chlorambucil has been researched along with Adenocarcinoma in 43 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three hundred and sixty-nine patients with advanced ovarian adenocarcinoma were treated in a prospective randomized trial comparing combination versus sequential therapy with chlorambucil and cisplatin." | 9.06 | Chemotherapy of advanced ovarian adenocarcinoma: a randomized comparison of combination versus sequential therapy using chlorambucil and cisplatin. ( , 1986) |
| "Fifty-six tumor specimens from patients with ovarian adenocarcinoma were tested for sensitivity to single and combination drug regimens in a short-term antimetabolic assay measuring inhibition of thymidine incorporation." | 7.68 | Combination chemotherapy tested in a short-term thymidine incorporation assay in primary cultures of ovarian adenocarcinomas. ( Hayward, IP; Hurst, T; Khoo, SK; Parsons, PG, 1992) |
| "Three hundred and sixty-nine patients with advanced ovarian adenocarcinoma were treated in a prospective randomized trial comparing combination versus sequential therapy with chlorambucil and cisplatin." | 5.06 | Chemotherapy of advanced ovarian adenocarcinoma: a randomized comparison of combination versus sequential therapy using chlorambucil and cisplatin. ( , 1986) |
| "Seventeen patients with advanced ovarian adenocarcinoma recurring or progressing after prior treatment with chlorambucil and cis-platinum were treated with cyclophosphamide, adriamycin, and cis-platinum (CAP) every 3 weeks." | 5.05 | Combined cyclophosphamide, adriamycin and cis-platinum in advanced ovarian cancer resistant to chlorambucil and cis-platinum. ( Malden, LT; Mann, GJ; Solomon, HJ; Tattersall, MH, 1985) |
| "The formation of the glutathione S-conjugate of monochlorobimane (GSH-bimane) in human colon adenocarcinoma cells was identified by HPLC-fluorimetry and its transport from the cells was found to be temperature-sensitive, saturable and ATP-dependent." | 3.69 | Active transport of glutathione S-conjugate in human colon adenocarcinoma cells. ( Wong, KP; Zhang, K, 1996) |
| "Fifty-six tumor specimens from patients with ovarian adenocarcinoma were tested for sensitivity to single and combination drug regimens in a short-term antimetabolic assay measuring inhibition of thymidine incorporation." | 3.68 | Combination chemotherapy tested in a short-term thymidine incorporation assay in primary cultures of ovarian adenocarcinomas. ( Hayward, IP; Hurst, T; Khoo, SK; Parsons, PG, 1992) |
| "We investigated the effect of pretreatment with difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor, on the cytocidal responses of four human adenocarcinoma cell lines to two alkylating and crosslinking agents: chlorambucil and N,N',N"-triethylenethiophosphoramide (thiotepa)." | 3.67 | Effects of DFMO-induced polyamine depletion on human tumor cell sensitivity to antineoplastic DNA-crosslinking drugs. ( Block, AL; Komar, KA; Naujokas, MF; Seidenfeld, J, 1986) |
| "Ninety-two patients with D2 prostatic cancer were studied." | 2.66 | Sequential hormonal therapy and sequential hormonal and chemotherapy for advanced prostatic cancer. ( Bezwoda, WR; Derman, DP; Ruff, P; Weaving, A, 1989) |
| "Ninety-eight patients with advanced ovarian cancer took part in a prospective, randomised trial comparing low-dose cisplatin and chlorambucil with low-dose cisplatin, chlorambucil, and doxorubicin." | 2.65 | Randomised trial comparing low-dose cisplatin and chlorambucil with low-dose cisplatin, chlorambucil, and doxorubicin in advanced ovarian carcinoma. ( Barker, GH; Wiltshaw, E, 1981) |
| "Two cases of recurrent breast carcinoma were treated with KM2210 in an early phase II study conducted at our institute and complete response (CR) was obtained." | 1.27 | [Two cases of recurrent breast carcinoma achieving CR (complete response) with KM2210]. ( Kawamura, E; Kubota, T; Kurokawa, T; Miyagawa, T; Toyoda, H; Yamada, Y, 1987) |
| " Eleven patients with advanced carcinoma of the lung (5 adenocarcinoma, 3 squamous cell carcinoma, 2 small cell carcinoma and 1 large cell carcinoma) were treated at a dosage of 40 mg." | 1.26 | Preliminary clinical study of prednimustine in lung cancer. ( Catane, H; Catane, R; Kaufman, JH; Mittelman, A; Murphy, GP; Takita, H, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (79.07) | 18.7374 |
| 1990's | 7 (16.28) | 18.2507 |
| 2000's | 1 (2.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, G | 1 |
| Nenavathu, BP | 1 |
| Imtiyaz, K | 1 |
| Moshahid A Rizvi, M | 1 |
| Zhang, K | 2 |
| Wong, KP | 2 |
| Chow, P | 1 |
| HORWITZ, H | 1 |
| WRIGHT, TL | 1 |
| PERRY, H | 1 |
| BARRETT, CM | 1 |
| LEBHERZ, TB | 2 |
| HUSTON, JW | 1 |
| AUSTIN, JA | 1 |
| BOYCE, CR | 1 |
| PARKER, RT | 1 |
| WILTSHAW, E | 3 |
| Barker, GH | 1 |
| Gaver, RC | 1 |
| Deeb, G | 1 |
| Pittman, KA | 1 |
| Issell, BF | 1 |
| Mittelman, A | 2 |
| Smyth, RD | 1 |
| Bernier, LG | 1 |
| Page, M | 1 |
| Gaudreault, RC | 1 |
| Joly, LP | 1 |
| Dousset, B | 1 |
| Boudet, MJ | 1 |
| Soubrane, O | 1 |
| Calmus, Y | 1 |
| Bernard, O | 1 |
| Houssin, D | 1 |
| Polenaković, M | 1 |
| Grcevska, L | 1 |
| Savage, PE | 1 |
| Carmody, RG | 1 |
| Highman, JH | 1 |
| Catane, H | 1 |
| Catane, R | 1 |
| Takita, H | 1 |
| Kaufman, JH | 1 |
| Murphy, GP | 1 |
| Piver, S | 1 |
| Barlow, JJ | 2 |
| Chung, WS | 1 |
| Lee, FT | 1 |
| Vongtama, V | 2 |
| Cziráki, L | 1 |
| Oó, M | 1 |
| Piver, MS | 2 |
| Lee, FJ | 1 |
| Hayward, IP | 1 |
| Hurst, T | 1 |
| Parsons, PG | 1 |
| Khoo, SK | 1 |
| Fujiwara, Y | 1 |
| Sugimoto, Y | 1 |
| Kasahara, K | 1 |
| Bungo, M | 1 |
| Yamakido, M | 1 |
| Tew, KD | 1 |
| Saijo, N | 1 |
| Cavaliere, A | 1 |
| Pietropaoli, N | 1 |
| Alberti, PF | 1 |
| Vitali, R | 1 |
| Gerding, MN | 1 |
| Blom van Assendelft, PM | 1 |
| Ruff, P | 1 |
| Derman, DP | 1 |
| Weaving, A | 1 |
| Bezwoda, WR | 1 |
| Seidenfeld, J | 1 |
| Komar, KA | 1 |
| Naujokas, MF | 1 |
| Block, AL | 1 |
| Tisdale, MJ | 1 |
| Okayasu, T | 1 |
| Masuda, T | 1 |
| Kawabata, M | 1 |
| Imai, T | 1 |
| Hashimoto, M | 1 |
| Inoue, K | 1 |
| Tanabe, T | 1 |
| Kubota, T | 1 |
| Yamada, Y | 1 |
| Kawamura, E | 1 |
| Toyoda, H | 1 |
| Miyagawa, T | 1 |
| Kurokawa, T | 1 |
| Mann, GJ | 1 |
| Malden, LT | 1 |
| Solomon, HJ | 1 |
| Tattersall, MH | 1 |
| Dendy, PP | 1 |
| Comis, RL | 1 |
| Carter, SK | 1 |
| Furnari, S | 1 |
| Pavone-Macaluso, M | 1 |
| Veroux, G | 1 |
| Mattea, E | 1 |
| Speckhard, ME | 1 |
| Hurley, JD | 1 |
| Fetherston, WC | 1 |
| Grueninger, AJ | 1 |
| Donovan, JF | 1 |
| Griffiths, CT | 1 |
| Grogan, RH | 1 |
| Hall, TC | 1 |
| Lleander, VC | 1 |
| Goldstein, G | 1 |
| Horsley, JS | 1 |
| Renner, K | 1 |
| Fagan, WT | 1 |
| Clark, CW | 1 |
| Karaivanova, MKh | 1 |
| Green, RA | 1 |
| Humphrey, E | 1 |
| Close, H | 1 |
| Patno, ME | 1 |
| Barry, RE | 1 |
| Salmon, PR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase III Trial of S-1 and Cisplatin (3 Weekly) Versus S-1 and Oxaliplatin Combination Chemotherapy for First Line Treatment of Advanced Gastric Cancer[NCT01671449] | Phase 3 | 338 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for chlorambucil and Adenocarcinoma
| Article | Year |
|---|---|
A review of chemotherapy in gastric cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Carmustine; Chlorambucil; Chromomycins; Cyclophosphamide; Cyt | 1974 |
Guidelines for the management of patients with ovarian adenocarcinoma.
Topics: Adenocarcinoma; Castration; Chlorambucil; Cobalt Isotopes; Female; Humans; Hysterectomy; Melphalan; | 1972 |
Nonhormonal chemotherapy of endometrial adenocarcinoma: a review.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Evaluation; Drug Therapy | 1974 |
6 trials available for chlorambucil and Adenocarcinoma
| Article | Year |
|---|---|
Randomised trial comparing low-dose cisplatin and chlorambucil with low-dose cisplatin, chlorambucil, and doxorubicin in advanced ovarian carcinoma.
Topics: Adenocarcinoma; Chlorambucil; Cisplatin; Clinical Trials as Topic; Doxorubicin; Drug Therapy, Combin | 1981 |
Primary treatment of advanced ovarian adenocarcinoma, stages III and IV.
Topics: Adenocarcinoma; Alkylating Agents; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Therapy, Combi | 1975 |
Sequential hormonal therapy and sequential hormonal and chemotherapy for advanced prostatic cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Modality Ther | 1989 |
Chemotherapy of advanced ovarian adenocarcinoma: a randomized comparison of combination versus sequential therapy using chlorambucil and cisplatin.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Clini | 1986 |
Combined cyclophosphamide, adriamycin and cis-platinum in advanced ovarian cancer resistant to chlorambucil and cis-platinum.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Clin | 1985 |
Alkylating agents in bronchogenic carcinoma.
Topics: Adenocarcinoma; Alkylating Agents; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Chl | 1969 |
34 other studies available for chlorambucil and Adenocarcinoma
| Article | Year |
|---|---|
Fabrication of chlorambucil loaded graphene- oxide nanocarrier and its application for improved antitumor activity.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Chlorambucil; De | 2020 |
Conjugation of chlorambucil with GSH by GST purified from human colon adenocarcinoma cells and its inhibition by plant polyphenols.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Chlorambucil; Chromatography, High Pressure Liqui | 2003 |
"SUPPRESSIVE" CHEMOTHERAPY IN BRONCHOGENIC CARCINOMA: A RANDOMIZED PROSPECTIVE CLINICAL TRIAL.
Topics: Adenocarcinoma; Biomedical Research; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; C | 1965 |
SUSTAINED PALLIATION IN OVARIAN CARCINOMA.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Carcinoma; Chlorambucil; Dysgerminoma; Female; Gr | 1965 |
CARCINOMA OF THE OVARY.
Topics: Adenocarcinoma; Chlorambucil; Dactinomycin; Drug Therapy; Female; Humans; Lung Neoplasms; Methotrexa | 1965 |
CHLORAMBUCIL IN THE TREATMENT OF PRIMARY ADENOCARCINOMA OF THE OVARY.
Topics: Adenocarcinoma; Chlorambucil; Drug Therapy; Female; Humans; Neoplasms, Glandular and Epithelial; Ova | 1965 |
A RETROSPECTIVE COMPARISON OF CHLORAMBUCIL AND RADIOTHERAPY IN THE TREATMENT OF OVARIAN ADENOCARCINOMA.
Topics: Adenocarcinoma; Carcinoma, Ovarian Epithelial; Chlorambucil; Drug Therapy; Female; Humans; Neoplasms | 1965 |
Disposition of orally administered 14C-prednimustine in cancer patients.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Carbon Radioisotopes; Chlorambucil; Colonic Neopl | 1983 |
A chlorambucil-anti-CEA conjugate cytotoxic for human colon adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Antibodies, Neoplasm; Carcinoembryonic Antigen; Cells, Cultured; Chlorambucil; Colon | 1984 |
Liver transplantation in patients with preexisting malignancy.
Topics: Adenocarcinoma; Adolescent; Adult; Carcinoma, Renal Cell; Child; Child, Preschool; Chlorambucil; Col | 1995 |
Development of bronchial adenocarcinoma 11 years after the onset of membranous nephropathy associated with chlorambucil therapy.
Topics: Adenocarcinoma; Adult; Bronchial Neoplasms; Chlorambucil; Glomerulonephritis, Membranous; Humans; Ma | 1995 |
Active transport of glutathione S-conjugate in human colon adenocarcinoma cells.
Topics: 2,4-Dinitrophenol; Adenocarcinoma; Adenosine Triphosphate; Antineoplastic Agents; Biological Transpo | 1996 |
Evaluation of gallium-67 in the diagnosis of bronchial carcinoma.
Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Chlorambucil; | 1976 |
Preliminary clinical study of prednimustine in lung cancer.
Topics: Adenocarcinoma; Aged; Carcinoma; Carcinoma, Squamous Cell; Chlorambucil; Female; Humans; Lung Neopla | 1977 |
[Combined leukeran-prednisolone therapy in metastasizing breast cancer].
Topics: Adenocarcinoma; Adult; Aged; Breast Neoplasms; Chlorambucil; Drug Therapy, Combination; Female; Huma | 1977 |
Sequential therapy for advanced ovarian adenocarcinoma: operation, chemotherapy, second-look laparotomy, and radiation therapy.
Topics: Adenocarcinoma; Chlorambucil; Cyclophosphamide; Dactinomycin; Female; Fluorouracil; Laparotomy; Melp | 1975 |
Combination chemotherapy tested in a short-term thymidine incorporation assay in primary cultures of ovarian adenocarcinomas.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cisplatin; Cyclophosph | 1992 |
Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Topics: Adenocarcinoma; Blotting, Northern; Cell Survival; Chlorambucil; Cisplatin; Drug Resistance; Glutath | 1990 |
Chlorambucil carcinogenesis in BALB/c mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Chlorambucil; Female; Incidence; Leukemia, Myeloid; L | 1990 |
Hypokalaemia and lactic acidosis in a patient with myelomonocytic leukemia.
Topics: Acidosis, Lactic; Adenocarcinoma; Chlorambucil; Female; Humans; Hypokalemia; Leukemia, Myelomonocyti | 1990 |
Effects of DFMO-induced polyamine depletion on human tumor cell sensitivity to antineoplastic DNA-crosslinking drugs.
Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Cell Line; Cell Survival; Chlorambucil; DN | 1986 |
Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Chlorambucil; Colonic Neoplasms; Dacarbaz | 1987 |
[A case of breast carcinoma with lung metastasis].
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Chlorambucil; Drug Evaluation; Estradiol; Female; Humans; L | 1987 |
[Two cases of recurrent breast carcinoma achieving CR (complete response) with KM2210].
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Papillary; Chlorambucil; Drug Combinations; Drug Evalua | 1987 |
Responses of freshly cultured tumour cells to certain selected chemotherapeutic agents.
Topics: Adenocarcinoma; Antineoplastic Agents; Chlorambucil; Colchicine; Culture Techniques; Cyclophosphamid | 1968 |
Cancer chemotherapy in urology.
Topics: Adenocarcinoma; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Cobal | 1971 |
Integrated therapy in the treatment of ovarian cancer with surgery, radiation and chemotherapy.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Chlorambucil; Cobalt Isotopes; Cyclophosphamide; | 1972 |
Advanced ovarian cancer: primary treatment with surgery, radiotherapy, and chemotherapy.
Topics: Adenocarcinoma; Carcinoma; Chlorambucil; Cyclophosphamide; Female; Humans; Nitrogen Mustard Compound | 1972 |
Chemotherapy in the management of metastatic cancer of unknown primary site.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Chlorambucil; Cyclopho | 1972 |
[New formation of malignant tumors during cytostatic therapy. Case report].
Topics: Adenocarcinoma; Adrenal Cortex Hormones; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Chlo | 1971 |
Successful treatment of inoperable hypernephroma in childhood.
Topics: Adenocarcinoma; Adolescent; Chlorambucil; Dactinomycin; Humans; Kidney Neoplasms; Lymph Node Excisio | 1970 |
[A method of primary selection of antitumor agents].
Topics: Adenocarcinoma; Animals; Carcinoma 256, Walker; Chlorambucil; Cyclophosphamide; Melphalan; Mercaptop | 1971 |
[Internal cancer therapy: cooperative clinical studies. Principles, organization and first results of the Swiss chemotherapy group].
Topics: Adenocarcinoma; Androgens; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Car | 1967 |
Recurrent leukaemoid reaction in pernicious anaemia complicated by gastric carcinoma.
Topics: Adenocarcinoma; Anemia, Pernicious; Chlorambucil; Chronic Disease; Diagnosis, Differential; Female; | 1969 |