclosporine; Dog Diseases; Dogs; Drug-Rela | 2022 |
Acute leukaemia following prolonged chlorambucil treatment for non-neoplastic disease - a study of two cases and literature review.
Topics: Adult; Aged; Chlorambucil; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Leukemia | 1983 |
8 other studies available for chlorambucil and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Purging with chlorambucil to prevent infusion-related reaction before obinutuzumab administration: A monocentric pilot experience.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Che | 2019 |
Efficacy and safety of the obinutuzumab-chlorambucil combination in the frontline treatment of elderly CLL patients with comorbidities - Polish Adult Leukemia Group (PALG) real-life analysis.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Pro | 2018 |
Accidental ingestion of a toxic dose of chlorambucil; report of a case in a child.
Topics: Child; Chlorambucil; Drug-Related Side Effects and Adverse Reactions; Humans; Mechlorethamine; Nitro | 1957 |
Chlorambucil infertility and sperm banking.
Topics: Chlorambucil; Disclosure; Drug-Related Side Effects and Adverse Reactions; Humans; Infertility; Info | 1992 |
Nonhuman primates in evaluation of hematotoxicity.
Topics: Animals; Busulfan; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug-Related Side Effects and Adver | 1969 |
[Treatment of malignant lymphomas: its repercussion in the genital region].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Chlorambucil; Cyclophosphamide; Drug-Related Side Effect | 1968 |