chlorambucil has been researched along with Adamantiades-Behcet Disease in 60 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Excerpt | Relevance | Reference |
---|---|---|
"To evaluate the effects of short-term chlorambucil therapy in the management of uveitis due to Behcet's disease." | 9.09 | Short-term chlorambucil for refractory uveitis in Behcet's disease. ( Arslan, MO; Burumcek, EY; Durlu, Y; Ergen, A; Ipcioglu, SU; Mudun, BA, 2001) |
"A patient with Behcet's syndrome in whom multiple pulmonary artery aneurysms were completely resolved after a combined treatment with corticosteroid and chlorambucil is reported." | 7.69 | Effects of corticosteroid and chlorambucil on multiple pulmonary artery aneurysms in Behcet's syndrome. A case report. ( Jung, TH; Kim, NS; Lee, JM; Park, JG; Park, JY; Won, JH, 1995) |
"Treatment with chlorambucil, 0." | 5.27 | Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease. ( Goldstein, NP; O'Duffy, JD; Robertson, DM, 1984) |
"To evaluate the effects of short-term chlorambucil therapy in the management of uveitis due to Behcet's disease." | 5.09 | Short-term chlorambucil for refractory uveitis in Behcet's disease. ( Arslan, MO; Burumcek, EY; Durlu, Y; Ergen, A; Ipcioglu, SU; Mudun, BA, 2001) |
" We recently observed a 39-year-old female patient with Behçet's disease developing a myelodysplastic syndrome (MDS) FAB subtype refractory anemia with excess of blasts in transformation [RAEB-t] with a monosomy 7 after being treated with cyclosporin A and chlorambucil for several years." | 3.70 | Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease. ( Bangerter, M; Griesshammer, M; Hafner, M; Heil, G; Heiss, M; Kern, P; Kern, W; Krauter, J; v Tirpitz, C, 1999) |
"A patient with Behcet's syndrome in whom multiple pulmonary artery aneurysms were completely resolved after a combined treatment with corticosteroid and chlorambucil is reported." | 3.69 | Effects of corticosteroid and chlorambucil on multiple pulmonary artery aneurysms in Behcet's syndrome. A case report. ( Jung, TH; Kim, NS; Lee, JM; Park, JG; Park, JY; Won, JH, 1995) |
" In 1976 she developed a mixed cryoglobulinemia and an immune complex mediated vasculitis manifested by purpura and neuropathy which improved on prednisone and chlorambucil therapy." | 3.66 | Behçet's disease associated with a lymphoproliferative disorder, mixed cryoglobulinemia, and an immune complex mediated vasculitis. ( Houston, KA; McDuffie, FC; O'duffy, JD, 1978) |
" However, tight and constant control of the CsA dosage as performed in this study has, so far, prevented clinical and biochemical nephrotoxic manifestations in patients assigned to this treatment." | 2.66 | Evaluation of conventional therapy versus cyclosporine A in Behçet's syndrome. ( BenEzra, D; Chajek, T; Cohen, E; de Courten, C; Friedman, G; Harris, W; Pizanti, S, 1988) |
"Five patients with Behcet's disease in the active and progressive stages were treated with chlorambucil (Leukeran)." | 2.64 | Treatment of Behcet's disease with chlorambucil. ( Tricoulis, D, 1976) |
"If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease." | 2.37 | Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986) |
"Treatment with chlorambucil was started in the early 1990s and continued for a period of 9 1/2 and 3(3/4) years, respectively, with the symptoms remitting during and after this therapy." | 1.36 | [Chlorambucil treatment of Behçet's syndrome. Retrospective evaluation of two cases]. ( Eichhorn, A; Kirch, W; Siepmann, M, 2010) |
"Behcet's syndrome, or Behcet's disease (BD), is a multisystem pathology, and survival is related to pulmonary involvement." | 1.35 | [Pulmonary involvement in Behcet's disease: a positive single-center experience with the use of immunosuppressive therapy]. ( Antunes, T; Barbas, CS; Barros, JM; Carvalho, CR; Kairalla, RA; Santana, AN, 2008) |
"Uveitis was total in 72% of cases." | 1.29 | [Outcome of Behçet disease in ophthalmologic practice in Morocco]. ( Benchekroun, N; Berraho-Hamani, A; Chaoui, Z; el Aouni, A; Hajji, Z; Ouazzani, B, 1995) |
"Treatment with chlorambucil, 0." | 1.27 | Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease. ( Goldstein, NP; O'Duffy, JD; Robertson, DM, 1984) |
"18 patients suffering from Behcet's disease were treated with chlorambucil." | 1.26 | [Immunosuppressive therapy of Behcet's syndrome. Long term follow-up evaluation (author's transl)]. ( Bonnet, M, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 43 (71.67) | 18.7374 |
1990's | 12 (20.00) | 18.2507 |
2000's | 4 (6.67) | 29.6817 |
2010's | 1 (1.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Santana, AN | 1 |
Antunes, T | 1 |
Barros, JM | 1 |
Kairalla, RA | 1 |
Carvalho, CR | 1 |
Barbas, CS | 1 |
Eichhorn, A | 1 |
Siepmann, M | 1 |
Kirch, W | 3 |
Palmer, RG | 1 |
Doré, CJ | 1 |
Denman, AM | 1 |
Elliott, JH | 1 |
Ballinger, WH | 1 |
Lardenet, F | 1 |
You, B | 1 |
Quercia, P | 1 |
Schooneman, F | 1 |
Raspiller, A | 1 |
O'Connor, GR | 2 |
Tabbara, KF | 1 |
O'Duffy, JD | 2 |
Robertson, DM | 1 |
Goldstein, NP | 1 |
Palimeris, G | 1 |
Koliopoulos, J | 1 |
Theodossiadis, G | 1 |
Roussos, J | 1 |
Tsimbidas, P | 1 |
Niessen, F | 1 |
Campinchi, R | 1 |
Bloch-Michel, E | 1 |
Bonnet, M | 4 |
Ouazzani, B | 1 |
Benchekroun, N | 1 |
el Aouni, A | 1 |
Hajji, Z | 1 |
Chaoui, Z | 1 |
Berraho-Hamani, A | 1 |
Janssen, MJ | 1 |
Donker, AJ | 1 |
Mateos-Colino, A | 1 |
Gonzalez-Gay, MA | 1 |
Cereijo, MJ | 1 |
Santiago, J | 1 |
Rabuñal, R | 1 |
Brañas, F | 1 |
Park, JY | 1 |
Park, JG | 1 |
Won, JH | 1 |
Lee, JM | 1 |
Kim, NS | 1 |
Jung, TH | 1 |
Bangerter, M | 1 |
Griesshammer, M | 1 |
v Tirpitz, C | 1 |
Krauter, J | 1 |
Heil, G | 1 |
Hafner, M | 1 |
Kern, W | 1 |
Heiss, M | 1 |
Kern, P | 1 |
Kaklamani, VG | 1 |
Kaklamanis, PG | 1 |
Sirianni, MC | 1 |
Barbone, B | 1 |
Monarca, B | 1 |
Nanni, M | 1 |
Laganà, B | 1 |
Aiuti, F | 1 |
Mudun, BA | 1 |
Ergen, A | 1 |
Ipcioglu, SU | 1 |
Burumcek, EY | 1 |
Durlu, Y | 1 |
Arslan, MO | 1 |
Bietti, GB | 1 |
Cerulli, L | 1 |
Pivetti-Pezzi, P | 1 |
BenEzra, D | 4 |
Nussenblatt, R | 1 |
James, DG | 1 |
Wolf, RE | 1 |
Fudenberg, HH | 1 |
Welch, TM | 1 |
Spitler, LE | 1 |
Ziff, M | 1 |
Dodson, MG | 1 |
Klegerman, ME | 1 |
Kerman, RH | 1 |
Lange, CF | 1 |
Tessler, HH | 2 |
O'Leary, JA | 1 |
Bonamour, G | 1 |
Houston, KA | 1 |
McDuffie, FC | 1 |
Frayha, RA | 1 |
Nasr, FW | 1 |
Ardouin, M | 1 |
Urvoy, M | 1 |
Perraut, JP | 1 |
Tricoulis, D | 1 |
Dinning, WJ | 2 |
Perkins, ES | 1 |
Smulders, FM | 1 |
Oosterhuis, JA | 1 |
Mamo, JG | 2 |
Clunie, GP | 1 |
Nüssel, F | 1 |
Wegmüller, H | 1 |
Laseyras, F | 1 |
Posse, S | 1 |
Herschkowitz, N | 1 |
Huber, P | 1 |
Amrom, D | 1 |
Buisseret, T | 1 |
Elidan, J | 1 |
Levi, H | 1 |
Cohen, E | 3 |
Schilling, H | 1 |
Bornfeld, N | 1 |
Windeck, R | 1 |
Wessing, A | 1 |
Woodrow, JC | 1 |
Graham, DR | 1 |
Evans, CC | 1 |
Jennings, T | 1 |
Clements, PJ | 1 |
Davis, J | 1 |
Leavitt, RY | 1 |
Fauci, AS | 1 |
Zelenski, JD | 1 |
Capraro, JA | 1 |
Holden, D | 1 |
Calabrese, LH | 1 |
Rimon, D | 1 |
Lahat, N | 1 |
Nir, E | 1 |
Cohen, L | 1 |
Pivetti Pezzi, P | 2 |
Catarinelli, G | 2 |
Paroli, MP | 1 |
Chajek, T | 1 |
Friedman, G | 1 |
Pizanti, S | 1 |
de Courten, C | 1 |
Harris, W | 1 |
Dührsen, U | 1 |
Ranselaar, CG | 1 |
Boone, RM | 1 |
Kluin-Nelemans, HC | 1 |
Hamza, MH | 1 |
Michels, SD | 1 |
McKenna, RW | 1 |
Arthur, DC | 1 |
Brunning, RD | 1 |
Gasparri, V | 1 |
De Liso, P | 1 |
Voipio-Pulkki, LM | 1 |
Nikoskelainen, J | 1 |
Nikoskelainen, E | 1 |
Repo, H | 1 |
Plotkin, GR | 1 |
Patel, BR | 1 |
Shah, VN | 1 |
Godfrey, WA | 1 |
Epstein, WV | 1 |
Kimura, SJ | 1 |
Hogan, MJ | 1 |
Nozik, RA | 1 |
Abdalla, MI | 1 |
el-D Bahoat, N | 1 |
Témime, P | 1 |
Bérard, P | 1 |
Privat, Y | 1 |
Oddoze, L | 1 |
Marchand, JP | 1 |
Azzam, SA | 1 |
5 reviews available for chlorambucil and Adamantiades-Behcet Disease
Article | Year |
---|---|
Behçet's disease and immunosuppressive treatment. Our personal experience.
Topics: Antilymphocyte Serum; Behcet Syndrome; Chlorambucil; Female; gamma-Globulins; Humans; Immunosuppress | 1976 |
Ocular manifestations of Behçet's disease.
Topics: Behcet Syndrome; Chlorambucil; Humans; Vision Disorders | 1978 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
Pulmonary vasculitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy | 1986 |
[Immunodepressors in ophthalmology].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antibiotics, Antineoplastic; Antilymphocyte Se | 1971 |
4 trials available for chlorambucil and Adamantiades-Behcet Disease
Article | Year |
---|---|
Short-term chlorambucil for refractory uveitis in Behcet's disease.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Child; Chlorambucil; Female; | 2001 |
Treatment of Behcet's disease with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Clinical Trials as Topic; Humans; Male; Middle Aged; Remission | 1976 |
Effect of cyclosporine A on the hearing loss in Behçet's disease.
Topics: Acoustic Impedance Tests; Adolescent; Adult; Audiometry, Evoked Response; Audiometry, Speech; Behcet | 1991 |
Evaluation of conventional therapy versus cyclosporine A in Behçet's syndrome.
Topics: Adrenal Cortex Hormones; Behcet Syndrome; Chlorambucil; Cyclosporins; Drug Evaluation; Humans; Rando | 1988 |
51 other studies available for chlorambucil and Adamantiades-Behcet Disease
Article | Year |
---|---|
[Pulmonary involvement in Behcet's disease: a positive single-center experience with the use of immunosuppressive therapy].
Topics: Adult; Aneurysm; Anti-Inflammatory Agents; Behcet Syndrome; Chlorambucil; Female; Hemorrhage; Humans | 2008 |
[Chlorambucil treatment of Behçet's syndrome. Retrospective evaluation of two cases].
Topics: Behcet Syndrome; Chlorambucil; Erythema Nodosum; Humans; Prednisone; Retrospective Studies | 2010 |
Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.
Topics: Adult; Behcet Syndrome; Chlorambucil; Chromosomes, Human; Dose-Response Relationship, Drug; Female; | 1984 |
Behçet's syndrome: treatment with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Female; Humans; Male; Middle Aged; Time Factors; Visual Acuity | 1984 |
[Behçet's disease: our experience with plasma exchange. Apropos of 7 cases].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Behcet Syndrome; Chlorambucil; Female; Humans; Male; Pla | 1983 |
Behçet's disease.
Topics: Adrenal Cortex Hormones; Behcet Syndrome; Chlorambucil; Female; Genetics; Humans; Immunosuppressive | 1983 |
Chlorambucil in Behçet's disease. A reappraisal.
Topics: Adolescent; Adult; Atrophy; Behcet Syndrome; Chlorambucil; Drug Administration Schedule; Humans; Mal | 1983 |
Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Behcet Syndrome; Chlorambucil; Female; Humans; Male; Men | 1984 |
The Adamantiadis-Behçet syndrome. Clinical and immunological observations.
Topics: Adolescent; Adult; Azathioprine; Behcet Syndrome; Child, Preschool; Chlorambucil; Complement C3; Fem | 1980 |
[Value and complications of immunosuppressive therapy in uveitis of Behcet's disease or of other etiology. Apropos of 40 cases].
Topics: Adult; Aged; Azathioprine; Behcet Syndrome; Child; Chlorambucil; Drug Therapy, Combination; Female; | 1982 |
[Immunosuppressive therapy of Behcet's syndrome. Long term follow-up evaluation (author's transl)].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Antilymphocyte Serum; Behcet Syndrome; Blindness; | 1981 |
[Evaluation of immunosuppressives in Behçet's syndrome].
Topics: Anemia, Aplastic; Antilymphocyte Serum; Behcet Syndrome; Chlorambucil; Eye Diseases; Humans; Immunos | 1981 |
[Outcome of Behçet disease in ophthalmologic practice in Morocco].
Topics: Adult; Behcet Syndrome; Chlorambucil; Cyclosporine; Eye Diseases; Female; Humans; Male; Morocco; Pre | 1995 |
[Behçet's disease].
Topics: Adult; Azathioprine; Behcet Syndrome; Chlorambucil; Drug Therapy, Combination; Humans; Male; Prednis | 1994 |
[Neuro-Behçet: a follow-up of 4 cases treated with chlorambucil].
Topics: Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Brain Diseases; Chlorambucil; Drug Therap | 1995 |
Effects of corticosteroid and chlorambucil on multiple pulmonary artery aneurysms in Behcet's syndrome. A case report.
Topics: Aneurysm; Behcet Syndrome; Chlorambucil; Drug Therapy, Combination; Humans; Male; Prednisone; Pulmon | 1995 |
Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet's disease.
Topics: Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Bone Marrow Cells; Chlorambucil; Chromoso | 1999 |
Treatment of Behçet's disease--an update.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Behcet Syndrome; Chl | 2001 |
A case of Behćet's disease complicated by visceral Leishmaniasis and myelodysplasia: clinical considerations.
Topics: Adult; Antineoplastic Agents, Alkylating; Autoimmune Diseases; Behcet Syndrome; Chlorambucil; Humans | 2001 |
Behcet's syndrome.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antigen-Antibody Complex; Azathioprine; Behcet Syndrome; | 1979 |
Treatment of Bechçet's syndrome with transfer factor.
Topics: Adult; Behcet Syndrome; Chlorambucil; Drug Interactions; Female; Humans; Male; Middle Aged; Predniso | 1977 |
Behcet syndrome: with immunologic evaluation.
Topics: Adult; Behcet Syndrome; Chlorambucil; Female; Follow-Up Studies; Humans; Immunoglobulins; Prednisone | 1978 |
[Immunosuppressive agents and Behçet's syndrome: critical analysis of results].
Topics: Antilymphocyte Serum; Behcet Syndrome; Chlorambucil; Drug Administration Schedule; Follow-Up Studies | 1978 |
Behçet's disease associated with a lymphoproliferative disorder, mixed cryoglobulinemia, and an immune complex mediated vasculitis.
Topics: Antigen-Antibody Complex; Behcet Syndrome; Chlorambucil; Cryoglobulins; Female; Follow-Up Studies; H | 1978 |
Erythema nodosum-arthopathy complex as an initial presentation of Behçet's disease. Report of five cases.
Topics: Adult; Arthritis; Behcet Syndrome; Chlorambucil; Erythema Nodosum; Humans; Male; Prednisone | 1978 |
[Pars planitis and Behçet's syndrome].
Topics: Adult; Behcet Syndrome; Chlorambucil; Ciliary Body; Humans; Male; Uveitis | 1978 |
Management of chronic uveitis.
Topics: Behcet Syndrome; Chlorambucil; Chronic Disease; Follow-Up Studies; Humans; Uveitis | 1976 |
Immunosuppressives in uveitis. A preliminary report of experience with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Endophthalmitis; Female; Follow-Up Studies; Humans; Leukopenia | 1975 |
Treatment of Behcet's disease with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Fluorescein Angiography; Humans; Male | 1975 |
Treatment of Behcet disease with chlorambucil. A follow-up report.
Topics: Adult; Behcet Syndrome; Chlorambucil; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; M | 1976 |
Behçet's disease.
Topics: Behcet Syndrome; Chlorambucil; Humans | 1992 |
Neuro-Behçet: acute and sequential aspects by MRI and MRS.
Topics: Adrenal Cortex Hormones; Adult; Aspartic Acid; Behcet Syndrome; Brain; Chlorambucil; Cyclophosphamid | 1991 |
Clinical-radiological correlation in the evolution of a neuro-Behçet's syndrome: case report.
Topics: Adult; Behcet Syndrome; Brain; Chlorambucil; Cyclosporine; Drug Therapy, Combination; Encephalitis; | 1991 |
[Cytostatic and immunosuppressive treatment of ocular Behçet syndrome].
Topics: Acyclovir; Adult; Antineoplastic Agents; Behcet Syndrome; Chlorambucil; Cyclophosphamide; Cyclospori | 1990 |
Behçet's syndrome in HLA-identical siblings.
Topics: Adult; Behcet Syndrome; Chlorambucil; Eye Diseases; HLA Antigens; Humans; Pedigree; Prednisolone; Pu | 1990 |
High-dose short-term chlorambucil for intractable sympathetic ophthalmia and Behçet's disease.
Topics: Adolescent; Adult; Behcet Syndrome; Child; Chlorambucil; Drug Administration Schedule; Female; Human | 1990 |
Central nervous system vasculitis in Behçet's syndrome: angiographic improvement after therapy with cytotoxic agents.
Topics: Adult; Antineoplastic Agents; Behcet Syndrome; Cerebral Angiography; Cerebrovascular Disorders; Chlo | 1989 |
Behçet's disease: clinical and immunological response to immunosuppressive therapy. A case report.
Topics: Adult; B-Lymphocytes; Behcet Syndrome; Chlorambucil; Humans; Immunosuppressive Agents; Leukocyte Cou | 1985 |
[Immunosuppressors in Behçet's disease].
Topics: Adult; Behcet Syndrome; Chlorambucil; Drug Administration Schedule; Humans; Immunosuppressive Agents | 1986 |
Therapeutic rounds.
Topics: Adult; Behcet Syndrome; Chlorambucil; Female; Humans; Stanozolol | 1986 |
Treatment and visual prognosis in Behçet's disease.
Topics: Azathioprine; Behcet Syndrome; Chlorambucil; Colchicine; Female; Humans; Male; Prednisone; Prognosis | 1986 |
Thalidomide in the treatment of neuro-Behçet's syndrome.
Topics: Adult; Behcet Syndrome; Chlorambucil; Drug Therapy, Combination; Humans; Male; Nervous System Diseas | 1986 |
Cancer complicating Behçet's disease treated with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Humans; Male; Neoplasms | 1986 |
Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Behcet Syndrome; Bone Marrow; Carcinoma; Child; Chil | 1985 |
Prognosis in Behcet's disease.
Topics: Adolescent; Adult; Behcet Syndrome; Central Nervous System Diseases; Chlorambucil; Eye Diseases; Fem | 1985 |
[Behçet's disease].
Topics: Adult; Behcet Syndrome; Chlorambucil; Drug Therapy, Combination; Humans; Male; Prednisone | 1985 |
Behçet's syndrome complicated by cutaneous leukocytoclastic vasculitis. Response to prednisone and chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Humans; Leg Ulcer; Male; Prednisone; Vasculitis, Leukocytoclas | 1985 |
The use of chlorambucil in intractable idiopathic uveitis.
Topics: Adolescent; Arthritis, Rheumatoid; Behcet Syndrome; Blood Cell Count; Blood Platelets; Chemical Phen | 1974 |
Long-lasting remission of Behcet's disease after chlorambucil therapy.
Topics: Adrenal Cortex Hormones; Adult; Arthritis; Behcet Syndrome; Chlorambucil; Erythema Nodosum; Female; | 1973 |
[Behcet syndrome treated with chlorambucil].
Topics: Adult; Behcet Syndrome; Chlorambucil; Humans; Male | 1969 |
Treatment of Behçet's disease with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Follow-Up Studies; Humans; Male; Prognosis; Time Factors | 1970 |