chlorambucil has been researched along with Acute Liver Injury, Drug-Induced in 11 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multicentric histiocytosis is a rare systemic disease with active episodes and prolonged periods of remission." | 1.29 | [Multicenter histiocytosis]. ( Bazex, J; Gorguet, B; Grolleau-Rochiccioli, P; Laplanche, G; Manzur, F; Schmitt, AM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Schmitt, AM | 1 |
| Grolleau-Rochiccioli, P | 1 |
| Laplanche, G | 1 |
| Gorguet, B | 1 |
| Manzur, F | 1 |
| Bazex, J | 1 |
| Pispirigos, K | 1 |
| Catsoulakos, P | 1 |
| Karakiulakis, G | 1 |
| Pichon, N | 1 |
| Debette-Gratien, M | 1 |
| Cessot, F | 1 |
| Paraf, F | 1 |
| Labrousse, F | 1 |
| Sautereau, D | 1 |
| Pillegand, B | 1 |
| Clements, PJ | 1 |
| Davis, J | 1 |
| Konrad, H | 1 |
| Engelmann, C | 1 |
| Zubaidi, G | 1 |
| Robert, J | 1 |
| Barbier, P | 1 |
| Manaster, J | 1 |
| Jacobs, E | 1 |
2 reviews available for chlorambucil and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Cytotoxic drugs: their clinical application to the rheumatic diseases.
Topics: Arthritis; Arthritis, Rheumatoid; Azathioprine; Behcet Syndrome; Bone Marrow; Cell Division; Chemica | 1986 |
9 other studies available for chlorambucil and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
[Multicenter histiocytosis].
Topics: Adult; Arthritis; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Histiocyto | 1994 |
Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransfera | 1993 |
[Acute cholestatic hepatitis due to chlorambucil].
Topics: Acute Disease; Aged; Antineoplastic Agents, Alkylating; Biopsy, Needle; Chemical and Drug Induced Li | 2001 |
[Cytostatic therapy of lymphogranulomatosis].
Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambucil; Cyclophosphamide; Cysti | 1972 |
[Hepatotoxicity of antimitotic treatments. Effect of hepatic tests].
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Chlorambu | 1968 |